David Jay Segal

Title(s)Professor, Biochemistry and Molecular Medicine
SchoolSchool of Medicine
Address4512 GBSF
CA 95616
Phone530-754-9134
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    Other Positions
    Title(s)Professor, Med: Pharmacology


    Collapse Research 
    Collapse Research Activities and Funding
    The Epigenetics Crossroads of Environmental Exposures and Early-Life Adversity
    NIH R21ES033460Sep 17, 2021 - Aug 31, 2023
    Role: Principal Investigator
    Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo
    NIH UH3EB028910Aug 1, 2021 - Jul 31, 2023
    Role: Co-Principal Investigator
    Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo
    NIH UH2EB028910Sep 15, 2019 - Jul 31, 2021
    Role: Co-Principal Investigator
    Determinants of Persistence in Epigenetic Editing
    NIH R21HG010559Apr 23, 2019 - Jan 31, 2021
    Role: Principal Investigator
    Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools
    NIH U42OD027094Apr 15, 2019 - Mar 31, 2024
    Role: Co-Principal Investigator
    Precision Nonhuman Primate Models for Congenital Diseases
    NIH R21NS104675May 1, 2018 - Apr 30, 2021
    Role: Co-Principal Investigator
    CRISPR-based epigenetic modifiers
    NIH R21CA204563Jun 15, 2016 - May 31, 2018
    Role: Principal Investigator
    NextGen DNA Binding Proteins Based on TAL Domains
    NIH R01GM097073Apr 1, 2011 - Mar 31, 2015
    Role: Principal Investigator
    Towards Gene Therapy for Angelman Syndrome
    NIH R21NS071028Sep 15, 2010 - Aug 31, 2012
    Role: Principal Investigator
    SEER - a novel method for the detection of genetic sequences
    NIH R01GM077403Jun 1, 2006 - May 31, 2011
    Role: Principal Investigator
    Inactivation of HIV by in vivo genetic modification
    NIH R21CA103651Jul 1, 2003 - Jun 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. De-novo DNA Methylation of Bivalent Promoters Induces Gene Activation through PRC2 Displacement. bioRxiv. 2025 Feb 08. O'Geen H, Mihalovits A, Brophy BD, Yang H, Miller MW, Lee CJ, Segal DJ, Tomkova M. PMID: 39975160; PMCID: PMC11839071.
      View in: PubMed   Mentions:
    2. Integration of CTCF loops, methylome, and transcriptome in differentiating LUHMES as a model for imprinting dynamics of the 15q11-q13 locus in human neurons. Hum Mol Genet. 2024 09 19; 33(19):1711-1725. Gutierrez Fugón OJ, Sharifi O, Heath N, Soto DC, Gomez JA, Yasui DH, Mendiola AJP, O'Geen H, Beitnere U, Tomkova M, Haghani V, Dillon G, Segal DJ, LaSalle JM. PMID: 39045627; PMCID: PMC11413648.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Integration of CTCF Loops, Methylome, and Transcriptome in Differentiating LUHMES as a Model for Imprinting Dynamics of the 15q11-q13 Locus in Human Neurons. bioRxiv. 2024 Mar 29. Fugon OJG, Sharifi O, Heath NG, Soto DC, Gomez JA, Yasui DH, Mendiola AJP, O'Geen H, Beitnere U, Tomkova M, Haghani V, Dillon G, Segal DJ, LaSalle J. PMID: 38586056; PMCID: PMC10996714.
      View in: PubMed   Mentions:
    4. CRISPR-Based Split Luciferase as a Biosensor for Unique DNA Sequences In Situ. Methods Mol Biol. 2024; 2784:285-299. Heath NG, Segal DJ. PMID: 38502493.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Dr.Nod: computational framework for discovery of regulatory non-coding drivers in tissue-matched distal regulatory elements. Nucleic Acids Res. 2023 02 28; 51(4):e23. Tomkova M, Tomek J, Chow J, McPherson JD, Segal DJ, Hormozdiari F. PMID: 36625266; PMCID: PMC9976879.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model. Mol Ther. 2023 04 05; 31(4):1088-1105. O'Geen H, Beitnere U, Garcia MS, Adhikari A, Cameron DL, Fenton TA, Copping NA, Deng P, Lock S, Halmai JANM, Villegas IJ, Liu J, Wang D, Fink KD, Silverman JL, Segal DJ. PMID: 36641623; PMCID: PMC10124086.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    7. Unique Features of the Gut Microbiome Characterized in Animal Models of Angelman Syndrome. mSystems. 2023 02 23; 8(1):e0060822. Beitnere U, Vilanova-Cuevas B, Christian SG, Taylor C, Berg EL, Copping NA, Dindot SV, Silverman JL, Gareau MG, Segal DJ. PMID: 36598241; PMCID: PMC9948700.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    8. The promise of gene editing: so close and yet so perilously far. Front Genome Ed. 2022; 4:974798. Segal DJ. PMID: 35910414; PMCID: PMC9334663.
      View in: PubMed   Mentions: 4  
    9. Aberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer. Br J Cancer. 2022 08; 127(3):436-448. Umeh-Garcia M, O'Geen H, Simion C, Gephart MH, Segal DJ, Sweeney CA. PMID: 35440669; PMCID: PMC9346006.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    10. Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing. Nucleic Acids Res. 2022 04 08; 50(6):3239-3253. O'Geen H, Tomkova M, Combs JA, Tilley EK, Segal DJ. PMID: 35234927; PMCID: PMC8989539.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    11. Imaging Unique DNA Sequences in Individual Cells Using a CRISPR-Cas9-Based, Split Luciferase Biosensor. Front Genome Ed. 2022; 4:867390. Heath NG, O'Geen H, Halmai NB, Corn JE, Segal DJ. PMID: 35403097; PMCID: PMC8990833.
      View in: PubMed   Mentions: 2  
    12. An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models. Front Mol Neurosci. 2021; 14:789913. Deng P, Halmai JANM, Beitnere U, Cameron D, Martinez ML, Lee CC, Waldo JJ, Thongphanh K, Adhikari A, Copping N, Petkova SP, Lee RD, Lock S, Palomares M, O'Geen H, Carter J, Gonzalez CE, Buchanan FKB, Anderson JD, Fierro FA, Nolta JA, Tarantal AF, Silverman JL, Segal DJ, Fink KD. PMID: 35153670; PMCID: PMC8829036.
      View in: PubMed   Mentions: 1  
    13. Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in the Ube3a Deletion Rat Model of Angelman Syndrome. J Neurosci. 2021 10 20; 41(42):8801-8814. Berg EL, Jami SA, Petkova SP, Berz A, Fenton TA, Lerch JP, Segal DJ, Gray JA, Ellegood J, Wöhr M, Silverman JL. PMID: 34475199; PMCID: PMC8528495.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells. Hum Mol Genet. 2021 06 09; 30(12):1067-1083. Adhikari A, Copping NA, Beegle J, Cameron DL, Deng P, O'Geen H, Segal DJ, Fink KD, Silverman JL, Anderson JS. PMID: 33856035; PMCID: PMC8188406.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    15. The NIH Somatic Cell Genome Editing program. Nature. 2021 04; 592(7853):195-204. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J, SCGE Consortium. PMID: 33828315; PMCID: PMC8026397.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    16. Early Developmental EEG and Seizure Phenotypes in a Full Gene Deletion of Ubiquitin Protein Ligase E3A Rat Model of Angelman Syndrome. eNeuro. 2021 Mar-Apr; 8(2). Born HA, Martinez LA, Levine AT, Harris SE, Mehra S, Lee WL, Dindot SV, Nash KR, Silverman JL, Segal DJ, Weeber EJ, Anderson AE. PMID: 33531368; PMCID: PMC8114899.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    17. Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation. Nat Commun. 2020 04 30; 11(1):2102. Seo JW, Ingham ES, Mahakian L, Tumbale S, Wu B, Aghevlian S, Shams S, Baikoghli M, Jain P, Ding X, Goeden N, Dobreva T, Flytzanis NC, Chavez M, Singhal K, Leib R, James ML, Segal DJ, Cheng RH, Silva EA, Gradinaru V, Ferrara KW. PMID: 32355221; PMCID: PMC7193641.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    18. Editorial: Precise Genome Editing Techniques and Applications. Front Genet. 2020; 11:412. Xu K, Segal DJ, Zhang Z. PMID: 32373168; PMCID: PMC7186389.
      View in: PubMed   Mentions: 1  
    19. Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. Nucleic Acids Res. 2020 03 18; 48(5):2372-2387. Halmai JANM, Deng P, Gonzalez CE, Coggins NB, Cameron D, Carter JL, Buchanan FKB, Waldo JJ, Lock SR, Anderson JD, O'Geen H, Segal DJ, Nolta J, Fink KD. PMID: 31925439; PMCID: PMC7049732.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    20. Versatile 3' Functionalization of CRISPR Single Guide RNA. Chembiochem. 2020 Jun 02; 21(11):1633-1640. Palumbo CM, Gutierrez-Bujari JM, O'Geen H, Segal DJ, Beal PA. PMID: 31943634; PMCID: PMC7323579.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    21. Grand Challenges in Gene and Epigenetic Editing for Neurologic Disease. Front Genome Ed. 2019; 1:1. Segal DJ. PMID: 34713209; PMCID: PMC8525068.
      View in: PubMed   Mentions: 2  
    22. Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion. Autism Res. 2020 03; 13(3):397-409. Dodge A, Peters MM, Greene HE, Dietrick C, Botelho R, Chung D, Willman J, Nenninger AW, Ciarlone S, Kamath SG, Houdek P, Sumová A, Anderson AE, Dindot SV, Berg EL, O'Geen H, Segal DJ, Silverman JL, Weeber EJ, Nash KR. PMID: 31961493; PMCID: PMC7787396.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    23. Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways. Hum Mol Genet. 2019 11 15; 28(22):3842-3852. Lopez SJ, Laufer BI, Beitnere U, Berg EL, Silverman JL, O'Geen H, Segal DJ, LaSalle JM. PMID: 31625566; PMCID: PMC7275372.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. The Right Tools for the Right Job: CRISPR-pass Could Offer Safe Gene Correction for Many Disorders. Mol Ther. 2019 08 07; 27(8):1346-1347. Segal DJ. PMID: 31248723; PMCID: PMC6698281.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    25. Live-Animal Epigenome Editing: Convergence of Novel Techniques. Trends Genet. 2019 07; 35(7):527-541. Gomez JA, Beitnere U, Segal DJ. PMID: 31128888; PMCID: PMC6608710.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. Epigenetics Chromatin. 2019 May 03; 12(1):26. O'Geen H, Bates SL, Carter SS, Nisson KA, Halmai J, Fink KD, Rhie SK, Farnham PJ, Segal DJ. PMID: 31053162; PMCID: PMC6498470.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    27. Exploring the suitability of RanBP2-type Zinc Fingers for RNA-binding protein design. Sci Rep. 2019 02 21; 9(1):2484. De Franco S, Vandenameele J, Brans A, Verlaine O, Bendak K, Damblon C, Matagne A, Segal DJ, Galleni M, Mackay JP, Vandevenne M. PMID: 30792407; PMCID: PMC6384913.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    28. UBE3A: An E3 Ubiquitin Ligase With Genome-Wide Impact in Neurodevelopmental Disease. Front Mol Neurosci. 2018; 11:476. Lopez SJ, Segal DJ, LaSalle JM. PMID: 30686997; PMCID: PMC6338038.
      View in: PubMed   Mentions: 21  
    29. Pathogen-specific DNA sensing with engineered zinc finger proteins immobilized on a polymer chip. Analyst. 2018 Aug 20; 143(17):4009-4016. Ha DT, Ghosh S, Ahn CH, Segal DJ, Kim MS. PMID: 30043772; PMCID: PMC6239418.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    30. Strategies for the Enrichment and Selection of Genetically Modified Cells. Trends Biotechnol. 2019 01; 37(1):56-71. Ren C, Xu K, Segal DJ, Zhang Z. PMID: 30135027.
      View in: PubMed   Mentions: 17     Fields:    
    31. Author Correction: Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance. Sci Rep. 2018 Apr 12; 8(1):6140. Coggins NB, Stultz J, O'Geen H, Carvajal-Carmona LG, Segal DJ. PMID: 29643450; PMCID: PMC5895592.
      View in: PubMed   Mentions:    Fields:    
    32. Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators. PLoS One. 2018; 13(3):e0193818. O'Geen H, Ren C, Coggins NB, Bates SL, Segal DJ. PMID: 29584750; PMCID: PMC5870970.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    33. Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):E2125-E2134. Gallego-Bartolomé J, Gardiner J, Liu W, Papikian A, Ghoshal B, Kuo HY, Zhao JM, Segal DJ, Jacobsen SE. PMID: 29444862; PMCID: PMC5834696.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    34. Purified Protein Delivery to Activate an Epigenetically Silenced Allele in Mouse Brain. Methods Mol Biol. 2018; 1767:227-239. Pyles B, Bailus BJ, O'Geen H, Segal DJ. PMID: 29524138; PMCID: PMC6281562.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    35. In Vivo Applications of Cell-Penetrating Zinc-Finger Transcription Factors. Methods Mol Biol. 2018; 1867:239-251. Ren C, Adams AN, Pyles B, Bailus BJ, O'Geen H, Segal DJ. PMID: 30155828; PMCID: PMC6296463.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance. Sci Rep. 2017 11 08; 7(1):15044. Coggins NB, Stultz J, O'Geen H, Carvajal-Carmona LG, Segal DJ. PMID: 29118424; PMCID: PMC5678142.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. UBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons. Epigenetics. 2017; 12(11):982-990. Lopez SJ, Dunaway K, Islam MS, Mordaunt C, Vogel Ciernia A, Meguro-Horike M, Horike SI, Segal DJ, LaSalle JM. PMID: 28925810; PMCID: PMC5788436.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    38. dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression. Nucleic Acids Res. 2017 Sep 29; 45(17):9901-9916. O'Geen H, Ren C, Nicolet CM, Perez AA, Halmai J, Le VM, Mackay JP, Farnham PJ, Segal DJ. PMID: 28973434; PMCID: PMC5622328.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    39. Blood-brain barrier disruption for the delivery of non-infectious viral vectors and proteins, preliminary study. 2017 IEEE International Ultrasonics Symposium (IUS). 2017 Sep 1; 1-1. Foiret FJ, Zhang ZH, Fite FB, Mahakian ML, Tam TS, Segal SD, Ferrara FK. .
      View in: Publisher Site   Mentions:
    40. Blood-Brain Barrier Disruption for the Delivery of Noninfectious Viral Vectors and Proteins, Preliminary Study. . 2017 Sep 1; 1-4. Foiret FJ, Zhang ZH, Fite FB, Ilovitsh IT, Mahakian ML, Tam TS, Beitnere BU, Pyles PB, Segal SD, Ferrara FK. .
      View in: Publisher Site   Mentions:
    41. Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer. Sci Transl Med. 2017 Aug 02; 9(401). Merino D, Whittle JR, Vaillant F, Serrano A, Gong JN, Giner G, Maragno AL, Chanrion M, Schneider E, Pal B, Li X, Dewson G, Gräsel J, Liu K, Lalaoui N, Segal D, Herold MJ, Huang DCS, Smyth GK, Geneste O, Lessene G, Visvader JE, Lindeman GJ. PMID: 28768804.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    42. Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo. Cell Death Differ. 2017 05; 24(5):878-888. Carrington EM, Zhan Y, Brady JL, Zhang JG, Sutherland RM, Anstee NS, Schenk RL, Vikstrom IB, Delconte RB, Segal D, Huntington ND, Bouillet P, Tarlinton DM, Huang DC, Strasser A, Cory S, Herold MJ, Lew AM. PMID: 28362427; PMCID: PMC5423112.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    43. Corrigendum: SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature. 2017 03 02; 543(7643):136. Johnson LM, Du J, Hale CJ, Bischof S, Feng S, Chodavarapu RK, Zhong X, Marson G, Pellegrini M, Segal DJ, Patel DJ, Jacobsen SE. PMID: 28178234.
      View in: PubMed   Mentions:    Fields:    
    44. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature. 2016 10 27; 538(7626):477-482. Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurno P, Chen I, Matassova N, Smith J, Pedder C, Graham C, Studeny A, Lysiak-Auvity G, Girard AM, Gravé F, Segal D, Riffkin CD, Pomilio G, Galbraith LC, Aubrey BJ, Brennan MS, Herold MJ, Chang C, Guasconi G, Cauquil N, Melchiore F, Guigal-Stephan N, Lockhart B, Colland F, Hickman JA, Roberts AW, Huang DC, Wei AH, Strasser A, Lessene G, Geneste O. PMID: 27760111.
      View in: PubMed   Mentions: 509     Fields:    Translation:HumansAnimalsCells
    45. Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts. Cell Transplant. 2016; 25(4):677-86. Fink KD, Deng P, Gutierrez J, Anderson JS, Torrest A, Komarla A, Kalomoiris S, Cary W, Anderson JD, Gruenloh W, Duffy A, Tempkin T, Annett G, Wheelock V, Segal DJ, Nolta JA. PMID: 26850319; PMCID: PMC6476541.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    46. Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells. Nucleic Acids Res. 2016 05 19; 44(9):4123-33. Tak YG, Hung Y, Yao L, Grimmer MR, Do A, Bhakta MS, O'Geen H, Segal DJ, Farnham PJ. PMID: 26743005; PMCID: PMC4872074.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    47. Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain. Mol Ther. 2016 Mar; 24(3):548-55. Bailus BJ, Pyles B, McAlister MM, O'Geen H, Lockwood SH, Adams AN, Nguyen JT, Yu A, Berman RF, Segal DJ. PMID: 26727042; PMCID: PMC4786922.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    48. How specific is CRISPR/Cas9 really? Curr Opin Chem Biol. 2015 Dec; 29:72-8. O'Geen H, Yu AS, Segal DJ. PMID: 26517564; PMCID: PMC4684463.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    49. The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres. PLoS Genet. 2015 Jul; 11(7):e1005410. Frank AK, Tran DC, Qu RW, Stohr BA, Segal DJ, Xu L. PMID: 26230315; PMCID: PMC4521702.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    50. A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture. Nucleic Acids Res. 2015 Mar 31; 43(6):3389-404. O'Geen H, Henry IM, Bhakta MS, Meckler JF, Segal DJ. PMID: 25712100; PMCID: PMC4381059.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    51. Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology. ACS Chem Biol. 2014 Aug 15; 9(8):1645-6. Rader C, Segal DJ, Shabat D. PMID: 25123302.
      View in: PubMed   Mentions:    Fields:    
    52. Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA. Angew Chem Int Ed Engl. 2014 Jul 21; 53(30):7848-52. Vandevenne M, O'Connell MR, Helder S, Shepherd NE, Matthews JM, Kwan AH, Segal DJ, Mackay JP. PMID: 25044781.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    53. Miz-1 activates gene expression via a novel consensus DNA binding motif. PLoS One. 2014; 9(7):e101151. Barrilleaux BL, Burow D, Lockwood SH, Yu A, Segal DJ, Knoepfler PS. PMID: 24983942; PMCID: PMC4077741.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    54. The functional significance of common polymorphisms in zinc finger transcription factors. G3 (Bethesda). 2014 Jun 26; 4(9):1647-55. Lockwood SH, Guan A, Yu AS, Zhang C, Zykovich A, Korf I, Rannala B, Segal DJ. PMID: 24970883; PMCID: PMC4169156.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    55. The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders. BMC Neurosci. 2014 Jun 19; 15:76. Bailus BJ, Segal DJ. PMID: 24946931; PMCID: PMC4069279.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    56. Further insights into the effects of pre-organizing the BimBH3 helix. ACS Chem Biol. 2014 Mar 21; 9(3):838-9. Okamoto T, Segal D, Zobel K, Fedorova A, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE. PMID: 24547872.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    57. SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature. 2014 03 06; 507(7490):124-128. Johnson LM, Du J, Hale CJ, Bischof S, Feng S, Chodavarapu RK, Zhong X, Marson G, Pellegrini M, Segal DJ, Patel DJ, Jacobsen SE. PMID: 24463519; PMCID: PMC3963826.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    58. Conformational elasticity can facilitate TALE-DNA recognition. Adv Protein Chem Struct Biol. 2014; 94:347-64. Lei H, Sun J, Baldwin EP, Segal DJ, Duan Y. PMID: 24629191; PMCID: PMC4334902.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    59. Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides? Trends Biochem Sci. 2013 Sep; 38(9):421-2. Mackay JP, Segal DJ, Crossley M. PMID: 23992945.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    60. Transcription activator like effector (TALE)-directed piggyBac transposition in human cells. Nucleic Acids Res. 2013 Oct; 41(19):9197-207. Owens JB, Mauro D, Stoytchev I, Bhakta MS, Kim MS, Segal DJ, Moisyadi S. PMID: 23921635; PMCID: PMC3799441.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    61. Genome engineering at the dawn of the golden age. Annu Rev Genomics Hum Genet. 2013; 14:135-58. Segal DJ, Meckler JF. PMID: 23701416.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    62. New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. J Biol Chem. 2013 Apr 12; 288(15):10616-27. Vandevenne M, Jacques DA, Artuz C, Nguyen CD, Kwan AH, Segal DJ, Matthews JM, Crossley M, Guss JM, Mackay JP. PMID: 23436653; PMCID: PMC3624442.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    63. Quantitative analysis of TALE-DNA interactions suggests polarity effects. Nucleic Acids Res. 2013 Apr; 41(7):4118-28. Meckler JF, Bhakta MS, Kim MS, Ovadia R, Habrian CH, Zykovich A, Yu A, Lockwood SH, Morbitzer R, Elsäesser J, Lahaye T, Segal DJ, Baldwin EP. PMID: 23408851; PMCID: PMC3627578.
      View in: PubMed   Mentions: 84     Fields:    Translation:Cells
    64. Bacteria herald a new era of gene editing. Elife. 2013 Jan 29; 2:e00563. Segal DJ. PMID: 23386979; PMCID: PMC3557904.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    65. Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing. J Neurosci. 2013 Jan 02; 33(1):315-26. Brenneis C, Kistner K, Puopolo M, Segal D, Roberson D, Sisignano M, Labocha S, Ferreirós N, Strominger A, Cobos EJ, Ghasemlou N, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. PMID: 23283344; PMCID: PMC3640269.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    66. Highly active zinc-finger nucleases by extended modular assembly. Genome Res. 2013 Mar; 23(3):530-8. Bhakta MS, Henry IM, Ousterout DG, Das KT, Lockwood SH, Meckler JF, Wallen MC, Zykovich A, Yu Y, Leo H, Xu L, Gersbach CA, Segal DJ. PMID: 23222846; PMCID: PMC3589541.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    67. Beyond the genome and into the clinic. Genome Med. 2012; 4(10):78. Segal DJ. PMID: 23114014; PMCID: PMC3580447.
      View in: PubMed   Mentions:    Fields:    
    68. Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. J Am Chem Soc. 2012 Oct 24; 134(42):17814-22. Meier JL, Yu AS, Korf I, Segal DJ, Dervan PB. PMID: 23013524; PMCID: PMC3483022.
      View in: PubMed   Mentions: 26     Fields:    
    69. Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA. Angew Chem Int Ed Engl. 2012 May 29; 51(22):5371-5. O'Connell MR, Vandevenne M, Nguyen CD, Matthews JM, Gamsjaeger R, Segal DJ, Mackay JP. PMID: 22517726.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    70. Chimeric piggyBac transposases for genomic targeting in human cells. Nucleic Acids Res. 2012 Aug; 40(14):6978-91. Owens JB, Urschitz J, Stoytchev I, Dang NC, Stoytcheva Z, Belcaid M, Maragathavally KJ, Coates CJ, Segal DJ, Moisyadi S. PMID: 22492708; PMCID: PMC3413120.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    71. Adding fingers to an engineered zinc finger nuclease can reduce activity. Biochemistry. 2011 Jun 07; 50(22):5033-41. Shimizu Y, Söllü C, Meckler JF, Adriaenssens A, Zykovich A, Cathomen T, Segal DJ. PMID: 21528840; PMCID: PMC3110833.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    72. The structural biology of Toll-like receptors. Structure. 2011 Apr 13; 19(4):447-59. Botos I, Segal DM, Davies DR. PMID: 21481769; PMCID: PMC3075535.
      View in: PubMed   Mentions: 282     Fields:    Translation:HumansAnimalsCells
    73. Erratum: The prospects for designer single-stranded RNA-binding proteins. Nature Structural & Molecular Biology. 2011 Apr 1; 18(4):516-516. Mackay MJ, Font FJ, Segal SD. .
      View in: Publisher Site   Mentions:
    74. The prospects for designer single-stranded RNA-binding proteins. Nat Struct Mol Biol. 2011 Mar; 18(3):256-61. Mackay JP, Font J, Segal DJ. PMID: 21358629.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    75. Zinc-finger nucleases transition to the CoDA. Nat Methods. 2011 Jan; 8(1):53-5. Segal DJ. PMID: 21191373.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    76. A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications. Nucleic Acids Res. 2011 Mar; 39(5):e29. Kim MS, Stybayeva G, Lee JY, Revzin A, Segal DJ. PMID: 21134909; PMCID: PMC3061069.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    77. Dimerization of Toll-like receptor 3 (TLR3) is required for ligand binding. J Biol Chem. 2010 Nov 19; 285(47):36836-41. Wang Y, Liu L, Davies DR, Segal DM. PMID: 20861016; PMCID: PMC2978612.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    78. Toward a general approach for RNA-templated hierarchical assembly of split-proteins. J Am Chem Soc. 2010 Aug 25; 132(33):11692-701. Furman JL, Badran AH, Ajulo O, Porter JR, Stains CI, Segal DJ, Ghosh I. PMID: 20681585; PMCID: PMC2954892.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    79. Chemerin, a novel adipokine in the regulation of angiogenesis. J Clin Endocrinol Metab. 2010 May; 95(5):2476-85. Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB. PMID: 20237162; PMCID: PMC2869547.
      View in: PubMed   Mentions: 101     Fields:    Translation:Humans
    80. Seeing genetic and epigenetic information without DNA denaturation using sequence-enabled reassembly (SEER). Methods Mol Biol. 2010; 649:365-82. Porter JR, Lockwood SH, Segal DJ, Ghosh I. PMID: 20680847.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    81. The generation of zinc finger proteins by modular assembly. Methods Mol Biol. 2010; 649:3-30. Bhakta MS, Segal DJ. PMID: 20680825; PMCID: PMC4323424.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    82. Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing. Nucleic Acids Res. 2009 Dec; 37(22):e151. Zykovich A, Korf I, Segal DJ. PMID: 19843614; PMCID: PMC2794170.
      View in: PubMed   Mentions: 71     Fields:    Translation:Cells
    83. The toll-like receptor 3:dsRNA signaling complex. Biochim Biophys Acta. 2009 Sep-Oct; 1789(9-10):667-74. Botos I, Liu L, Wang Y, Segal DM, Davies DR. PMID: 19595807; PMCID: PMC2784288.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    84. Human methamphetamine pharmacokinetics simulated in the rat: behavioral and neurochemical effects of a 72-h binge. Neuropsychopharmacology. 2009 Oct; 34(11):2430-41. Kuczenski R, Segal DS, Melega WP, Lacan G, McCunney SJ. PMID: 19571794; PMCID: PMC2778493.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    85. Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA. Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3748-51. Furman JL, Badran AH, Shen S, Stains CI, Hannallah J, Segal DJ, Ghosh I. PMID: 19457665; PMCID: PMC2709697.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    86. Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker. Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3970-2. Shimizu Y, Bhakta MS, Segal DJ. PMID: 19289279; PMCID: PMC2709702.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    87. Critical parameters for genome editing using zinc finger nucleases. Mini Rev Med Chem. 2008 Jun; 8(7):669-76. Camenisch TD, Brilliant MH, Segal DJ. PMID: 18537722.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    88. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science. 2008 Apr 18; 320(5874):379-81. Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR. PMID: 18420935; PMCID: PMC2761030.
      View in: PubMed   Mentions: 316     Fields:    Translation:HumansAnimalsCells
    89. The protein-binding potential of C2H2 zinc finger domains. Cell Biochem Biophys. 2008; 51(1):9-19. Brayer KJ, Kulshreshtha S, Segal DJ. PMID: 18286240.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    90. Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains. Cell Biochem Biophys. 2008; 50(3):111-31. Brayer KJ, Segal DJ. PMID: 18253864.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
    91. The TLR3 signaling complex forms by cooperative receptor dimerization. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):258-63. Leonard JN, Ghirlando R, Askins J, Bell JK, Margulies DH, Davies DR, Segal DM. PMID: 18172197; PMCID: PMC2224197.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    92. Generation and functional analysis of zinc finger nucleases. Methods Mol Biol. 2008; 434:277-90. Cathomen T, Segal DJ, Brondani V, Müller-Lerch F. PMID: 18470651.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    93. Split beta-lactamase sensor for the sequence-specific detection of DNA methylation. Anal Chem. 2007 Sep 01; 79(17):6702-8. Porter JR, Stains CI, Segal DJ, Ghosh I. PMID: 17685552.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    94. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol. 2007 Jul; 25(7):786-93. Szczepek M, Brondani V, Büchel J, Serrano L, Segal DJ, Cathomen T. PMID: 17603476.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansCells
    95. Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment. Mol Carcinog. 2007 May; 46(5):391-401. Gommans WM, McLaughlin PM, Lindhout BI, Segal DJ, Wiegman DJ, Haisma HJ, van der Zaal BJ, Rots MG. PMID: 17186549.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    96. Uranyl acetate as a direct inhibitor of DNA-binding proteins. Chem Res Toxicol. 2007 May; 20(5):784-9. Hartsock WJ, Cohen JD, Segal DJ. PMID: 17432879.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    97. Active integration: new strategies for transgenesis. Transgenic Res. 2007 Jun; 16(3):333-9. Shinohara ET, Kaminski JM, Segal DJ, Pelczar P, Kolhe R, Ryan T, Coates CJ, Fraser MJ, Handler AM, Yanagimachi R, Moisyadi S. PMID: 17340207.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    98. Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge. Synapse. 2006 Nov; 60(6):465-73. O'Neil ML, Kuczenski R, Segal DS, Cho AK, Lacan G, Melega WP. PMID: 16897726.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    99. Direct detection of double-stranded DNA: Molecular methods and applications for DNA diagnostics. Mol Biosyst. 2006 Nov; 2(11):551-60. Ghosh I, Stains CI, Ooi AT, Segal DJ. PMID: 17216036.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    100. Cytoplasmic targeting motifs control localization of toll-like receptor 9. J Biol Chem. 2006 Nov 17; 281(46):35585-92. Leifer CA, Brooks JC, Hoelzer K, Lopez J, Kennedy MN, Mazzoni A, Segal DM. PMID: 16990271; PMCID: PMC2758030.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    101. Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA. J Mol Biol. 2006 Oct 20; 363(2):405-21. Segal DJ, Crotty JW, Bhakta MS, Barbas CF, Horton NC. PMID: 16963084.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    102. Site-specific detection of DNA methylation utilizing mCpG-SEER. J Am Chem Soc. 2006 Aug 02; 128(30):9761-5. Stains CI, Furman JL, Segal DJ, Ghosh I. PMID: 16866532.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    103. Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. J Immunol. 2006 Jul 01; 177(1):322-32. Rallabhandi P, Bell J, Boukhvalova MS, Medvedev A, Lorenz E, Arditi M, Hemming VG, Blanco JC, Segal DM, Vogel SN. PMID: 16785528.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    104. The dsRNA binding site of human Toll-like receptor 3. Proc Natl Acad Sci U S A. 2006 Jun 06; 103(23):8792-7. Bell JK, Askins J, Hall PR, Davies DR, Segal DM. PMID: 16720699; PMCID: PMC1482657.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    105. Sequence-enabled reassembly of beta-lactamase (SEER-LAC): a sensitive method for the detection of double-stranded DNA. Biochemistry. 2006 Mar 21; 45(11):3620-5. Ooi AT, Stains CI, Ghosh I, Segal DJ. PMID: 16533044; PMCID: PMC2688710.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    106. Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. J Virol. 2006 Mar; 80(6):2873-83. Eberhardy SR, Goncalves J, Coelho S, Segal DJ, Berkhout B, Barbas CF. PMID: 16501096; PMCID: PMC1395442.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    107. Design, construction and in vitro testing of zinc finger nucleases. Nat Protoc. 2006; 1(3):1329-41. Carroll D, Morton JJ, Beumer KJ, Segal DJ. PMID: 17406419.
      View in: PubMed   Mentions: 58     Fields:    Translation:Cells
    108. Custom zinc-finger nucleases for use in human cells. Mol Ther. 2005 Oct; 12(4):610-7. Alwin S, Gere MB, Guhl E, Effertz K, Barbas CF, Segal DJ, Weitzman MD, Cathomen T. PMID: 16039907.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    109. Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem. 2005 Oct 21; 280(42):35588-97. Dreier B, Fuller RP, Segal DJ, Lund CV, Blancafort P, Huber A, Koksch B, Barbas CF. PMID: 16107335.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    110. DNA sequence-enabled reassembly of the green fluorescent protein. J Am Chem Soc. 2005 Aug 10; 127(31):10782-3. Stains CI, Porter JR, Ooi AT, Segal DJ, Ghosh I. PMID: 16076155.
      View in: PubMed   Mentions: 31     Fields:    
    111. Site-directed genome modification: derivatives of DNA-modifying enzymes as targeting tools. Trends Biotechnol. 2005 Aug; 23(8):407-19. Coates CJ, Kaminski JM, Summers JB, Segal DJ, Miller AD, Kolb AF. PMID: 15993503.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    112. Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction. Trends Biotechnol. 2005 Aug; 23(8):399-406. Kolb AF, Coates CJ, Kaminski JM, Summers JB, Miller AD, Segal DJ. PMID: 15982766.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    113. The molecular structure of the Toll-like receptor 3 ligand-binding domain. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):10976-80. Bell JK, Botos I, Hall PR, Askins J, Shiloach J, Segal DM, Davies DR. PMID: 16043704; PMCID: PMC1182468.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    114. Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-finger zinc-finger peptide, bound to DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 01; 61(Pt 6):573-6. Crotty JW, Etzkorn C, Barbas CF, Segal DJ, Horton NC. PMID: 16511099; PMCID: PMC1952332.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    115. Designing transcription factor architectures for drug discovery. Mol Pharmacol. 2004 Dec; 66(6):1361-71. Blancafort P, Segal DJ, Barbas CF. PMID: 15340042.
      View in: PubMed   Mentions: 59     Fields:    
    116. TLR9 is localized in the endoplasmic reticulum prior to stimulation. J Immunol. 2004 Jul 15; 173(2):1179-83. Leifer CA, Kennedy MN, Mazzoni A, Lee C, Kruhlak MJ, Segal DM. PMID: 15240708; PMCID: PMC2757936.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    117. A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4. J Biol Chem. 2004 Aug 13; 279(33):34698-704. Kennedy MN, Mullen GE, Leifer CA, Lee C, Mazzoni A, Dileepan KN, Segal DM. PMID: 15175334.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    118. Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays. Exp Hematol. 2004 May; 32(5):476-82. Håkansson P, Segal D, Lassen C, Gullberg U, Morse HC, Fioretos T, Meltzer PS. PMID: 15145216.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    119. Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites. J Virol. 2004 Feb; 78(3):1301-13. Tan W, Zhu K, Segal DJ, Barbas CF, Chow SA. PMID: 14722285; PMCID: PMC321411.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    120. Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J Biol Chem. 2004 Apr 09; 279(15):14509-19. Segal DJ, Gonçalves J, Eberhardy S, Swan CH, Torbett BE, Li X, Barbas CF. PMID: 14734553.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    121. Zinc fingers and a green thumb: manipulating gene expression in plants. Curr Opin Plant Biol. 2003 Apr; 6(2):163-8. Segal DJ, Stege JT, Barbas CF. PMID: 12667874.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    122. Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins. Biochemistry. 2003 Feb 25; 42(7):2137-48. Segal DJ, Beerli RR, Blancafort P, Dreier B, Effertz K, Huber A, Koksch B, Lund CV, Magnenat L, Valente D, Barbas CF. PMID: 12590603.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    123. Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine. J Neurosci. 2002 Aug 15; 22(16):7264-71. Kuczenski R, Segal DS. PMID: 12177221; PMCID: PMC6757883.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    124. Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells. Eur J Immunol. 2002 04; 32(4):1182-7. Spitzer JH, Visintin A, Mazzoni A, Kennedy MN, Segal DM. PMID: 11932926.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    125. Brain macrophage surface marker expression with HIV-1 infection and drug abuse: a preliminary study. J NeuroAIDS. 2002; 2(3):37-50. Shapshak P, Stewart RV, Rodriguez de la Vega P, Dominguez B, Fujimura R, Segal DM, Sun NC, Delgado S, Petito C. PMID: 16873198.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    126. The use of zinc finger peptides to study the role of specific factor binding sites in the chromatin environment. Methods. 2002 Jan; 26(1):76-83. Segal DJ. PMID: 12054906.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    127. Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins. Curr Opin Biotechnol. 2001 Dec; 12(6):632-7. Segal DJ, Barbas CF. PMID: 11849947.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    128. Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem. 2001 Aug 03; 276(31):29466-78. Dreier B, Beerli RR, Segal DJ, Flippin JD, Barbas CF. PMID: 11340073.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    129. Stimulation of homologous recombination through targeted cleavage by chimeric nucleases. Mol Cell Biol. 2001 Jan; 21(1):289-97. Bibikova M, Carroll D, Segal DJ, Trautman JK, Smith J, Kim YG, Chandrasegaran S. PMID: 11113203; PMCID: PMC88802.
      View in: PubMed   Mentions: 233     Fields:    Translation:AnimalsCells
    130. Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains. J Mol Biol. 2000 Nov 03; 303(4):489-502. Dreier B, Segal DJ, Barbas CF. PMID: 11054286.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    131. Design of novel sequence-specific DNA-binding proteins. Curr Opin Chem Biol. 2000 Feb; 4(1):34-9. Segal DJ, Barbas CF. PMID: 10679372.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    132. From catalytic asymmetric synthesis to the transcriptional regulation of genes: in vivo and in vitro evolution of proteins. Adv Protein Chem. 2000; 55:317-66. Barbas CF, Rader C, Segal DJ, List B, Turner JM. PMID: 11050938.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    133. Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2758-63. Segal DJ, Dreier B, Beerli RR, Barbas CF. PMID: 10077584; PMCID: PMC15842.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    134. Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14628-33. Beerli RR, Segal DJ, Dreier B, Barbas CF. PMID: 9843940; PMCID: PMC24500.
      View in: PubMed   Mentions: 223     Fields:    Translation:HumansAnimalsCells
    135. Processing of targeted psoralen cross-links in Xenopus oocytes. Mol Cell Biol. 1997 Nov; 17(11):6645-52. Segal DJ, Faruqi AF, Glazer PM, Carroll D. PMID: 9343428; PMCID: PMC232518.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    136. Design of polydactyl zinc-finger proteins for unique addressing within complex genomes. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5525-30. Liu Q, Segal DJ, Ghiara JB, Barbas CF. PMID: 9159105; PMCID: PMC20811.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    137. Recombination induced by triple-helix-targeted DNA damage in mammalian cells. Mol Cell Biol. 1996 Dec; 16(12):6820-8. Faruqi AF, Seidman MM, Segal DJ, Carroll D, Glazer PM. PMID: 8943337; PMCID: PMC231685.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    138. Endonuclease-induced, targeted homologous extrachromosomal recombination in Xenopus oocytes. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):806-10. Segal DJ, Carroll D. PMID: 7846056; PMCID: PMC42709.
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