Yoshikazu Takada

Title(s)Professor, Dermatology
vCardDownload vCard

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Fujita M, Davari P, Takada YK, Takada Y. Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4. Biochem J. 2018 02 16; 475(4):723-732. PMID: 29301984.
      View in: PubMed
    2. Takada YK, Yu J, Fujita M, Saegusa J, Wu CY, Takada Y. Direct binding to integrins and loss of disulfide linkage in interleukin-1ß (IL-1ß) are involved in the agonistic action of IL-1ß. J Biol Chem. 2017 12 08; 292(49):20067-20075. PMID: 29030430.
      View in: PubMed
    3. Cedano Prieto DM, Cheng Y, Chang CC, Yu J, Takada YK, Takada Y. Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling. PLoS One. 2017; 12(9):e0184285. PMID: 28873464.
      View in: PubMed
    4. Mori S, Hatori N, Kawaguchi N, Hamada Y, Shih TC, Wu CY, Lam KS, Matsuura N, Yamamoto H, Takada YK, Takada Y. The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis. Biosci Rep. 2017 04 28; 37(2). PMID: 28302677.
      View in: PubMed
    5. Takada Y, Takada YK, Fujita M. Crosstalk between insulin-like growth factor (IGF) receptor and integrins through direct integrin binding to IGF1. Cytokine Growth Factor Rev. 2017 Apr; 34:67-72. PMID: 28190785.
      View in: PubMed
    6. Takada Y, Fujita M. Secreted Phospholipase A2 Type IIA (sPLA2-IIA) Activates Integrins in an Allosteric Manner. Adv Exp Med Biol. 2017; 925:103-115. PMID: 27864802.
      View in: PubMed
    7. Yu J, Lee CY, Changou CA, Cedano-Prieto DM, Takada YK, Takada Y. The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin avß3. Biochem J. 2017 02 15; 474(4):589-596. PMID: 27993971.
      View in: PubMed
    8. Wang Y, Xiao W, Zhang Y, Meza L, Tseng H, Takada Y, Ames JB, Lam KS. Optimization of RGD-Containing Cyclic Peptides against avß3 Integrin. Mol Cancer Ther. 2016 Feb; 15(2):232-40. PMID: 26719578; PMCID: PMC4747864 [Available on 02/01/17].
    9. Mori S, Kodaira M, Ito A, Okazaki M, Kawaguchi N, Hamada Y, Takada Y, Matsuura N. Enhanced Expression of Integrin avß3 Induced by TGF-ß Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-ß-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. PLoS One. 2015; 10(9):e0137486. PMID: 26334633; PMCID: PMC4559424.
    10. Fujita M, Zhu K, Fujita CK, Zhao M, Lam KS, Kurth MJ, Takada YK, Takada Y. Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins avß3, a4ß1, and a5ß1. J Biol Chem. 2015 Jan 02; 290(1):259-71. PMID: 25398877; PMCID: PMC4281730.
    11. Fujita M, Takada YK, Takada Y. The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site. PLoS One. 2014; 9(5):e96372. PMID: 24789099; PMCID: PMC4008574.
    12. Fujita M, Takada YK, Izumiya Y, Takada Y. The binding of monomeric C-reactive protein (mCRP) to Integrins avß3 and a4ß1 is related to its pro-inflammatory action. PLoS One. 2014; 9(4):e93738. PMID: 24695572; PMCID: PMC3973595.
    13. Fujita M, Ieguchi K, Cedano-Prieto DM, Fong A, Wilkerson C, Chen JQ, Wu M, Lo SH, Cheung AT, Wilson MD, Cardiff RD, Borowsky AD, Takada YK, Takada Y. An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R. J Biol Chem. 2013 Jul 05; 288(27):19593-603. PMID: 23696648; PMCID: PMC3707660.
    14. Mori S, Tran V, Nishikawa K, Kaneda T, Hamada Y, Kawaguchi N, Fujita M, Saegusa J, Takada YK, Matsuura N, Zhao M, Takada Y. A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. PLoS One. 2013; 8(2):e57927. PMID: 23469107; PMCID: PMC3585250.
    15. Fujita M, Takada YK, Takada Y. Insulin-like growth factor (IGF) signaling requires avß3-IGF1-IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation. J Biol Chem. 2013 Feb 01; 288(5):3059-69. PMID: 23243309; PMCID: PMC3561530.
    16. Fujita M, Takada YK, Takada Y. Integrins avß3 and a4ß1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1. J Immunol. 2012 Dec 15; 189(12):5809-19. PMID: 23125415; PMCID: PMC3518660.
    17. Ye L, Dickerson T, Kaur H, Takada YK, Fujita M, Liu R, Knapp JM, Lam KS, Schore NE, Kurth MJ, Takada Y. Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin avß3. Bioorg Med Chem Lett. 2013 Jan 01; 23(1):340-5. PMID: 23164706; PMCID: PMC4570851.
    18. Takada Y. Potential role of kringle-integrin interaction in plasmin and uPA actions (a hypothesis). J Biomed Biotechnol. 2012; 2012:136302. PMID: 23125522; PMCID: PMC3480031.
    19. Fujita M, Ieguchi K, Davari P, Yamaji S, Taniguchi Y, Sekiguchi K, Takada YK, Takada Y. Cross-talk between integrin a6ß4 and insulin-like growth factor-1 receptor (IGF1R) through direct a6ß4 binding to IGF1 and subsequent a6ß4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions. J Biol Chem. 2012 Apr 06; 287(15):12491-500. PMID: 22351760; PMCID: PMC3320998.
    20. Jiang JX, Chen X, Hsu DK, Baghy K, Serizawa N, Scott F, Takada Y, Takada Y, Fukada H, Chen J, Devaraj S, Adamson R, Liu FT, Török NJ. Galectin-3 modulates phagocytosis-induced stellate cell activation and liver fibrosis in vivo. Am J Physiol Gastrointest Liver Physiol. 2012 Feb 15; 302(4):G439-46. PMID: 22159281; PMCID: PMC3287392.
    21. Shih YP, Takada Y, Lo SH. Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells. Mol Cancer Res. 2012 Jan; 10(1):34-9. PMID: 22064653; PMCID: PMC3262057.
    22. Haudenschild DR, Hong E, Yik JH, Chromy B, Mörgelin M, Snow KD, Acharya C, Takada Y, Di Cesare PE. Enhanced activity of transforming growth factor ß1 (TGF-ß1) bound to cartilage oligomeric matrix protein. J Biol Chem. 2011 Dec 16; 286(50):43250-8. PMID: 21940632; PMCID: PMC3234822.
    23. Fleming FE, Graham KL, Takada Y, Coulson BS. Determinants of the specificity of rotavirus interactions with the alpha2beta1 integrin. J Biol Chem. 2011 Feb 25; 286(8):6165-74. PMID: 21138834; PMCID: PMC3057834.
    24. Xiao W, Wang Y, Lau EY, Luo J, Yao N, Shi C, Meza L, Tseng H, Maeda Y, Kumaresan P, Liu R, Lightstone FC, Takada Y, Lam KS. The use of one-bead one-compound combinatorial library technology to discover high-affinity avß3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 2010 Oct; 9(10):2714-23. PMID: 20858725.
      View in: PubMed
    25. Ieguchi K, Fujita M, Ma Z, Davari P, Taniguchi Y, Sekiguchi K, Wang B, Takada YK, Takada Y. Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling. J Biol Chem. 2010 Oct 08; 285(41):31388-98. PMID: 20682778; PMCID: PMC2951213.
    26. Yamaji S, Saegusa J, Ieguchi K, Fujita M, Mori S, Takada YK, Takada Y. A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist. PLoS One. 2010 Apr 21; 5(4):e10273. PMID: 20422052; PMCID: PMC2858075.
    27. Takada Y, Ono Y, Saegusa J, Sagusa J, Mitsiades C, Mitsiades N, Tsai J, He Y, Maningding E, Coleman A, Ramirez-Maverakis D, Rodrigues R, Rodriquez R, Takada Y, Maverakis E. A T cell-binding fragment of fibrinogen can prevent autoimmunity. J Autoimmun. 2010 Jun; 34(4):453-9. PMID: 20036106; PMCID: PMC2860040.
    28. Saegusa J, Yamaji S, Ieguchi K, Wu CY, Lam KS, Liu FT, Takada YK, Takada Y. The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling. J Biol Chem. 2009 Sep 04; 284(36):24106-14. PMID: 19578119; PMCID: PMC2782004.
    29. Yao N, Xiao W, Wang X, Marik J, Park SH, Takada Y, Lam KS. Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method. J Med Chem. 2009 Jan 08; 52(1):126-33. PMID: 19055415; PMCID: PMC2836207.
    30. Guo M, Daines D, Tang J, Shen Q, Perrin RM, Takada Y, Yuan SY, Wu MH. Fibrinogen-gamma C-terminal fragments induce endothelial barrier dysfunction and microvascular leak via integrin-mediated and RhoA-dependent mechanism. Arterioscler Thromb Vasc Biol. 2009 Mar; 29(3):394-400. PMID: 19122172; PMCID: PMC2737386.
    31. Saegusa J, Akakura N, Wu CY, Hoogland C, Ma Z, Lam KS, Liu FT, Takada YK, Takada Y. Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner. J Biol Chem. 2008 Sep 19; 283(38):26107-15. PMID: 18635536; PMCID: PMC2533795.
    32. Mori S, Wu CY, Yamaji S, Saegusa J, Shi B, Ma Z, Kuwabara Y, Lam KS, Isseroff RR, Takada YK, Takada Y. Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J Biol Chem. 2008 Jun 27; 283(26):18066-75. PMID: 18441324; PMCID: PMC2440593.
    33. Takada Y, Ye X, Simon S. The integrins. Genome Biol. 2007; 8(5):215. PMID: 17543136; PMCID: PMC1929136.
    34. Akakura N, Hoogland C, Takada YK, Saegusa J, Ye X, Liu FT, Cheung AT, Takada Y. The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth. Cancer Res. 2006 Oct 01; 66(19):9691-7. PMID: 17018627.
      View in: PubMed
    35. Peng L, Liu R, Marik J, Wang X, Takada Y, Lam KS. Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging. Nat Chem Biol. 2006 Jul; 2(7):381-9. PMID: 16767086.
      View in: PubMed
    36. Tarui T, Akakura N, Majumdar M, Andronicos N, Takagi J, Mazar AP, Bdeir K, Kuo A, Yarovoi SV, Cines DB, Takada Y. Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation. Thromb Haemost. 2006 Mar; 95(3):524-34. PMID: 16525582.
      View in: PubMed
    37. Wu PL, Lee SC, Chuang CC, Mori S, Akakura N, Wu WG, Takada Y. Non-cytotoxic cobra cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption. Identification of cardiotoxins as non-RGD integrin-binding proteins of the Ly-6 family. J Biol Chem. 2006 Mar 24; 281(12):7937-45. PMID: 16407244.
      View in: PubMed
    38. Graham KL, Fleming FE, Halasz P, Hewish MJ, Nagesha HS, Holmes IH, Takada Y, Coulson BS. Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligands. J Gen Virol. 2005 Dec; 86(Pt 12):3397-408. PMID: 16298987.
      View in: PubMed
    39. Muramatsu H, Zou P, Suzuki H, Oda Y, Chen GY, Sakaguchi N, Sakuma S, Maeda N, Noda M, Takada Y, Muramatsu T. alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor. J Cell Sci. 2004 Oct 15; 117(Pt 22):5405-15. PMID: 15466886.
      View in: PubMed
    40. Mikawa M, Wang H, Guo L, Liu R, Marik J, Takada Y, Lam K, Lau D. Novel peptide ligands for integrin alpha 4 beta 1 overexpressed in cancer cells. Mol Cancer Ther. 2004 Oct; 3(10):1329-34. PMID: 15486200.
      View in: PubMed
    41. Majumdar M, Tarui T, Shi B, Akakura N, Ruf W, Takada Y. Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1). J Biol Chem. 2004 Sep 03; 279(36):37528-34. PMID: 15247268.
      View in: PubMed
    42. Kamata T, Ambo H, Puzon-McLaughlin W, Tieu KK, Handa M, Ikeda Y, Takada Y. Critical cysteine residues for regulation of integrin alphaIIbbeta3 are clustered in the epidermal growth factor domains of the beta3 subunit. Biochem J. 2004 Mar 15; 378(Pt 3):1079-82. PMID: 14690453; PMCID: PMC1224037.
    43. Londrigan SL, Graham KL, Takada Y, Halasz P, Coulson BS. Monkey rotavirus binding to alpha2beta1 integrin requires the alpha2 I domain and is facilitated by the homologous beta1 subunit. J Virol. 2003 Sep; 77(17):9486-501. PMID: 12915563; PMCID: PMC187378.
    44. Tarui T, Andronicos N, Czekay RP, Mazar AP, Bdeir K, Parry GC, Kuo A, Loskutoff DJ, Cines DB, Takada Y. Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling. J Biol Chem. 2003 Aug 08; 278(32):29863-72. PMID: 12754207.
      View in: PubMed
    45. Kariya Y, Tsubota Y, Hirosaki T, Mizushima H, Puzon-McLaughlin W, Takada Y, Miyazaki K. Differential regulation of cellular adhesion and migration by recombinant laminin-5 forms with partial deletion or mutation within the G3 domain of alpha3 chain. J Cell Biochem. 2003 Feb 15; 88(3):506-20. PMID: 12532327.
      View in: PubMed
    46. Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM. ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. J Biol Chem. 2003 Mar 14; 278(11):9576-84. PMID: 12509413.
      View in: PubMed
    47. Legge GB, Morris GM, Sanner MF, Takada Y, Olson AJ, Grynszpan F. Model of the alphaLbeta2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificity. Proteins. 2002 Aug 01; 48(2):151-60. PMID: 12112684.
      View in: PubMed
    48. Lévesque JP, Takada Y, Puzon-McLaughlin W, Simmons PJ. A novel monoclonal antibody recognizing a cation-dependent epitope within the regulatory loop of human beta(1) integrin (CD29). Hybrid Hybridomics. 2002 Aug; 21(4):253-60. PMID: 12193278.
      View in: PubMed
    49. Tarui T, Majumdar M, Miles LA, Ruf W, Takada Y. Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin. J Biol Chem. 2002 Sep 13; 277(37):33564-70. PMID: 12087108.
      View in: PubMed
    50. Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy JY, Takada Y, Usami S, Chien S. Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci. 2002 May 15; 115(Pt 10):2199-206. PMID: 11973360.
      View in: PubMed
    51. Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. J Biol Chem. 2002 May 17; 277(20):17804-10. PMID: 11882657.
      View in: PubMed
    52. Kamata T, Tieu KK, Tarui T, Puzon-McLaughlin W, Hogg N, Takada Y. The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1). J Immunol. 2002 Mar 01; 168(5):2296-301. PMID: 11859118.
      View in: PubMed
    53. Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J, Honjo T, Chien KR. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 01 10; 415(6868):171-5. PMID: 11805835.
      View in: PubMed
    54. Kikkawa H, Kaihou M, Horaguchi N, Uchida T, Imafuku H, Takiguchi A, Yamazaki Y, Koike C, Kuruto R, Kakiuchi T, Tsukada H, Takada Y, Matsuura N, Oku N. Role of integrin alpha(v)beta3 in the early phase of liver metastasis: PET and IVM analyses. Clin Exp Metastasis. 2002; 19(8):717-25. PMID: 12553378.
      View in: PubMed