Brent William Weyers

Title(s)Researcher, Biomedical Engineering
SchoolCollege of Engineering
Emailbwweyers@ucdavis.edu
ORCID ORCID Icon0000-0002-1939-3401 Additional info
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    University of California, Davis, DavisPh.D.Biomedical Engineering

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    Brent Weyers is currently a post-doctoral researcher in the Marcu Laboratory at the University of California Davis. In June 2022, Brent received his PhD from UC Davis in the Department of Biomedical Engineering. He also holds a credential as a Certified Associate in Project Management (CAPM).

    Brent's doctoral research investigated the use of Fluorescence lifetime imaging to optimize upper aerodigestive oncologic surgery through real-time surgical margin delineation. This work was motivated by the understanding that successful surgical oncology outcomes depend on a surgeon's ability to completely extirpate the full extent of a patient’s cancer volume, both gross and microscopic. Currently, there is a lack of technology capable of providing surgeons with real-time feedback to quantify the extent of tumor; therefore, cancer may be missed, or surgeons may potentially compromise benign tissue.

    Brent's research investigated head & neck cancer from N=100 human patients, comprising N=45 patients with oral cavity cancer and N=55 patients with cancer of the oropharynx. This work demonstrated the ability for FLIm to integrate into classification algorithms to predict cancer probability; the technique was successful at demarcating both conventional primary and elusive occult primary tumors. This research involved translational aspects, requiring the coordination of research activities, and the establishment of validation, across clinical and engineering teams. Collectively, this investigation established proof-of-concept for optimizing surgical decision-making, thereby motivating further investigation to materialize this technology towards an intraoperative diagnostic modality.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Intraoperative delineation of p16+ oropharyngeal carcinoma of unknown primary origin with fluorescence lifetime imaging: Preliminary report. Head Neck. 2022 08; 44(8):1765-1776. Weyers BW, Birkeland AC, Marsden MA, Tam A, Bec J, Frusciante RP, Gui D, Bewley AF, Abouyared M, Marcu L, Farwell DG. PMID: 35511208.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Mesoscopic fluorescence lifetime imaging: Fundamental principles, clinical applications and future directions. J Biophotonics. 2021 06; 14(6):e202000472. Alfonso-Garcia A, Bec J, Weyers B, Marsden M, Zhou X, Li C, Marcu L. PMID: 33710785; PMCID: PMC8579869.
      View in: PubMed   Mentions: 1     Fields:    
    3. Intraoperative Margin Assessment in Oral and Oropharyngeal Cancer Using Label-Free Fluorescence Lifetime Imaging and Machine Learning. IEEE Trans Biomed Eng. 2021 03; 68(3):857-868. Marsden M, Weyers BW, Bec J, Sun T, Gandour-Edwards RF, Birkeland AC, Abouyared M, Bewley AF, Farwell DG, Marcu L. PMID: 32746066; PMCID: PMC8960054.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    4. FLImBrush: dynamic visualization of intraoperative free-hand fiber-based fluorescence lifetime imaging. Biomed Opt Express. 2020 Sep 01; 11(9):5166-5180. Marsden M, Fukazawa T, Deng YC, Weyers BW, Bec J, Gregory Farwell D, Marcu L. PMID: 33014606; PMCID: PMC7510860.
      View in: PubMed   Mentions: 7  
    5. Fluorescence lifetime imaging for intraoperative cancer delineation in transoral robotic surgery. Transl Biophotonics. 2019 Dec; 1(1-2). Weyers BW, Marsden M, Sun T, Bec J, Bewley AF, Gandour-Edwards RF, Moore MG, Farwell DG, Marcu L. PMID: 32656529; PMCID: PMC7351319.
      View in: PubMed   Mentions: 7  
    6. Simultaneous intraluminal imaging of tissue autofluorescence and eGFP-labeled cells in engineered vascular grafts inside a bioreactor. Methods Appl Fluoresc. 2019 Sep 20; 7(4):044003. Li C, Alfonso-Garcia A, McMasters J, Bec J, Weyers B, Uyesaka L, Griffiths L, Panitch A, Marcu L. PMID: 31505471; PMCID: PMC7539617.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Multi-dimensional studies of synthetic genetic promoters enabled by microfluidic impact printing. Lab Chip. 2017 06 27; 17(13):2198-2207. Fan J, Villarreal F, Weyers B, Ding Y, Tseng KH, Li J, Li B, Tan C, Pan T. PMID: 28613297; PMCID: PMC5572659.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    8. Deletion of the cytoplasmic domain of N-cadherin reduces, but does not eliminate, traction force-transmission. Biochem Biophys Res Commun. 2016 09 30; 478(4):1640-6. Lee E, Ewald ML, Sedarous M, Kim T, Weyers BW, Truong RH, Yamada S. PMID: 27596967; PMCID: PMC5030185.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells