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Discovery, Design, and Structural Characterization of Alkane-Producing Enzymes across the Ferritin-like Superfamily. Biochemistry. 2020 10 13; 59(40):3834-3843.
Mak WS, Wang X, Arenas R, Cui Y, Bertolani S, Deng WQ, Tagkopoulos I, Wilson DK, Siegel JB. PMID: 32935984.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Conformational flexibility related to enzyme activity: evidence for a dynamic active-site gatekeeper function of Tyr(215) in Aerococcus viridans lactate oxidase. Sci Rep. 2016 06 15; 6:27892.
Stoisser T, Brunsteiner M, Wilson DK, Nidetzky B. PMID: 27302031; PMCID: PMC4908395.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Speeding up the product release: a second-sphere contribution from Tyr191 to the reactivity of L-lactate oxidase revealed in crystallographic and kinetic studies of site-directed variants. FEBS J. 2015 Nov; 282(21):4130-40.
Stoisser T, Klimacek M, Wilson DK, Nidetzky B. PMID: 26260739.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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The Ala95-to-Gly substitution in Aerococcus viridans l-lactate oxidase revisited - structural consequences at the catalytic site and effect on reactivity with O2 and other electron acceptors. FEBS J. 2015 Feb; 282(3):562-78.
Stoisser T, Rainer D, Leitgeb S, Wilson DK, Nidetzky B. PMID: 25423902.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Identification, characterization, and crystal structure of an aldo-keto reductase (AKR2E4) from the silkworm Bombyx mori. Arch Biochem Biophys. 2013 Oct 15; 538(2):156-63.
Yamamoto K, Wilson DK. PMID: 24012638.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Crystallographic observation of pH-induced conformational changes in the Amyelois transitella pheromone-binding protein AtraPBP1. PLoS One. 2013; 8(2):e53840.
di Luccio E, Ishida Y, Leal WS, Wilson DK. PMID: 23418423; PMCID: PMC3572114.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Comprehensive X-ray structural studies of the quinolinate phosphoribosyl transferase (BNA6) from Saccharomyces cerevisiae. Biochemistry. 2008 Apr 01; 47(13):4039-50.
di Luccio E, Wilson DK. PMID: 18321072.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Identification of formyl kynurenine formamidase and kynurenine aminotransferase from Saccharomyces cerevisiae using crystallographic, bioinformatic and biochemical evidence. Biochemistry. 2008 Feb 12; 47(6):1608-21.
Wogulis M, Chew ER, Donohoue PD, Wilson DK. PMID: 18205391.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies. Biochem J. 2006 Nov 15; 400(1):105-14.
Di Luccio E, Elling RA, Wilson DK. PMID: 16813561; PMCID: PMC1635432.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Structural and kinetic studies of induced fit in xylulose kinase from Escherichia coli. J Mol Biol. 2007 Jan 19; 365(3):783-98.
Di Luccio E, Petschacher B, Voegtli J, Chou HT, Stahlberg H, Nidetzky B, Wilson DK. PMID: 17123542; PMCID: PMC1995121.
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PubMed Mentions:
24 Fields:
Translation:
Cells
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Catalytic mechanism and substrate selectivity of aldo-keto reductases: insights from structure-function studies of Candida tenuis xylose reductase. IUBMB Life. 2006 Sep; 58(9):499-507.
Kratzer R, Wilson DK, Nidetzky B. PMID: 17002977.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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On-bead combinatorial techniques for the identification of selective aldose reductase inhibitors. Bioorg Med Chem. 2006 Dec 01; 14(23):7728-35.
Robins LI, Dixon SM, Wilson DK, Kurth MJ. PMID: 16931029.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta. Biochemistry. 2006 Apr 04; 45(13):4045-57.
Wogulis M, Wheelock CE, Kamita SG, Hinton AC, Whetstone PA, Hammock BD, Wilson DK. PMID: 16566578; PMCID: PMC4275126.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Structure-guided engineering of xylitol dehydrogenase cosubstrate specificity. Structure. 2006 Mar; 14(3):567-75.
Ehrensberger AH, Elling RA, Wilson DK. PMID: 16531240.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Probing the substrate binding site of Candida tenuis xylose reductase (AKR2B5) with site-directed mutagenesis. Biochem J. 2006 Jan 01; 393(Pt 1):51-8.
Kratzer R, Leitgeb S, Wilson DK, Nidetzky B. PMID: 16336198; PMCID: PMC1383663.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism. Biochem Biophys Res Commun. 2006 Jan 06; 339(1):157-64.
Wogulis M, Morgan T, Ishida Y, Leal WS, Wilson DK. PMID: 16300742.
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PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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The structure of Sif2p, a WD repeat protein functioning in the SET3 corepressor complex. J Mol Biol. 2005 Aug 26; 351(4):923-35.
Cerna D, Wilson DK. PMID: 16051270.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Discovery of selective aldo-keto reductase ligands--an on-bead assay strategy. Bioorg Med Chem Lett. 2005 Jun 02; 15(11):2938-42.
Dixon S, Robins L, Elling RA, Liu R, Lam KS, Wilson DK, Kurth MJ. PMID: 15911284.
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PubMed Mentions: Fields:
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Fine tuning of coenzyme specificity in family 2 aldo-keto reductases revealed by crystal structures of the Lys-274-->Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NAD+ and NADP+. FEBS Lett. 2005 Jan 31; 579(3):763-7.
Leitgeb S, Petschacher B, Wilson DK, Nidetzky B. PMID: 15670843.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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The 1.1-angstrom structure of the spindle checkpoint protein Bub3p reveals functional regions. J Biol Chem. 2005 Apr 08; 280(14):13944-51.
Wilson DK, Cerna D, Chew E. PMID: 15644329.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography. Biochem J. 2005 Jan 01; 385(Pt 1):75-83.
Petschacher B, Leitgeb S, Kavanagh KL, Wilson DK, Nidetzky B. PMID: 15320875; PMCID: PMC1134675.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure. Protein Sci. 2004 Jun; 13(6):1557-65.
Madrona AY, Wilson DK. PMID: 15152089; PMCID: PMC2279974.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Studies of the enzymic mechanism of Candida tenuis xylose reductase (AKR 2B5): X-ray structure and catalytic reaction profile for the H113A mutant. Biochemistry. 2004 May 04; 43(17):4944-54.
Kratzer R, Kavanagh KL, Wilson DK, Nidetzky B. PMID: 15109252.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Structural and catalytic diversity in the two family 11 aldo-keto reductases. J Mol Biol. 2004 Mar 26; 337(3):661-73.
Ehrensberger AH, Wilson DK. PMID: 15019785.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Structure of Toxoplasma gondii LDH1: active-site differences from human lactate dehydrogenases and the structural basis for efficient APAD+ use. Biochemistry. 2004 Feb 03; 43(4):879-89.
Kavanagh KL, Elling RA, Wilson DK. PMID: 14744130.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Juvenile hormone (JH) esterase: why are you so JH specific? Insect Biochem Mol Biol. 2003 Dec; 33(12):1261-73.
Kamita SG, Hinton AC, Wheelock CE, Wogulis MD, Wilson DK, Wolf NM, Stok JE, Hock B, Hammock BD. PMID: 14599498.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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On the role of Brønsted catalysis in Pseudomonas fluorescens mannitol 2-dehydrogenase. Biochem J. 2003 Oct 01; 375(Pt 1):141-9.
Klimacek M, Kavanagh KL, Wilson DK, Nidetzky B. PMID: 12826012; PMCID: PMC1223657.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases. Biochem J. 2003 Jul 15; 373(Pt 2):319-26.
Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK. PMID: 12733986; PMCID: PMC1223518.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization. J Biol Chem. 2003 Sep 05; 278(36):34373-9.
Voegtli WC, Madrona AY, Wilson DK. PMID: 12807914.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase: evidence for a very divergent long-chain dehydrogenase family. Chem Biol Interact. 2003 Feb 01; 143-144:551-8.
Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK. PMID: 12604241.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Pseudomonas fluorescens mannitol 2-dehydrogenase and the family of polyol-specific long-chain dehydrogenases/reductases: sequence-based classification and analysis of structure-function relationships. Chem Biol Interact. 2003 Feb 01; 143-144:559-82.
Klimacek M, Kavanagh KL, Wilson DK, Nidetzky B. PMID: 12604242.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Altering dimer contacts in xylose reductase from Candida tenuis by site-directed mutagenesis: structural and functional properties of R180A mutant. Chem Biol Interact. 2003 Feb 01; 143-144:523-32.
Klimacek M, Wührer F, Kavanagh KL, Wilson DK, Nidetzky B. PMID: 12604238.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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The xylose reductase (AKR2B5) structure: homology and divergence from other aldo-keto reductases and opportunities for protein engineering. Chem Biol Interact. 2003 Feb 01; 143-144:515-21.
Wilson DK, Kavanagh KL, Klimacek M, Nidetzky B. PMID: 12604237.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Expression, crystallization and activities of the two family 11 aldo-keto reductases from Bacillus subtilis. Acta Crystallogr D Biol Crystallogr. 2003 Feb; 59(Pt 2):375-7.
Ehrensberger A, Wilson DK. PMID: 12554958.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis. Biochemistry. 2002 Jul 16; 41(28):8785-95.
Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK. PMID: 12102621.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells