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Paul G FitzGerald

Title(s)Professor, Cell Biology and Human Anatomy
SchoolUniversity of California, Davis
Phone530-752-7130
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gae DD, Budamagunta MS, Hess JF, McCarrick RM, Lorigan GA, FitzGerald PG, Voss JC. Completion of the Vimentin Rod Domain Structure Using Experimental Restraints: A New Tool for Exploring Intermediate Filament Assembly and Mutations. Structure. 2019 Oct 01; 27(10):1547-1560.e4. PMID: 31402219.
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    2. Gerhart J, Behling K, Paessler M, Milton L, Bramblett G, Garcia D, Pitts M, Hurtt R, Crawford M, Lackman R, Nguyen D, Infanti J, FitzGerald P, George-Weinstein M. Rhabdomyosarcoma and Wilms tumors contain a subpopulation of noggin producing, myogenic cells immunoreactive for lens beaded filament proteins. PLoS One. 2019; 14(4):e0214758. PMID: 30973903.
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    3. Kim S, Thomasy SM, Raghunathan VK, Teixeira LBC, Moshiri A, FitzGerald P, Murphy CJ. Ocular phenotypic consequences of a single copy deletion of the Yap1 gene (Yap1+/-) in mice. Mol Vis. 2019; 25:129-142. PMID: 30820148.
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    4. Swarup A, Bell BA, Du J, Han JYS, Soto J, Abel ED, Bravo-Nuevo A, FitzGerald PG, Peachey NS, Philp NJ. Deletion of GLUT1 in mouse lens epithelium leads to cataract formation. Exp Eye Res. 2018 07; 172:45-53. PMID: 29604281.
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    5. Gerhart J, Withers C, Gerhart C, Werner L, Mamalis N, Bravo-Nuevo A, Scheinfeld V, FitzGerald P, Getts R, George-Weinstein M. Myo/Nog cells are present in the ciliary processes, on the zonule of Zinn and posterior capsule of the lens following cataract surgery. Exp Eye Res. 2018 06; 171:101-105. PMID: 29559302.
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    6. Budamagunta MS, Guo F, Sun N, Shibata B, FitzGerald PG, Voss JC, Hess JF. Production of recombinant human tektin 1, 2, and 4 and in vitro assembly of human tektin 1. Cytoskeleton (Hoboken). 2018 01; 75(1):3-11. PMID: 29108134.
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    7. Liu L, Hess J, Sahu ID, FitzGerald PG, McCarrick RM, Lorigan GA. Probing the Local Secondary Structure of Human Vimentin with Electron Spin Echo Envelope Modulation (ESEEM) Spectroscopy. J Phys Chem B. 2016 12 08; 120(48):12321-12326. PMID: 27934222.
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    8. FitzGerald P, Sun N, Shibata B, Hess JF. Expression of the type VI intermediate filament proteins CP49 and filensin in the mouse lens epithelium. Mol Vis. 2016; 22:970-89. PMID: 27559293.
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    9. Cheng C, Nowak RB, Biswas SK, Lo WK, FitzGerald PG, Fowler VM. Tropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber Cells. Invest Ophthalmol Vis Sci. 2016 08 01; 57(10):4084-99. PMID: 27537257.
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    10. Ofri R, Reilly CM, Maggs DJ, Fitzgerald PG, Shilo-Benjamini Y, Good KL, Grahn RA, Splawski DD, Lyons LA. Characterization of an Early-Onset, Autosomal Recessive, Progressive Retinal Degeneration in Bengal Cats. Invest Ophthalmol Vis Sci. 2015 Aug; 56(9):5299-308. PMID: 26258614.
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    11. Sindhu Kumari S, Gupta N, Shiels A, FitzGerald PG, Menon AG, Mathias RT, Varadaraj K. Role of Aquaporin 0 in lens biomechanics. Biochem Biophys Res Commun. 2015 Jul 10; 462(4):339-45. PMID: 25960294.
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    12. Sun N, Shibata B, Hess JF, FitzGerald PG. An alternative means of retaining ocular structure and improving immunoreactivity for light microscopy studies. Mol Vis. 2015; 21:428-42. PMID: 25991907.
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    13. Levine ES, Zam A, Zhang P, Pechko A, Wang X, FitzGerald P, Pugh EN, Zawadzki RJ, Burns ME. Rapid light-induced activation of retinal microglia in mice lacking Arrestin-1. Vision Res. 2014 Sep; 102:71-9. PMID: 25091460.
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    14. Gerhart J, Greenbaum M, Scheinfeld V, Fitzgerald P, Crawford M, Bravo-Nuevo A, Pitts M, George-Weinstein M. Myo/Nog cells: targets for preventing the accumulation of skeletal muscle-like cells in the human lens. PLoS One. 2014; 9(4):e95262. PMID: 24736495.
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    15. Manthey AL, Lachke SA, FitzGerald PG, Mason RW, Scheiblin DA, McDonald JH, Duncan MK. Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mech Dev. 2014 Feb; 131:86-110. PMID: 24161570.
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    16. Stewart DN, Lango J, Nambiar KP, Falso MJ, FitzGerald PG, Rocke DM, Hammock BD, Buchholz BA. Carbon turnover in the water-soluble protein of the adult human lens. Mol Vis. 2013; 19:463-75. PMID: 23441119.
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    17. Hess JF, Budamagunta MS, Aziz A, FitzGerald PG, Voss JC. Electron paramagnetic resonance analysis of the vimentin tail domain reveals points of order in a largely disordered region and conformational adaptation upon filament assembly. Protein Sci. 2013 Jan; 22(1):47-55. PMID: 23109052.
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    18. Fan J, Dong L, Mishra S, Chen Y, FitzGerald P, Wistow G. A role for ?S-crystallin in the organization of actin and fiber cell maturation in the mouse lens. FEBS J. 2012 Aug; 279(16):2892-904. PMID: 22715935.
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    19. Aziz A, Hess JF, Budamagunta MS, Voss JC, Kuzin AP, Huang YJ, Xiao R, Montelione GT, FitzGerald PG, Hunt JF. The structure of vimentin linker 1 and rod 1B domains characterized by site-directed spin-labeling electron paramagnetic resonance (SDSL-EPR) and X-ray crystallography. J Biol Chem. 2012 Aug 17; 287(34):28349-61. PMID: 22740688.
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    20. Park SS, Caballero S, Bauer G, Shibata B, Roth A, Fitzgerald PG, Forward KI, Zhou P, McGee J, Telander DG, Grant MB, Nolta JA. Long-term effects of intravitreal injection of GMP-grade bone-marrow-derived CD34+ cells in NOD-SCID mice with acute ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 2012 Feb; 53(2):986-94. PMID: 22247454.
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    21. Weikel KA, Fitzgerald P, Shang F, Caceres MA, Bian Q, Handa JT, Stitt AW, Taylor A. Natural history of age-related retinal lesions that precede AMD in mice fed high or low glycemic index diets. Invest Ophthalmol Vis Sci. 2012 Feb 02; 53(2):622-32. PMID: 22205601.
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    22. Shi Y, De Maria AB, Wang H, Mathias RT, FitzGerald PG, Bassnett S. Further analysis of the lens phenotype in Lim2-deficient mice. Invest Ophthalmol Vis Sci. 2011 Sep 21; 52(10):7332-9. PMID: 21775657.
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    23. Castorino JJ, Gallagher-Colombo SM, Levin AV, Fitzgerald PG, Polishook J, Kloeckener-Gruissem B, Ostertag E, Philp NJ. Juvenile cataract-associated mutation of solute carrier SLC16A12 impairs trafficking of the protein to the plasma membrane. Invest Ophthalmol Vis Sci. 2011 Aug 29; 52(9):6774-84. PMID: 21778275.
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    24. Fudge DS, McCuaig JV, Van Stralen S, Hess JF, Wang H, Mathias RT, FitzGerald PG. Intermediate filaments regulate tissue size and stiffness in the murine lens. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3860-7. PMID: 21345981.
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    25. Aziz A, Hess JF, Budamagunta MS, Voss JC, Fitzgerald PG. Site-directed spin labeling and electron paramagnetic resonance determination of vimentin head domain structure. J Biol Chem. 2010 May 14; 285(20):15278-85. PMID: 20231271.
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    26. Lindstrom SH, Nacsa N, Blankenship T, Fitzgerald PG, Weller C, Vaney DI, Wilson M. Distribution and structure of efferent synapses in the chicken retina. Vis Neurosci. 2009 Mar-Apr; 26(2):215-26. PMID: 19439107.
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    27. Aziz A, Hess JF, Budamagunta MS, FitzGerald PG, Voss JC. Head and rod 1 interactions in vimentin: identification of contact sites, structure, and changes with phosphorylation using site-directed spin labeling and electron paramagnetic resonance. J Biol Chem. 2009 Mar 13; 284(11):7330-8. PMID: 19117942.
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    28. FitzGerald PG. Lens intermediate filaments. Exp Eye Res. 2009 Feb; 88(2):165-72. PMID: 19071112.
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    29. Yoon KH, FitzGerald PG. Periplakin interactions with lens intermediate and beaded filaments. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1283-9. PMID: 19029034.
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    30. Pittenger JT, Hess JF, Budamagunta MS, Voss JC, Fitzgerald PG. Identification of phosphorylation-induced changes in vimentin intermediate filaments by site-directed spin labeling and electron paramagnetic resonance. Biochemistry. 2008 Oct 14; 47(41):10863-70. PMID: 18803396.
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    31. Yoon KH, Blankenship T, Shibata B, Fitzgerald PG. Resisting the effects of aging: a function for the fiber cell beaded filament. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1030-6. PMID: 18326727.
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    32. Pittenger JT, Hess JF, Fitzgerald PG. Identifying the role of specific motifs in the lens fiber cell specific intermediate filament phakosin. Invest Ophthalmol Vis Sci. 2007 Nov; 48(11):5132-41. PMID: 17962466.
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    33. Lagerstedt JO, Cavigiolio G, Roberts LM, Hong HS, Jin LW, Fitzgerald PG, Oda MN, Voss JC. Mapping the structural transition in an amyloidogenic apolipoprotein A-I. Biochemistry. 2007 Aug 28; 46(34):9693-9. PMID: 17665932.
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    34. Blankenship T, Bradshaw L, Shibata B, Fitzgerald P. Structural specializations emerging late in mouse lens fiber cell differentiation. Invest Ophthalmol Vis Sci. 2007 Jul; 48(7):3269-76. PMID: 17591898.
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    35. Hess JF, FitzGerald PG. Treatment of keratin intermediate filaments with sulfur mustard analogs. Biochem Biophys Res Commun. 2007 Aug 03; 359(3):616-21. PMID: 17548056.
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    36. Budamagunta M, Hess J, Fitzgerald P, Voss J. Describing the structure and assembly of protein filaments by EPR spectroscopy of spin-labeled side chains. Cell Biochem Biophys. 2007; 48(1):45-53. PMID: 17703067.
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    37. Hess JF, Budamagunta MS, Shipman RL, FitzGerald PG, Voss JC. Characterization of the linker 2 region in human vimentin using site-directed spin labeling and electron paramagnetic resonance. Biochemistry. 2006 Oct 03; 45(39):11737-43. PMID: 17002274.
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    38. Hess JF, Budamagunta MS, FitzGerald PG, Voss JC. Characterization of structural changes in vimentin bearing an epidermolysis bullosa simplex-like mutation using site-directed spin labeling and electron paramagnetic resonance. J Biol Chem. 2005 Jan 21; 280(3):2141-6. PMID: 15556930.
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    39. Hess JF, Budamagunta MS, Voss JC, FitzGerald PG. Structural characterization of human vimentin rod 1 and the sequencing of assembly steps in intermediate filament formation in vitro using site-directed spin labeling and electron paramagnetic resonance. J Biol Chem. 2004 Oct 22; 279(43):44841-6. PMID: 15231822.
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    40. Alizadeh A, Clark J, Seeberger T, Hess J, Blankenship T, FitzGerald PG. Characterization of a mutation in the lens-specific CP49 in the 129 strain of mouse. Invest Ophthalmol Vis Sci. 2004 Mar; 45(3):884-91. PMID: 14985306.
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    41. Seeberger TM, Matsumoto Y, Alizadeh A, Fitzgerald PG, Clark JI. Digital image capture and quantification of subtle lens opacities in rodents. J Biomed Opt. 2004 Jan-Feb; 9(1):116-20. PMID: 14715062.
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    42. Alizadeh A, Clark J, Seeberger T, Hess J, Blankenship T, FitzGerald PG. Targeted deletion of the lens fiber cell-specific intermediate filament protein filensin. Invest Ophthalmol Vis Sci. 2003 Dec; 44(12):5252-8. PMID: 14638724.
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    43. DePianto DJ, Blankenship TN, Hess JF, FitzGerald PG. Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice. Mol Vis. 2003 Jun 30; 9:288-94. PMID: 12835653.
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    44. DePianto DJ, Hess JF, Blankenship TN, FitzGerald PG. Isolation and characterization of the human CP49 gene promoter. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):235-43. PMID: 12506080.
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    45. Alizadeh A, Clark JI, Seeberger T, Hess J, Blankenship T, Spicer A, FitzGerald PG. Targeted genomic deletion of the lens-specific intermediate filament protein CP49. Invest Ophthalmol Vis Sci. 2002 Dec; 43(12):3722-7. PMID: 12454043.
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    46. Hess JF, Voss JC, FitzGerald PG. Real-time observation of coiled-coil domains and subunit assembly in intermediate filaments. J Biol Chem. 2002 Sep 20; 277(38):35516-22. PMID: 12122019.
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    47. Binkley PA, Hess J, Casselman J, FitzGerald P. Unexpected variation in unique features of the lens-specific type I cytokeratin CP49. Invest Ophthalmol Vis Sci. 2002 Jan; 43(1):225-35. PMID: 11773035.
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    48. Schwab IR, Yuen CK, Buyukmihci NC, Blankenship TN, Fitzgerald PG. Evolution of the tapetum. Trans Am Ophthalmol Soc. 2002; 100:187-99; discussion 199-200. PMID: 12545693.
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    49. Hess JF, Casselman JT, FitzGerald P. Modified version of pACT-2 that simplifies cloning with NdeI. Biotechniques. 2001 Jun; 30(6):1204, 1207. PMID: 11414205.
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    50. Blankenship TN, Hess JF, FitzGerald PG. Development- and differentiation-dependent reorganization of intermediate filaments in fiber cells. Invest Ophthalmol Vis Sci. 2001 Mar; 42(3):735-42. PMID: 11222535.
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    51. Schwab IR, Ho V, Roth A, Blankenship TN, Fitzgerald PG. Evolutionary attempts at 4 eyes in vertebrates. Trans Am Ophthalmol Soc. 2001; 99:145-56; discussion 156-7. PMID: 11797302.
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    52. Yoshikawa M, Anderson K, Sakaguchi H, Flannery JG, Fitzgerald PG, Ishida AT. Voltage-gated Na+ channel EOIII-segment-like immunoreactivity in fish retinal ganglion cells. Vis Neurosci. 2000 Jul-Aug; 17(4):647-55. PMID: 11016582.
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    53. Conley YP, Erturk D, Keverline A, Mah TS, Keravala A, Barnes LR, Bruchis A, Hess JF, FitzGerald PG, Weeks DE, Ferrell RE, Gorin MB. A juvenile-onset, progressive cataract locus on chromosome 3q21-q22 is associated with a missense mutation in the beaded filament structural protein-2. Am J Hum Genet. 2000 Apr; 66(4):1426-31. PMID: 10729115.
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    54. Jakobs PM, Hess JF, FitzGerald PG, Kramer P, Weleber RG, Litt M. Autosomal-dominant congenital cataract associated with a deletion mutation in the human beaded filament protein gene BFSP2. Am J Hum Genet. 2000 Apr; 66(4):1432-6. PMID: 10739768.
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    55. Hess JF, FitzGerald PG. Protection of a restriction enzyme from heat inactivation by [alpha]-crystallin. Mol Vis. 1998 Dec 15; 4:29. PMID: 9873067.
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    56. Hess JF, Casselman JT, Kong AP, FitzGerald PG. Primary sequence, secondary structure, gene structure, and assembly properties suggests that the lens-specific cytoskeletal protein filensin represents a novel class of intermediate filament protein. Exp Eye Res. 1998 May; 66(5):625-44. PMID: 9628810.
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    57. Hess JF, FitzGerald P. Lack of DNase I mRNA sequences in murine lenses. Mol Vis. 1996 Jun 26; 2:8. PMID: 9238085.
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    58. Hess JF, Casselman JT, FitzGerald PG. Gene structure and cDNA sequence identify the beaded filament protein CP49 as a highly divergent type I intermediate filament protein. J Biol Chem. 1996 Mar 22; 271(12):6729-35. PMID: 8636093.
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    59. Sandilands A, Prescott AR, Hutcheson AM, Quinlan RA, Casselman JT, FitzGerald PG. Filensin is proteolytically processed during lens fiber cell differentiation by multiple independent pathways. Eur J Cell Biol. 1995 Jul; 67(3):238-53. PMID: 7588880.
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    60. Sandilands A, Prescott AR, Carter JM, Hutcheson AM, Quinlan RA, Richards J, FitzGerald PG. Vimentin and CP49/filensin form distinct networks in the lens which are independently modulated during lens fibre cell differentiation. J Cell Sci. 1995 Apr; 108 ( Pt 4):1397-406. PMID: 7615661.
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    61. Hess JF, Casselman JT, FitzGerald PG. Chromosomal locations of the genes for the beaded filament proteins CP 115 and CP 47. Curr Eye Res. 1995 Jan; 14(1):11-8. PMID: 7720401.
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    62. Hess JF, Casselman JT, FitzGerald PG. Nucleotide sequence of the bovine vimentin-encoding cDNA. Gene. 1994 Mar 25; 140(2):257-9. PMID: 8144034.
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    63. Grimes PA, Favor J, Koeberlein B, Silvers WK, Fitzgerald PG, Stambolian D. Lens development in a dominant X-linked congenital cataract of the mouse. Exp Eye Res. 1993 Nov; 57(5):587-94. PMID: 8282045.
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    64. Gounari F, Merdes A, Quinlan R, Hess J, FitzGerald PG, Ouzounis CA, Georgatos SD. Bovine filensin possesses primary and secondary structure similarity to intermediate filament proteins. J Cell Biol. 1993 May; 121(4):847-53. PMID: 8491777.
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    65. Hess JF, Casselman JT, FitzGerald PG. cDNA analysis of the 49 kDa lens fiber cell cytoskeletal protein: a new, lens-specific member of the intermediate filament family? Curr Eye Res. 1993 Jan; 12(1):77-88. PMID: 7679620.
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    66. FitzGerald PG, Graham D. Ultrastructural localization of alpha A-crystallin to the bovine lens fiber cell cytoskeleton. Curr Eye Res. 1991 May; 10(5):417-36. PMID: 1889228.
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    67. FitzGerald PG, Casselman J. Immunologic conservation of the fiber cell beaded filament. Curr Eye Res. 1991 May; 10(5):471-8. PMID: 1889232.
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    68. FitzGerald PG. Methods for the circumvention of problems associated with the study of the ocular lens plasma membrane-cytoskeleton complex. Curr Eye Res. 1990 Nov; 9(11):1083-97. PMID: 2095320.
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    69. FitzGerald PG, Casselman J. Discrimination between the lens fiber cell 115 kd cytoskeletal protein and alpha-actinin. Curr Eye Res. 1990 Sep; 9(9):873-82. PMID: 1700943.
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    70. Thirkill CE, FitzGerald P, Sergott RC, Roth AM, Tyler NK, Keltner JL. Cancer-associated retinopathy (CAR syndrome) with antibodies reacting with retinal, optic-nerve, and cancer cells. N Engl J Med. 1989 Dec 07; 321(23):1589-94. PMID: 2555714.
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    71. FitzGerald PG, Gottlieb W. The Mr 115 kd fiber cell-specific protein is a component of the lens cytoskeleton. Curr Eye Res. 1989 Aug; 8(8):801-11. PMID: 2791627.
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    72. FitzGerald PG. Age-related changes in a fiber cell-specific extrinsic membrane protein. Curr Eye Res. 1988 Dec; 7(12):1255-62. PMID: 3229136.
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    73. FitzGerald PG. Immunochemical characterization of a Mr 115 lens fiber cell-specific extrinsic membrane protein. Curr Eye Res. 1988 Dec; 7(12):1243-53. PMID: 3229135.
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    74. FitzGerald PG. Main intrinsic polypeptide proteolysis and fiber cell membrane domains. Invest Ophthalmol Vis Sci. 1987 May; 28(5):795-805. PMID: 3553058.
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    75. FitzGerald PG, Goodenough DA. Rat lens cultures: MIP expression and domains of intercellular coupling. Invest Ophthalmol Vis Sci. 1986 May; 27(5):755-71. PMID: 3700025.
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    76. FitzGerald PG, Bok D, Horwitz J. The distribution of the main intrinsic membrane polypeptide in ocular lens. Curr Eye Res. 1985 Nov; 4(11):1203-18. PMID: 3907985.
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    77. Fitzgerald PG, Bok D, Horwitz J. Immunocytochemical localization of the main intrinsic polypeptide (MIP) in ultrathin frozen sections of rat lens. J Cell Biol. 1983 Nov; 97(5 Pt 1):1491-9. PMID: 6355119.
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