Roger Sciammas

Title(s)Associate Professor, VM: Anatomy Physiology & Cell Biology
SchoolSchool of Veterinary Medicine
AddressCCM; County Rd. 98 Hutchison Dr
CA 95616
Phone530-754-4419
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    Other Positions
    Title(s)Associate Professor, VM: Anatomy Physiology & Cell Biology


    Collapse Research 
    Collapse Research Activities and Funding
    Heterogeneity of plasma cell states is regulated by the dynamics of IRF4 expression
    NIH R21AI151610Feb 1, 2020 - Jan 31, 2022
    Role: Principal Investigator
    Role of the SET-like domain of Blimp-1 in plasma cell function and Immunoglobulin secretion
    NIH R21AI139793May 23, 2018 - Apr 30, 2021
    Role: Principal Investigator
    Role of IRF4 in T helper cell fate decisions
    NIH R01AI113145Dec 1, 2014 - Nov 30, 2020
    Role: Principal Investigator
    Deconstructing the allo-specific memory B cell response
    NIH R01AI110513Aug 1, 2014 - Jul 31, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts. Cell Rep. 2025 Feb 08; 44(2):115283. Sievert EP, Franke MC, Thomas KB, Yoon Y, Shi Y, Sciammas R. PMID: 39923238.
      View in: PubMed   Mentions:    Fields:    
    2. Isolation and Analysis of B-cell Progenitors from Bone Marrow by Flow Cytometry. Bio Protoc. 2023 Oct 05; 13(19):e4835. Zhao H, Sciammas R, Barlow JH. PMID: 37817907; PMCID: PMC10560687.
      View in: PubMed   Mentions:
    3. Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18. J Immunol. 2023 07 15; 211(2):180-185. Depew CE, Nguyen AT, Franke MC, Calderon J, Sciammas R, McSorley SJ. PMID: 37283516; PMCID: PMC10330511.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination. Elife. 2022 12 21; 11. Zhao H, Hartono SR, de Vera KMF, Yu Z, Satchi K, Zhao T, Sciammas R, Sanz L, Chédin F, Barlow J. PMID: 36542058; PMCID: PMC9771370.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    5. B Cell-Intrinsic IRF4 Haploinsufficiency Impairs Affinity Maturation. J Immunol. 2021 12 15; 207(12):2992-3003. Cook SL, Sievert EP, Sciammas R. PMID: 34759017; PMCID: PMC9085970.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. Protocol for in vitro BCR-mediated plasma cell differentiation and purification of chromatin-associated proteins. STAR Protoc. 2021 09 17; 2(3):100633. Ochiai K, Shima H, Ikura T, Franke MC, Sievert EP, Sciammas R, Igarashi K. PMID: 34258594; PMCID: PMC8255920.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4. Cell Rep. 2020 12 22; 33(12):108517. Ochiai K, Yamaoka M, Swaminathan A, Shima H, Hiura H, Matsumoto M, Kurotaki D, Nakabayashi J, Funayama R, Nakayama K, Arima T, Ikawa T, Tamura T, Sciammas R, Bouvet P, Kundu TK, Igarashi K. PMID: 33357426.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    8. Development of canine PD-1/PD-L1 specific monoclonal antibodies and amplification of canine T cell function. PLoS One. 2020; 15(7):e0235518. Choi JW, Withers SS, Chang H, Spanier JA, De La Trinidad VL, Panesar H, Fife BT, Sciammas R, Sparger EE, Moore PF, Kent MS, Rebhun RB, McSorley SJ. PMID: 32614928; PMCID: PMC7332054.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    9. Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells. J Clin Invest. 2020 07 01; 130(7):3453-3466. Khiew SH, Jain D, Chen J, Yang J, Yin D, Young JS, Dent A, Sciammas R, Alegre ML, Chong AS. PMID: 32452834; PMCID: PMC7329196.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    10. A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response. Trends Immunol. 2020 07; 41(7):614-628. Cook SL, Franke MC, Sievert EP, Sciammas R. PMID: 32467029; PMCID: PMC8722497.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    11. Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses. Elife. 2020 02 04; 9. Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, Sciammas R, Webster NJ, Raz E. PMID: 32014112; PMCID: PMC7000221.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    12. Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction. Immunity. 2017 12 19; 47(6):1114-1128.e6. Wu J, Zhang H, Shi X, Xiao X, Fan Y, Minze LJ, Wang J, Ghobrial RM, Xia J, Sciammas R, Li XC, Chen W. PMID: 29221730; PMCID: PMC5759774.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    13. Igβ ubiquitination activates PI3K signals required for endosomal sorting. J Exp Med. 2017 Dec 04; 214(12):3775-3790. Veselits M, Tanaka A, Chen Y, Hamel K, Mandal M, Kandasamy M, Manicassamy B, O'Neill SK, Wilson P, Sciammas R, Clark MR. PMID: 29141870; PMCID: PMC5716028.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    14. Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice. Front Immunol. 2017; 8:1169. Young JS, Khiew SH, Yang J, Vannier A, Yin D, Sciammas R, Alegre ML, Chong AS. PMID: 28970838; PMCID: PMC5609110.
      View in: PubMed   Mentions: 8     Fields:    
    15. The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate. Immunity. 2017 09 19; 47(3):481-497.e7. Krishnamoorthy V, Kannanganat S, Maienschein-Cline M, Cook SL, Chen J, Bahroos N, Sievert E, Corse E, Chong A, Sciammas R. PMID: 28930660; PMCID: PMC5661949.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    16. CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients. JCI Insight. 2017 May 04; 2(9). Khiew SH, Yang J, Young JS, Chen J, Wang Q, Yin D, Vu V, Miller ML, Sciammas R, Alegre ML, Chong AS. PMID: 28469082; PMCID: PMC5414557.
      View in: PubMed   Mentions: 6     Fields:    
    17. Tracing Donor-MHC Class II Reactive B cells in Mouse Cardiac Transplantation: Delayed CTLA4-Ig Treatment Prevents Memory Alloreactive B-Cell Generation. Transplantation. 2016 08; 100(8):1683-91. Yang J, Chen J, Young JS, Wang Q, Yin D, Sciammas R, Chong AS. PMID: 27362308; PMCID: PMC4961602.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    18. Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection. Am J Transplant. 2016 08; 16(8):2312-23. Young JS, Chen J, Miller ML, Vu V, Tian C, Moon JJ, Alegre ML, Sciammas R, Chong AS. PMID: 26928966; PMCID: PMC4956497.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    19. Cutting Edge: CTLA-4Ig Inhibits Memory B Cell Responses and Promotes Allograft Survival in Sensitized Recipients. J Immunol. 2015 Nov 01; 195(9):4069-73. Chen J, Wang Q, Yin D, Vu V, Sciammas R, Chong AS. PMID: 26416270; PMCID: PMC4610858.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    20. Memory B cells in transplantation. Transplantation. 2015 Jan; 99(1):21-8. Chong AS, Sciammas R. PMID: 25525921; PMCID: PMC4273865.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    21. Impact of immunosuppression on recall immune responses to influenza vaccination in stable renal transplant recipients. Transplantation. 2014 Apr 27; 97(8):846-53. Cowan M, Chon WJ, Desai A, Andrews S, Bai Y, Veguilla V, Katz JM, Josephson MA, Wilson PC, Sciammas R, Chong AS. PMID: 24366008; PMCID: PMC4843769.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    22. Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes. PLoS One. 2014; 9(3):e89792. Veselits M, Tanaka A, Lipkowitz S, O'Neill S, Sciammas R, Finnegan A, Zhang J, Clark MR. PMID: 24651487; PMCID: PMC3961229.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    23. The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation. Biomaterials. 2013 Nov; 34(34):8776-85. Chen J, Pompano RR, Santiago FW, Maillat L, Sciammas R, Sun T, Han H, Topham DJ, Chong AS, Collier JH. PMID: 23953841; PMCID: PMC3814015.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    24. Reversing endogenous alloreactive B cell GC responses with anti-CD154 or CTLA-4Ig. Am J Transplant. 2013 Sep; 13(9):2280-92. Chen J, Yin H, Xu J, Wang Q, Edelblum KL, Sciammas R, Chong AS. PMID: 23855587; PMCID: PMC3797532.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    25. B cells assist allograft rejection in the deficiency of protein kinase c-theta. Transpl Int. 2013 Sep; 26(9):919-27. Yan W, Xu R, Ma LL, Han W, Geevarghese SK, Williams PE, Sciammas R, Chong AS, Yin DP. PMID: 23841454.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    26. Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4. Immunity. 2013 May 23; 38(5):918-29. Ochiai K, Maienschein-Cline M, Simonetti G, Chen J, Rosenthal R, Brink R, Chong AS, Klein U, Dinner AR, Singh H, Sciammas R. PMID: 23684984; PMCID: PMC3690549.
      View in: PubMed   Mentions: 218     Fields:    Translation:AnimalsCells
    27. Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation. Nat Commun. 2013; 4:2990. Williams JW, Tjota MY, Clay BS, Vander Lugt B, Bandukwala HS, Hrusch CL, Decker DC, Blaine KM, Fixsen BR, Singh H, Sciammas R, Sperling AI. PMID: 24356538; PMCID: PMC4003872.
      View in: PubMed   Mentions: 203     Fields:    Translation:AnimalsCells
    28. Plasma cell densities and glomerular filtration rates predict renal allograft outcomes following acute rejection. Transpl Int. 2012 Oct; 25(10):1050-8. Chang A, Moore JM, Cowan ML, Josephson MA, Chon WJ, Sciammas R, Du Z, Marino SR, Meehan SM, Millis M, David MZ, Williams JW, Chong AS. PMID: 22805456; PMCID: PMC3439557.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    29. A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nat Immunol. 2012 Jan 22; 13(3):300-7. Ochiai K, Maienschein-Cline M, Mandal M, Triggs JR, Bertolino E, Sciammas R, Dinner AR, Clark MR, Singh H. PMID: 22267219; PMCID: PMC4028049.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    30. IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors. Blood. 2012 Mar 01; 119(9):2003-12. Becker AM, Michael DG, Satpathy AT, Sciammas R, Singh H, Bhattacharya D. PMID: 22238324; PMCID: PMC3311244.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    31. Discovering transcription factor regulatory targets using gene expression and binding data. Bioinformatics. 2012 Jan 15; 28(2):206-13. Maienschein-Cline M, Zhou J, White KP, Sciammas R, Dinner AR. PMID: 22084256; PMCID: PMC3259433.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    32. Matchmaking the B-cell signature of tolerance to regulatory B cells. Am J Transplant. 2011 Dec; 11(12):2555-60. Chong AS, Sciammas R. PMID: 21967001; PMCID: PMC3846176.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    33. Experimental models of B cell tolerance in transplantation. Semin Immunol. 2012 Apr; 24(2):77-85. Cowan ML, Sciammas R, Chong AS. PMID: 21925896; PMCID: PMC3246558.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    34. An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling. Mol Syst Biol. 2011 May 24; 7:495. Sciammas R, Li Y, Warmflash A, Song Y, Dinner AR, Singh H. PMID: 21613984; PMCID: PMC3130558.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    35. The B Cell Response to Transplantation Antigens. . 2010 Apr 16; 38-53. Sciammas SR, Chong CA, Colvin CR. .
      View in: Publisher Site   Mentions:
    36. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 2006 Aug 25; 126(4):755-66. Laslo P, Spooner CJ, Warmflash A, Lancki DW, Lee HJ, Sciammas R, Gantner BN, Dinner AR, Singh H. PMID: 16923394.
      View in: PubMed   Mentions: 304     Fields:    Translation:AnimalsCells
    37. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity. 2006 Aug; 25(2):225-36. Sciammas R, Shaffer AL, Schatz JH, Zhao H, Staudt LM, Singh H. PMID: 16919487.
      View in: PubMed   Mentions: 283     Fields:    Translation:AnimalsCells
    38. Shedding B cell identity. Immunity. 2006 Mar; 24(3):239-40. Singh H, Sciammas R. PMID: 16546090.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    39. The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. Development. 2005 Mar; 132(6):1315-25. Vincent SD, Dunn NR, Sciammas R, Shapiro-Shalef M, Davis MM, Calame K, Bikoff EK, Robertson EJ. PMID: 15750184.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    40. Blimp-1; immunoglobulin secretion and the switch to plasma cells. Curr Top Microbiol Immunol. 2005; 290:201-24. Sciammas R, Davis MM. PMID: 16480044.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    41. Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol. 2004 May 01; 172(9):5427-40. Sciammas R, Davis MM. PMID: 15100284.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    42. TCRgammadelta cells and viruses. Microbes Infect. 1999 Mar; 1(3):203-12. Sciammas R, Bluestone JA. PMID: 10801231.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    43. HSV-1 glycoprotein I-reactive TCR gamma delta cells directly recognize the peptide backbone in a conformationally dependent manner. J Immunol. 1998 Nov 15; 161(10):5187-92. Sciammas R, Bluestone JA. PMID: 9820489.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    44. T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J Exp Med. 1997 Jun 02; 185(11):1969-75. Sciammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA. PMID: 9166426; PMCID: PMC2196341.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    45. TCR gamma delta cells: a specialized T-cell subset in the immune system. Annu Rev Cell Dev Biol. 1995; 11:307-53. Bluestone JA, Khattri R, Sciammas R, Sperling AI. PMID: 8689560.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    46. Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell. J Immunol. 1994 Jun 01; 152(11):5392-7. Sciammas R, Johnson RM, Sperling AI, Brady W, Linsley PS, Spear PG, Fitch FW, Bluestone JA. PMID: 8189058.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    47. TCR gamma delta cells: mysterious cells of the immune system. Immunol Res. 1994; 13(4):268-79. Sciammas R, Tatsumi Y, Sperling AI, Arunan K, Bluestone JA. PMID: 7616054.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
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