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David Segal

TitleAssoc Prof
InstitutionUniversity of California Davis
Address
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Coggins NB, Stultz J, O'Geen H, Carvajal-Carmona LG, Segal D. Author Correction: Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance. Sci Rep. 2018 Apr 12; 8(1):6140. PMID: 29643450.
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    2. O'Geen H, Ren C, Coggins NB, Bates SL, Segal D. Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators. PLoS One. 2018; 13(3):e0193818. PMID: 29584750.
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    3. Pyles B, Bailus BJ, O'Geen H, Segal D. Purified Protein Delivery to Activate an Epigenetically Silenced Allele in Mouse Brain. Methods Mol Biol. 2018; 1767:227-239. PMID: 29524138.
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    4. Coggins NB, Stultz J, O'Geen H, Carvajal-Carmona LG, Segal D. Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance. Sci Rep. 2017 Nov 08; 7(1):15044. PMID: 29118424.
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    5. Lopez SJ, Dunaway K, Islam MS, Mordaunt C, Vogel Ciernia A, Meguro-Horike M, Horike SI, Segal D, LaSalle JM. UBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons. Epigenetics. 2017; 12(11):982-990. PMID: 28925810.
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    6. O'Geen H, Ren C, Nicolet CM, Perez AA, Halmai J, Le VM, Mackay JP, Farnham PJ, Segal D. dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression. Nucleic Acids Res. 2017 Sep 29; 45(17):9901-9916. PMID: 28973434.
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    7. Fink KD, Deng P, Gutierrez J, Anderson JS, Torrest A, Komarla A, Kalomoiris S, Cary W, Anderson JD, Gruenloh W, Duffy A, Tempkin T, Annett G, Wheelock V, Segal D, Nolta JA. Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts. Cell Transplant. 2016; 25(4):677-86. PMID: 26850319.
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    8. Tak YG, Hung Y, Yao L, Grimmer MR, Do A, Bhakta MS, O'Geen H, Segal D, Farnham PJ. Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells. Nucleic Acids Res. 2016 05 19; 44(9):4123-33. PMID: 26743005; PMCID: PMC4872074.
    9. Bailus BJ, Pyles B, McAlister MM, O'Geen H, Lockwood SH, Adams AN, Nguyen JT, Yu A, Berman RF, Segal D. Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain. Mol Ther. 2016 Mar; 24(3):548-55. PMID: 26727042; PMCID: PMC4786922.
    10. O'Geen H, Yu AS, Segal D. How specific is CRISPR/Cas9 really? Curr Opin Chem Biol. 2015 Dec; 29:72-8. PMID: 26517564; PMCID: PMC4684463 [Available on 12/01/16].
    11. Frank AK, Tran DC, Qu RW, Stohr BA, Segal D, Xu L. The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres. PLoS Genet. 2015 Jul; 11(7):e1005410. PMID: 26230315; PMCID: PMC4521702.
    12. O'Geen H, Henry IM, Bhakta MS, Meckler JF, Segal D. A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture. Nucleic Acids Res. 2015 Mar 31; 43(6):3389-404. PMID: 25712100; PMCID: PMC4381059.
    13. Rader C, Segal D, Shabat D. Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology. ACS Chem Biol. 2014 Aug 15; 9(8):1645-6. PMID: 25123302.
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    14. Vandevenne M, O'Connell MR, Helder S, Shepherd NE, Matthews JM, Kwan AH, Segal D, Mackay JP. Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA. Angew Chem Int Ed Engl. 2014 Jul 21; 53(30):7848-52. PMID: 25044781.
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    15. Barrilleaux BL, Burow D, Lockwood SH, Yu A, Segal D, Knoepfler PS. Miz-1 activates gene expression via a novel consensus DNA binding motif. PLoS One. 2014; 9(7):e101151. PMID: 24983942; PMCID: PMC4077741.
    16. Lockwood SH, Guan A, Yu AS, Zhang C, Zykovich A, Korf I, Rannala B, Segal D. The functional significance of common polymorphisms in zinc finger transcription factors. G3 (Bethesda). 2014 Jun 26; 4(9):1647-55. PMID: 24970883; PMCID: PMC4169156.
    17. Bailus BJ, Segal D. The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders. BMC Neurosci. 2014 Jun 19; 15:76. PMID: 24946931; PMCID: PMC4069279.
    18. Johnson LM, Du J, Hale CJ, Bischof S, Feng S, Chodavarapu RK, Zhong X, Marson G, Pellegrini M, Segal D, Patel DJ, Jacobsen SE. SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature. 2014 03 06; 507(7490):124-128. PMID: 24463519; PMCID: PMC3963826.
    19. Lei H, Sun J, Baldwin EP, Segal D, Duan Y. Conformational elasticity can facilitate TALE-DNA recognition. Adv Protein Chem Struct Biol. 2014; 94:347-64. PMID: 24629191; PMCID: PMC4334902.
    20. Mackay JP, Segal D, Crossley M. Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides? Trends Biochem Sci. 2013 Sep; 38(9):421-2. PMID: 23992945.
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    21. Owens JB, Mauro D, Stoytchev I, Bhakta MS, Kim MS, Segal D, Moisyadi S. Transcription activator like effector (TALE)-directed piggyBac transposition in human cells. Nucleic Acids Res. 2013 Oct; 41(19):9197-207. PMID: 23921635.
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    22. Segal D, Meckler JF. Genome engineering at the dawn of the golden age. Annu Rev Genomics Hum Genet. 2013; 14:135-58. PMID: 23701416.
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    23. Vandevenne M, Jacques DA, Artuz C, Nguyen CD, Kwan AH, Segal D, Matthews JM, Crossley M, Guss JM, Mackay JP. New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. J Biol Chem. 2013 Apr 12; 288(15):10616-27. PMID: 23436653; PMCID: PMC3624442.
    24. Meckler JF, Bhakta MS, Kim MS, Ovadia R, Habrian CH, Zykovich A, Yu A, Lockwood SH, Morbitzer R, Elsäesser J, Lahaye T, Segal D, Baldwin EP. Quantitative analysis of TALE-DNA interactions suggests polarity effects. Nucleic Acids Res. 2013 Apr; 41(7):4118-28. PMID: 23408851; PMCID: PMC3627578.
    25. Segal D. Bacteria herald a new era of gene editing. Elife. 2013 Jan 29; 2:e00563. PMID: 23386979; PMCID: PMC3557904.
    26. Burns CJ, Segal D, Wilks AF. The Use of JAK-specific inhibitors as chemical biology tools. Methods Mol Biol. 2013; 967:99-113. PMID: 23296724.
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    27. Bhakta MS, Henry IM, Ousterout DG, Das KT, Lockwood SH, Meckler JF, Wallen MC, Zykovich A, Yu Y, Leo H, Xu L, Gersbach CA, Segal D. Highly active zinc-finger nucleases by extended modular assembly. Genome Res. 2013 Mar; 23(3):530-8. PMID: 23222846; PMCID: PMC3589541.
    28. Segal D. Beyond the genome and into the clinic. Genome Med. 2012; 4(10):78. PMID: 23114014; PMCID: PMC3580447.
    29. Meier JL, Yu AS, Korf I, Segal D, Dervan PB. Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. J Am Chem Soc. 2012 Oct 24; 134(42):17814-22. PMID: 23013524; PMCID: PMC3483022.
    30. O'Connell MR, Vandevenne M, Nguyen CD, Matthews JM, Gamsjaeger R, Segal D, Mackay JP. Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA. Angew Chem Int Ed Engl. 2012 May 29; 51(22):5371-5. PMID: 22517726.
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    31. Owens JB, Urschitz J, Stoytchev I, Dang NC, Stoytcheva Z, Belcaid M, Maragathavally KJ, Coates CJ, Segal D, Moisyadi S. Chimeric piggyBac transposases for genomic targeting in human cells. Nucleic Acids Res. 2012 Aug; 40(14):6978-91. PMID: 22492708.
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    32. Shimizu Y, Söllü C, Meckler JF, Adriaenssens A, Zykovich A, Cathomen T, Segal D. Adding fingers to an engineered zinc finger nuclease can reduce activity. Biochemistry. 2011 Jun 07; 50(22):5033-41. PMID: 21528840; PMCID: PMC3110833.
    33. Botos I, Segal D, Davies DR. The structural biology of Toll-like receptors. Structure. 2011 Apr 13; 19(4):447-59. PMID: 21481769.
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    34. Mackay JP, Font J, Segal D. The prospects for designer single-stranded RNA-binding proteins. Nat Struct Mol Biol. 2011 Mar; 18(3):256-61. PMID: 21358629.
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    35. Segal D. Zinc-finger nucleases transition to the CoDA. Nat Methods. 2011 Jan; 8(1):53-5. PMID: 21191373.
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    36. Kim MS, Stybayeva G, Lee JY, Revzin A, Segal D. A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications. Nucleic Acids Res. 2011 Mar; 39(5):e29. PMID: 21134909; PMCID: PMC3061069.
    37. Bhakta MS, Segal D. The generation of zinc finger proteins by modular assembly. Methods Mol Biol. 2010; 649:3-30. PMID: 20680825; PMCID: PMC4323424.
    38. Porter JR, Lockwood SH, Segal D, Ghosh I. Seeing genetic and epigenetic information without DNA denaturation using sequence-enabled reassembly (SEER). Methods Mol Biol. 2010; 649:365-82. PMID: 20680847.
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    39. Zykovich A, Korf I, Segal D. Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing. Nucleic Acids Res. 2009 Dec; 37(22):e151. PMID: 19843614; PMCID: PMC2794170.
    40. Furman JL, Badran AH, Shen S, Stains CI, Hannallah J, Segal D, Ghosh I. Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA. Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3748-51. PMID: 19457665; PMCID: PMC2709697.
    41. Shimizu Y, Bhakta MS, Segal D. Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker. Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3970-2. PMID: 19289279; PMCID: PMC2709702.
    42. Leonard JN, Bell JK, Segal D. Predicting Toll-like receptor structures and characterizing ligand binding. Methods Mol Biol. 2009; 517:55-67. PMID: 19378017.
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    43. Camenisch TD, Brilliant MH, Segal D. Critical parameters for genome editing using zinc finger nucleases. Mini Rev Med Chem. 2008 Jun; 8(7):669-76. PMID: 18537722.
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    44. Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal D, Davies DR. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science. 2008 Apr 18; 320(5874):379-81. PMID: 18420935.
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    45. Brayer KJ, Kulshreshtha S, Segal D. The protein-binding potential of C2H2 zinc finger domains. Cell Biochem Biophys. 2008; 51(1):9-19. PMID: 18286240.
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    46. Brayer KJ, Segal D. Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains. Cell Biochem Biophys. 2008; 50(3):111-31. PMID: 18253864.
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    47. Leonard JN, Ghirlando R, Askins J, Bell JK, Margulies DH, Davies DR, Segal D. The TLR3 signaling complex forms by cooperative receptor dimerization. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):258-63. PMID: 18172197; PMCID: PMC2224197.
    48. Cathomen T, Segal D, Brondani V, Müller-Lerch F. Generation and functional analysis of zinc finger nucleases. Methods Mol Biol. 2008; 434:277-90. PMID: 18470651.
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    49. Porter JR, Stains CI, Segal D, Ghosh I. Split beta-lactamase sensor for the sequence-specific detection of DNA methylation. Anal Chem. 2007 Sep 01; 79(17):6702-8. PMID: 17685552.
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    50. Szczepek M, Brondani V, Büchel J, Serrano L, Segal D, Cathomen T. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol. 2007 Jul; 25(7):786-93. PMID: 17603476.
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    51. Gommans WM, McLaughlin PM, Lindhout BI, Segal D, Wiegman DJ, Haisma HJ, van der Zaal BJ, Rots MG. Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment. Mol Carcinog. 2007 May; 46(5):391-401. PMID: 17186549.
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    52. Shinohara ET, Kaminski JM, Segal D, Pelczar P, Kolhe R, Ryan T, Coates CJ, Fraser MJ, Handler AM, Yanagimachi R, Moisyadi S. Active integration: new strategies for transgenesis. Transgenic Res. 2007 Jun; 16(3):333-9. PMID: 17340207.
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    53. O'Neil ML, Kuczenski R, Segal D, Cho AK, Lacan G, Melega WP. Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge. Synapse. 2006 Nov; 60(6):465-73. PMID: 16897726.
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    54. Ghosh I, Stains CI, Ooi AT, Segal D. Direct detection of double-stranded DNA: Molecular methods and applications for DNA diagnostics. Mol Biosyst. 2006 Nov; 2(11):551-60. PMID: 17216036.
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    55. Segal D, Crotty JW, Bhakta MS, Barbas CF, Horton NC. Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA. J Mol Biol. 2006 Oct 20; 363(2):405-21. PMID: 16963084.
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    56. Stains CI, Furman JL, Segal D, Ghosh I. Site-specific detection of DNA methylation utilizing mCpG-SEER. J Am Chem Soc. 2006 Aug 02; 128(30):9761-5. PMID: 16866532.
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    57. Ooi AT, Stains CI, Ghosh I, Segal D. Sequence-enabled reassembly of beta-lactamase (SEER-LAC): a sensitive method for the detection of double-stranded DNA. Biochemistry. 2006 Mar 21; 45(11):3620-5. PMID: 16533044; PMCID: PMC2688710.
    58. Eberhardy SR, Goncalves J, Coelho S, Segal D, Berkhout B, Barbas CF. Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. J Virol. 2006 Mar; 80(6):2873-83. PMID: 16501096; PMCID: PMC1395442.
    59. Carroll D, Morton JJ, Beumer KJ, Segal D. Design, construction and in vitro testing of zinc finger nucleases. Nat Protoc. 2006; 1(3):1329-41. PMID: 17406419.
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    60. Alwin S, Gere MB, Guhl E, Effertz K, Barbas CF, Segal D, Weitzman MD, Cathomen T. Custom zinc-finger nucleases for use in human cells. Mol Ther. 2005 Oct; 12(4):610-7. PMID: 16039907.
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    61. Dreier B, Fuller RP, Segal D, Lund CV, Blancafort P, Huber A, Koksch B, Barbas CF. Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem. 2005 Oct 21; 280(42):35588-97. PMID: 16107335.
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    62. Bell JK, Botos I, Hall PR, Askins J, Shiloach J, Segal D, Davies DR. The molecular structure of the Toll-like receptor 3 ligand-binding domain. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):10976-80. PMID: 16043704; PMCID: PMC1182468.
    63. Crotty JW, Etzkorn C, Barbas CF, Segal D, Horton NC. Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-finger zinc-finger peptide, bound to DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 01; 61(Pt 6):573-6. PMID: 16511099; PMCID: PMC1952332.
    64. Blancafort P, Segal D, Barbas CF. Designing transcription factor architectures for drug discovery. Mol Pharmacol. 2004 Dec; 66(6):1361-71. PMID: 15340042.
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    65. Tan W, Zhu K, Segal D, Barbas CF, Chow SA. Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites. J Virol. 2004 Feb; 78(3):1301-13. PMID: 14722285; PMCID: PMC321411.
    66. Segal D, Gonçalves J, Eberhardy S, Swan CH, Torbett BE, Li X, Barbas CF. Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J Biol Chem. 2004 Apr 09; 279(15):14509-19. PMID: 14734553.
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    67. Segal D, Stege JT, Barbas CF. Zinc fingers and a green thumb: manipulating gene expression in plants. Curr Opin Plant Biol. 2003 Apr; 6(2):163-8. PMID: 12667874.
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    68. Segal D, Beerli RR, Blancafort P, Dreier B, Effertz K, Huber A, Koksch B, Lund CV, Magnenat L, Valente D, Barbas CF. Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins. Biochemistry. 2003 Feb 25; 42(7):2137-48. PMID: 12590603.
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    69. Segal D. The use of zinc finger peptides to study the role of specific factor binding sites in the chromatin environment. Methods. 2002 Jan; 26(1):76-83. PMID: 12054906.
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