David Segal

Title(s)Professor, Biochemistry and Molecular Medicine
SchoolUniversity of California, Davis
Address4512 GBSF
CA 95616
Phone530-754-9134
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    The Epigenetics Crossroads of Environmental Exposures and Early-Life Adversity
    NIH R21ES033460Sep 17, 2021 - Aug 31, 2023
    Role: Principal Investigator
    Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo
    NIH UH3EB028910Aug 1, 2021 - Jul 31, 2023
    Role: Co-Principal Investigator
    Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo
    NIH UH2EB028910Sep 15, 2019 - Jul 31, 2021
    Role: Co-Principal Investigator
    Determinants of Persistence in Epigenetic Editing
    NIH R21HG010559Apr 23, 2019 - Jan 31, 2021
    Role: Principal Investigator
    Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools
    NIH U42OD027094Apr 15, 2019 - Mar 31, 2024
    Role: Co-Principal Investigator
    Precision Nonhuman Primate Models for Congenital Diseases
    NIH R21NS104675May 1, 2018 - Apr 30, 2021
    Role: Co-Principal Investigator
    CRISPR-based epigenetic modifiers
    NIH R21CA204563Jun 15, 2016 - May 31, 2018
    Role: Principal Investigator
    NextGen DNA Binding Proteins Based on TAL Domains
    NIH R01GM097073Apr 1, 2011 - Mar 31, 2015
    Role: Principal Investigator
    Towards Gene Therapy for Angelman Syndrome
    NIH R21NS071028Sep 15, 2010 - Aug 31, 2012
    Role: Principal Investigator
    SEER - a novel method for the detection of genetic sequences
    NIH R01GM077403Jun 1, 2006 - May 31, 2011
    Role: Principal Investigator
    Inactivation of HIV by in vivo genetic modification
    NIH/NCI R21CA103651Jul 1, 2003 - Jun 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Excessive laughter-like vocalizations, microcephaly, and translational outcomes in the Ube3a deletion rat model of Angelman Syndrome. J Neurosci. 2021 Sep 02. Berg EL, Jami SA, Petkova SP, Berz A, Fenton TA, Lerch JP, Segal DJ, Gray JA, Ellegood J, Wöhr M, Silverman JL. PMID: 34475199.
      View in: PubMed   Mentions: 1     Fields:    
    2. Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells. Hum Mol Genet. 2021 Jun 09; 30(12):1067-1083. Adhikari A, Copping NA, Beegle J, Cameron DL, Deng P, O'Geen H, Segal DJ, Fink KD, Silverman JL, Anderson JS. PMID: 33856035.
      View in: PubMed   Mentions: 3     Fields:    
    3. The NIH Somatic Cell Genome Editing program. Nature. 2021 04; 592(7853):195-204. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J, SCGE Consortium . PMID: 33828315.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Early Developmental EEG and Seizure Phenotypes in a Full Gene Deletion of Ubiquitin Protein Ligase E3A Rat Model of Angelman Syndrome. eNeuro. 2021 Mar-Apr; 8(2). Born HA, Martinez LA, Levine AT, Harris SE, Mehra S, Lee WL, Dindot SV, Nash KR, Silverman JL, Segal DJ, Weeber EJ, Anderson AE. PMID: 33531368.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    5. Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation. Nat Commun. 2020 04 30; 11(1):2102. Seo JW, Ingham ES, Mahakian L, Tumbale S, Wu B, Aghevlian S, Shams S, Baikoghli M, Jain P, Ding X, Goeden N, Dobreva T, Flytzanis NC, Chavez M, Singhal K, Leib R, James ML, Segal DJ, Cheng RH, Silva EA, Gradinaru V, Ferrara KW. PMID: 32355221.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    6. Editorial: Precise Genome Editing Techniques and Applications. Front Genet. 2020; 11:412. Xu K, Segal DJ, Zhang Z. PMID: 32373168.
      View in: PubMed   Mentions:
    7. Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. Nucleic Acids Res. 2020 03 18; 48(5):2372-2387. Halmai JANM, Deng P, Gonzalez CE, Coggins NB, Cameron D, Carter JL, Buchanan FKB, Waldo JJ, Lock SR, Anderson JD, O'Geen H, Segal DJ, Nolta J, Fink KD. PMID: 31925439.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    8. Versatile 3' Functionalization of CRISPR Single Guide RNA. Chembiochem. 2020 06 02; 21(11):1633-1640. Palumbo CM, Gutierrez-Bujari JM, O'Geen H, Segal DJ, Beal PA. PMID: 31943634.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Grand Challenges in Gene and Epigenetic Editing for Neurologic Disease. Front Genome Ed. 2019; 1:1. Segal DJ. PMID: 34713209; PMCID: PMC8525068.
      View in: PubMed   Mentions:
    10. Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion. Autism Res. 2020 03; 13(3):397-409. Dodge A, Peters MM, Greene HE, Dietrick C, Botelho R, Chung D, Willman J, Nenninger AW, Ciarlone S, Kamath SG, Houdek P, Sumová A, Anderson AE, Dindot SV, Berg EL, O'Geen H, Segal DJ, Silverman JL, Weeber EJ, Nash KR. PMID: 31961493.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    11. Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways. Hum Mol Genet. 2019 11 15; 28(22):3842-3852. Lopez SJ, Laufer BI, Beitnere U, Berg EL, Silverman JL, O'Geen H, Segal DJ, LaSalle JM. PMID: 31625566.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. The Right Tools for the Right Job: CRISPR-pass Could Offer Safe Gene Correction for Many Disorders. Mol Ther. 2019 08 07; 27(8):1346-1347. Segal DJ. PMID: 31248723.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. Live-Animal Epigenome Editing: Convergence of Novel Techniques. Trends Genet. 2019 07; 35(7):527-541. Gomez JA, Beitnere U, Segal DJ. PMID: 31128888.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    14. Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. Epigenetics Chromatin. 2019 05 03; 12(1):26. O'Geen H, Bates SL, Carter SS, Nisson KA, Halmai J, Fink KD, Rhie SK, Farnham PJ, Segal DJ. PMID: 31053162.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    15. Exploring the suitability of RanBP2-type Zinc Fingers for RNA-binding protein design. Sci Rep. 2019 02 21; 9(1):2484. De Franco S, Vandenameele J, Brans A, Verlaine O, Bendak K, Damblon C, Matagne A, Segal DJ, Galleni M, Mackay JP, Vandevenne M. PMID: 30792407.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. UBE3A: An E3 Ubiquitin Ligase With Genome-Wide Impact in Neurodevelopmental Disease. Front Mol Neurosci. 2018; 11:476. Lopez SJ, Segal DJ, LaSalle JM. PMID: 30686997.
      View in: PubMed   Mentions: 8  
    17. Pathogen-specific DNA sensing with engineered zinc finger proteins immobilized on a polymer chip. Analyst. 2018 Aug 20; 143(17):4009-4016. Ha DT, Ghosh S, Ahn CH, Segal DJ, Kim MS. PMID: 30043772.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    18. Strategies for the Enrichment and Selection of Genetically Modified Cells. Trends Biotechnol. 2019 01; 37(1):56-71. Ren C, Xu K, Segal DJ, Zhang Z. PMID: 30135027.
      View in: PubMed   Mentions: 9     Fields:    
    19. Author Correction: Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance. Sci Rep. 2018 Apr 12; 8(1):6140. Coggins NB, Stultz J, O'Geen H, Carvajal-Carmona LG, Segal DJ. PMID: 29643450.
      View in: PubMed   Mentions:    Fields:    
    20. Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators. PLoS One. 2018; 13(3):e0193818. O'Geen H, Ren C, Coggins NB, Bates SL, Segal DJ. PMID: 29584750.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):E2125-E2134. Gallego-Bartolomé J, Gardiner J, Liu W, Papikian A, Ghoshal B, Kuo HY, Zhao JM, Segal DJ, Jacobsen SE. PMID: 29444862.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    22. In Vivo Applications of Cell-Penetrating Zinc-Finger Transcription Factors. Methods Mol Biol. 2018; 1867:239-251. Ren C, Adams AN, Pyles B, Bailus BJ, O'Geen H, Segal DJ. PMID: 30155828.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. Purified Protein Delivery to Activate an Epigenetically Silenced Allele in Mouse Brain. Methods Mol Biol. 2018; 1767:227-239. Pyles B, Bailus BJ, O'Geen H, Segal DJ. PMID: 29524138.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    24. Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance. Sci Rep. 2017 11 08; 7(1):15044. Coggins NB, Stultz J, O'Geen H, Carvajal-Carmona LG, Segal DJ. PMID: 29118424.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. UBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons. Epigenetics. 2017; 12(11):982-990. Lopez SJ, Dunaway K, Islam MS, Mordaunt C, Vogel Ciernia A, Meguro-Horike M, Horike SI, Segal DJ, LaSalle JM. PMID: 28925810.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    26. dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression. Nucleic Acids Res. 2017 Sep 29; 45(17):9901-9916. O'Geen H, Ren C, Nicolet CM, Perez AA, Halmai J, Le VM, Mackay JP, Farnham PJ, Segal DJ. PMID: 28973434.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    27. Blood-Brain Barrier Disruption for the Delivery of Noninfectious Viral Vectors and Proteins, Preliminary Study. . 2017 Sep 1; 1-4. Foiret FJ, Zhang ZH, Fite FB, Ilovitsh IT, Mahakian ML, Tam TS, Beitnere BU, Pyles PB, Segal SD, Ferrara FK. .
      View in: Publisher Site   Mentions:
    28. Blood-brain barrier disruption for the delivery of non-infectious viral vectors and proteins, preliminary study. 2017 IEEE International Ultrasonics Symposium (IUS). 2017 Sep 1; 1-1. Foiret FJ, Zhang ZH, Fite FB, Mahakian ML, Tam TS, Segal SD, Ferrara FK. .
      View in: Publisher Site   Mentions:
    29. Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo. Cell Death Differ. 2017 05; 24(5):878-888. Carrington EM, Zhan Y, Brady JL, Zhang JG, Sutherland RM, Anstee NS, Schenk RL, Vikstrom IB, Delconte RB, Segal D, Huntington ND, Bouillet P, Tarlinton DM, Huang DC, Strasser A, Cory S, Herold MJ, Lew AM. PMID: 28362427.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    30. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature. 2016 10 27; 538(7626):477-482. Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurno P, Chen I, Matassova N, Smith J, Pedder C, Graham C, Studeny A, Lysiak-Auvity G, Girard AM, Gravé F, Segal D, Riffkin CD, Pomilio G, Galbraith LC, Aubrey BJ, Brennan MS, Herold MJ, Chang C, Guasconi G, Cauquil N, Melchiore F, Guigal-Stephan N, Lockhart B, Colland F, Hickman JA, Roberts AW, Huang DC, Wei AH, Strasser A, Lessene G, Geneste O. PMID: 27760111.
      View in: PubMed   Mentions: 298     Fields:    Translation:HumansAnimalsCells
    31. Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts. Cell Transplant. 2016; 25(4):677-86. Fink KD, Deng P, Gutierrez J, Anderson JS, Torrest A, Komarla A, Kalomoiris S, Cary W, Anderson JD, Gruenloh W, Duffy A, Tempkin T, Annett G, Wheelock V, Segal DJ, Nolta JA, Fink KD, Deng P, Gutierrez J, Anderson JS, Torrest A, Komarla A, Kalomoiris S, Cary W, Anderson JD, Gruenloh W, Duffy A, Tempkin T, Annett G, Wheelock V, Segal DJ, Nolta JA. PMID: 26850319; PMCID: PMC6476541.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    32. Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells. Nucleic Acids Res. 2016 05 19; 44(9):4123-33. Tak YG, Hung Y, Yao L, Grimmer MR, Do A, Bhakta MS, O'Geen H, Segal DJ, Farnham PJ, Tak YG, Hung Y, Yao L, Grimmer MR, Do A, Bhakta MS, O'Geen H, Segal DJ, Farnham PJ. PMID: 26743005; PMCID: PMC4872074.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    33. Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain. Mol Ther. 2016 Mar; 24(3):548-55. Bailus BJ, Pyles B, McAlister MM, O'Geen H, Lockwood SH, Adams AN, Nguyen JT, Yu A, Berman RF, Segal DJ, Bailus BJ, Pyles B, McAlister MM, O'Geen H, Lockwood SH, Adams AN, Nguyen JT, Yu A, Berman RF, Segal DJ. PMID: 26727042; PMCID: PMC4786922.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    34. How specific is CRISPR/Cas9 really? Curr Opin Chem Biol. 2015 Dec; 29:72-8. O'Geen H, Yu AS, Segal DJ, O'Geen H, Yu AS, Segal DJ. PMID: 26517564; PMCID: PMC4684463.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    35. The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres. PLoS Genet. 2015 Jul; 11(7):e1005410. Frank AK, Tran DC, Qu RW, Stohr BA, Segal DJ, Xu L, Frank AK, Tran DC, Qu RW, Stohr BA, Segal DJ, Xu L. PMID: 26230315; PMCID: PMC4521702.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    36. A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture. Nucleic Acids Res. 2015 Mar 31; 43(6):3389-404. O'Geen H, Henry IM, Bhakta MS, Meckler JF, Segal DJ, O'Geen H, Henry IM, Bhakta MS, Meckler JF, Segal DJ. PMID: 25712100; PMCID: PMC4381059.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    37. Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology. ACS Chem Biol. 2014 Aug 15; 9(8):1645-6. Rader C, Segal DJ, Shabat D, Rader C, Segal DJ, Shabat D. PMID: 25123302.
      View in: PubMed   Mentions:    Fields:    
    38. Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA. Angew Chem Int Ed Engl. 2014 Jul 21; 53(30):7848-52. Vandevenne M, O'Connell MR, Helder S, Shepherd NE, Matthews JM, Kwan AH, Segal DJ, Mackay JP, Vandevenne M, O'Connell MR, Helder S, Shepherd NE, Matthews JM, Kwan AH, Segal DJ, Mackay JP. PMID: 25044781.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    39. Miz-1 activates gene expression via a novel consensus DNA binding motif. PLoS One. 2014; 9(7):e101151. Barrilleaux BL, Burow D, Lockwood SH, Yu A, Segal DJ, Knoepfler PS, Barrilleaux BL, Burow D, Lockwood SH, Yu A, Segal DJ, Knoepfler PS. PMID: 24983942; PMCID: PMC4077741.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    40. The functional significance of common polymorphisms in zinc finger transcription factors. G3 (Bethesda). 2014 Jun 26; 4(9):1647-55. Lockwood SH, Guan A, Yu AS, Zhang C, Zykovich A, Korf I, Rannala B, Segal DJ, Lockwood SH, Guan A, Yu AS, Zhang C, Zykovich A, Korf I, Rannala B, Segal DJ. PMID: 24970883; PMCID: PMC4169156.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    41. The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders. BMC Neurosci. 2014 Jun 19; 15:76. Bailus BJ, Segal DJ, Bailus BJ, Segal DJ. PMID: 24946931; PMCID: PMC4069279.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    42. Further insights into the effects of pre-organizing the BimBH3 helix. ACS Chem Biol. 2014 Mar 21; 9(3):838-9. Okamoto T, Segal D, Zobel K, Fedorova A, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE, Okamoto T, Segal D, Zobel K, Fedorova A, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE. PMID: 24547872.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    43. SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature. 2014 03 06; 507(7490):124-128. Johnson LM, Du J, Hale CJ, Bischof S, Feng S, Chodavarapu RK, Zhong X, Marson G, Pellegrini M, Segal DJ, Patel DJ, Jacobsen SE, Johnson LM, Du J, Hale CJ, Bischof S, Feng S, Chodavarapu RK, Zhong X, Marson G, Pellegrini M, Segal DJ, Patel DJ, Jacobsen SE. PMID: 24463519; PMCID: PMC3963826.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    44. Conformational elasticity can facilitate TALE-DNA recognition. Adv Protein Chem Struct Biol. 2014; 94:347-64. Lei H, Sun J, Baldwin EP, Segal DJ, Duan Y, Lei H, Sun J, Baldwin EP, Segal DJ, Duan Y. PMID: 24629191; PMCID: PMC4334902.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    45. Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides? Trends Biochem Sci. 2013 Sep; 38(9):421-2. Mackay JP, Segal DJ, Crossley M, Mackay JP, Segal DJ, Crossley M. PMID: 23992945.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    46. Transcription activator like effector (TALE)-directed piggyBac transposition in human cells. Nucleic Acids Res. 2013 Oct; 41(19):9197-207. Owens JB, Mauro D, Stoytchev I, Bhakta MS, Kim MS, Segal DJ, Moisyadi S, Owens JB, Mauro D, Stoytchev I, Bhakta MS, Kim MS, Segal DJ, Moisyadi S. PMID: 23921635; PMCID: PMC3799441.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    47. Genome engineering at the dawn of the golden age. Annu Rev Genomics Hum Genet. 2013; 14:135-58. Segal DJ, Meckler JF, Segal DJ, Meckler JF. PMID: 23701416.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    48. New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. J Biol Chem. 2013 Apr 12; 288(15):10616-27. Vandevenne M, Jacques DA, Artuz C, Nguyen CD, Kwan AH, Segal DJ, Matthews JM, Crossley M, Guss JM, Mackay JP, Vandevenne M, Jacques DA, Artuz C, Nguyen CD, Kwan AH, Segal DJ, Matthews JM, Crossley M, Guss JM, Mackay JP. PMID: 23436653; PMCID: PMC3624442.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    49. Quantitative analysis of TALE-DNA interactions suggests polarity effects. Nucleic Acids Res. 2013 Apr; 41(7):4118-28. Meckler JF, Bhakta MS, Kim MS, Ovadia R, Habrian CH, Zykovich A, Yu A, Lockwood SH, Morbitzer R, Elsäesser J, Lahaye T, Segal DJ, Baldwin EP, Meckler JF, Bhakta MS, Kim MS, Ovadia R, Habrian CH, Zykovich A, Yu A, Lockwood SH, Morbitzer R, Elsäesser J, Lahaye T, Segal DJ, Baldwin EP. PMID: 23408851; PMCID: PMC3627578.
      View in: PubMed   Mentions: 72     Fields:    Translation:Cells
    50. Bacteria herald a new era of gene editing. Elife. 2013 Jan 29; 2:e00563. Segal DJ, Segal DJ. PMID: 23386979; PMCID: PMC3557904.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    51. Highly active zinc-finger nucleases by extended modular assembly. Genome Res. 2013 Mar; 23(3):530-8. Bhakta MS, Henry IM, Ousterout DG, Das KT, Lockwood SH, Meckler JF, Wallen MC, Zykovich A, Yu Y, Leo H, Xu L, Gersbach CA, Segal DJ, Bhakta MS, Henry IM, Ousterout DG, Das KT, Lockwood SH, Meckler JF, Wallen MC, Zykovich A, Yu Y, Leo H, Xu L, Gersbach CA, Segal DJ. PMID: 23222846; PMCID: PMC3589541.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    52. Beyond the genome and into the clinic. Genome Med. 2012; 4(10):78. Segal DJ, Segal DJ. PMID: 23114014; PMCID: PMC3580447.
      View in: PubMed   Mentions:    Fields:    
    53. Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. J Am Chem Soc. 2012 Oct 24; 134(42):17814-22. Meier JL, Yu AS, Korf I, Segal DJ, Dervan PB, Meier JL, Yu AS, Korf I, Segal DJ, Dervan PB. PMID: 23013524; PMCID: PMC3483022.
      View in: PubMed   Mentions: 19     Fields:    
    54. Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA. Angew Chem Int Ed Engl. 2012 May 29; 51(22):5371-5. O'Connell MR, Vandevenne M, Nguyen CD, Matthews JM, Gamsjaeger R, Segal DJ, Mackay JP, O'Connell MR, Vandevenne M, Nguyen CD, Matthews JM, Gamsjaeger R, Segal DJ, Mackay JP. PMID: 22517726.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    55. Chimeric piggyBac transposases for genomic targeting in human cells. Nucleic Acids Res. 2012 Aug; 40(14):6978-91. Owens JB, Urschitz J, Stoytchev I, Dang NC, Stoytcheva Z, Belcaid M, Maragathavally KJ, Coates CJ, Segal DJ, Moisyadi S, Owens JB, Urschitz J, Stoytchev I, Dang NC, Stoytcheva Z, Belcaid M, Maragathavally KJ, Coates CJ, Segal DJ, Moisyadi S. PMID: 22492708; PMCID: PMC3413120.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    56. Adding fingers to an engineered zinc finger nuclease can reduce activity. Biochemistry. 2011 Jun 07; 50(22):5033-41. Shimizu Y, Söllü C, Meckler JF, Adriaenssens A, Zykovich A, Cathomen T, Segal DJ, Shimizu Y, Söllü C, Meckler JF, Adriaenssens A, Zykovich A, Cathomen T, Segal DJ. PMID: 21528840; PMCID: PMC3110833.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    57. Erratum: The prospects for designer single-stranded RNA-binding proteins. Nature Structural & Molecular Biology. 2011 Apr 1; 18(4):516-516. Mackay MJ, Font FJ, Segal SD. .
      View in: Publisher Site   Mentions:
    58. The prospects for designer single-stranded RNA-binding proteins. Nat Struct Mol Biol. 2011 Mar; 18(3):256-61. Mackay JP, Font J, Segal DJ, Mackay JP, Font J, Segal DJ. PMID: 21358629.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    59. Zinc-finger nucleases transition to the CoDA. Nat Methods. 2011 Jan; 8(1):53-5. Segal DJ, Segal DJ. PMID: 21191373.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    60. A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications. Nucleic Acids Res. 2011 Mar; 39(5):e29. Kim MS, Stybayeva G, Lee JY, Revzin A, Segal DJ, Kim MS, Stybayeva G, Lee JY, Revzin A, Segal DJ. PMID: 21134909; PMCID: PMC3061069.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    61. Dimerization of Toll-like receptor 3 (TLR3) is required for ligand binding. J Biol Chem. 2010 Nov 19; 285(47):36836-41. Wang Y, Liu L, Davies DR, Segal DM, Wang Y, Liu L, Davies DR, Segal DM. PMID: 20861016; PMCID: PMC2978612.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    62. Toward a general approach for RNA-templated hierarchical assembly of split-proteins. J Am Chem Soc. 2010 Aug 25; 132(33):11692-701. Furman JL, Badran AH, Ajulo O, Porter JR, Stains CI, Segal DJ, Ghosh I, Furman JL, Badran AH, Ajulo O, Porter JR, Stains CI, Segal DJ, Ghosh I. PMID: 20681585; PMCID: PMC2954892.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    63. Seeing genetic and epigenetic information without DNA denaturation using sequence-enabled reassembly (SEER). Methods Mol Biol. 2010; 649:365-82. Porter JR, Lockwood SH, Segal DJ, Ghosh I, Porter JR, Lockwood SH, Segal DJ, Ghosh I. PMID: 20680847.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    64. The generation of zinc finger proteins by modular assembly. Methods Mol Biol. 2010; 649:3-30. Bhakta MS, Segal DJ, Bhakta MS, Segal DJ. PMID: 20680825; PMCID: PMC4323424.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    65. Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing. Nucleic Acids Res. 2009 Dec; 37(22):e151. Zykovich A, Korf I, Segal DJ, Zykovich A, Korf I, Segal DJ. PMID: 19843614; PMCID: PMC2794170.
      View in: PubMed   Mentions: 62     Fields:    Translation:Cells
    66. Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA. Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3748-51. Furman JL, Badran AH, Shen S, Stains CI, Hannallah J, Segal DJ, Ghosh I, Furman JL, Badran AH, Shen S, Stains CI, Hannallah J, Segal DJ, Ghosh I. PMID: 19457665; PMCID: PMC2709697.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    67. Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker. Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3970-2. Shimizu Y, Bhakta MS, Segal DJ, Shimizu Y, Bhakta MS, Segal DJ. PMID: 19289279; PMCID: PMC2709702.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    68. Critical parameters for genome editing using zinc finger nucleases. Mini Rev Med Chem. 2008 Jun; 8(7):669-76. Camenisch TD, Brilliant MH, Segal DJ, Camenisch TD, Brilliant MH, Segal DJ. PMID: 18537722.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    69. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science. 2008 Apr 18; 320(5874):379-81. Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR, Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR. PMID: 18420935; PMCID: PMC2761030.
      View in: PubMed   Mentions: 259     Fields:    Translation:HumansAnimalsCells
    70. The protein-binding potential of C2H2 zinc finger domains. Cell Biochem Biophys. 2008; 51(1):9-19. Brayer KJ, Kulshreshtha S, Segal DJ, Brayer KJ, Kulshreshtha S, Segal DJ. PMID: 18286240.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    71. Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains. Cell Biochem Biophys. 2008; 50(3):111-31. Brayer KJ, Segal DJ, Brayer KJ, Segal DJ. PMID: 18253864.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCells
    72. Generation and functional analysis of zinc finger nucleases. Methods Mol Biol. 2008; 434:277-90. Cathomen T, Segal DJ, Brondani V, Müller-Lerch F, Cathomen T, Segal DJ, Brondani V, Müller-Lerch F. PMID: 18470651.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    73. Split beta-lactamase sensor for the sequence-specific detection of DNA methylation. Anal Chem. 2007 Sep 01; 79(17):6702-8. Porter JR, Stains CI, Segal DJ, Ghosh I, Porter JR, Stains CI, Segal DJ, Ghosh I. PMID: 17685552.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    74. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol. 2007 Jul; 25(7):786-93. Szczepek M, Brondani V, Büchel J, Serrano L, Segal DJ, Cathomen T, Szczepek M, Brondani V, Büchel J, Serrano L, Segal DJ, Cathomen T. PMID: 17603476.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansCells
    75. Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment. Mol Carcinog. 2007 May; 46(5):391-401. Gommans WM, McLaughlin PM, Lindhout BI, Segal DJ, Wiegman DJ, Haisma HJ, van der Zaal BJ, Rots MG, Gommans WM, McLaughlin PM, Lindhout BI, Segal DJ, Wiegman DJ, Haisma HJ, van der Zaal BJ, Rots MG. PMID: 17186549.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    76. Uranyl acetate as a direct inhibitor of DNA-binding proteins. Chem Res Toxicol. 2007 May; 20(5):784-9. Hartsock WJ, Cohen JD, Segal DJ, Hartsock WJ, Cohen JD, Segal DJ. PMID: 17432879.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    77. Active integration: new strategies for transgenesis. Transgenic Res. 2007 Jun; 16(3):333-9. Shinohara ET, Kaminski JM, Segal DJ, Pelczar P, Kolhe R, Ryan T, Coates CJ, Fraser MJ, Handler AM, Yanagimachi R, Moisyadi S, Shinohara ET, Kaminski JM, Segal DJ, Pelczar P, Kolhe R, Ryan T, Coates CJ, Fraser MJ, Handler AM, Yanagimachi R, Moisyadi S. PMID: 17340207.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    78. Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge. Synapse. 2006 Nov; 60(6):465-73. O'Neil ML, Kuczenski R, Segal DS, Cho AK, Lacan G, Melega WP, O'Neil ML, Kuczenski R, Segal DS, Cho AK, Lacan G, Melega WP. PMID: 16897726.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    79. Direct detection of double-stranded DNA: Molecular methods and applications for DNA diagnostics. Mol Biosyst. 2006 Nov; 2(11):551-60. Ghosh I, Stains CI, Ooi AT, Segal DJ, Ghosh I, Stains CI, Ooi AT, Segal DJ. PMID: 17216036.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    80. Cytoplasmic targeting motifs control localization of toll-like receptor 9. J Biol Chem. 2006 Nov 17; 281(46):35585-92. Leifer CA, Brooks JC, Hoelzer K, Lopez J, Kennedy MN, Mazzoni A, Segal DM, Leifer CA, Brooks JC, Hoelzer K, Lopez J, Kennedy MN, Mazzoni A, Segal DM. PMID: 16990271; PMCID: PMC2758030.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    81. Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA. J Mol Biol. 2006 Oct 20; 363(2):405-21. Segal DJ, Crotty JW, Bhakta MS, Barbas CF, Horton NC, Segal DJ, Crotty JW, Bhakta MS, Barbas CF, Horton NC. PMID: 16963084.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    82. Site-specific detection of DNA methylation utilizing mCpG-SEER. J Am Chem Soc. 2006 Aug 02; 128(30):9761-5. Stains CI, Furman JL, Segal DJ, Ghosh I, Stains CI, Furman JL, Segal DJ, Ghosh I. PMID: 16866532.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    83. Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. J Immunol. 2006 Jul 01; 177(1):322-32. Rallabhandi P, Bell J, Boukhvalova MS, Medvedev A, Lorenz E, Arditi M, Hemming VG, Blanco JC, Segal DM, Vogel SN, Rallabhandi P, Bell J, Boukhvalova MS, Medvedev A, Lorenz E, Arditi M, Hemming VG, Blanco JC, Segal DM, Vogel SN. PMID: 16785528.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    84. The dsRNA binding site of human Toll-like receptor 3. Proc Natl Acad Sci U S A. 2006 Jun 06; 103(23):8792-7. Bell JK, Askins J, Hall PR, Davies DR, Segal DM, Bell JK, Askins J, Hall PR, Davies DR, Segal DM. PMID: 16720699; PMCID: PMC1482657.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    85. Sequence-enabled reassembly of beta-lactamase (SEER-LAC): a sensitive method for the detection of double-stranded DNA. Biochemistry. 2006 Mar 21; 45(11):3620-5. Ooi AT, Stains CI, Ghosh I, Segal DJ, Ooi AT, Stains CI, Ghosh I, Segal DJ. PMID: 16533044; PMCID: PMC2688710.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    86. Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. J Virol. 2006 Mar; 80(6):2873-83. Eberhardy SR, Goncalves J, Coelho S, Segal DJ, Berkhout B, Barbas CF, Eberhardy SR, Goncalves J, Coelho S, Segal DJ, Berkhout B, Barbas CF. PMID: 16501096; PMCID: PMC1395442.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    87. Design, construction and in vitro testing of zinc finger nucleases. Nat Protoc. 2006; 1(3):1329-41. Carroll D, Morton JJ, Beumer KJ, Segal DJ, Carroll D, Morton JJ, Beumer KJ, Segal DJ. PMID: 17406419.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
    88. Custom zinc-finger nucleases for use in human cells. Mol Ther. 2005 Oct; 12(4):610-7. Alwin S, Gere MB, Guhl E, Effertz K, Barbas CF, Segal DJ, Weitzman MD, Cathomen T, Alwin S, Gere MB, Guhl E, Effertz K, Barbas CF, Segal DJ, Weitzman MD, Cathomen T. PMID: 16039907.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    89. Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem. 2005 Oct 21; 280(42):35588-97. Dreier B, Fuller RP, Segal DJ, Lund CV, Blancafort P, Huber A, Koksch B, Barbas CF, Dreier B, Fuller RP, Segal DJ, Lund CV, Blancafort P, Huber A, Koksch B, Barbas CF. PMID: 16107335.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    90. DNA sequence-enabled reassembly of the green fluorescent protein. J Am Chem Soc. 2005 Aug 10; 127(31):10782-3. Stains CI, Porter JR, Ooi AT, Segal DJ, Ghosh I, Stains CI, Porter JR, Ooi AT, Segal DJ, Ghosh I. PMID: 16076155.
      View in: PubMed   Mentions: 31     Fields:    
    91. Site-directed genome modification: derivatives of DNA-modifying enzymes as targeting tools. Trends Biotechnol. 2005 Aug; 23(8):407-19. Coates CJ, Kaminski JM, Summers JB, Segal DJ, Miller AD, Kolb AF, Coates CJ, Kaminski JM, Summers JB, Segal DJ, Miller AD, Kolb AF. PMID: 15993503.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    92. Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction. Trends Biotechnol. 2005 Aug; 23(8):399-406. Kolb AF, Coates CJ, Kaminski JM, Summers JB, Miller AD, Segal DJ, Kolb AF, Coates CJ, Kaminski JM, Summers JB, Miller AD, Segal DJ. PMID: 15982766.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    93. The molecular structure of the Toll-like receptor 3 ligand-binding domain. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):10976-80. Bell JK, Botos I, Hall PR, Askins J, Shiloach J, Segal DM, Davies DR, Bell JK, Botos I, Hall PR, Askins J, Shiloach J, Segal DM, Davies DR. PMID: 16043704; PMCID: PMC1182468.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    94. Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-finger zinc-finger peptide, bound to DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 01; 61(Pt 6):573-6. Crotty JW, Etzkorn C, Barbas CF, Segal DJ, Horton NC, Crotty JW, Etzkorn C, Barbas CF, Segal DJ, Horton NC. PMID: 16511099; PMCID: PMC1952332.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    95. Designing transcription factor architectures for drug discovery. Mol Pharmacol. 2004 Dec; 66(6):1361-71. Blancafort P, Segal DJ, Barbas CF, Blancafort P, Segal DJ, Barbas CF. PMID: 15340042.
      View in: PubMed   Mentions: 62     Fields:    Translation:Cells
    96. Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites. J Virol. 2004 Feb; 78(3):1301-13. Tan W, Zhu K, Segal DJ, Barbas CF, Chow SA, Tan W, Zhu K, Segal DJ, Barbas CF, Chow SA. PMID: 14722285; PMCID: PMC321411.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    97. Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J Biol Chem. 2004 Apr 09; 279(15):14509-19. Segal DJ, Gonçalves J, Eberhardy S, Swan CH, Torbett BE, Li X, Barbas CF, Segal DJ, Gonçalves J, Eberhardy S, Swan CH, Torbett BE, Li X, Barbas CF. PMID: 14734553.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    98. Zinc fingers and a green thumb: manipulating gene expression in plants. Curr Opin Plant Biol. 2003 Apr; 6(2):163-8. Segal DJ, Stege JT, Barbas CF, Segal DJ, Stege JT, Barbas CF. PMID: 12667874.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    99. Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins. Biochemistry. 2003 Feb 25; 42(7):2137-48. Segal DJ, Beerli RR, Blancafort P, Dreier B, Effertz K, Huber A, Koksch B, Lund CV, Magnenat L, Valente D, Barbas CF, Segal DJ, Beerli RR, Blancafort P, Dreier B, Effertz K, Huber A, Koksch B, Lund CV, Magnenat L, Valente D, Barbas CF. PMID: 12590603.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    100. Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells. Eur J Immunol. 2002 04; 32(4):1182-7. Spitzer JH, Visintin A, Mazzoni A, Kennedy MN, Segal DM, Spitzer JH, Visintin A, Mazzoni A, Kennedy MN, Segal DM. PMID: 11932926.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    101. The use of zinc finger peptides to study the role of specific factor binding sites in the chromatin environment. Methods. 2002 Jan; 26(1):76-83. Segal DJ, Segal DJ. PMID: 12054906.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    102. Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins. Curr Opin Biotechnol. 2001 Dec; 12(6):632-7. Segal DJ, Barbas CF, Segal DJ, Barbas CF. PMID: 11849947.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    103. Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem. 2001 Aug 03; 276(31):29466-78. Dreier B, Beerli RR, Segal DJ, Flippin JD, Barbas CF, Dreier B, Beerli RR, Segal DJ, Flippin JD, Barbas CF. PMID: 11340073.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    104. Stimulation of homologous recombination through targeted cleavage by chimeric nucleases. Mol Cell Biol. 2001 Jan; 21(1):289-97. Bibikova M, Carroll D, Segal DJ, Trautman JK, Smith J, Kim YG, Chandrasegaran S, Bibikova M, Carroll D, Segal DJ, Trautman JK, Smith J, Kim YG, Chandrasegaran S. PMID: 11113203; PMCID: PMC88802.
      View in: PubMed   Mentions: 206     Fields:    Translation:AnimalsCells
    105. Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains. J Mol Biol. 2000 Nov 03; 303(4):489-502. Dreier B, Segal DJ, Barbas CF, Dreier B, Segal DJ, Barbas CF. PMID: 11054286.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    106. Design of novel sequence-specific DNA-binding proteins. Curr Opin Chem Biol. 2000 Feb; 4(1):34-9. Segal DJ, Barbas CF, Segal DJ, Barbas CF. PMID: 10679372.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    107. From catalytic asymmetric synthesis to the transcriptional regulation of genes: in vivo and in vitro evolution of proteins. Adv Protein Chem. 2000; 55:317-66. Barbas CF, Rader C, Segal DJ, List B, Turner JM, Barbas CF, Rader C, Segal DJ, List B, Turner JM. PMID: 11050938.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    108. Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2758-63. Segal DJ, Dreier B, Beerli RR, Barbas CF, Segal DJ, Dreier B, Beerli RR, Barbas CF. PMID: 10077584; PMCID: PMC15842.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    109. Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14628-33. Beerli RR, Segal DJ, Dreier B, Barbas CF, Beerli RR, Segal DJ, Dreier B, Barbas CF. PMID: 9843940; PMCID: PMC24500.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimalsCells
    110. Processing of targeted psoralen cross-links in Xenopus oocytes. Mol Cell Biol. 1997 Nov; 17(11):6645-52. Segal DJ, Faruqi AF, Glazer PM, Carroll D, Segal DJ, Faruqi AF, Glazer PM, Carroll D. PMID: 9343428; PMCID: PMC232518.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    111. Design of polydactyl zinc-finger proteins for unique addressing within complex genomes. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5525-30. Liu Q, Segal DJ, Ghiara JB, Barbas CF, Liu Q, Segal DJ, Ghiara JB, Barbas CF. PMID: 9159105; PMCID: PMC20811.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    112. Recombination induced by triple-helix-targeted DNA damage in mammalian cells. Mol Cell Biol. 1996 Dec; 16(12):6820-8. Faruqi AF, Seidman MM, Segal DJ, Carroll D, Glazer PM, Faruqi AF, Seidman MM, Segal DJ, Carroll D, Glazer PM. PMID: 8943337; PMCID: PMC231685.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    113. Endonuclease-induced, targeted homologous extrachromosomal recombination in Xenopus oocytes. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):806-10. Segal DJ, Carroll D, Segal DJ, Carroll D. PMID: 7846056; PMCID: PMC42709.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    David's Networks
    Concepts (422)
    Derived automatically from this person's publications.
    _
    Co-Authors (24)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _