Marie E Burns

Title(s)Professor, Ophthalmology and Vision Science
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    Collapse Research 
    Collapse Research Activities and Funding
    Rhodopsin dimerization: mechanistic basis and functional consequences
    NIH/NEI R01EY027969Sep 30, 2017 - May 31, 2021
    Role: Co-Principal Investigator
    FASEB SRC on The Biology and Chemistry of Vision
    NIH/NEI R13EY028019Jun 1, 2017 - May 31, 2018
    Role: Principal Investigator
    Microglial Activation during Photoreceptor Degeneration
    NIH/NEI R01EY024320Sep 1, 2015 - Aug 31, 2019
    Role: Principal Investigator
    Training Program in Vision Science
    NIH/NEI T32EY015387Sep 30, 2003 - Aug 31, 2023
    Role: Co-Principal Investigator
    Deactivation Mechanisms of Rod Phototransduction
    NIH/NEI R01EY014047May 1, 2002 - Apr 30, 2021
    Role: Principal Investigator
    NIH/NIMH F31MH011073Feb 25, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Karlen SJ, Miller EB, Wang X, Levine ES, Zawadzki RJ, Burns ME. Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration. J Neuroinflammation. 2018 Dec 15; 15(1):344. PMID: 30553275.
      View in: PubMed
    2. Goswami M, Wang X, Zhang P, Xiao W, Karlen SJ, Li Y, Zawadzki RJ, Burns ME, Lam KS, Pugh EN. Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacy in vivo. Biomed Opt Express. 2019 Jan 01; 10(1):151-166. PMID: 30775090.
      View in: PubMed
    3. Burns ME, Stevens B. Report on the National Eye Institute's Audacious Goals Initiative: Creating a Cellular Environment for Neuroregeneration. eNeuro. 2018 Mar-Apr; 5(2). PMID: 29766041.
      View in: PubMed
    4. Ronning KE, Allina GP, Miller EB, Zawadzki RJ, Pugh EN, Herrmann R, Burns ME. Loss of cone function without degeneration in a novel Gnat2 knock-out mouse. Exp Eye Res. 2018 06; 171:111-118. PMID: 29518352.
      View in: PubMed
    5. Fairchild CL, Hino K, Han JS, Miltner AM, Peinado Allina G, Brown CE, Burns ME, La Torre A, Simó S. RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 02 02; 145(3). PMID: 29361558.
      View in: PubMed
    6. Wang X, Miller EB, Goswami M, Zhang P, Ronning KE, Karlen SJ, Zawadzki RJ, Pugh EN, Burns ME. Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130. J Neuroinflammation. 2017 06 23; 14(1):121. PMID: 28645275.
      View in: PubMed
    7. Zhang P, Zawadzki RJ, Goswami M, Nguyen PT, Yarov-Yarovoy V, Burns ME, Pugh EN. In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2937-E2946. PMID: 28320964.
      View in: PubMed
    8. Peinado Allina G, Fortenbach C, Naarendorp F, Gross OP, Pugh EN, Burns ME. Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9. J Gen Physiol. 2017 Apr 03; 149(4):443-454. PMID: 28302678.
      View in: PubMed
    9. Burns ME, Levine ES, Miller EB, Zam A, Zhang P, Zawadzki RJ, Pugh EN. New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo. Adv Exp Med Biol. 2016; 854:269-75. PMID: 26427421; PMCID: PMC4603285 [Available on 01/01/17].
    10. Zawadzki RJ, Zhang P, Zam A, Miller EB, Goswami M, Wang X, Jonnal RS, Lee SH, Kim DY, Flannery JG, Werner JS, Burns ME, Pugh EN. Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina. Biomed Opt Express. 2015 Jun 01; 6(6):2191-210. PMID: 26114038.
      View in: PubMed
    11. Fortenbach CR, Kessler C, Peinado Allina G, Burns ME. Speeding rod recovery improves temporal resolution in the retina. Vision Res. 2015 May; 110(Pt A):57-67. PMID: 25748270; PMCID: PMC4410083.
    12. Gross OP, Pugh EN, Burns ME. cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses. Front Mol Neurosci. 2015; 8:6. PMID: 25788876.
      View in: PubMed
    13. Zhang P, Zam A, Jian Y, Wang X, Li Y, Lam KS, Burns ME, Sarunic MV, Pugh EN, Zawadzki RJ. In vivo wide-field multispectral scanning laser ophthalmoscopy-optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature. J Biomed Opt. 2015; 20(12):126005. PMID: 26677070; PMCID: PMC4681314 [Available on 12/16/16].
    14. Levine ES, Zam A, Zhang P, Pechko A, Wang X, FitzGerald P, Pugh EN, Zawadzki RJ, Burns ME. Rapid light-induced activation of retinal microglia in mice lacking Arrestin-1. Vision Res. 2014 Sep; 102:71-9. PMID: 25091460; PMCID: PMC4162662.
    15. Arshavsky VY, Burns ME. Current understanding of signal amplification in phototransduction. Cell Logist. 2014; 4:e29390. PMID: 25279249.
      View in: PubMed
    16. Kessler C, Tillman M, Burns ME, Pugh EN. Rhodopsin in the rod surface membrane regenerates more rapidly than bulk rhodopsin in the disc membranes in vivo. J Physiol. 2014 Jul 01; 592(13):2785-97. PMID: 24801306; PMCID: PMC4221820.
    17. Long JH, Arshavsky VY, Burns ME. Absence of synaptic regulation by phosducin in retinal slices. PLoS One. 2013; 8(12):e83970. PMID: 24376776; PMCID: PMC3869837.
    18. Gross OP, Pugh EN, Burns ME. Calcium feedback to cGMP synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes. Neuron. 2012 Oct 18; 76(2):370-82. PMID: 23083739; PMCID: PMC3594095.
    19. Gross OP, Pugh EN, Burns ME. Spatiotemporal cGMP dynamics in living mouse rods. Biophys J. 2012 Apr 18; 102(8):1775-84. PMID: 22768933; PMCID: PMC3328695.
    20. Arshavsky VY, Burns ME. Photoreceptor signaling: supporting vision across a wide range of light intensities. J Biol Chem. 2012 Jan 13; 287(3):1620-6. PMID: 22074925; PMCID: PMC3265842.
    21. Gospe SM, Baker SA, Kessler C, Brucato MF, Winter JR, Burns ME, Arshavsky VY. Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors. J Neurosci. 2011 Oct 12; 31(41):14660-8. PMID: 21994382; PMCID: PMC3207252.
    22. Burns ME, Pugh EN. Lessons from photoreceptors: turning off g-protein signaling in living cells. Physiology (Bethesda). 2010 Apr; 25(2):72-84. PMID: 20430952; PMCID: PMC2880230.
    23. Herrmann R, Lobanova ES, Hammond T, Kessler C, Burns ME, Frishman LJ, Arshavsky VY. Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse. J Neurosci. 2010 Mar 03; 30(9):3239-53. PMID: 20203183; PMCID: PMC2927985.
    24. Gross OP, Burns ME. Control of rhodopsin's active lifetime by arrestin-1 expression in mammalian rods. J Neurosci. 2010 Mar 03; 30(9):3450-7. PMID: 20203204; PMCID: PMC2841010.
    25. Burns ME. Deactivation mechanisms of rod phototransduction: the Cogan lecture. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1282-8. PMID: 20185839; PMCID: PMC2845640.
    26. Larsen DD, Luu JD, Burns ME, Krubitzer L. What are the Effects of Severe Visual Impairment on the Cortical Organization and Connectivity of Primary Visual Cortex? Front Neuroanat. 2009; 3:30. PMID: 20057935; PMCID: PMC2802552.
    27. Burns ME, Pugh EN. RGS9 concentration matters in rod phototransduction. Biophys J. 2009 Sep 16; 97(6):1538-47. PMID: 19751658; PMCID: PMC2749774.
    28. Song X, Vishnivetskiy SA, Gross OP, Emelianoff K, Mendez A, Chen J, Gurevich EV, Burns ME, Gurevich VV. Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation. Curr Biol. 2009 Apr 28; 19(8):700-5. PMID: 19361994; PMCID: PMC2768495.
    29. Martemyanov KA, Krispel CM, Lishko PV, Burns ME, Arshavsky VY. Functional comparison of RGS9 splice isoforms in a living cell. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20988-93. PMID: 19098104; PMCID: PMC2634932.
    30. Lobanova ES, Finkelstein S, Herrmann R, Chen YM, Kessler C, Michaud NA, Trieu LH, Strissel KJ, Burns ME, Arshavsky VY. Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability. J Neurosci. 2008 Mar 26; 28(13):3510-20. PMID: 18367617; PMCID: PMC2795350.
    31. Kerov V, Rubin WW, Natochin M, Melling NA, Burns ME, Artemyev NO. N-terminal fatty acylation of transducin profoundly influences its localization and the kinetics of photoresponse in rods. J Neurosci. 2007 Sep 19; 27(38):10270-7. PMID: 17881533.
      View in: PubMed
    32. Krispel CM, Sokolov M, Chen YM, Song H, Herrmann R, Arshavsky VY, Burns ME. Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation. J Gen Physiol. 2007 Sep; 130(3):303-12. PMID: 17724163; PMCID: PMC2151643.
    33. Chan S, Rubin WW, Mendez A, Liu X, Song X, Hanson SM, Craft CM, Gurevich VV, Burns ME, Chen J. Functional comparisons of visual arrestins in rod photoreceptors of transgenic mice. Invest Ophthalmol Vis Sci. 2007 May; 48(5):1968-75. PMID: 17460248; PMCID: PMC2933836.
    34. Krispel CM, Chen D, Melling N, Chen YJ, Martemyanov KA, Quillinan N, Arshavsky VY, Wensel TG, Chen CK, Burns ME. RGS expression rate-limits recovery of rod photoresponses. Neuron. 2006 Aug 17; 51(4):409-16. PMID: 16908407.
      View in: PubMed
    35. Moussaif M, Rubin WW, Kerov V, Reh R, Chen D, Lem J, Chen CK, Hurley JB, Burns ME, Artemyev NO. Phototransduction in a transgenic mouse model of Nougaret night blindness. J Neurosci. 2006 Jun 21; 26(25):6863-72. PMID: 16793893.
      View in: PubMed
    36. Burns ME, Mendez A, Chen CK, Almuete A, Quillinan N, Simon MI, Baylor DA, Chen J. Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants. J Neurosci. 2006 Jan 18; 26(3):1036-44. PMID: 16421323.
      View in: PubMed
    37. Burns ME, Arshavsky VY. Beyond counting photons: trials and trends in vertebrate visual transduction. Neuron. 2005 Nov 03; 48(3):387-401. PMID: 16269358.
      View in: PubMed
    38. Keresztes G, Martemyanov KA, Krispel CM, Mutai H, Yoo PJ, Maison SF, Burns ME, Arshavsky VY, Heller S. Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. J Biol Chem. 2004 Jan 16; 279(3):1581-4. PMID: 14625292.
      View in: PubMed
    39. Martemyanov KA, Lishko PV, Calero N, Keresztes G, Sokolov M, Strissel KJ, Leskov IB, Hopp JA, Kolesnikov AV, Chen CK, Lem J, Heller S, Burns ME, Arshavsky VY. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. J Neurosci. 2003 Nov 12; 23(32):10175-81. PMID: 14614075.
      View in: PubMed
    40. Krispel CM, Chen CK, Simon MI, Burns ME. Novel form of adaptation in mouse retinal rods speeds recovery of phototransduction. J Gen Physiol. 2003 Dec; 122(6):703-12. PMID: 14610022; PMCID: PMC2229593.
    41. Krispel CM, Chen CK, Simon MI, Burns ME. Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- mice. J Neurosci. 2003 Aug 06; 23(18):6965-71. PMID: 12904457.
      View in: PubMed
    42. Burns ME, Wensel TG. From molecules to behavior: new clues for RGS function in the striatum. Neuron. 2003 Jun 19; 38(6):853-6. PMID: 12818171.
      View in: PubMed
    43. Burns ME, Mendez A, Chen J, Baylor DA. Dynamics of cyclic GMP synthesis in retinal rods. Neuron. 2002 Sep 26; 36(1):81-91. PMID: 12367508.
      View in: PubMed