Edward N Pugh Jr

Title(s)Professor, Cell Biology and Human Anatomy
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Translocation of soluble proteins in rod photoreceptors
    NIH/NEI R01EY016453Jun 1, 2005 - May 31, 2010
    Role: Principal Investigator
    Nanomedicine:Supra-molecular cellular compartments (RMI)
    NIH/NEI PN1EY016555Sep 30, 2004 - Mar 31, 2005
    Role: Principal Investigator
    NIH/NEI R01EY013074Sep 7, 2000 - Aug 31, 2004
    Role: Principal Investigator
    NIH/NEI R01EY008206Jul 1, 1989 - Jun 30, 1993
    Role: Principal Investigator
    Mechanisms of Visual Transduction
    NIH/NEI R01EY002660Aug 1, 1978 - Feb 28, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Zhang P, Manna SK, Miller EB, Jian Y, Meleppat RK, Sarunic MV, Pugh EN, Zawadzki RJ. Aperture phase modulation with adaptive optics: a novel approach for speckle reduction and structure extraction in optical coherence tomography. Biomed Opt Express. 2019 Feb 01; 10(2):552-570. PMID: 30800499.
      View in: PubMed
    2. Goswami M, Wang X, Zhang P, Xiao W, Karlen SJ, Li Y, Zawadzki RJ, Burns ME, Lam KS, Pugh EN. Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacy in vivo. Biomed Opt Express. 2019 Jan 01; 10(1):151-166. PMID: 30775090.
      View in: PubMed
    3. Zhang P, Mocci J, Wahl DJ, Meleppat RK, Manna SK, Quintavalla M, Muradore R, Sarunic MV, Bonora S, Pugh EN, Zawadzki RJ. Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations. Exp Eye Res. 2018 07; 172:86-93. PMID: 29604280.
      View in: PubMed
    4. Ronning KE, Allina GP, Miller EB, Zawadzki RJ, Pugh EN, Herrmann R, Burns ME. Loss of cone function without degeneration in a novel Gnat2 knock-out mouse. Exp Eye Res. 2018 06; 171:111-118. PMID: 29518352.
      View in: PubMed
    5. Pugh EN. The discovery of the ability of rod photoreceptors to signal single photons. J Gen Physiol. 2018 Feb 21. PMID: 29467164.
      View in: PubMed
    6. Zhang P, Zawadzki RJ, Goswami M, Nguyen PT, Yarov-Yarovoy V, Burns ME, Pugh EN. In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2937-E2946. PMID: 28320964.
      View in: PubMed
    7. Peinado Allina G, Fortenbach C, Naarendorp F, Gross OP, Pugh EN, Burns ME. Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9. J Gen Physiol. 2017 Apr 03; 149(4):443-454. PMID: 28302678.
      View in: PubMed
    8. Burns ME, Levine ES, Miller EB, Zam A, Zhang P, Zawadzki RJ, Pugh EN. New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo. Adv Exp Med Biol. 2016; 854:269-75. PMID: 26427421; PMCID: PMC4603285 [Available on 01/01/17].
    9. Pugh EN. Photoreceptor disc morphogenesis: The classical evagination model prevails. J Cell Biol. 2015 Nov 09; 211(3):491-3. PMID: 26527745; PMCID: PMC4639855.
    10. Zawadzki RJ, Zhang P, Zam A, Miller EB, Goswami M, Wang X, Jonnal RS, Lee SH, Kim DY, Flannery JG, Werner JS, Burns ME, Pugh EN. Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina. Biomed Opt Express. 2015 Jun 01; 6(6):2191-210. PMID: 26114038.
      View in: PubMed
    11. Zhang P, Zam A, Jian Y, Wang X, Li Y, Lam KS, Burns ME, Sarunic MV, Pugh EN, Zawadzki RJ. In vivo wide-field multispectral scanning laser ophthalmoscopy-optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature. J Biomed Opt. 2015; 20(12):126005. PMID: 26677070; PMCID: PMC4681314 [Available on 12/16/16].
    12. Levine ES, Zam A, Zhang P, Pechko A, Wang X, FitzGerald P, Pugh EN, Zawadzki RJ, Burns ME. Rapid light-induced activation of retinal microglia in mice lacking Arrestin-1. Vision Res. 2014 Sep; 102:71-9. PMID: 25091460; PMCID: PMC4162662.
    13. Pugh EN, Gordon SE. Embracing the principles of the San Francisco Declaration of Research Assessment: Robert Balaban's editorial. J Gen Physiol. 2013 Sep; 142(3):175. PMID: 23980189; PMCID: PMC3753606.
    14. Pugh EN. Introducing the viewpoint. J Gen Physiol. 2012 Dec; 140(6):579. PMID: 23183691; PMCID: PMC3514731.
    15. Sheu SS, Dirksen RT, Pugh EN. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondria take center stage. J Gen Physiol. 2012 Jun; 139(6):391-3. PMID: 22641633; PMCID: PMC3362527.
    16. Sheu SS, Dirksen RT, Pugh EN. The 65th Symposium of the Society for General Physiologists: energizing research in mitochondrial physiology and medicine. J Gen Physiol. 2011 Dec; 138(6):563-7. PMID: 22124113; PMCID: PMC3226972.
    17. Pugh EN. Redefining our menu: communications and reviews. J Gen Physiol. 2011 Aug; 138(2):131. PMID: 21788608; PMCID: PMC3149441.
    18. Ellis-Davies GC, Pugh EN. The 64th Symposium of the Society for General Physiologists: optogenetics and superresolution microscopy take center stage. J Gen Physiol. 2011 Jul; 138(1):1-11. PMID: 21708951; PMCID: PMC3135327.
    19. Pugh EN. Good scientists do reach and hold divergent views on important issues. J Gen Physiol. 2011 Mar; 137(3):253. PMID: 21357731; PMCID: PMC3047605.
    20. Pugh EN. We were there... J Gen Physiol. 2010 Nov; 136(5):495. PMID: 20974770; PMCID: PMC2964518.
    21. Dirksen RT, Pugh EN. Emerging questions about the macromolecular machines of muscle. J Gen Physiol. 2010 Jul; 136(1):3-5. PMID: 20584886; PMCID: PMC2894551.
    22. Calvert PD, Schiesser WE, Pugh EN. Diffusion of a soluble protein, photoactivatable GFP, through a sensory cilium. J Gen Physiol. 2010 Mar; 135(3):173-96. PMID: 20176852; PMCID: PMC2828910.
    23. Pugh EN. Enlisting young physiologists. J Gen Physiol. 2009 Dec; 134(6):451-2. PMID: 19948996; PMCID: PMC2806425.
    24. Pugh EN. Kudos to reviewers for the JGP: you make our science better. J Gen Physiol. 2009 Feb; 133(2):129-30. PMID: 19171768; PMCID: PMC2638203.
    25. Pugh EN, Andersen OS. Models and mechanistic insight. J Gen Physiol. 2008 Jun; 131(6):515-9. PMID: 18504312; PMCID: PMC2391249.
    26. Nikonov SS, Kholodenko R, Lem J, Pugh EN. Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings. J Gen Physiol. 2006 Apr; 127(4):359-74. PMID: 16567464; PMCID: PMC2151510.
    27. Nikonov SS, Daniele LL, Zhu X, Craft CM, Swaroop A, Pugh EN. Photoreceptors of Nrl -/- mice coexpress functional S- and M-cone opsins having distinct inactivation mechanisms. J Gen Physiol. 2005 Mar; 125(3):287-304. PMID: 15738050; PMCID: PMC2234018.
    28. Peet JA, Bragin A, Calvert PD, Nikonov SS, Mani S, Zhao X, Besharse JC, Pierce EA, Knox BE, Pugh EN. Quantification of the cytoplasmic spaces of living cells with EGFP reveals arrestin-EGFP to be in disequilibrium in dark adapted rod photoreceptors. J Cell Sci. 2004 Jun 15; 117(Pt 14):3049-59. PMID: 15197244.
      View in: PubMed