Paul Knoepfler

InstitutionUniversity of California Davis
Address633A Shriners Hospital
CA 95817
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Klein RH, Tung PY, Somanath P, Fehling HJ, Knoepfler P. Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer. Stem Cell Res. 2018 Jul 19; 31:83-94. PMID: 30031967.
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    2. Knoepfler P. Too Much Carrot and Not Enough Stick in New Stem Cell Oversight Trends. Cell Stem Cell. 2018 Jul 05; 23(1):18-20. PMID: 29937201.
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    3. Somanath P, Bush KM, Knoepfler P. ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells. Stem Cells. 2018 May; 36(5):671-682. PMID: 29327467.
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    4. Knoepfler P, Turner LG. The FDA and the US direct-to-consumer marketplace for stem cell interventions: a temporal analysis. Regen Med. 2018 Jan; 13(1):19-27. PMID: 29327974.
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    5. Somanath P, Herndon Klein R, Knoepfler P. CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells. PLoS One. 2017; 12(10):e0185627. PMID: 28982113.
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    6. Martínez-Cerdeño V, Barrilleaux BL, McDonough A, Ariza J, Yuen BTK, Somanath P, Le CT, Steward C, Horton-Sparks K, Knoepfler P. Behavior of Xeno-Transplanted Undifferentiated Human Induced Pluripotent Stem Cells Is Impacted by Microenvironment Without Evidence of Tumors. Stem Cells Dev. 2017 Oct 01; 26(19):1409-1423. PMID: 28693365.
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    7. Chen KY, Knoepfler P. To CRISPR and beyond: the evolution of genome editing in stem cells. Regen Med. 2016 12; 11(8):801-816. PMID: 27905217.
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    8. Knoepfler P. The Stem Cell Hard Sell: Report from a Clinic's Patient Recruitment Seminar. Stem Cells Transl Med. 2017 Jan; 6(1):14-16. PMID: 28170181.
      View in: PubMed
    9. Turner L, Knoepfler P. Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry. Cell Stem Cell. 2016 08 04; 19(2):154-157. PMID: 27374789.
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    10. Knoepfler P. When patients reach out, scientists should reach back carefully. Nat Med. 2016 Mar; 22(3):230. PMID: 26937614.
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    11. Knoepfler P. Reviewing post-publication peer review. Trends Genet. 2015 May; 31(5):221-3. PMID: 25851694; PMCID: PMC4472664.
    12. Knoepfler P. From bench to FDA to bedside: US regulatory trends for new stem cell therapies. Adv Drug Deliv Rev. 2015 Mar; 82-83:192-6. PMID: 25489841; PMCID: PMC4398607.
    13. Yuen BT, Bush KM, Barrilleaux BL, Cotterman R, Knoepfler P. Histone H3.3 regulates dynamic chromatin states during spermatogenesis. Development. 2014 Sep; 141(18):3483-94. PMID: 25142466; PMCID: PMC4197731.
    14. Barrilleaux BL, Burow D, Lockwood SH, Yu A, Segal DJ, Knoepfler P. Miz-1 activates gene expression via a novel consensus DNA binding motif. PLoS One. 2014; 9(7):e101151. PMID: 24983942; PMCID: PMC4077741.
    15. Yuen BT, Knoepfler P. Histone H3.3 mutations: a variant path to cancer. Cancer Cell. 2013 Nov 11; 24(5):567-74. PMID: 24229707; PMCID: PMC3882088.
    16. Tung PY, Varlakhanova NV, Knoepfler P. Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes. Stem Cells. 2013 Nov; 31(11):2330-42. PMID: 23963736; PMCID: PMC3922068.
    17. Knoepfler P. Key action items for the stem cell field: looking ahead to 2014. Stem Cells Dev. 2013 Dec; 22 Suppl 1:10-2. PMID: 24147571; PMCID: PMC4361222.
    18. Knoepfler P. Scientists: you really need to get out of the lab more. Nat Med. 2013 Sep; 19(9):1086. PMID: 24013741; PMCID: PMC4342999.
    19. Laskowski AI, Knoepfler P. Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain. Biochem Biophys Res Commun. 2013 Jun 14; 435(4):551-6. PMID: 23665319; PMCID: PMC3694802.
    20. Bush KM, Yuen BT, Barrilleaux BL, Riggs JW, O'Geen H, Cotterman RF, Knoepfler P. Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development. Epigenetics Chromatin. 2013 Apr 09; 6(1):7. PMID: 23570311; PMCID: PMC3635903.
    21. Knoepfler P. Call for fellowship programs in stem cell-based regenerative and cellular medicine: new stem cell training is essential for physicians. Regen Med. 2013 Mar; 8(2):223-5. PMID: 23477401; PMCID: PMC3698965.
    22. Barrilleaux BL, Cotterman R, Knoepfler P. Chromatin immunoprecipitation assays for Myc and N-Myc. Methods Mol Biol. 2013; 1012:117-33. PMID: 24006062; PMCID: PMC4349432.
    23. Laskowski AI, Knoepfler P. Utf1: Goldilocks for ESC bivalency. Cell Stem Cell. 2012 Dec 07; 11(6):732-4. PMID: 23217417; PMCID: PMC3684620.
    24. Riggs JW, Barrilleaux BL, Varlakhanova N, Bush KM, Chan V, Knoepfler P. Induced pluripotency and oncogenic transformation are related processes. Stem Cells Dev. 2013 Jan 01; 22(1):37-50. PMID: 22998387; PMCID: PMC3528096.
    25. Meissen JK, Yuen BT, Kind T, Riggs JW, Barupal DK, Knoepfler P, Fiehn O. Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism. PLoS One. 2012; 7(10):e46770. PMID: 23077522; PMCID: PMC3471894.
    26. Knoepfler P. Key anticipated regulatory issues for clinical use of human induced pluripotent stem cells. Regen Med. 2012 Sep; 7(5):713-20. PMID: 22830621; PMCID: PMC3684269.
    27. Martínez-Cerdeño V, Lemen JM, Chan V, Wey A, Lin W, Dent SR, Knoepfler P. N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells. PLoS One. 2012; 7(6):e39456. PMID: 22745758; PMCID: PMC3383708.
    28. Pshenichnaya I, Schouwey K, Armaro M, Larue L, Knoepfler P, Eisenman RN, Trumpp A, Delmas V, Beermann F. Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc. Pigment Cell Melanoma Res. 2012 May; 25(3):312-25. PMID: 22420299; PMCID: PMC3541053.
    29. Varlakhanova N, Cotterman R, Bradnam K, Korf I, Knoepfler P. Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells. Epigenetics Chromatin. 2011 Nov 04; 4:20. PMID: 22053792; PMCID: PMC3226433.
    30. Barrilleaux B, Knoepfler P. Inducing iPSCs to escape the dish. Cell Stem Cell. 2011 Aug 05; 9(2):103-11. PMID: 21816362; PMCID: PMC3500137.
    31. Knoepfler P. My year as a stem-cell blogger. Nature. 2011 Jul 27; 475(7357):425. PMID: 21796162; PMCID: PMC4342992.
    32. Barrilleaux B, Knoepfler P. Transduction of human cells with polymer-complexed ecotropic lentivirus for enhanced biosafety. J Vis Exp. 2011 Jul 24; (53). PMID: 21808229; PMCID: PMC3196183.
    33. Domínguez-Frutos E, López-Hernández I, Vendrell V, Neves J, Gallozzi M, Gutsche K, Quintana L, Sharpe J, Knoepfler P, Eisenman RN, Trumpp A, Giráldez F, Schimmang T. N-myc controls proliferation, morphogenesis, and patterning of the inner ear. J Neurosci. 2011 May 11; 31(19):7178-89. PMID: 21562282; PMCID: PMC4349441.
    34. Wey A, Martinez Cerdeno V, Pleasure D, Knoepfler P. c- and N-myc regulate neural precursor cell fate, cell cycle, and metabolism to direct cerebellar development. Cerebellum. 2010 Dec; 9(4):537-47. PMID: 20658325; PMCID: PMC2996535.
    35. Wey A, Knoepfler P. c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain. Oncotarget. 2010 Jun; 1(2):120-30. PMID: 20651942.
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    36. Varlakhanova NV, Cotterman RF, deVries WN, Morgan J, Donahue LR, Murray S, Knowles BB, Knoepfler P. myc maintains embryonic stem cell pluripotency and self-renewal. Differentiation. 2010 Jul; 80(1):9-19. PMID: 20537458; PMCID: PMC2916696.
    37. Kuwahara A, Hirabayashi Y, Knoepfler P, Taketo MM, Sakai J, Kodama T, Gotoh Y. Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex. Development. 2010 Apr; 137(7):1035-44. PMID: 20215343.
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    38. Knoepfler P, Bush KM. The death of MyMouseHouse: lessons for systems for the efficient management of mouse colonies. Dis Model Mech. 2010 Jan-Feb; 3(1-2):9-10. PMID: 20075375.
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    39. Chen D, Pacal M, Wenzel P, Knoepfler P, Leone G, Bremner R. Division and apoptosis of E2f-deficient retinal progenitors. Nature. 2009 Dec 17; 462(7275):925-9. PMID: 20016601; PMCID: PMC2813224.
    40. Varlakhanova NV, Knoepfler P. Acting locally and globally: Myc's ever-expanding roles on chromatin. Cancer Res. 2009 Oct 01; 69(19):7487-90. PMID: 19773445.
      View in: PubMed
    41. Cotterman R, Knoepfler P. N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b. PLoS One. 2009 Jun 04; 4(6):e5799. PMID: 19495417.
      View in: PubMed
    42. Knoepfler P. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells. 2009 May; 27(5):1050-6. PMID: 19415771; PMCID: PMC2733374.
    43. Knoepfler P. Journal club. A cell biologist looks at the risk and promise of a new insight into stem cells and cancer. Nature. 2009 Jan 22; 457(7228):361. PMID: 19158746.
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    44. Laurenti E, Varnum-Finney B, Wilson A, Ferrero I, Blanco-Bose WE, Ehninger A, Knoepfler P, Cheng PF, MacDonald HR, Eisenman RN, Bernstein ID, Trumpp A. Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell. 2008 Dec 04; 3(6):611-24. PMID: 19041778; PMCID: PMC2635113.
    45. Cotterman R, Jin VX, Krig SR, Lemen JM, Wey A, Farnham PJ, Knoepfler P. N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor. Cancer Res. 2008 Dec 01; 68(23):9654-62. PMID: 19047142; PMCID: PMC2637654.
    46. Knoepfler P. Stem cells on the brain. Arch Neurol. 2008 Mar; 65(3):311-5. PMID: 18332242.
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    47. Martins RA, Zindy F, Donovan S, Zhang J, Pounds S, Wey A, Knoepfler P, Eisenman RN, Roussel MF, Dyer MA. N-myc coordinates retinal growth with eye size during mouse development. Genes Dev. 2008 Jan 15; 22(2):179-93. PMID: 18198336; PMCID: PMC2192753.
    48. Knoepfler P. Why myc? An unexpected ingredient in the stem cell cocktail. Cell Stem Cell. 2008 Jan 10; 2(1):18-21. PMID: 18371417.
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    49. Habib T, Park H, Tsang M, de Alborán IM, Nicks A, Wilson L, Knoepfler P, Andrews S, Rawlings DJ, Eisenman RN, Iritani BM. Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. J Cell Biol. 2007 Nov 19; 179(4):717-31. PMID: 17998397; PMCID: PMC2080907.
    50. Knoepfler P. Myc goes global: new tricks for an old oncogene. Cancer Res. 2007 Jun 01; 67(11):5061-3. PMID: 17545579.
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    51. Ota S, Zhou ZQ, Keene DR, Knoepfler P, Hurlin PJ. Activities of N-Myc in the developing limb link control of skeletal size with digit separation. Development. 2007 Apr; 134(8):1583-92. PMID: 17360777.
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    52. Hatton BA, Knoepfler P, Kenney AM, Rowitch DH, de Alborán IM, Olson JM, Eisenman RN. N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res. 2006 Sep 01; 66(17):8655-61. PMID: 16951180.
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    53. Zindy F, Knoepfler P, Xie S, Sherr CJ, Eisenman RN, Roussel MF. N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11579-83. PMID: 16864777; PMCID: PMC1518798.
    54. Knoepfler P, Zhang XY, Cheng PF, Gafken PR, McMahon SB, Eisenman RN. Myc influences global chromatin structure. EMBO J. 2006 Jun 21; 25(12):2723-34. PMID: 16724113; PMCID: PMC1500848.
    55. Knoepfler P, Kenney AM. Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes. Cell Cycle. 2006 Jan; 5(1):47-52. PMID: 16322694.
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    56. Okubo T, Knoepfler P, Eisenman RN, Hogan BL. Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. Development. 2005 Mar; 132(6):1363-74. PMID: 15716345.
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    57. Berkes CA, Bergstrom DA, Penn BH, Seaver KJ, Knoepfler P, Tapscott SJ. Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential. Mol Cell. 2004 May 21; 14(4):465-77. PMID: 15149596.
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    58. Knoepfler P, Cheng PF, Eisenman RN. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev. 2002 Oct 15; 16(20):2699-712. PMID: 12381668; PMCID: PMC187459.