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Wolf-Dietrich Heyer

TitleProf/Chair
InstitutionUniversity of California Davis
DepartmentMicrobiology
Address3163 Life Sciences
CA 95616
Phone530-752-3001
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Piazza A, Heyer WD. Multi-Invasion-Induced Rearrangements as a Pathway for Physiological and Pathological Recombination. Bioessays. 2018 May; 40(5):e1700249. PMID: 29578583.
      View in: PubMed
    2. Piazza A, Wright WD, Heyer WD. Multi-invasions Are Recombination Byproducts that Induce Chromosomal Rearrangements. Cell. 2017 Aug 10; 170(4):760-773.e15. PMID: 28781165.
      View in: PubMed
    3. Liu J, Ede C, Wright WD, Gore SK, Jenkins SS, Freudenthal BD, Todd Washington M, Veaute X, Heyer WD. Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase d-extending D-loops. Elife. 2017 05 23; 6. PMID: 28535142.
      View in: PubMed
    4. Muñoz-Galván S, Tous C, Blanco MG, Schwartz EK, Ehmsen KT, West SC, Heyer WD, Aguilera A. Correction for Muñoz-Galván et al., "Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange". Mol Cell Biol. 2017 Jun 01; 37(11). PMID: 28512214.
      View in: PubMed
    5. McVey M, Khodaverdian VY, Meyer D, Cerqueira PG, Heyer WD. Eukaryotic DNA Polymerases in Homologous Recombination. Annu Rev Genet. 2016 Nov 23; 50:393-421. PMID: 27893960.
      View in: PubMed
    6. Ganai RA, Zhang XP, Heyer WD, Johansson E. Strand displacement synthesis by yeast DNA polymerase e. Nucleic Acids Res. 2016 09 30; 44(17):8229-40. PMID: 27325747.
      View in: PubMed
    7. Spies J, Waizenegger A, Barton O, Sürder M, Wright WD, Heyer WD, Löbrich M. Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability. Mol Cell. 2016 06 16; 62(6):903-917. PMID: 27264870.
      View in: PubMed
    8. Janke R, Kong J, Braberg H, Cantin G, Yates JR, Krogan NJ, Heyer WD. Nonsense-mediated decay regulates key components of homologous recombination. Nucleic Acids Res. 2016 06 20; 44(11):5218-30. PMID: 27001511.
      View in: PubMed
    9. Crawley JN, Heyer WD, LaSalle JM. Autism and Cancer Share Risk Genes, Pathways, and Drug Targets. Trends Genet. 2016 Mar; 32(3):139-146. PMID: 26830258; PMCID: PMC4769654 [Available on 03/01/17].
    10. Meyer D, Fu BX, Heyer WD. DNA polymerases d and ? cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):E6907-16. PMID: 26607450; PMCID: PMC4687552.
    11. Heyer WD. Regulation of recombination and genomic maintenance. Cold Spring Harb Perspect Biol. 2015 Aug 03; 7(8):a016501. PMID: 26238353.
      View in: PubMed
    12. Mason JM, Dusad K, Wright WD, Grubb J, Budke B, Heyer WD, Connell PP, Weichselbaum RR, Bishop DK. RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells. Nucleic Acids Res. 2015 Mar 31; 43(6):3180-96. PMID: 25765654; PMCID: PMC4381078.
    13. Fasching CL, Cejka P, Kowalczykowski SC, Heyer WD. Top3-Rmi1 dissolve Rad51-mediated D loops by a topoisomerase-based mechanism. Mol Cell. 2015 Feb 19; 57(4):595-606. PMID: 25699708.
      View in: PubMed
    14. Mukherjee S, Wright WD, Ehmsen KT, Heyer WD. The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage. Nucleic Acids Res. 2014 Jun; 42(10):6511-22. PMID: 24744239; PMCID: PMC4041439.
    15. Wright WD, Heyer WD. Rad54 functions as a heteroduplex DNA pump modulated by its DNA substrates and Rad51 during D loop formation. Mol Cell. 2014 Feb 06; 53(3):420-32. PMID: 24486020; PMCID: PMC4059524.
    16. Zhang XP, Janke R, Kingsley J, Luo J, Fasching C, Ehmsen KT, Heyer WD. A conserved sequence extending motif III of the motor domain in the Snf2-family DNA translocase Rad54 is critical for ATPase activity. PLoS One. 2013; 8(12):e82184. PMID: 24358152; PMCID: PMC3864901.
    17. Zinovyev A, Kuperstein I, Barillot E, Heyer WD. Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps. PLoS Comput Biol. 2013 Apr; 9(4):e1003016. PMID: 23592964; PMCID: PMC3617211.
    18. Sneeden JL, Grossi SM, Tappin I, Hurwitz J, Heyer WD. Reconstitution of recombination-associated DNA synthesis with human proteins. Nucleic Acids Res. 2013 May; 41(9):4913-25. PMID: 23535143; PMCID: PMC3643601.
    19. Schwartz EK, Wright WD, Ehmsen KT, Evans JE, Stahlberg H, Heyer WD. Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair. Mol Cell Biol. 2012 Aug; 32(15):3065-80. PMID: 22645308; PMCID: PMC3434506.
    20. Muñoz-Galván S, Tous C, Blanco MG, Schwartz EK, Ehmsen KT, West SC, Heyer WD, Aguilera A. Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange. Mol Cell Biol. 2012 May; 32(9):1592-603. PMID: 22354996; PMCID: PMC3347241.
    21. Liu J, Renault L, Veaute X, Fabre F, Stahlberg H, Heyer WD. Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formation. Nature. 2011 Oct 23; 479(7372):245-8. PMID: 22020281; PMCID: PMC3213327.
    22. Ceballos SJ, Heyer WD. Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination. Biochim Biophys Acta. 2011 Sep; 1809(9):509-23. PMID: 21704205; PMCID: PMC3171615.
    23. Liu J, Ehmsen KT, Heyer WD, Morrical SW. Presynaptic filament dynamics in homologous recombination and DNA repair. Crit Rev Biochem Mol Biol. 2011 Jun; 46(3):240-70. PMID: 21599536; PMCID: PMC4083101.
    24. Schwartz EK, Heyer WD. Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes. Chromosoma. 2011 Apr; 120(2):109-27. PMID: 21369956; PMCID: PMC3057012.
    25. Wright WD, Ehmsen KT, Heyer WD. Assays for structure-selective DNA endonucleases. Methods Mol Biol. 2011; 745:345-62. PMID: 21660704; PMCID: PMC4096161.
    26. Liu J, Sneeden J, Heyer WD. In vitro assays for DNA pairing and recombination-associated DNA synthesis. Methods Mol Biol. 2011; 745:363-83. PMID: 21660705; PMCID: PMC4095852.
    27. Zhang XP, Heyer WD. Quality control of purified proteins involved in homologous recombination. Methods Mol Biol. 2011; 745:329-43. PMID: 21660703; PMCID: PMC4064682.
    28. Liu J, Heyer WD. Who's who in human recombination: BRCA2 and RAD52. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):441-2. PMID: 21189297; PMCID: PMC3021045.
    29. Liu J, Doty T, Gibson B, Heyer WD. Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nat Struct Mol Biol. 2010 Oct; 17(10):1260-2. PMID: 20729859; PMCID: PMC2952495.
    30. Janke R, Herzberg K, Rolfsmeier M, Mar J, Bashkirov VI, Haghnazari E, Cantin G, Yates JR, Heyer WD. A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae. Nucleic Acids Res. 2010 Apr; 38(7):2302-13. PMID: 20061370; PMCID: PMC2853130.
    31. Heyer WD, Ehmsen KT, Liu J. Regulation of homologous recombination in eukaryotes. Annu Rev Genet. 2010; 44:113-39. PMID: 20690856; PMCID: PMC4114321.
    32. Li X, Stith CM, Burgers PM, Heyer WD. PCNA is required for initiation of recombination-associated DNA synthesis by DNA polymerase delta. Mol Cell. 2009 Nov 25; 36(4):704-13. PMID: 19941829; PMCID: PMC2784891.
    33. Ehmsen KT, Heyer WD. A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4. Nucleic Acids Res. 2009 Apr; 37(6):2026-36. PMID: 19211663; PMCID: PMC2665226.
    34. Li X, Heyer WD. RAD54 controls access to the invading 3'-OH end after RAD51-mediated DNA strand invasion in homologous recombination in Saccharomyces cerevisiae. Nucleic Acids Res. 2009 Feb; 37(2):638-46. PMID: 19074197; PMCID: PMC2632917.
    35. Zhang XP, Galkin VE, Yu X, Egelman EH, Heyer WD. Loop 2 in Saccharomyces cerevisiae Rad51 protein regulates filament formation and ATPase activity. Nucleic Acids Res. 2009 Jan; 37(1):158-71. PMID: 19033358; PMCID: PMC2615628.
    36. Ehmsen KT, Heyer WD. Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates. Genome Dyn Stab. 2008 Apr 05; 3:91. PMID: 20098639.
      View in: PubMed
    37. Ehmsen KT, Heyer WD. Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease. Nucleic Acids Res. 2008 Apr; 36(7):2182-95. PMID: 18281703; PMCID: PMC2367710.
    38. Li X, Heyer WD. Homologous recombination in DNA repair and DNA damage tolerance. Cell Res. 2008 Jan; 18(1):99-113. PMID: 18166982; PMCID: PMC3087377.
    39. Li X, Zhang XP, Solinger JA, Kiianitsa K, Yu X, Egelman EH, Heyer WD. Rad51 and Rad54 ATPase activities are both required to modulate Rad51-dsDNA filament dynamics. Nucleic Acids Res. 2007; 35(12):4124-40. PMID: 17567608; PMCID: PMC1919488.
    40. Heyer WD. Biochemistry of eukaryotic homologous recombination. Top Curr Genet. 2007 Mar 01; 17:95-133. PMID: 21552479.
      View in: PubMed
    41. Mimida N, Kitamoto H, Osakabe K, Nakashima M, Ito Y, Heyer WD, Toki S, Ichikawa H. Two alternatively spliced transcripts generated from OsMUS81, a rice homolog of yeast MUS81, are up-regulated by DNA-damaging treatments. Plant Cell Physiol. 2007 Apr; 48(4):648-54. PMID: 17327258.
      View in: PubMed
    42. Symington LS, Heyer WD. Some disassembly required: role of DNA translocases in the disruption of recombination intermediates and dead-end complexes. Genes Dev. 2006 Sep 15; 20(18):2479-86. PMID: 16980577.
      View in: PubMed
    43. Herzberg K, Bashkirov VI, Rolfsmeier M, Haghnazari E, McDonald WH, Anderson S, Bashkirova EV, Yates JR, Heyer WD. Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forks. Mol Cell Biol. 2006 Nov; 26(22):8396-409. PMID: 16966380; PMCID: PMC1636779.
    44. Heyer WD, Li X, Rolfsmeier M, Zhang XP. Rad54: the Swiss Army knife of homologous recombination? Nucleic Acids Res. 2006; 34(15):4115-25. PMID: 16935872; PMCID: PMC1616967.
    45. Kiianitsa K, Solinger JA, Heyer WD. Terminal association of Rad54 protein with the Rad51-dsDNA filament. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):9767-72. PMID: 16785421; PMCID: PMC1502528.
    46. Galkin VE, Wu Y, Zhang XP, Qian X, He Y, Yu X, Heyer WD, Luo Y, Egelman EH. The Rad51/RadA N-terminal domain activates nucleoprotein filament ATPase activity. Structure. 2006 Jun; 14(6):983-92. PMID: 16765891.
      View in: PubMed
    47. Chin JK, Bashkirov VI, Heyer WD, Romesberg FE. Esc4/Rtt107 and the control of recombination during replication. DNA Repair (Amst). 2006 May 10; 5(5):618-28. PMID: 16569515; PMCID: PMC2881479.
    48. Bashkirov VI, Herzberg K, Haghnazari E, Vlasenko AS, Heyer WD. DNA damage-induced phosphorylation of Rad55 protein as a sentinel for DNA damage checkpoint activation in S. cerevisiae. Methods Enzymol. 2006; 409:166-82. PMID: 16793401.
      View in: PubMed
    49. Zhang XP, Lee KI, Solinger JA, Kiianitsa K, Heyer WD. Gly-103 in the N-terminal domain of Saccharomyces cerevisiae Rad51 protein is critical for DNA binding. J Biol Chem. 2005 Jul 15; 280(28):26303-11. PMID: 15908697.
      View in: PubMed
    50. Heyer WD. Damage signaling: RecQ sends an SOS to you. Curr Biol. 2004 Oct 26; 14(20):R895-7. PMID: 15498482.
      View in: PubMed
    51. Heyer WD, Kanaar R. Recombination mechanisms; fortieth anniversary meeting of the Holliday model. Mol Cell. 2004 Oct 08; 16(1):1-9. PMID: 15469817.
      View in: PubMed
    52. Haghnazari E, Heyer WD. The DNA damage checkpoint pathways exert multiple controls on the efficiency and outcome of the repair of a double-stranded DNA gap. Nucleic Acids Res. 2004; 32(14):4257-68. PMID: 15304563; PMCID: PMC514360.
    53. Haghnazari E, Heyer WD. The Hog1 MAP kinase pathway and the Mec1 DNA damage checkpoint pathway independently control the cellular responses to hydrogen peroxide. DNA Repair (Amst). 2004 Jul 02; 3(7):769-76. PMID: 15177185.
      View in: PubMed
    54. Heyer WD. A new deal for Holliday junctions. Nat Struct Mol Biol. 2004 Feb; 11(2):117-9. PMID: 14749772.
      View in: PubMed
    55. Heyer WD. Recombination: Holliday junction resolution and crossover formation. Curr Biol. 2004 Jan 20; 14(2):R56-8. PMID: 14738748.
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    56. Kiianitsa K, Solinger JA, Heyer WD. NADH-coupled microplate photometric assay for kinetic studies of ATP-hydrolyzing enzymes with low and high specific activities. Anal Biochem. 2003 Oct 15; 321(2):266-71. PMID: 14511695.
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    57. Heyer WD, Ehmsen KT, Solinger JA. Holliday junctions in the eukaryotic nucleus: resolution in sight? Trends Biochem Sci. 2003 Oct; 28(10):548-57. PMID: 14559184.
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    58. Mallory JC, Bashkirov VI, Trujillo KM, Solinger JA, Dominska M, Sung P, Heyer WD, Petes TD. Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. DNA Repair (Amst). 2003 Sep 18; 2(9):1041-64. PMID: 12967660.
      View in: PubMed
    59. Bashkirov VI, Bashkirova EV, Haghnazari E, Heyer WD. Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase. Mol Cell Biol. 2003 Feb; 23(4):1441-52. PMID: 12556502; PMCID: PMC141154.
    60. Schmuckli-Maurer J, Rolfsmeier M, Nguyen H, Heyer WD. Genome instability in rad54 mutants of Saccharomyces cerevisiae. Nucleic Acids Res. 2003 Feb 01; 31(3):1013-23. PMID: 12560498; PMCID: PMC149210.
    61. Fabre F, Chan A, Heyer WD, Gangloff S. Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16887-92. PMID: 12475932; PMCID: PMC139239.
    62. Solinger JA, Kiianitsa K, Heyer WD. Rad54, a Swi2/Snf2-like recombinational repair protein, disassembles Rad51:dsDNA filaments. Mol Cell. 2002 Nov; 10(5):1175-88. PMID: 12453424.
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    63. Kiianitsa K, Solinger JA, Heyer WD. Rad54 protein exerts diverse modes of ATPase activity on duplex DNA partially and fully covered with Rad51 protein. J Biol Chem. 2002 Nov 29; 277(48):46205-15. PMID: 12359723.
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    64. Kim PM, Paffett KS, Solinger JA, Heyer WD, Nickoloff JA. Spontaneous and double-strand break-induced recombination, and gene conversion tract lengths, are differentially affected by overexpression of wild-type or ATPase-defective yeast Rad54. Nucleic Acids Res. 2002 Jul 01; 30(13):2727-35. PMID: 12087154; PMCID: PMC117068.
    65. Walsh L, Schmuckli-Maurer J, Billinton N, Barker MG, Heyer WD, Walmsley RM. DNA-damage induction of RAD54 can be regulated independently of the RAD9- and DDC1-dependent checkpoints that regulate RNR2. Curr Genet. 2002 Jul; 41(4):232-40. PMID: 12172964.
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