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Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway. Stem Cell Res Ther. 2022 05 26; 13(1):218.
Wu H, Tang X, Wang Y, Wang N, Chen Q, Xie J, Liu S, Zhong Z, Qiu Y, Situ P, Zern MA, Wang J, Chen H, Duan Y. PMID: 35619172; PMCID: PMC9137216.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway. J Nanobiotechnology. 2021 Dec 20; 19(1):437.
Wang N, Li X, Zhong Z, Qiu Y, Liu S, Wu H, Tang X, Chen C, Fu Y, Chen Q, Guo T, Li J, Zhang S, Zern MA, Ma K, Wang B, Ou Y, Gu W, Cao J, Chen H, Duan Y. PMID: 34930304; PMCID: PMC8686281.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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The combination of dextran sulphate and polyvinyl alcohol prevents excess aggregation and promotes proliferation of pluripotent stem cells in suspension culture. Cell Prolif. 2021 Sep; 54(9):e13112.
Tang X, Wu H, Xie J, Wang N, Chen Q, Zhong Z, Qiu Y, Wang J, Li X, Situ P, Lai L, Zern MA, Chen H, Duan Y. PMID: 34390064; PMCID: PMC8450127.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Corrigendum to Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms Cellular Signaling, 2007, 2339-2350, 07.013. Cell Signal. 2021 Apr; 80:109925.
Zhang Y, Venogopal SK, He S, Liu P, Wu J, Zern MA. PMID: 33495057.
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Salvianolic Acid B Enhances Hepatic Differentiation of Human Embryonic Stem Cells Through Upregulation of WNT Pathway and Inhibition of Notch Pathway. Stem Cells Dev. 2018 02 15; 27(4):252-261.
Chen J, Tschudy-Seney B, Ma X, Zern MA, Liu P, Duan Y. PMID: 29256825; PMCID: PMC5813732.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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The diversity and plasticity of adult hepatic progenitor cells and their niche. Liver Int. 2017 09; 37(9):1260-1271.
Chen J, Chen L, Zern MA, Theise ND, Diehl AM, Liu P, Duan Y. PMID: 28135758; PMCID: PMC5534384.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu. Sci Rep. 2016 Jan 06; 6:18841.
Chen J, Gao W, Zhou P, Ma X, Tschudy-Seney B, Liu C, Zern MA, Liu P, Duan Y. PMID: 26733102; PMCID: PMC4702137.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Inhibition of notch signaling pathway prevents cholestatic liver fibrosis by decreasing the differentiation of hepatic progenitor cells into cholangiocytes. Lab Invest. 2016 Mar; 96(3):350-60.
Zhang X, Du G, Xu Y, Li X, Fan W, Chen J, Liu C, Chen G, Liu C, Zern MA, Mu Y, Liu P. PMID: 26692291.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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CD34(+) Liver Cancer Stem Cells Were Formed by Fusion of Hepatobiliary Stem/Progenitor Cells with Hematopoietic Precursor-Derived Myeloid Intermediates. Stem Cells Dev. 2015 Nov 01; 24(21):2467-78.
Zeng C, Zhang Y, Park SC, Eun JR, Nguyen NT, Tschudy-Seney B, Jung YJ, Theise ND, Zern MA, Duan Y. PMID: 26192559; PMCID: PMC4620524.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Hepatic Progenitor Cells Contribute to the Progression of 2-Acetylaminofluorene/Carbon Tetrachloride-Induced Cirrhosis via the Non-Canonical Wnt Pathway. PLoS One. 2015; 10(6):e0130310.
Chen J, Zhang X, Xu Y, Li X, Ren S, Zhou Y, Duan Y, Zern M, Zhang H, Chen G, Liu C, Mu Y, Liu P. PMID: 26087010; PMCID: PMC4473299.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Clonogenically Culturing and Expanding CD34+ Liver Cancer Stem Cells in Vitro. Stem Cells Dev. 2015 Jul 01; 24(13):1506-14.
Park SC, Zeng C, Tschudy-Seney B, Nguyen NT, Eun JR, Zhang Y, Ramsamooj R, Zhang Y, Zhao M, Theise ND, Zhou H, Zern MA, Duan Y. PMID: 25867583; PMCID: PMC4499771.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Aberrant hedgehog signaling is responsible for the highly invasive behavior of a subpopulation of hepatoma cells. Oncogene. 2016 Jan 07; 35(1):116-24.
Fan YH, Ding J, Nguyen S, Liu XJ, Xu G, Zhou HY, Duan NN, Yang SM, Zern MA, Wu J. PMID: 25772244.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Identification of cancer stem cell subpopulations of CD34(+) PLC/PRF/5 that result in three types of human liver carcinomas. Stem Cells Dev. 2015 Apr 15; 24(8):1008-21.
Park SC, Nguyen NT, Eun JR, Zhang Y, Jung YJ, Tschudy-Seney B, Trotsyuk A, Lam A, Ramsamooj R, Zhang Y, Theise ND, Zern MA, Duan Y. PMID: 25519836; PMCID: PMC4390116.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro. PLoS One. 2014; 9(11):e112698.
Gao W, Zhou P, Ma X, Tschudy-Seney B, Chen J, Magner NL, Revzin A, Nolta JA, Zern MA, Duan Y. PMID: 25393427; PMCID: PMC4231066.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Hepatoma SK Hep-1 cells exhibit characteristics of oncogenic mesenchymal stem cells with highly metastatic capacity. PLoS One. 2014; 9(10):e110744.
Eun JR, Jung YJ, Zhang Y, Zhang Y, Tschudy-Seney B, Ramsamooj R, Wan YJ, Theise ND, Zern MA, Duan Y. PMID: 25338121; PMCID: PMC4206444.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Insulin and IGFs enhance hepatocyte differentiation from human embryonic stem cells via the PI3K/AKT pathway. Stem Cells. 2013 Oct; 31(10):2095-103.
Magner NL, Jung Y, Wu J, Nolta JA, Zern MA, Zhou P. PMID: 23836547; PMCID: PMC7593984.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells. Stem Cells Transl Med. 2013 Jun; 2(6):409-19.
Ma X, Duan Y, Tschudy-Seney B, Roll G, Behbahan IS, Ahuja TP, Tolstikov V, Wang C, McGee J, Khoobyari S, Nolta JA, Willenbring H, Zern MA. PMID: 23681950; PMCID: PMC3673753.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Hepatic differentiation of human embryonic stem cells on growth factor-containing surfaces. J Tissue Eng Regen Med. 2014 Nov; 8(11):886-95.
Ghaedi M, Duan Y, Zern MA, Revzin A. PMID: 23086797.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Human ESC self-renewal promoting microRNAs induce epithelial-mesenchymal transition in hepatocytes by controlling the PTEN and TGFβ tumor suppressor signaling pathways. Mol Cancer Res. 2012 Jul; 10(7):979-91.
Jung CJ, Iyengar S, Blahnik KR, Jiang JX, Tahimic C, Torok NJ, de vere White RW, Farnham PJ, Zern M. PMID: 22622027; PMCID: PMC4166560.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation. PLoS One. 2011; 6(11):e27740.
Jung CJ, Iyengar S, Blahnik KR, Ajuha TP, Jiang JX, Farnham PJ, Zern M. PMID: 22140464; PMCID: PMC3225380.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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New approaches in the differentiation of human embryonic stem cells and induced pluripotent stem cells toward hepatocytes. Stem Cell Rev Rep. 2011 Sep; 7(3):748-59.
Behbahan IS, Duan Y, Lam A, Khoobyari S, Ma X, Ahuja TP, Zern MA. PMID: 21336836; PMCID: PMC3137783.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Decellularized liver matrix as a carrier for the transplantation of human fetal and primary hepatocytes in mice. Liver Transpl. 2011 Apr; 17(4):418-27.
Zhou P, Lessa N, Estrada DC, Severson EB, Lingala S, Zern MA, Nolta JA, Wu J. PMID: 21445925; PMCID: PMC3079538.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Bottom-up signaling from HGF-containing surfaces promotes hepatic differentiation of mesenchymal stem cells. Biochem Biophys Res Commun. 2011 Apr 08; 407(2):295-300.
Ghaedi M, Tuleuova N, Zern MA, Wu J, Revzin A. PMID: 21382341; PMCID: PMC3075384.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations. J Hepatol. 2011 Oct; 55(4):838-45.
Chen X, Lingala S, Khoobyari S, Nolta J, Zern MA, Wu J. PMID: 21334406; PMCID: PMC3177032.
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PubMed Mentions:
100 Fields:
Translation:
HumansAnimalsCells
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Label-free imaging and analysis of the effects of lipolysis products on primary hepatocytes. J Biophotonics. 2011 Jun; 4(6):425-34.
Schie IW, Wu J, Weeks T, Zern MA, Rutledge JC, Huser T. PMID: 20878906; PMCID: PMC3696389.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Using growth factor arrays and micropatterned co-cultures to induce hepatic differentiation of embryonic stem cells. Biomaterials. 2010 Dec; 31(35):9221-31.
Tuleuova N, Lee JY, Lee J, Ramanculov E, Zern MA, Revzin A. PMID: 20832855; PMCID: PMC2956853.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Autologous hematopoietic stem cell transplantation in 48 patients with end-stage chronic liver diseases. Cell Transplant. 2010; 19(11):1475-86.
Salama H, Zekri AR, Zern M, Bahnassy A, Loutfy S, Shalaby S, Vigen C, Burke W, Mostafa M, Medhat E, Alfi O, Huttinger E. PMID: 20587151.
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PubMed Mentions:
43 Fields:
Translation:
Humans
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Cultivating hepatocytes on printed arrays of HGF and BMP7 to characterize protective effects of these growth factors during in vitro alcohol injury. Biomaterials. 2010 Aug; 31(23):5936-44.
Jones CN, Tuleuova N, Lee JY, Ramanculov E, Reddi AH, Zern MA, Revzin A. PMID: 20488537; PMCID: PMC2893270.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Immunohistochemical staining of cancer stem cell markers in hepatocellular carcinoma. Exp Mol Pathol. 2010 Aug; 89(1):27-35.
Lingala S, Cui YY, Chen X, Ruebner BH, Qian XF, Zern MA, Wu J. PMID: 20511115; PMCID: PMC2900434.
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PubMed Mentions:
54 Fields:
Translation:
HumansCells
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Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells. Stem Cells. 2010 Apr; 28(4):674-86.
Duan Y, Ma X, Ma X, Zou W, Wang C, Bahbahan IS, Ahuja TP, Tolstikov V, Zern MA. PMID: 20135682.
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PubMed Mentions:
76 Fields:
Translation:
HumansCells
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Acute liver injury upregulates microRNA-491-5p in mice, and its overexpression sensitizes Hep G2 cells for tumour necrosis factor-alpha-induced apoptosis. Liver Int. 2010 Mar; 30(3):376-87.
Yoon S, Kim TH, Natarajan A, Wang SS, Choi J, Wu J, Zern MA, Venugopal SK. PMID: 20015148.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation. Am J Physiol Gastrointest Liver Physiol. 2010 Jan; 298(1):G101-6.
Venugopal SK, Jiang J, Kim TH, Li Y, Wang SS, Torok NJ, Wu J, Zern MA. PMID: 19892940; PMCID: PMC2806096.
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PubMed Mentions:
100 Fields:
Translation:
HumansAnimalsCells
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Directing hepatic differentiation of embryonic stem cells with protein microarray-based co-cultures. Integr Biol (Camb). 2009 Jul; 1(7):460-8.
Lee JY, Tuleuova N, Jones CN, Ramanculov E, Zern MA, Revzin A. PMID: 20023756.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Cultivating liver cells on printed arrays of hepatocyte growth factor. Biomaterials. 2009 Aug; 30(22):3733-41.
Jones CN, Tuleuova N, Lee JY, Ramanculov E, Reddi AH, Zern MA, Revzin A. PMID: 19375794.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Cell transplantation to replace whole liver transplantation. Gastroenterology. 2009 Mar; 136(3):767-9.
Zern MA. PMID: 19167399.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1. Gastroenterology. 2009 May; 136(5):1783-95.e10.
Tatsukawa H, Fukaya Y, Frampton G, Martinez-Fuentes A, Suzuki K, Kuo TF, Nagatsuma K, Shimokado K, Okuno M, Wu J, Iismaa S, Matsuura T, Tsukamoto H, Zern MA, Graham RM, Kojima S. PMID: 19208340; PMCID: PMC4960455.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells. Biochem Biophys Res Commun. 2009 Feb 20; 379(4):876-81.
Kim TH, Venugopal SK, Zhu M, Wang SS, Lau D, Lam KS, Clemens DL, Zern MA. PMID: 19133235.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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The differentiation of hepatocyte-like cells from monkey embryonic stem cells. Cloning Stem Cells. 2008 Dec; 10(4):485-93.
Ma X, Duan Y, Jung CJ, Wu J, VandeVoort CA, Zern MA. PMID: 18795869; PMCID: PMC2981381.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Multifunctional protein microarrays for cultivation of cells and immunodetection of secreted cellular products. Anal Chem. 2008 Aug 15; 80(16):6351-7.
Jones CN, Lee JY, Zhu J, Stybayeva G, Ramanculov E, Zern MA, Revzin A. PMID: 18642875.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Use of bioluminescent imaging to assay the transplantation of immortalized human fetal hepatocytes into mice. Cell Transplant. 2008; 17(8):899-909.
Choi MS, Catana AM, Wu J, Kim YS, Yoon SJ, Borowsky AD, Gambhir SS, Gupta S, Zern MA. PMID: 19069633.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Lentivirus-mediated superoxide dismutase1 gene delivery protects against oxidative stress-induced liver injury in mice. Liver Int. 2007 Dec; 27(10):1311-22.
Venugopal SK, Wu J, Catana AM, Eisenbud L, He SQ, Duan YY, Follenzi A, Zern MA. PMID: 18036097.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo. Stem Cells. 2007 Dec; 25(12):3058-68.
Duan Y, Catana A, Meng Y, Yamamoto N, He S, Gupta S, Gambhir SS, Zern MA. PMID: 17885076.
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PubMed Mentions:
78 Fields:
Translation:
HumansAnimalsCells
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Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells. J Biol Chem. 2007 Nov 02; 282(44):31900-8.
Venugopal SK, Chen J, Zhang Y, Clemens D, Follenzi A, Zern MA. PMID: 17848570.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms. Cell Signal. 2007 Nov; 19(11):2339-50.
Zhang Y, Venugopal SK, He S, Liu P, Wu J, Zern MA. PMID: 17728104.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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De novo nonalcoholic fatty liver disease after liver transplantation. Liver Transpl. 2007 Jun; 13(6):844-7.
Seo S, Maganti K, Khehra M, Ramsamooj R, Tsodikov A, Bowlus C, McVicar J, Zern M, Torok N. PMID: 17029282.
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PubMed Mentions:
51 Fields:
Translation:
Humans
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Short hairpin RNA causes the methylation of transforming growth factor-beta receptor II promoter and silencing of the target gene in rat hepatic stellate cells. Biochem Biophys Res Commun. 2007 Jul 27; 359(2):292-7.
Kim JW, Zhang YH, Zern MA, Rossi JJ, Wu J. PMID: 17533113; PMCID: PMC2474738.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Analysis of local tissue-specific gene expression in cellular micropatterns. Anal Chem. 2006 Dec 15; 78(24):8305-12.
Lee JY, Jones C, Zern MA, Revzin A. PMID: 17165820.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Delivery of antioxidative enzyme genes protects against ischemia/reperfusion-induced liver injury in mice. Liver Transpl. 2006 Dec; 12(12):1869-79.
He SQ, Zhang YH, Venugopal SK, Dicus CW, Perez RV, Ramsamooj R, Nantz MH, Zern MA, Wu J. PMID: 17133584.
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PubMed Mentions:
37 Fields:
Translation:
Animals
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An optimal culture condition maintains human hepatocyte phenotype after long-term culture. Hepatol Res. 2006 Jul; 35(3):169-77.
Yamamoto N, Wu J, Zhang Y, Catana AM, Cai H, Strom S, Novikoff PM, Zern MA. PMID: 16807086.
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PubMed Mentions:
6
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Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo. Hepatology. 2006 Mar; 43(3):435-43.
Zhan SS, Jiang JX, Wu J, Halsted C, Friedman SL, Zern MA, Torok NJ. PMID: 16496318.
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PubMed Mentions:
143 Fields:
Translation:
HumansAnimalsCells
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Factors associated with advanced liver disease in adults with alpha1-antitrypsin deficiency. Clin Gastroenterol Hepatol. 2005 Apr; 3(4):390-6.
Bowlus CL, Willner I, Zern MA, Reuben A, Chen P, Holladay B, Xie L, Woolson RF, Strange C. PMID: 15822045.
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PubMed Mentions:
24 Fields:
Translation:
Humans
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Gene therapy for human alpha1-antitrypsin deficiency in an animal model using SV40-derived vectors. Gastroenterology. 2004 Oct; 127(4):1222-32.
Duan YY, Wu J, Zhu JL, Liu SL, Ozaki I, Strayer DS, Zern MA. PMID: 15480999.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Liposome-mediated extracellular superoxide dismutase gene delivery protects against acute liver injury in mice. Hepatology. 2004 Jul; 40(1):195-204.
Wu J, Liu L, Yen RD, Catana A, Nantz MH, Zern MA. PMID: 15239103.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Tissue transglutaminase, a key enzyme involved in liver diseases. Hepatol Res. 2004 May; 29(1):1-8.
Wu J, Zern MA. PMID: 15135339.
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PubMed Mentions:
6
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Differentiation of human and mouse embryonic stem cells along a hepatocyte lineage. Cell Transplant. 2004; 13(3):197-211.
Shirahashi H, Wu J, Yamamoto N, Catana A, Wege H, Wager B, Okita K, Zern MA. PMID: 15191158.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7253-8.
Zalzman M, Gupta S, Giri RK, Berkovich I, Sappal BS, Karnieli O, Zern MA, Fleischer N, Efrat S. PMID: 12756298; PMCID: PMC165862.
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PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
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HIV-1 proprotein processing as a target for gene therapy. Gene Ther. 2003 Mar; 10(6):467-77.
Cordelier P, Zern MA, Strayer DS. PMID: 12621451.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Gastroenterology. 2003 Feb; 124(2):432-44.
Wege H, Le HT, Chui MS, Liu L, Wu J, Giri R, Malhi H, Sappal BS, Kumaran V, Gupta S, Zern MA. PMID: 12557149.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity. Nucleic Acids Res. 2003 Jan 15; 31(2):E3-3.
Wege H, Chui MS, Le HT, Tran JM, Zern MA. PMID: 12527792; PMCID: PMC140528.
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PubMed Mentions:
67 Fields:
Translation:
HumansCells
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In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging. Cell Transplant. 2003; 12(8):897-906.
Wege H, Chui MS, Le HT, Strom SC, Zern MA. PMID: 14763510.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Poly(cationic lipid)-mediated in vivo gene delivery to mouse liver. Gene Ther. 2003 Jan; 10(2):180-7.
Liu L, Zern MA, Lizarzaburu ME, Nantz MH, Wu J. PMID: 12571647.
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PubMed Mentions:
16 Fields:
Translation:
Animals
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What can SV40-derived vectors do for gene therapy? Curr Opin Mol Ther. 2002 Aug; 4(4):313-23.
Strayer DS, Zern MA, Chowdhury JR. PMID: 12222869.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Durability of transgene expression and vector integration: recombinant SV40-derived gene therapy vectors. Mol Ther. 2002 Aug; 6(2):227-37.
Strayer D, Branco F, Zern MA, Yam P, Calarota SA, Nichols CN, Zaia JA, Rossi J, Li H, Parashar B, Ghosh S, Chowdhury JR. PMID: 12161189.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Targeting hepatocytes for drug and gene delivery: emerging novel approaches and applications. Front Biosci. 2002 Mar 01; 7:d717-25.
Wu J, Nantz MH, Zern MA. PMID: 11861224.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Cationic lipid polymerization as a novel approach for constructing new DNA delivery agents. Bioconjug Chem. 2001 Mar-Apr; 12(2):251-7.
Wu J, Lizarzaburu ME, Kurth MJ, Liu L, Wege H, Zern MA, Nantz MH. PMID: 11312686.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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No evidence of Helicobacter pylori sequences in pancreatic juices of patients affected by chronic pancreatitis. Int J Pancreatol. 2000 Dec; 28(3):181-5.
Di Campli C, Nocente R, Costamagna G, Gentiloni N, Burioni R, Wu J, Armuzzi A, Zern MA, Gasbarrini G, Gasbarrini A. PMID: 11373055.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Roles of tissue transglutaminase in ethanol-induced inhibition of hepatocyte proliferation and alpha 1-adrenergic signal transduction. J Biol Chem. 2000 Jul 21; 275(29):22213-9.
Wu J, Liu SL, Zhu JL, Norton PA, Nojiri S, Hoek JB, Zern MA. PMID: 10801782.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Hepatic stellate cells: a target for the treatment of liver fibrosis. J Gastroenterol. 2000; 35(9):665-72.
Wu J, Zern MA. PMID: 11023037.
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PubMed Mentions:
82 Fields:
Translation:
HumansCells
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Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology. 1999 Nov; 117(5):1198-204.
Zhu J, Wu J, Frizell E, Liu SL, Bashey R, Rubin R, Norton P, Zern MA. PMID: 10535884.
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PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
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[Recent progress of pathogenesis and treatment in alpha 1-antitrypsin deficiency]. Nihon Rinsho. 1999 Sep; 57(9):2145-51.
Ozaki I, Zern MA. PMID: 10497421.
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PubMed Mentions: Fields:
Translation:
Humans
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Ribozyme-mediated specific gene replacement of the alpha1-antitrypsin gene in human hepatoma cells. J Hepatol. 1999 Jul; 31(1):53-60.
Ozaki I, Zern MA, Liu S, Wei DL, Pomerantz RJ, Duan L. PMID: 10424283.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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NF-kappa B, liposomes and pathogenesis of hepatic injury and fibrosis. Front Biosci. 1999 Jun 15; 4:D520-7.
Wu J, Zern MA. PMID: 10369809.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Targeting of therapeutics to the liver: liposomes and viral vectors. Alcohol Clin Exp Res. 1999 May; 23(5):950-4.
Di Campli C, Wu J, Zern MA. PMID: 10371421.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Toxicity of hepatotoxins: new insights into mechanisms and therapy. Expert Opin Investig Drugs. 1999 May; 8(5):585-607.
Wu J, Danielsson A, Zern MA. PMID: 15992118.
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PubMed Mentions:
14 Fields:
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Gene therapy for human liver diseases. Eur J Gastroenterol Hepatol. 1999 Apr; 11(4):421-9.
Di Campli C, Wu J, Gasbarrini A, Gasbarrini G, Zern MA. PMID: 10321760.
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PubMed Mentions:
2 Translation:
Humans
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A novel SV40-based vector successfully transduces and expresses an alpha 1-antitrypsin ribozyme in a human hepatoma-derived cell line. Gene Ther. 1999 Jan; 6(1):114-20.
Zern MA, Ozaki I, Duan L, Pomerantz R, Liu SL, Strayer DS. PMID: 10341883.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Gene delivery to the liver using simian virus 40-derived vectors. Semin Liver Dis. 1999; 19(1):71-81.
Strayer DS, Zern MA. PMID: 10349685.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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The prospects of hepatic drug delivery and gene therapy. Expert Opin Investig Drugs. 1998 Nov; 7(11):1795-817.
Wu J, Wu GY, Zern MA. PMID: 15991930.
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PubMed Mentions:
1 Fields:
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TGF-beta isoforms in alcoholic liver disease. J Gastroenterol. 1998 Jun; 33(3):383-9.
Santos RM, Norton P, Degli Esposti S, Zern MA. PMID: 9658318.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Inhibitory effect of glycyrrhizin on NF-kappaB binding activity in CCl4- plus ethanol-induced liver cirrhosis in rats. Liver. 1998 Jun; 18(3):180-5.
Wang JY, Guo JS, Li H, Liu SL, Zern MA. PMID: 9716228.
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PubMed Mentions:
18 Fields:
Translation:
Animals
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Increased liver uptake of liposomes and improved targeting efficacy by labeling with asialofetuin in rodents. Hepatology. 1998 Mar; 27(3):772-8.
Wu J, Liu P, Zhu JL, Maddukuri S, Zern MA. PMID: 9500706.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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TNF-alpha modulates expression of the tissue transglutaminase gene in liver cells. Am J Physiol. 1998 02; 274(2):G240-5.
Kuncio GS, Tsyganskaya M, Zhu J, Liu SL, Nagy L, Thomazy V, Davies PJ, Zern MA. PMID: 9486175.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Hepatic drug delivery and gene therapy. Hepatology. 1997 Feb; 25(2):484-91.
Zern MA, Kresina TF. PMID: 9021968.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB. Am J Physiol. 1997 Feb; 272(2 Pt 1):G281-8.
Mirza A, Liu SL, Frizell E, Zhu J, Maddukuri S, Martinez J, Davies P, Schwarting R, Norton P, Zern MA. PMID: 9124352.
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PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
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The antioxidant function of the physiological content of vitamin C. Mol Pharmacol. 1996 Oct; 50(4):994-9.
Glascott PA, Tsyganskaya M, Gilfor E, Zern MA, Farber JL. PMID: 8863846.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Modification of liposomes for liver targeting. J Hepatol. 1996 Jun; 24(6):757-63.
Wu J, Zern MA. PMID: 8835753.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding. Hepatology. 1995 Nov; 22(5):1474-81.
Liu SL, Degli Esposti S, Yao T, Diehl AM, Zern MA. PMID: 7590666.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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An ounce of prevention: the development of viral hepatitis vaccines. Compr Ther. 1995 Jun; 21(6):283-9.
Nguyen MT, Zern MA. PMID: 7664539.
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PubMed Mentions: Fields:
Translation:
Humans
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Expression of SPARC in normal and fibrotic livers. Hepatology. 1995 Mar; 21(3):847-54.
Frizell E, Liu SL, Abraham A, Ozaki I, Eghbali M, Sage EH, Zern MA. PMID: 7875683.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimals
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Molecular biological aspects of alcohol-induced liver disease. Alcohol Clin Exp Res. 1995 Feb; 19(1):247-56.
Arnon R, Esposti SD, Zern MA. PMID: 7771656.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Fish oil, alcohol, and liver pathology: role of cytochrome P450 2E1. Proc Soc Exp Biol Med. 1994 Nov; 207(2):197-205.
Morimoto M, Zern MA, Hagbjörk AL, Ingelman-Sundberg M, French SW. PMID: 7938050.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Gene expression of transforming growth factor beta 1 and extracellular matrix proteins in murine Schistosoma mansoni infection. Gastroenterology. 1994 Sep; 107(3):773-80.
Kresina TF, He Q, Degli Esposti S, Zern MA. PMID: 8076764.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Inhibition of carbon tetrachloride-induced liver injury by liposomes containing vitamin E. Am J Physiol. 1994 Sep; 267(3 Pt 1):G476-84.
Yao T, Degli Esposti S, Huang L, Arnon R, Spangenberger A, Zern MA. PMID: 7943246.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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FK506 enhances fibrogenesis in in vitro and in vivo models of liver fibrosis in rats. Gastroenterology. 1994 Aug; 107(2):492-8.
Frizell E, Abraham A, Doolittle M, Bashey R, Kresina T, Van Thiel D, Zern MA. PMID: 7518783.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Effect of vitamin E on reoxygenation injury experienced by isolated rat hepatocytes. Life Sci. 1994; 55(18):1427-32.
Caraceni P, Yao T, Degli Esposti S, Gasbarrini A, Bowie BT, Zern M, Borle AB, Van Thiel DH. PMID: 7934654.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Hepatic fibrosis and gene expression changes induced by praziquantel treatment during immune modulation of Schistosoma japonicum infection. Parasitology. 1993 Nov; 107 ( Pt 4):397-404.
Kresina TF, He Q, Degli Esposti S, Zern MA. PMID: 7506405.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Role of the cyclic AMP response element in rat fibronectin gene expression. Hepatology. 1993 May; 17(5):882-90.
Miao S, Suri PK, Shu-Ling L, Abraham A, Cook N, Milos P, Zern MA. PMID: 8387949.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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A role for cytokines as regulators of hepatic fibrogenesis. Gastroenterol Jpn. 1993 Mar; 28 Suppl 4:97-101; discussion 112-5.
Weiner FR, Esposti SD, Zern MA. PMID: 8486236.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Cytokines, hepatic fibrosis and schistosomiasis. R I Med. 1992 Apr; 75(4):191-5.
Kresina TF, He Q, Zern MA. PMID: 1600253.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Increased transforming growth factor-beta 1 gene expression in human liver disease. J Hepatol. 1992 Mar; 14(2-3):259-64.
Annoni G, Weiner FR, Zern MA. PMID: 1380023.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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The effects of hepatic fibrosis on Ito cell gene expression. Matrix. 1992 Feb; 12(1):36-43.
Weiner FR, Shah A, Biempica L, Zern MA, Czaja MJ. PMID: 1560788.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Albumin and procollagen type I gene regulation in alcohol and viral-induced human liver disease. Boll Ist Sieroter Milan. 1991-1992; 70(1-2):391-7.
Annoni G, Arosio B, Santambrogio D, Gagliano N, Zern MA. PMID: 1670041.
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PubMed Mentions: Fields:
Translation:
Humans
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Two rat models of hepatic fibrosis. A morphologic and molecular comparison. Lab Invest. 1990 Oct; 63(4):467-75.
Sun MA, Wang BE, Annoni G, Degli Esposti S, Biempica L, Zern MA. PMID: 2232702.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Ito-cell gene expression and collagen regulation. Hepatology. 1990 Jan; 11(1):111-7.
Weiner FR, Giambrone MA, Czaja MJ, Shah A, Annoni G, Takahashi S, Eghbali M, Zern MA. PMID: 2295461.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Albumin and collagen gene regulation in alcohol- and virus-induced human liver disease. Gastroenterology. 1990 Jan; 98(1):197-202.
Annoni G, Weiner FR, Colombo M, Czaja MJ, Zern MA. PMID: 2293578.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Hepatocellular copper toxicity and its attenuation by zinc. J Clin Invest. 1989 Nov; 84(5):1562-8.
Schilsky ML, Blank RR, Czaja MJ, Zern MA, Scheinberg IH, Stockert RJ, Sternlieb I. PMID: 2478589; PMCID: PMC304022.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Gamma-interferon treatment inhibits collagen deposition in murine schistosomiasis. Hepatology. 1989 Nov; 10(5):795-800.
Czaja MJ, Weiner FR, Takahashi S, Giambrone MA, van der Meide PH, Schellekens H, Biempica L, Zern MA. PMID: 2509321.
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PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
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In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis. J Cell Biol. 1989 Jun; 108(6):2477-82.
Czaja MJ, Weiner FR, Flanders KC, Giambrone MA, Wind R, Biempica L, Zern MA. PMID: 2500447; PMCID: PMC2115595.
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PubMed Mentions:
86 Fields:
Translation:
AnimalsCells
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Regulation of collagen gene expression in 3T3-L1 cells. Effects of adipocyte differentiation and tumor necrosis factor alpha. Biochemistry. 1989 May 02; 28(9):4094-9.
Weiner FR, Shah A, Smith PJ, Rubin CS, Zern MA. PMID: 2752011.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization. J Mol Cell Cardiol. 1989 Jan; 21(1):103-13.
Eghbali M, Blumenfeld OO, Seifter S, Buttrick PM, Leinwand LA, Robinson TF, Zern MA, Giambrone MA. PMID: 2716064.
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PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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Expression of tumor necrosis factor-alpha and transforming growth factor-beta 1 in acute liver injury. Growth Factors. 1989; 1(3):219-26.
Czaja MJ, Flanders KC, Biempica L, Klein C, Zern MA, Weiner FR. PMID: 2698219.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Collagen chain mRNAs in isolated heart cells from young and adult rats. J Mol Cell Cardiol. 1988 Mar; 20(3):267-76.
Eghbali M, Czaja MJ, Zeydel M, Weiner FR, Zern MA, Seifter S, Blumenfeld OO. PMID: 3398057.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Haplotype analysis of a type I collagen gene and its association with alcoholic cirrhosis in man. Mol Aspects Med. 1988; 10(2):159-68.
Weiner FR, Eskreis DS, Compton KV, Orrego H, Zern MA. PMID: 2906396.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Molecular studies of ceruloplasmin deficiency in Wilson's disease. J Clin Invest. 1987 Oct; 80(4):1200-4.
Czaja MJ, Weiner FR, Schwarzenberg SJ, Sternlieb I, Scheinberg IH, Van Thiel DH, LaRusso NF, Giambrone MA, Kirschner R, Koschinsky ML, et al. PMID: 3654978; PMCID: PMC442366.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Differential effects of gamma-interferon on collagen and fibronectin gene expression. J Biol Chem. 1987 Sep 25; 262(27):13348-51.
Czaja MJ, Weiner FR, Eghbali M, Giambrone MA, Eghbali M, Zern MA. PMID: 3115979.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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The effects of dexamethasone on in vitro collagen gene expression. J Biol Chem. 1987 May 25; 262(15):6955-8.
Weiner FR, Czaja MJ, Jefferson DM, Giambrone MA, Tur-Kaspa R, Reid LM, Zern MA. PMID: 3584102.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Transcriptional and posttranscriptional effects of dexamethasone on albumin and procollagen messenger RNAs in murine schistosomiasis. Biochemistry. 1987 Mar 24; 26(6):1557-62.
Weiner FR, Czaja MJ, Giambrone MA, Takahashi S, Biempica L, Zern MA. PMID: 3109466.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Development of molecular hybridization technology to evaluate albumin and procollagen mRNA content in baboons and man. Hepatology. 1987 Jan-Feb; 7(1 Suppl):19S-25S.
Weiner FR, Czaja MJ, Giambrone MA, Wu CH, Wu GY, Zern MA. PMID: 3804213.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Transcriptional switch from albumin to alpha-fetoprotein and changes in transcription of other genes during carbon tetrachloride induced liver regeneration. Biochemistry. 1986 Mar 25; 25(6):1414-20.
Panduro A, Shalaby F, Weiner FR, Biempica L, Zern MA, Shafritz DA. PMID: 2421766.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Increased type I procollagen mRNA levels and in vitro protein synthesis in the baboon model of chronic alcoholic liver disease. Gastroenterology. 1985 Nov; 89(5):1123-31.
Zern MA, Leo MA, Giambrone MA, Lieber CS. PMID: 4043669.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Ascorbate-generated endogenous extracellular matrix affects cell protein synthesis in calf aortic smooth muscle cells. Exp Cell Res. 1985 Oct; 160(2):307-18.
Zern MA, Schwartz E, Giambrone MA, Blumenfeld OO. PMID: 2412866.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes. Hepatology. 1985 Jan-Feb; 5(1):14-20.
Jefferson DM, Reid LM, Giambrone MA, Shafritz DA, Zern MA. PMID: 3967856.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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Effects of chronic renal failure on protein synthesis and albumin messenger ribonucleic acid in rat liver. J Clin Invest. 1984 Apr; 73(4):1167-74.
Zern MA, Yap SH, Strair RK, Kaysen GA, Shafritz DA. PMID: 6707209; PMCID: PMC425130.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Molecular mechanisms for changes in hepatic protein synthesis induced by schistosomiasis infection in mice. Biochemistry. 1983 Dec 20; 22(26):6072-7.
Zern MA, Saber MA, Shafritz DA. PMID: 6661426.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Changes in collagen and albumin mRNA in liver tissue of mice infected with Schistosoma mansoni as determined by in situ hybridization. J Cell Biol. 1983 Oct; 97(4):986-92.
Saber MA, Shafritz DA, Zern MA. PMID: 6619195; PMCID: PMC2112628.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Use of in situ hybridization to identify collagen and albumin mRNAs in isolated mouse hepatocytes. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):4017-20.
Saber MA, Zern MA, Shafritz DA. PMID: 6575392; PMCID: PMC394191.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Development and use of a rat albumin cDNA clone to evaluate the effect of chronic ethanol administration on hepatic protein synthesis. Hepatology. 1983 May-Jun; 3(3):317-22.
Zern MA, Chakraborty PR, Ruiz-Opazo N, Yap SH, Shafritz DA. PMID: 6840678.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Recombinant DNA and the liver: studies with albumin, alpha-fetoprotein, hepatitis B virus, and other DNA probes. Prog Liver Dis. 1982; 7:429-49.
Shafritz DA, Shouval D, Zern MA. PMID: 6180454.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells