David E Pleasure

Title(s)Professor, Neurology
SchoolUniversity of California, Davis
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    1. Pleasure D, Guo F, Chechneva O, Bannerman P, McDonough J, Burns T, Wang Y, Hull V. Pathophysiology and Treatment of Canavan Disease. Neurochem Res. 2018 Dec 08. PMID: 30535831.
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    2. Bannerman P, Burns T, Xu J, Miers L, Pleasure D. Correction: Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. PLoS One. 2018; 13(9):e0204536. PMID: 30226905.
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    3. Bannerman P, Guo F, Chechneva O, Burns T, Zhu X, Wang Y, Kim B, Singhal NK, McDonough JA, Pleasure D. Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model. Mol Ther. 2018 03 07; 26(3):793-800. PMID: 29456021.
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    4. Horiuchi M, Suzuki-Horiuchi Y, Akiyama T, Itoh A, Pleasure D, Carstens E, Itoh T. Differing intrinsic biological properties between forebrain and spinal oligodendroglial lineage cells. J Neurochem. 2017 08; 142(3):378-391. PMID: 28512742.
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    5. Pleasure D. New hearts for Friedreich patients. J Neurol Sci. 2017 04 15; 375:474-475. PMID: 28131391.
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    6. Sohn J, Bannerman P, Guo F, Burns T, Miers L, Croteau C, Singhal NK, McDonough JA, Pleasure D. Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy. J Neurosci. 2017 01 11; 37(2):413-421. PMID: 28077719.
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    7. Bannerman P, Burns T, Xu J, Miers L, Pleasure D. Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. PLoS One. 2016; 11(12):e0167573. PMID: 27907123.
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    8. Lee E, Chamanara S, Pleasure D, Soulika AM. Erratum to: IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci. J Neuroinflammation. 2016 Aug 30; 13(1):216. PMID: 27576305.
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    9. Liu XB, Shen Y, Pleasure DE, Deng W. The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. BMC Neurosci. 2016 Jan 05; 17:2. PMID: 26733225; PMCID: PMC4702373.
    10. Moreno MA, Burns T, Yao P, Miers L, Pleasure D, Soulika AM. Therapeutic depletion of monocyte-derived cells protects from long-term axonal loss in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2016 Jan 15; 290:36-46. PMID: 26711567.
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    11. Guo F, Bannerman P, Mills Ko E, Miers L, Xu J, Burns T, Li S, Freeman E, McDonough JA, Pleasure D. Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model. Ann Neurol. 2015 May; 77(5):884-8. PMID: 25712859.
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    12. Hammond E, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W, Guo F. The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/ß-catenin signaling. J Neurosci. 2015 Mar 25; 35(12):5007-22. PMID: 25810530.
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    13. Guo F, Lang J, Sohn J, Hammond E, Chang M, Pleasure D. Canonical Wnt signaling in the oligodendroglial lineage--puzzles remain. Glia. 2015 Oct; 63(10):1671-93. PMID: 25782433.
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    14. Sohn J, Orosco L, Guo F, Chung SH, Bannerman P, Mills Ko E, Zarbalis K, Deng W, Pleasure D. The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice. J Neurosci. 2015 Mar 04; 35(9):3756-63. PMID: 25740506.
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    15. Itoh T, Pleasure D. The future of research in neuropathy. JAMA Neurol. 2015 Jan; 72(1):5-7. PMID: 25364864.
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    16. Itoh T, Horiuchi M, Ikeda RH, Xu J, Bannerman P, Pleasure D, Penninger JM, Tournier C, Itoh A. ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. J Neurosci. 2014 Aug 06; 34(32):10729-42. PMID: 25100604; PMCID: PMC4200111.
    17. Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC, Loring JF, Liu Y, Deng W. Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. Nat Commun. 2014 Jul 18; 5:4430. PMID: 25034944; PMCID: PMC4109022.
    18. Mills Ko E, Ma JH, Guo F, Miers L, Lee E, Bannerman P, Burns T, Ko D, Sohn J, Soulika AM, Pleasure D. Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. J Neuroinflammation. 2014 Jun 12; 11:105. PMID: 24924222; PMCID: PMC4066277.
    19. Moreno M, Bannerman P, Ma J, Guo F, Miers L, Soulika AM, Pleasure D. Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE. J Neurosci. 2014 Jun 11; 34(24):8175-85. PMID: 24920622; PMCID: PMC4051973.
    20. Burns T, Miers L, Xu J, Man A, Moreno M, Pleasure D, Bannerman P. Neuronopathy in the motor neocortex in a chronic model of multiple sclerosis. J Neuropathol Exp Neurol. 2014 Apr; 73(4):335-44. PMID: 24607968; PMCID: PMC4229074.
    21. Chetty S, Friedman AR, Taravosh-Lahn K, Kirby ED, Mirescu C, Guo F, Krupik D, Nicholas A, Geraghty A, Krishnamurthy A, Tsai MK, Covarrubias D, Wong A, Francis D, Sapolsky RM, Palmer TD, Pleasure D, Kaufer D. Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Mol Psychiatry. 2014 Dec; 19(12):1275-1283. PMID: 24514565; PMCID: PMC4128957.
    22. Gan Q, Lee A, Suzuki R, Yamagami T, Stokes A, Nguyen BC, Pleasure D, Wang J, Chen HW, Zhou CJ. Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. Stem Cells. 2014 Jan; 32(1):45-58. PMID: 24115331; PMCID: PMC3963407.
    23. Jiang P, Chen C, Liu XB, Selvaraj V, Liu W, Feldman DH, Liu Y, Pleasure DE, Li RA, Deng W. Generation and characterization of spiking and nonspiking oligodendroglial progenitor cells from embryonic stem cells. Stem Cells. 2013 Dec; 31(12):2620-31. PMID: 23940003.
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    24. Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ. ß-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development. 2014 Jan; 141(1):148-57. PMID: 24284205; PMCID: PMC3865756.
    25. Daugherty DJ, Selvaraj V, Chechneva OV, Liu XB, Pleasure DE, Deng W. A TSPO ligand is protective in a mouse model of multiple sclerosis. EMBO Mol Med. 2013 Jun; 5(6):891-903. PMID: 23681668; PMCID: PMC3779450.
    26. Lang J, Maeda Y, Bannerman P, Xu J, Horiuchi M, Pleasure D, Guo F. Adenomatous polyposis coli regulates oligodendroglial development. J Neurosci. 2013 Feb 13; 33(7):3113-30. PMID: 23407966; PMCID: PMC3711764.
    27. Moreno M, Guo F, Mills Ko E, Bannerman P, Soulika A, Pleasure D. Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE. J Neurol Sci. 2013 Oct 15; 333(1-2):55-9. PMID: 23294494; PMCID: PMC3624040.
    28. Jiang P, Chen C, Wang R, Chechneva OV, Chung SH, Rao MS, Pleasure DE, Liu Y, Zhang Q, Deng W. hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury. Nat Commun. 2013; 4:2196. PMID: 23880652; PMCID: PMC3903179.
    29. Horiuchi M, Wakayama K, Itoh A, Kawai K, Pleasure D, Ozato K, Itoh T. Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia. J Neuroinflammation. 2012 Sep 28; 9:227. PMID: 23020843; PMCID: PMC3546867.
    30. Sohn J, Selvaraj V, Wakayama K, Orosco L, Lee E, Crawford SE, Guo F, Lang J, Horiuchi M, Zarbalis K, Itoh T, Deng W, Pleasure D. PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci. 2012 Aug 29; 32(35):12152-64. PMID: 22933798; PMCID: PMC3457640.
    31. Lee E, Chanamara S, Pleasure D, Soulika AM. IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci. J Neuroinflammation. 2012 Jan 16; 9:7. PMID: 22248039; PMCID: PMC3293042.
    32. Guo F, Maeda Y, Ko EM, Delgado M, Horiuchi M, Soulika A, Miers L, Burns T, Itoh T, Shen H, Lee E, Sohn J, Pleasure D. Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development. J Neurosci. 2012 Jan 11; 32(2):639-45. PMID: 22238099; PMCID: PMC3403747.
    33. Itoh T, Horiuchi M, Wakayama K, Itoh A, Pleasure D. [Demyelination and oligodendrocytes]. Rinsho Shinkeigaku. 2011 Nov; 51(11):1036-9. PMID: 22277471.
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    34. Guo F, Maeda Y, Ma J, Delgado M, Sohn J, Miers L, Ko EM, Bannerman P, Xu J, Wang Y, Zhou C, Takebayashi H, Pleasure D. Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. J Neurosci. 2011 Aug 17; 31(33):11914-28. PMID: 21849552; PMCID: PMC3167226.
    35. Shen Y, Liu XB, Pleasure DE, Deng W. Axon-glia synapses are highly vulnerable to white matter injury in the developing brain. J Neurosci Res. 2012 Jan; 90(1):105-21. PMID: 21812016.
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    36. Chechneva OV, Mayrhofer F, Daugherty DJ, Pleasure DE, Hong JS, Deng W. Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord. Neurobiol Dis. 2011 Oct; 44(1):63-72. PMID: 21704706.
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    37. Soundarapandian MM, Selvaraj V, Lo UG, Golub MS, Feldman DH, Pleasure DE, Deng W. Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination. Sci Rep. 2011; 1:2. PMID: 22355521; PMCID: PMC3210692.
    38. Itoh A, Horiuchi M, Wakayama K, Xu J, Bannerman P, Pleasure D, Itoh T. ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons. J Neurosci. 2011 May 18; 31(20):7223-8. PMID: 21593306; PMCID: PMC3138193.
    39. Liu W, Shen Y, Plane JM, Pleasure DE, Deng W. Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia. Exp Neurol. 2011 Aug; 230(2):227-39. PMID: 21596035.
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    40. Pleasure D. Advances in translational research in neuromuscular diseases. Arch Neurol. 2011 Apr; 68(4):429-33. PMID: 21482923.
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    41. Horiuchi M, Itoh A, Pleasure D, Ozato K, Itoh T. Cooperative contributions of interferon regulatory factor 1 (IRF1) and IRF8 to interferon-?-mediated cytotoxic effects on oligodendroglial progenitor cells. J Neuroinflammation. 2011 Jan 24; 8:8. PMID: 21261980; PMCID: PMC3039583.
    42. Wey A, Martinez Cerdeno V, Pleasure D, Knoepfler PS. c- and N-myc regulate neural precursor cell fate, cell cycle, and metabolism to direct cerebellar development. Cerebellum. 2010 Dec; 9(4):537-47. PMID: 20658325; PMCID: PMC2996535.
    43. Chung SH, Calafiore M, Plane JM, Pleasure DE, Deng W. Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration. Neurobiol Dis. 2011 Feb; 41(2):445-57. PMID: 20974255.
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    44. Guo F, Maeda Y, Ma J, Xu J, Horiuchi M, Miers L, Vaccarino F, Pleasure D. Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. J Neurosci. 2010 Sep 08; 30(36):12036-49. PMID: 20826667; PMCID: PMC2940828.
    45. Plane JM, Shen Y, Pleasure DE, Deng W. Prospects for minocycline neuroprotection. Arch Neurol. 2010 Dec; 67(12):1442-8. PMID: 20697034; PMCID: PMC3127230.
    46. Horiuchi M, Lindsten T, Pleasure D, Itoh T. Differing in vitro survival dependency of mouse and rat NG2+ oligodendroglial progenitor cells. J Neurosci Res. 2010 Apr; 88(5):957-70. PMID: 19908280; PMCID: PMC2872551.
    47. Soulika AM, Lee E, McCauley E, Miers L, Bannerman P, Pleasure D. Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. J Neurosci. 2009 Nov 25; 29(47):14965-79. PMID: 19940192; PMCID: PMC2990681.
    48. Kawai K, Itoh T, Itoh A, Horiuchi M, Wakayama K, Bannerman P, Garbern JY, Pleasure D, Lindsten T. Maintenance of the relative proportion of oligodendrocytes to axons even in the absence of BAX and BAK. Eur J Neurosci. 2009 Dec 03; 30(11):2030-41. PMID: 20128842; PMCID: PMC2830116.
    49. Selvaraj V, Soundarapandian MM, Chechneva O, Williams AJ, Sidorov MK, Soulika AM, Pleasure DE, Deng W. PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. J Biol Chem. 2009 Sep 18; 284(38):26070-84. PMID: 19628872; PMCID: PMC2758007.
    50. Guo F, Ma J, McCauley E, Bannerman P, Pleasure D. Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo. J Neurosci. 2009 Jun 03; 29(22):7256-70. PMID: 19494148; PMCID: PMC2717630.
    51. Itoh A, Horiuchi M, Bannerman P, Pleasure D, Itoh T. Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice. Biochem Biophys Res Commun. 2009 May 29; 383(2):258-62. PMID: 19358824.
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    52. Wang YZ, Molotkov A, Song L, Li Y, Pleasure DE, Zhou CJ. Activation of the Wnt/beta-catenin signaling reporter in developing mouse olfactory nerve layer marks a specialized subgroup of olfactory ensheathing cells. Dev Dyn. 2008 Nov; 237(11):3157-68. PMID: 18816448; PMCID: PMC2895989.
    53. Bannerman P, Ara J, Hahn A, Hong L, McCauley E, Friesen K, Pleasure D. Peripheral nerve regeneration is delayed in neuropilin 2-deficient mice. J Neurosci Res. 2008 Nov 01; 86(14):3163-9. PMID: 18615644; PMCID: PMC2574585.
    54. Deng W, Pleasure J, Pleasure D. Progress in periventricular leukomalacia. Arch Neurol. 2008 Oct; 65(10):1291-5. PMID: 18852342; PMCID: PMC2898886.
    55. Feldman DH, Horiuchi M, Keachie K, Mccauley E, Bannerman P, Itoh A, Itoh T, Pleasure D. Characterization of acid-sensing ion channel expression in oligodendrocyte-lineage cells. Glia. 2008 Aug 15; 56(11):1238-49. PMID: 18452213; PMCID: PMC2895986.
    56. Pleasure D. Diagnostic and pathogenic significance of glutamate receptor autoantibodies. Arch Neurol. 2008 May; 65(5):589-92. PMID: 18474732; PMCID: PMC2898900.
    57. Ara J, See J, Mamontov P, Hahn A, Bannerman P, Pleasure D, Grinspan JB. Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis. J Neurosci Res. 2008 Jan; 86(1):125-35. PMID: 17722066.
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    58. Bannerman P, Horiuchi M, Feldman D, Hahn A, Itoh A, See J, Jia ZP, Itoh T, Pleasure D. GluR2-free alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors intensify demyelination in experimental autoimmune encephalomyelitis. J Neurochem. 2007 Aug; 102(4):1064-70. PMID: 17472701.
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    59. Bannerman P, Hahn A, Soulika A, Gallo V, Pleasure D. Astrogliosis in EAE spinal cord: derivation from radial glia, and relationships to oligodendroglia. Glia. 2007 Jan 01; 55(1):57-64. PMID: 17009237.
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    60. Horiuchi M, Itoh A, Pleasure D, Itoh T. MEK-ERK signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells. J Biol Chem. 2006 Jul 21; 281(29):20095-106. PMID: 16728393.
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    61. Pleasure D, Soulika A, Singh SK, Gallo V, Bannerman P. Inflammation in white matter: clinical and pathophysiological aspects. Ment Retard Dev Disabil Res Rev. 2006; 12(2):141-6. PMID: 16807906.
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    62. Ara J, Bannerman P, Hahn A, Ramirez S, Pleasure D. Modulation of sciatic nerve expression of class 3 semaphorins by nerve injury. Neurochem Res. 2004 Jun; 29(6):1153-9. PMID: 15176472.
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    63. Wang X, Douglas SD, Commons KG, Pleasure DE, Lai J, Ho C, Bannerman P, Williams M, Ho W. A non-peptide substance P antagonist (CP-96,345) inhibits morphine-induced NF-kappa B promoter activation in human NT2-N neurons. J Neurosci Res. 2004 Feb 15; 75(4):544-53. PMID: 14743438.
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    64. Scarlato M, Ara J, Bannerman P, Scherer S, Pleasure D. Induction of neuropilins-1 and -2 and their ligands, Sema3A, Sema3F, and VEGF, during Wallerian degeneration in the peripheral nervous system. Exp Neurol. 2003 Oct; 183(2):489-98. PMID: 14552889.
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    65. Guo CJ, Douglas SD, Lai JP, Pleasure DE, Li Y, Williams M, Bannerman P, Song L, Ho WZ. Interleukin-1beta stimulates macrophage inflammatory protein-1alpha and -1beta expression in human neuronal cells (NT2-N). J Neurochem. 2003 Mar; 84(5):997-1005. PMID: 12603824; PMCID: PMC4009624.
    66. Li Y, Douglas SD, Pleasure DE, Lai J, Guo C, Bannerman P, Williams M, Ho W. Human neuronal cells (NT2-N) express functional substance P and neurokinin-1 receptor coupled to MIP-1 beta expression. J Neurosci Res. 2003 Feb 15; 71(4):559-66. PMID: 12548712; PMCID: PMC4015112.
    67. Pleasure D, Bannerman P, Ara J, Scarlato M, Itoh T. Prospects for vascular endothelial growth factor neurotherapeutics. Arch Neurol. 2002 May; 59(5):692-4. PMID: 12020247.
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