Paul Knoepfler

Title(s)Professor, Cell Biology and Human Anatomy
SchoolSchool of Medicine
Address633A Shriners Hospital
CA 95817
Phone916-453-2289
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    Collapse Overview 
    Collapse Overview
    The Knoepfler Lab is interested in epigenetics and chromatin, and the cellular machinery that regulates these states normally in stem cells and aberrantly in cancer, particularly pediatric brain tumors, as well as during faulty brain development such as occurs with microcephaly. There are many, exciting open questions in these areas of research. For instance, what are the shared and distinct molecular events in normal and cancer stem cells? Do some of these same molecules impact brain growth in microcephaly? What about childhood brain tumors?

    We use cutting edge molecular, cellular and developmental biology methods as well as genomic and gene editing technologies to attack these questions. We are particularly interested now in the roles that the MYC family, DPPA4, and the histone variant H3.3 play in stem cells and cancer. How do these factors link together the epigenome to cellular behaviors and tissue growth?

    Our big picture goal is to impact human health through discoveries in development, cancer and stem cell biology.

    Join us!

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting the Mutant H3.3 Pathway in Glioma
    NIH R01NS106878Sep 30, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Targeting a novel H3.3 epigenetic switch to regulate health and disease
    NIH R01GM116919Sep 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Myc Regulation of Embryonic Stem Cell Self-Renewal and Pluripotency
    NIH R01GM100782Jul 1, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Analyzing Myc function in neural cancers and development
    NIH K01CA114400Jul 1, 2005 - Jun 30, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Noncanonical function of folate through folate receptor 1 during neural tube formation. Nat Commun. 2024 Feb 22; 15(1):1642. Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN. PMID: 38388461; PMCID: PMC10883926.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Knockout tales: the versatile roles of histone H3.3 in development and disease. Epigenetics Chromatin. 2023 10 10; 16(1):38. Klein RH, Knoepfler PS. PMID: 37814296; PMCID: PMC10563256.
      View in: PubMed   Mentions:    Fields:    
    3. Non-canonical function of folate/folate receptor 1 during neural tube formation. bioRxiv. 2023 Jul 21. Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN. PMID: 37503108; PMCID: PMC10370062.
      View in: PubMed   Mentions:
    4. A knockout-first model of H3f3a gene targeting leads to developmental lethality. Genesis. 2023 03; 61(1-2):e23507. Bush K, Cervantes V, Yee JQ, Klein RH, Knoepfler PS. PMID: 36656301; PMCID: PMC10038898.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG. Epigenetics Chromatin. 2022 05 19; 15(1):18. Lewis NA, Klein RH, Kelly C, Yee J, Knoepfler PS. PMID: 35590427; PMCID: PMC9121554.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium. Front Cell Dev Biol. 2022; 10:786031. Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Takemoto Y, Hatanaka F, Yoshida K, Prieto J, Sahu SK, Takahashi Y, Reddy P, O'Keefe DD, Rodriguez Esteban C, Knoepfler PS, Nuñez Delicado E, Castells A, Campistol JM, Kato R, Nakagawa H, Izpisua Belmonte JC. PMID: 35309931; PMCID: PMC8931341.
      View in: PubMed   Mentions: 1  
    7. DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer. Stem Cell Reports. 2021 12 14; 16(12):2844-2851. Klein RH, Knoepfler PS. PMID: 34767751; PMCID: PMC8693620.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Anticipated impact of stem cell and other cellular medicine clinical trials for COVID-19. Regen Med. 2021 06; 16(6):525-533. Kim M, Knoepfler PS. PMID: 34114493; PMCID: PMC8202509.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Stem cell models help crack regional oncohistone codes driving childhood gliomas. Cell Stem Cell. 2021 05 06; 28(5):785-787. Klein RH, Knoepfler PS. PMID: 33961758.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling. Commun Biol. 2020 07 09; 3(1):363. Chen KY, Bush K, Klein RH, Cervantes V, Lewis N, Naqvi A, Carcaboso AM, Lechpammer M, Knoepfler PS. PMID: 32647372; PMCID: PMC7347881.
      View in: PubMed   Mentions: 22  Translation:HumansAnimalsCells
    11. Rapid change of a cohort of 570 unproven stem cell clinics in the USA over 3 years. Regen Med. 2019 08; 14(8):735-740. Knoepfler PS. PMID: 31456478.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. Gene editing: sloppy definitions mislead. Nature. 2018 12; 564(7736):345. Knoepfler P. PMID: 30568213.
      View in: PubMed   Mentions:    Fields:    
    13. Mapping and driving the stem cell ecosystem. Regen Med. 2018 10; 13(7):845-858. Knoepfler PS. PMID: 30289055.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer. Stem Cell Res. 2018 08; 31:83-94. Klein RH, Tung PY, Somanath P, Fehling HJ, Knoepfler PS. PMID: 30031967; PMCID: PMC6133722.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. Too Much Carrot and Not Enough Stick in New Stem Cell Oversight Trends. Cell Stem Cell. 2018 07 05; 23(1):18-20. Knoepfler PS. PMID: 29937201.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells. Stem Cells. 2018 05; 36(5):671-682. Somanath P, Bush KM, Knoepfler PS. PMID: 29327467; PMCID: PMC5918234.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. The FDA and the US direct-to-consumer marketplace for stem cell interventions: a temporal analysis. Regen Med. 2018 Jan; 13(1):19-27. Knoepfler PS, Turner LG. PMID: 29327974.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    18. CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells. PLoS One. 2017; 12(10):e0185627. Somanath P, Herndon Klein R, Knoepfler PS. PMID: 28982113; PMCID: PMC5628847.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    19. Behavior of Xeno-Transplanted Undifferentiated Human Induced Pluripotent Stem Cells Is Impacted by Microenvironment Without Evidence of Tumors. Stem Cells Dev. 2017 10 01; 26(19):1409-1423. Martínez-Cerdeño V, Barrilleaux BL, McDonough A, Ariza J, Yuen BTK, Somanath P, Le CT, Steward C, Horton-Sparks K, Knoepfler PS. PMID: 28693365; PMCID: PMC5647528.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    20. To CRISPR and beyond: the evolution of genome editing in stem cells. Regen Med. 2016 12; 11(8):801-816. Chen KY, Knoepfler PS. PMID: 27905217; PMCID: PMC5221123.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    21. The Stem Cell Hard Sell: Report from a Clinic's Patient Recruitment Seminar. Stem Cells Transl Med. 2017 01; 6(1):14-16. Knoepfler PS. PMID: 28170181; PMCID: PMC5442738.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    22. Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry. Cell Stem Cell. 2016 08 04; 19(2):154-157. Turner L, Knoepfler P. PMID: 27374789.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCells
    23. When patients reach out, scientists should reach back carefully. Nat Med. 2016 Mar; 22(3):230. Knoepfler PS. PMID: 26937614.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Reviewing post-publication peer review. Trends Genet. 2015 May; 31(5):221-3. Knoepfler P. PMID: 25851694; PMCID: PMC4472664.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    25. From bench to FDA to bedside: US regulatory trends for new stem cell therapies. Adv Drug Deliv Rev. 2015 Mar; 82-83:192-6. Knoepfler PS. PMID: 25489841; PMCID: PMC4398607.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    26. Histone H3.3 regulates dynamic chromatin states during spermatogenesis. Development. 2014 Sep; 141(18):3483-94. Yuen BT, Bush KM, Barrilleaux BL, Cotterman R, Knoepfler PS. PMID: 25142466; PMCID: PMC4197731.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    27. Miz-1 activates gene expression via a novel consensus DNA binding motif. PLoS One. 2014; 9(7):e101151. Barrilleaux BL, Burow D, Lockwood SH, Yu A, Segal DJ, Knoepfler PS. PMID: 24983942; PMCID: PMC4077741.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    28. Epigenetic mechanisms of tumorigenicity manifesting in stem cells. Oncogene. 2015 Apr 30; 34(18):2288-96. Tung PY, Knoepfler PS. PMID: 24931168; PMCID: PMC4268091.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    29. Histone H3.3 mutations: a variant path to cancer. Cancer Cell. 2013 Nov 11; 24(5):567-74. Yuen BT, Knoepfler PS. PMID: 24229707; PMCID: PMC3882088.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    30. Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes. Stem Cells. 2013 Nov; 31(11):2330-42. Tung PY, Varlakhanova NV, Knoepfler PS. PMID: 23963736; PMCID: PMC3922068.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    31. Key action items for the stem cell field: looking ahead to 2014. Stem Cells Dev. 2013 Dec; 22 Suppl 1:10-2. Knoepfler PS. PMID: 24147571; PMCID: PMC4361222.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    32. Scientists: you really need to get out of the lab more. Nat Med. 2013 Sep; 19(9):1086. Knoepfler PS. PMID: 24013741; PMCID: PMC4342999.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    33. Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain. Biochem Biophys Res Commun. 2013 Jun 14; 435(4):551-6. Laskowski AI, Knoepfler PS. PMID: 23665319; PMCID: PMC3694802.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    34. Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development. Epigenetics Chromatin. 2013 Apr 09; 6(1):7. Bush KM, Yuen BT, Barrilleaux BL, Riggs JW, O'Geen H, Cotterman RF, Knoepfler PS. PMID: 23570311; PMCID: PMC3635903.
      View in: PubMed   Mentions: 52     Fields:    
    35. Call for fellowship programs in stem cell-based regenerative and cellular medicine: new stem cell training is essential for physicians. Regen Med. 2013 Mar; 8(2):223-5. Knoepfler PS. PMID: 23477401; PMCID: PMC3698965.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    36. Chromatin immunoprecipitation assays for Myc and N-Myc. Methods Mol Biol. 2013; 1012:117-33. Barrilleaux BL, Cotterman R, Knoepfler PS. PMID: 24006062; PMCID: PMC4349432.
      View in: PubMed   Mentions: 5     Fields:    
    37. Utf1: Goldilocks for ESC bivalency. Cell Stem Cell. 2012 Dec 07; 11(6):732-4. Laskowski AI, Knoepfler PS. PMID: 23217417; PMCID: PMC3684620.
      View in: PubMed   Mentions: 5     Fields:    
    38. Induced pluripotency and oncogenic transformation are related processes. Stem Cells Dev. 2013 Jan 01; 22(1):37-50. Riggs JW, Barrilleaux BL, Varlakhanova N, Bush KM, Chan V, Knoepfler PS. PMID: 22998387; PMCID: PMC3528096.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    39. Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism. PLoS One. 2012; 7(10):e46770. Meissen JK, Yuen BT, Kind T, Riggs JW, Barupal DK, Knoepfler PS, Fiehn O. PMID: 23077522; PMCID: PMC3471894.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    40. Key anticipated regulatory issues for clinical use of human induced pluripotent stem cells. Regen Med. 2012 Sep; 7(5):713-20. Knoepfler PS. PMID: 22830621; PMCID: PMC3684269.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    41. N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells. PLoS One. 2012; 7(6):e39456. Martínez-Cerdeño V, Lemen JM, Chan V, Wey A, Lin W, Dent SR, Knoepfler PS. PMID: 22745758; PMCID: PMC3383708.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    42. Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc. Pigment Cell Melanoma Res. 2012 May; 25(3):312-25. Pshenichnaya I, Schouwey K, Armaro M, Larue L, Knoepfler PS, Eisenman RN, Trumpp A, Delmas V, Beermann F. PMID: 22420299; PMCID: PMC3541053.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells. Epigenetics Chromatin. 2011 Nov 04; 4:20. Varlakhanova N, Cotterman R, Bradnam K, Korf I, Knoepfler PS. PMID: 22053792; PMCID: PMC3226433.
      View in: PubMed   Mentions: 24     Fields:    
    44. Inducing iPSCs to escape the dish. Cell Stem Cell. 2011 Aug 05; 9(2):103-11. Barrilleaux B, Knoepfler PS. PMID: 21816362; PMCID: PMC3500137.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    45. My year as a stem-cell blogger. Nature. 2011 Jul 27; 475(7357):425. Knoepfler P. PMID: 21796162; PMCID: PMC4342992.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    46. Transduction of human cells with polymer-complexed ecotropic lentivirus for enhanced biosafety. J Vis Exp. 2011 Jul 24; (53). Barrilleaux B, Knoepfler P. PMID: 21808229; PMCID: PMC3196183.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    47. N-myc controls proliferation, morphogenesis, and patterning of the inner ear. J Neurosci. 2011 May 11; 31(19):7178-89. Domínguez-Frutos E, López-Hernández I, Vendrell V, Neves J, Gallozzi M, Gutsche K, Quintana L, Sharpe J, Knoepfler PS, Eisenman RN, Trumpp A, Giráldez F, Schimmang T. PMID: 21562282; PMCID: PMC4349441.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    48. c- and N-myc regulate neural precursor cell fate, cell cycle, and metabolism to direct cerebellar development. Cerebellum. 2010 Dec; 9(4):537-47. Wey A, Martinez Cerdeno V, Pleasure D, Knoepfler PS. PMID: 20658325; PMCID: PMC2996535.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    49. Arrestin' the hedgehog: Shh limits its own signaling via β-Arrestin1. Cell Cycle. 2010 Nov 01; 9(21):4260-1. Knoepfler PS. PMID: 21057198.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    50. c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain. Oncotarget. 2010 Jun; 1(2):120-30. Wey A, Knoepfler PS. PMID: 20651942; PMCID: PMC2907900.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    51. myc maintains embryonic stem cell pluripotency and self-renewal. Differentiation. 2010 Jul; 80(1):9-19. Varlakhanova NV, Cotterman RF, deVries WN, Morgan J, Donahue LR, Murray S, Knowles BB, Knoepfler PS. PMID: 20537458; PMCID: PMC2916696.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    52. Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex. Development. 2010 Apr; 137(7):1035-44. Kuwahara A, Hirabayashi Y, Knoepfler PS, Taketo MM, Sakai J, Kodama T, Gotoh Y. PMID: 20215343.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    53. The death of MyMouseHouse: lessons for systems for the efficient management of mouse colonies. Dis Model Mech. 2010 Jan-Feb; 3(1-2):9-10. Knoepfler PS, Bush KM. PMID: 20075375.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    54. Division and apoptosis of E2f-deficient retinal progenitors. Nature. 2009 Dec 17; 462(7275):925-9. Chen D, Pacal M, Wenzel P, Knoepfler PS, Leone G, Bremner R. PMID: 20016601; PMCID: PMC2813224.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    55. Acting locally and globally: Myc's ever-expanding roles on chromatin. Cancer Res. 2009 Oct 01; 69(19):7487-90. Varlakhanova NV, Knoepfler PS. PMID: 19773445.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    56. N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b. PLoS One. 2009 Jun 04; 4(6):e5799. Cotterman R, Knoepfler PS. PMID: 19495417; PMCID: PMC2686170.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    57. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells. 2009 May; 27(5):1050-6. Knoepfler PS. PMID: 19415771; PMCID: PMC2733374.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    58. Journal club. A cell biologist looks at the risk and promise of a new insight into stem cells and cancer. Nature. 2009 Jan 22; 457(7228):361. Knoepfler P. PMID: 19158746.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    59. Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell. 2008 Dec 04; 3(6):611-24. Laurenti E, Varnum-Finney B, Wilson A, Ferrero I, Blanco-Bose WE, Ehninger A, Knoepfler PS, Cheng PF, MacDonald HR, Eisenman RN, Bernstein ID, Trumpp A. PMID: 19041778; PMCID: PMC2635113.
      View in: PubMed   Mentions: 150     Fields:    Translation:AnimalsCells
    60. N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor. Cancer Res. 2008 Dec 01; 68(23):9654-62. Cotterman R, Jin VX, Krig SR, Lemen JM, Wey A, Farnham PJ, Knoepfler PS. PMID: 19047142; PMCID: PMC2637654.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    61. Stem cells on the brain. Arch Neurol. 2008 Mar; 65(3):311-5. Knoepfler PS. PMID: 18332242.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    62. N-myc coordinates retinal growth with eye size during mouse development. Genes Dev. 2008 Jan 15; 22(2):179-93. Martins RA, Zindy F, Donovan S, Zhang J, Pounds S, Wey A, Knoepfler PS, Eisenman RN, Roussel MF, Dyer MA. PMID: 18198336; PMCID: PMC2192753.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    63. Why myc? An unexpected ingredient in the stem cell cocktail. Cell Stem Cell. 2008 Jan 10; 2(1):18-21. Knoepfler PS. PMID: 18371417.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    64. Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. J Cell Biol. 2007 Nov 19; 179(4):717-31. Habib T, Park H, Tsang M, de Alborán IM, Nicks A, Wilson L, Knoepfler PS, Andrews S, Rawlings DJ, Eisenman RN, Iritani BM. PMID: 17998397; PMCID: PMC2080907.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    65. Myc goes global: new tricks for an old oncogene. Cancer Res. 2007 Jun 01; 67(11):5061-3. Knoepfler PS. PMID: 17545579.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    66. Activities of N-Myc in the developing limb link control of skeletal size with digit separation. Development. 2007 Apr; 134(8):1583-92. Ota S, Zhou ZQ, Keene DR, Knoepfler P, Hurlin PJ. PMID: 17360777.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    67. N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res. 2006 Sep 01; 66(17):8655-61. Hatton BA, Knoepfler PS, Kenney AM, Rowitch DH, de Alborán IM, Olson JM, Eisenman RN. PMID: 16951180.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    68. N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11579-83. Zindy F, Knoepfler PS, Xie S, Sherr CJ, Eisenman RN, Roussel MF. PMID: 16864777; PMCID: PMC1518798.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    69. Myc influences global chromatin structure. EMBO J. 2006 Jun 21; 25(12):2723-34. Knoepfler PS, Zhang XY, Cheng PF, Gafken PR, McMahon SB, Eisenman RN. PMID: 16724113; PMCID: PMC1500848.
      View in: PubMed   Mentions: 215     Fields:    Translation:HumansAnimalsCells
    70. Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes. Cell Cycle. 2006 Jan; 5(1):47-52. Knoepfler PS, Kenney AM. PMID: 16322694.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    71. Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. Development. 2005 Mar; 132(6):1363-74. Okubo T, Knoepfler PS, Eisenman RN, Hogan BL. PMID: 15716345.
      View in: PubMed   Mentions: 143     Fields:    Translation:AnimalsCells
    72. Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors. Cold Spring Harb Symp Quant Biol. 2005; 70:299-307. Orian A, Grewal SS, Knoepfler PS, Edgar BA, Parkhurst SM, Eisenman RN. PMID: 16869766.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    73. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nat Struct Mol Biol. 2004 Aug; 11(8):738-46. Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I. PMID: 15235594.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    74. Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential. Mol Cell. 2004 May 21; 14(4):465-77. Berkes CA, Bergstrom DA, Penn BH, Seaver KJ, Knoepfler PS, Tapscott SJ. PMID: 15149596.
      View in: PubMed   Mentions: 184     Fields:    Translation:AnimalsCells
    75. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev. 2002 Oct 15; 16(20):2699-712. Knoepfler PS, Cheng PF, Eisenman RN. PMID: 12381668; PMCID: PMC187459.
      View in: PubMed   Mentions: 233     Fields:    Translation:AnimalsCells
    76. Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13120-5. Calvo KR, Knoepfler PS, Sykes DB, Pasillas MP, Kamps MP. PMID: 11687616; PMCID: PMC60834.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    77. HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. Oncogene. 2001 Sep 06; 20(39):5440-8. Knoepfler PS, Sykes DB, Pasillas M, Kamps MP. PMID: 11571641.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    78. The Smad transcriptional corepressor TGIF recruits mSin3. Cell Growth Differ. 2001 Sep; 12(9):457-63. Wotton D, Knoepfler PS, Laherty CD, Eisenman RN, Massagué J. PMID: 11571228.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    79. Direct interaction of two homeoproteins, homothorax and extradenticle, is essential for EXD nuclear localization and function. Mech Dev. 2000 Mar 01; 91(1-2):279-91. Jaw TJ, You LR, Knoepfler PS, Yao LC, Pai CY, Tang CY, Chang LP, Berthelsen J, Blasi F, Kamps MP, Sun YH. PMID: 10704852.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    80. An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1. Oncogene. 1999 Dec 23; 18(56):8033-43. Calvo KR, Knoepfler P, McGrath S, Kamps MP. PMID: 10637514.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    81. Sin meets NuRD and other tails of repression. Cell. 1999 Nov 24; 99(5):447-50. Knoepfler PS, Eisenman RN. PMID: 10589671.
      View in: PubMed   Mentions: 106     Fields:    
    82. A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1. Nucleic Acids Res. 1999 Sep 15; 27(18):3752-61. Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP. PMID: 10471746; PMCID: PMC148632.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    83. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14553-8. Knoepfler PS, Calvo KR, Chen H, Antonarakis SE, Kamps MP. PMID: 9405651; PMCID: PMC25052.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    84. The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subset of Pbx-recognition elements. Oncogene. 1997 May 29; 14(21):2521-31. Knoepfler PS, Kamps MP. PMID: 9191052.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    85. The Pbx family of proteins is strongly upregulated by a post-transcriptional mechanism during retinoic acid-induced differentiation of P19 embryonal carcinoma cells. Mech Dev. 1997 Apr; 63(1):5-14. Knoepfler PS, Kamps MP. PMID: 9178252.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    86. Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif. Nucleic Acids Res. 1996 Jun 15; 24(12):2288-94. Knoepfler PS, Lu Q, Kamps MP. PMID: 8710498; PMCID: PMC145957.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    87. The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1. Mol Cell Biol. 1995 Oct; 15(10):5811-9. Knoepfler PS, Kamps MP. PMID: 7565734; PMCID: PMC230833.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    88. Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol Cell Biol. 1995 Jul; 15(7):3786-95. Lu Q, Knoepfler PS, Scheele J, Wright DD, Kamps MP. PMID: 7791786; PMCID: PMC230617.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    89. Gene expression in a swine model of right ventricular hypertrophy: intercellular adhesion molecule, vascular endothelial growth factor and plasminogen activators are upregulated during pressure overload. J Mol Cell Cardiol. 1995 Jul; 27(7):1427-41. Carroll SM, Nimmo LE, Knoepfler PS, White FC, Bloor CM. PMID: 7473788.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    90. Urokinase plasminogen activator activity is increased in the myocardium during coronary artery occlusion. J Mol Cell Cardiol. 1995 Jun; 27(6):1317-24. Knoepfler PS, Bloor CM, Carroll SM. PMID: 8531214.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
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