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Marie E Burns

Title(s)Professor, Ophthalmology and Vision Science
SchoolUniversity of California, Davis
Phone530-754-7164
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    Collapse Research 
    Collapse Research Activities and Funding
    Rhodopsin dimerization: mechanistic basis and functional consequences
    NIH/NEI R01EY027969Sep 30, 2017 - May 31, 2021
    Role: Co-Principal Investigator
    FASEB SRC on The Biology and Chemistry of Vision
    NIH/NEI R13EY028019Jun 1, 2017 - May 31, 2018
    Role: Principal Investigator
    Microglial Activation during Photoreceptor Degeneration
    NIH/NEI R01EY024320Sep 1, 2015 - Aug 31, 2019
    Role: Principal Investigator
    Training Program in Vision Science
    NIH/NEI T32EY015387Sep 30, 2003 - Aug 31, 2023
    Role: Co-Principal Investigator
    Deactivation Mechanisms of Rod Phototransduction
    NIH/NEI R01EY014047May 1, 2002 - Apr 30, 2021
    Role: Principal Investigator
    ROLES OF RAB3 AND RABPHILIN IN NEUROTRANSMITTER
    NIH/NIMH F31MH011073Feb 25, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Miller EB, Zhang P, Ching K, Pugh EN, Burns ME. In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury. Proc Natl Acad Sci U S A. 2019 Jul 26. PMID: 31350349.
      View in: PubMed
    2. Peinado Allina G, Burns ME. Harnessing the Sun to See Anew. Neuron. 2019 Jun 19; 102(6):1093-1095. PMID: 31220441.
      View in: PubMed
    3. Spencer WJ, Ding JD, Lewis TR, Yu C, Phan S, Pearring JN, Kim KY, Thor A, Mathew R, Kalnitsky J, Hao Y, Travis AM, Biswas SK, Lo WK, Besharse JC, Ellisman MH, Saban DR, Burns ME, Arshavsky VY. PRCD is essential for high-fidelity photoreceptor disc formation. Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26):13087-13096. PMID: 31189593.
      View in: PubMed
    4. Ronning KE, Karlen SJ, Miller EB, Burns ME. Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing. Sci Rep. 2019 Mar 19; 9(1):4858. PMID: 30890724.
      View in: PubMed
    5. Karlen SJ, Miller EB, Wang X, Levine ES, Zawadzki RJ, Burns ME. Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration. J Neuroinflammation. 2018 Dec 15; 15(1):344. PMID: 30553275.
      View in: PubMed
    6. Goswami M, Wang X, Zhang P, Xiao W, Karlen SJ, Li Y, Zawadzki RJ, Burns ME, Lam KS, Pugh EN. Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacy in vivo. Biomed Opt Express. 2019 Jan 01; 10(1):151-166. PMID: 30775090.
      View in: PubMed
    7. Burns ME, Stevens B. Report on the National Eye Institute's Audacious Goals Initiative: Creating a Cellular Environment for Neuroregeneration. eNeuro. 2018 Mar-Apr; 5(2). PMID: 29766041.
      View in: PubMed
    8. Ronning KE, Allina GP, Miller EB, Zawadzki RJ, Pugh EN, Herrmann R, Burns ME. Loss of cone function without degeneration in a novel Gnat2 knock-out mouse. Exp Eye Res. 2018 06; 171:111-118. PMID: 29518352.
      View in: PubMed
    9. Fairchild CL, Hino K, Han JS, Miltner AM, Peinado Allina G, Brown CE, Burns ME, La Torre A, Simó S. RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 02 02; 145(3). PMID: 29361558.
      View in: PubMed
    10. Wang X, Miller EB, Goswami M, Zhang P, Ronning KE, Karlen SJ, Zawadzki RJ, Pugh EN, Burns ME. Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130. J Neuroinflammation. 2017 06 23; 14(1):121. PMID: 28645275.
      View in: PubMed
    11. Zhang P, Zawadzki RJ, Goswami M, Nguyen PT, Yarov-Yarovoy V, Burns ME, Pugh EN. In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2937-E2946. PMID: 28320964.
      View in: PubMed
    12. Peinado Allina G, Fortenbach C, Naarendorp F, Gross OP, Pugh EN, Burns ME. Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9. J Gen Physiol. 2017 Apr 03; 149(4):443-454. PMID: 28302678.
      View in: PubMed
    13. Burns ME, Levine ES, Miller EB, Zam A, Zhang P, Zawadzki RJ, Pugh EN. New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo. Adv Exp Med Biol. 2016; 854:269-75. PMID: 26427421.
      View in: PubMed
    14. Fortenbach CR, Kessler C, Peinado Allina G, Burns ME. Speeding rod recovery improves temporal resolution in the retina. Vision Res. 2015 May; 110(Pt A):57-67. PMID: 25748270.
      View in: PubMed
    15. Gross OP, Pugh EN, Burns ME. cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses. Front Mol Neurosci. 2015; 8:6. PMID: 25788876.
      View in: PubMed
    16. Zhang P, Zam A, Jian Y, Wang X, Li Y, Lam KS, Burns ME, Sarunic MV, Pugh EN, Zawadzki RJ. In vivo wide-field multispectral scanning laser ophthalmoscopy-optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature. J Biomed Opt. 2015; 20(12):126005. PMID: 26677070.
      View in: PubMed
    17. Levine ES, Zam A, Zhang P, Pechko A, Wang X, FitzGerald P, Pugh EN, Zawadzki RJ, Burns ME. Rapid light-induced activation of retinal microglia in mice lacking Arrestin-1. Vision Res. 2014 Sep; 102:71-9. PMID: 25091460.
      View in: PubMed
    18. Arshavsky VY, Burns ME. Current understanding of signal amplification in phototransduction. Cell Logist. 2014; 4:e29390. PMID: 25279249.
      View in: PubMed
    19. Kessler C, Tillman M, Burns ME, Pugh EN. Rhodopsin in the rod surface membrane regenerates more rapidly than bulk rhodopsin in the disc membranes in vivo. J Physiol. 2014 Jul 01; 592(13):2785-97. PMID: 24801306.
      View in: PubMed
    20. Long JH, Arshavsky VY, Burns ME. Absence of synaptic regulation by phosducin in retinal slices. PLoS One. 2013; 8(12):e83970. PMID: 24376776.
      View in: PubMed
    21. Gross OP, Pugh EN, Burns ME. Calcium feedback to cGMP synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes. Neuron. 2012 Oct 18; 76(2):370-82. PMID: 23083739.
      View in: PubMed
    22. Gross OP, Pugh EN, Burns ME. Spatiotemporal cGMP dynamics in living mouse rods. Biophys J. 2012 Apr 18; 102(8):1775-84. PMID: 22768933.
      View in: PubMed
    23. Arshavsky VY, Burns ME. Photoreceptor signaling: supporting vision across a wide range of light intensities. J Biol Chem. 2012 Jan 13; 287(3):1620-6. PMID: 22074925.
      View in: PubMed
    24. Gospe SM, Baker SA, Kessler C, Brucato MF, Winter JR, Burns ME, Arshavsky VY. Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors. J Neurosci. 2011 Oct 12; 31(41):14660-8. PMID: 21994382.
      View in: PubMed
    25. Sherry DM, Murray AR, Kanan Y, Arbogast KL, Hamilton RA, Fliesler SJ, Burns ME, Moore KL, Al-Ubaidi MR. Lack of protein-tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy. Eur J Neurosci. 2010 Nov; 32(9):1461-72. PMID: 21039965.
      View in: PubMed
    26. Burns ME, Pugh EN. Lessons from photoreceptors: turning off g-protein signaling in living cells. Physiology (Bethesda). 2010 Apr; 25(2):72-84. PMID: 20430952.
      View in: PubMed
    27. Herrmann R, Lobanova ES, Hammond T, Kessler C, Burns ME, Frishman LJ, Arshavsky VY. Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse. J Neurosci. 2010 Mar 03; 30(9):3239-53. PMID: 20203183.
      View in: PubMed
    28. Gross OP, Burns ME. Control of rhodopsin's active lifetime by arrestin-1 expression in mammalian rods. J Neurosci. 2010 Mar 03; 30(9):3450-7. PMID: 20203204.
      View in: PubMed
    29. Burns ME. Deactivation mechanisms of rod phototransduction: the Cogan lecture. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1282-8. PMID: 20185839.
      View in: PubMed
    30. Larsen DD, Luu JD, Burns ME, Krubitzer L. What are the Effects of Severe Visual Impairment on the Cortical Organization and Connectivity of Primary Visual Cortex? Front Neuroanat. 2009; 3:30. PMID: 20057935.
      View in: PubMed
    31. Burns ME, Pugh EN. RGS9 concentration matters in rod phototransduction. Biophys J. 2009 Sep 16; 97(6):1538-47. PMID: 19751658.
      View in: PubMed
    32. Song X, Vishnivetskiy SA, Gross OP, Emelianoff K, Mendez A, Chen J, Gurevich EV, Burns ME, Gurevich VV. Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation. Curr Biol. 2009 Apr 28; 19(8):700-5. PMID: 19361994.
      View in: PubMed
    33. Martemyanov KA, Krispel CM, Lishko PV, Burns ME, Arshavsky VY. Functional comparison of RGS9 splice isoforms in a living cell. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20988-93. PMID: 19098104.
      View in: PubMed
    34. Lobanova ES, Finkelstein S, Herrmann R, Chen YM, Kessler C, Michaud NA, Trieu LH, Strissel KJ, Burns ME, Arshavsky VY. Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability. J Neurosci. 2008 Mar 26; 28(13):3510-20. PMID: 18367617.
      View in: PubMed
    35. Kerov V, Rubin WW, Natochin M, Melling NA, Burns ME, Artemyev NO. N-terminal fatty acylation of transducin profoundly influences its localization and the kinetics of photoresponse in rods. J Neurosci. 2007 Sep 19; 27(38):10270-7. PMID: 17881533.
      View in: PubMed
    36. Krispel CM, Sokolov M, Chen YM, Song H, Herrmann R, Arshavsky VY, Burns ME. Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation. J Gen Physiol. 2007 Sep; 130(3):303-12. PMID: 17724163.
      View in: PubMed
    37. Chan S, Rubin WW, Mendez A, Liu X, Song X, Hanson SM, Craft CM, Gurevich VV, Burns ME, Chen J. Functional comparisons of visual arrestins in rod photoreceptors of transgenic mice. Invest Ophthalmol Vis Sci. 2007 May; 48(5):1968-75. PMID: 17460248.
      View in: PubMed
    38. Krispel CM, Chen D, Melling N, Chen YJ, Martemyanov KA, Quillinan N, Arshavsky VY, Wensel TG, Chen CK, Burns ME. RGS expression rate-limits recovery of rod photoresponses. Neuron. 2006 Aug 17; 51(4):409-16. PMID: 16908407.
      View in: PubMed
    39. Moussaif M, Rubin WW, Kerov V, Reh R, Chen D, Lem J, Chen CK, Hurley JB, Burns ME, Artemyev NO. Phototransduction in a transgenic mouse model of Nougaret night blindness. J Neurosci. 2006 Jun 21; 26(25):6863-72. PMID: 16793893.
      View in: PubMed
    40. Burns ME, Mendez A, Chen CK, Almuete A, Quillinan N, Simon MI, Baylor DA, Chen J. Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants. J Neurosci. 2006 Jan 18; 26(3):1036-44. PMID: 16421323.
      View in: PubMed
    41. Burns ME, Arshavsky VY. Beyond counting photons: trials and trends in vertebrate visual transduction. Neuron. 2005 Nov 03; 48(3):387-401. PMID: 16269358.
      View in: PubMed
    42. Makino CL, Dodd RL, Chen J, Burns ME, Roca A, Simon MI, Baylor DA. Recoverin regulates light-dependent phosphodiesterase activity in retinal rods. J Gen Physiol. 2004 Jun; 123(6):729-41. PMID: 15173221.
      View in: PubMed
    43. Keresztes G, Martemyanov KA, Krispel CM, Mutai H, Yoo PJ, Maison SF, Burns ME, Arshavsky VY, Heller S. Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. J Biol Chem. 2004 Jan 16; 279(3):1581-4. PMID: 14625292.
      View in: PubMed
    44. Martemyanov KA, Lishko PV, Calero N, Keresztes G, Sokolov M, Strissel KJ, Leskov IB, Hopp JA, Kolesnikov AV, Chen CK, Lem J, Heller S, Burns ME, Arshavsky VY. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. J Neurosci. 2003 Nov 12; 23(32):10175-81. PMID: 14614075.
      View in: PubMed
    45. Krispel CM, Chen CK, Simon MI, Burns ME. Novel form of adaptation in mouse retinal rods speeds recovery of phototransduction. J Gen Physiol. 2003 Dec; 122(6):703-12. PMID: 14610022.
      View in: PubMed
    46. Krispel CM, Chen CK, Simon MI, Burns ME. Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- mice. J Neurosci. 2003 Aug 06; 23(18):6965-71. PMID: 12904457.
      View in: PubMed
    47. Burns ME, Wensel TG. From molecules to behavior: new clues for RGS function in the striatum. Neuron. 2003 Jun 19; 38(6):853-6. PMID: 12818171.
      View in: PubMed
    48. Burns ME, Mendez A, Chen J, Baylor DA. Dynamics of cyclic GMP synthesis in retinal rods. Neuron. 2002 Sep 26; 36(1):81-91. PMID: 12367508.
      View in: PubMed
    49. Mendez A, Burns ME, Sokal I, Dizhoor AM, Baehr W, Palczewski K, Baylor DA, Chen J. Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9948-53. PMID: 11493703.
      View in: PubMed
    50. Burns ME, Baylor DA. Activation, deactivation, and adaptation in vertebrate photoreceptor cells. Annu Rev Neurosci. 2001; 24:779-805. PMID: 11520918.
      View in: PubMed
    51. Mendez A, Burns ME, Roca A, Lem J, Wu LW, Simon MI, Baylor DA, Chen J. Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites. Neuron. 2000 Oct; 28(1):153-64. PMID: 11086991.
      View in: PubMed
    52. Chen CK, Burns ME, He W, Wensel TG, Baylor DA, Simon MI. Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature. 2000 Feb 03; 403(6769):557-60. PMID: 10676965.
      View in: PubMed
    53. Augustine GJ, Burns ME, DeBello WM, Hilfiker S, Morgan JR, Schweizer FE, Tokumaru H, Umayahara K. Proteins involved in synaptic vesicle trafficking. J Physiol. 1999 Oct 01; 520 Pt 1:33-41. PMID: 10517798.
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    54. Chen CK, Burns ME, Spencer M, Niemi GA, Chen J, Hurley JB, Baylor DA, Simon MI. Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3718-22. PMID: 10097103.
      View in: PubMed
    55. Tsang SH, Burns ME, Calvert PD, Gouras P, Baylor DA, Goff SP, Arshavsky VY. Role for the target enzyme in deactivation of photoreceptor G protein in vivo. Science. 1998 Oct 02; 282(5386):117-21. PMID: 9756475.
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    56. Dresbach T, Burns ME, O'Connor V, DeBello WM, Betz H, Augustine GJ. A neuronal Sec1 homolog regulates neurotransmitter release at the squid giant synapse. J Neurosci. 1998 Apr 15; 18(8):2923-32. PMID: 9526009.
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    57. Burns ME, Sasaki T, Takai Y, Augustine GJ. Rabphilin-3A: a multifunctional regulator of synaptic vesicle traffic. J Gen Physiol. 1998 Feb; 111(2):243-55. PMID: 9450942.
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    58. Baylor DA, Burns ME. Control of rhodopsin activity in vision. Eye (Lond). 1998; 12 ( Pt 3b):521-5. PMID: 9775212.
      View in: PubMed
    59. Augustine GJ, Burns ME, DeBello WM, Pettit DL, Schweizer FE. Exocytosis: proteins and perturbations. Annu Rev Pharmacol Toxicol. 1996; 36:659-701. PMID: 8725405.
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    60. Burns ME, Augustine GJ. Synaptic structure and function: dynamic organization yields architectural precision. Cell. 1995 Oct 20; 83(2):187-94. PMID: 7585936.
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    61. Burns ME, Beushausen SA, Chin GJ, Tang D, DeBello WM, Dresbach T, O'Connor V, Schweizer FE, Wang SS, Whiteheart SW. Proteins involved in synaptic vesicle docking and fusion. Cold Spring Harb Symp Quant Biol. 1995; 60:337-48. PMID: 8824407.
      View in: PubMed
    62. Burton JL, Burns ME, Gatti E, Augustine GJ, De Camilli P. Specific interactions of Mss4 with members of the Rab GTPase subfamily. EMBO J. 1994 Dec 01; 13(23):5547-58. PMID: 7988552.
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