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Jay V. Solnick

TitlePROF-HCOMP
InstitutionUniversity of California Davis
DepartmentMED INT MED-INFECTIOUS DISEASE
AddressPSSB/UCDMC
CA 95817
Phone916-734-3815
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    Collapse Research 
    Collapse Research Activities and Funding
    Functional Plasticity in the Helicobacter pylori Type IV Secretion System
    NIH/NIAID R01AI108713Jul 7, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Role of Helicobacter Pylori in the Pathogenesis of Childhood Asthma
    NIH/NIAID R56AI091893Aug 16, 2012 - Jul 31, 2014
    Role: Co-Principal Investigator
    Defensin gene copy number and mucosal innate immunity
    NIH/NIAID RC1AI086597Jun 14, 2010 - May 31, 2012
    Role: Co-Principal Investigator
    Serum biomarkers for early detection of H. pylori-associated gastric cancer
    NIH/NCI R01CA136647Jul 21, 2009 - May 31, 2014
    Role: Principal Investigator
    Role of H. pylori Outer Membrane Proteins in Colonization and Host Response
    NIH/NIAID R01AI081037Jul 15, 2009 - Jun 30, 2014
    Role: Principal Investigator
    Helicobacter pylori and the gastric microbial community in rhesus macaques
    NIH/NIAID R21AI080788May 15, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    NIH/NIAID R01AI070803Aug 1, 2008 - Jul 31, 2013
    Role: Principal Investigator
    Prophylactic and Therapeutic Immunization against H. pylori in Rhesus Macaques
    NIH/NIAID R21AI072134Aug 1, 2007 - Jul 31, 2010
    Role: Principal Investigator
    Gene Expression during H. pylori-host interactions
    NIH/FIC R03TW007460Jan 1, 2006 - Dec 31, 2008
    Role: Principal Investigator
    Animal Models of Infectious Diseases Training Program
    NIH/NIAID T32AI060555Sep 1, 2004 - May 31, 2021
    Role: Principal Investigator
    Transmission of H. pylori infection in the rhesus monkey
    NIH/NCRR R01RR014298Sep 12, 2001 - Aug 31, 2007
    Role: Principal Investigator
    Transcription of H. pylori Genes in the Rhesus Monkey
    NIH/NCRR R21RR015293May 20, 2001 - May 31, 2004
    Role: Principal Investigator
    Gene expression during H. pylori-host interactions
    NIH/NIAID R01AI042081Dec 1, 1997 - Dec 31, 2008
    Role: Principal Investigator
    REGULATION OF VIRULENCE GENES IN HELICOBACTER PYLORI
    NIH/NIAID K08AI001399Aug 1, 1996 - Jul 31, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Skoog EC, Morikis VA, Martin ME, Foster GA, Cai LP, Hansen LM, Li B, Gaddy JA, Simon SI, Solnick J. CagY-Dependent Regulation of Type IV Secretion in Helicobacter pylori Is Associated with Alterations in Integrin Binding. MBio. 2018 May 15; 9(3). PMID: 29764950.
      View in: PubMed
    2. Flahou B, Rossi M, Bakker J, Langermans JA, Heuvelman E, Solnick J, Martin ME, O'Rourke J, Ngoan LD, Hoa NX, Nakamura M, Øverby A, Matsui H, Ota H, Matsumoto T, Foss DL, Kopta LA, Omotosho O, Franciosini MP, Casagrande Proietti P, Guo A, Liu H, Borilova G, Bracarense AP, Lindén SK, De Bruyckere S, Zhang G, De Witte C, Smet A, Pasmans F, Ducatelle R, Corander J, Haesebrouck F. Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs. ISME J. 2018 Jan; 12(1):77-86. PMID: 28885626.
      View in: PubMed
    3. Dela Pena-Ponce MG, Jimenez MT, Hansen LM, Solnick J, Miller LA. The Helicobacter pylori type IV secretion system promotes IL-8 synthesis in a model of pediatric airway epithelium via p38 MAP kinase. PLoS One. 2017; 12(8):e0183324. PMID: 28813514.
      View in: PubMed
    4. Hansen LM, Gideonsson P, Canfield DR, Borén T, Solnick J. Dynamic Expression of the BabA Adhesin and Its BabB Paralog during Helicobacter pylori Infection in Rhesus Macaques. Infect Immun. 2017 06; 85(6). PMID: 28396320.
      View in: PubMed
    5. Kable ME, Hansen LM, Styer CM, Deck SL, Rakhimova O, Shevtsova A, Eaton KA, Martin ME, Gideonsson P, Borén T, Solnick J. Host Determinants of Expression of the Helicobacter pylori BabA Adhesin. Sci Rep. 2017 Apr 18; 7:46499. PMID: 28418004.
      View in: PubMed
    6. Bugaytsova JA, Björnham O, Chernov YA, Gideonsson P, Henriksson S, Mendez M, Sjöström R, Mahdavi J, Shevtsova A, Ilver D, Moonens K, Quintana-Hayashi MP, Moskalenko R, Aisenbrey C, Bylund G, Schmidt A, Åberg A, Brännström K, Königer V, Vikström S, Rakhimova L, Hofer A, Ögren J, Liu H, Goldman MD, Whitmire JM, Ådén J, Younson J, Kelly CG, Gilman RH, Chowdhury A, Mukhopadhyay AK, Nair GB, Papadakos KS, Martinez-Gonzalez B, Sgouras DN, Engstrand L, Unemo M, Danielsson D, Suerbaum S, Oscarson S, Morozova-Roche LA, Olofsson A, Gröbner G, Holgersson J, Esberg A, Strömberg N, Landström M, Eldridge AM, Chromy BA, Hansen LM, Solnick J, Lindén SK, Haas R, Dubois A, Merrell DS, Schedin S, Remaut H, Arnqvist A, Berg DE, Borén T. Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence. Cell Host Microbe. 2017 Mar 08; 21(3):376-389. PMID: 28279347.
      View in: PubMed
    7. Draper JL, Hansen LM, Bernick DL, Abedrabbo S, Underwood JG, Kong N, Huang BC, Weis AM, Weimer BC, van Vliet AH, Pourmand N, Solnick J, Karplus K, Ottemann KM. Fallacy of the Unique Genome: Sequence Diversity within Single Helicobacter pylori Strains. MBio. 2017 02 21; 8(1). PMID: 28223462.
      View in: PubMed
    8. Skoog EC, Deck SL, Entwistle HD, Hansen LM, Solnick J. Characterization of the Cag pathogenicity island in Helicobacter pylori from naturally infected rhesus macaques. FEMS Microbiol Lett. 2016 12; 363(24). PMID: 27940463.
      View in: PubMed
    9. Barrozo RM, Hansen LM, Lam AM, Skoog EC, Martin ME, Cai LP, Lin Y, Latoscha A, Suerbaum S, Canfield DR, Solnick J. CagY Is an Immune-Sensitive Regulator of the Helicobacter pylori Type IV Secretion System. Gastroenterology. 2016 12; 151(6):1164-1175.e3. PMID: 27569724.
      View in: PubMed
    10. Polage CR, Solnick J, Cohen SH. Toxin Immunoassays and Clostridium difficile Infection-Reply. JAMA Intern Med. 2016 Mar; 176(3):414-5. PMID: 26954051.
      View in: PubMed
    11. Moonens K, Gideonsson P, Subedi S, Bugaytsova J, Romaõ E, Mendez M, Nordén J, Fallah M, Rakhimova L, Shevtsova A, Lahmann M, Castaldo G, Brännström K, Coppens F, Lo AW, Ny T, Solnick J, Vandenbussche G, Oscarson S, Hammarström L, Arnqvist A, Berg DE, Muyldermans S, Borén T, Remaut H. Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori. Cell Host Microbe. 2016 Jan 13; 19(1):55-66. PMID: 26764597; PMCID: PMC4793151 [Available on 01/13/17].
    12. Polage CR, Gyorke CE, Kennedy MA, Leslie JL, Chin DL, Wang S, Nguyen HH, Huang B, Tang YW, Lee LW, Kim K, Taylor S, Romano PS, Panacek EA, Goodell PB, Solnick J, Cohen SH. Overdiagnosis of Clostridium difficile Infection in the Molecular Test Era. JAMA Intern Med. 2015 Nov; 175(11):1792-801. PMID: 26348734; PMCID: PMC4948649.
    13. Solnick J. Invited review articles: do they inform or do they advertise? Clin Infect Dis. 2015 Aug 01; 61(3):484. PMID: 25956889.
      View in: PubMed
    14. Ruhaak LR, Barkauskas DA, Torres J, Cooke CL, Wu LD, Stroble C, Ozcan S, Williams CC, Camorlinga M, Rocke DM, Lebrilla CB, Solnick J. The Serum Immunoglobulin G Glycosylation Signature of Gastric Cancer. EuPA Open Proteom. 2015 Mar 01; 6:1-9. PMID: 25685702.
      View in: PubMed
    15. Linz B, Windsor HM, McGraw JJ, Hansen LM, Gajewski JP, Tomsho LP, Hake CM, Solnick J, Schuster SC, Marshall BJ. A mutation burst during the acute phase of Helicobacter pylori infection in humans and rhesus macaques. Nat Commun. 2014 Jun 13; 5:4165. PMID: 24924186.
      View in: PubMed
    16. Martin ME, Solnick J. The gastric microbial community, Helicobacter pylori colonization, and disease. Gut Microbes. 2014 May-Jun; 5(3):345-50. PMID: 24642475; PMCID: PMC4153772.
    17. Ozcan S, Barkauskas DA, Renee Ruhaak L, Torres J, Cooke CL, An HJ, Hua S, Williams CC, Dimapasoc LM, Han Kim J, Camorlinga-Ponce M, Rocke D, Lebrilla CB, Solnick J. Serum glycan signatures of gastric cancer. Cancer Prev Res (Phila). 2014 Feb; 7(2):226-35. PMID: 24327722.
      View in: PubMed
    18. Moore ME, Lam A, Bhatnagar S, Solnick J. Environmental determinants of transformation efficiency in Helicobacter pylori. J Bacteriol. 2014 Jan; 196(2):337-44. PMID: 24187089; PMCID: PMC3911246.
    19. Martin ME, Bhatnagar S, George MD, Paster BJ, Canfield DR, Eisen JA, Solnick J. The impact of Helicobacter pylori infection on the gastric microbiota of the rhesus macaque. PLoS One. 2013; 8(10):e76375. PMID: 24116104; PMCID: PMC3792980.
    20. Cooke CL, Torres J, Solnick J. Biomarkers of Helicobacter pylori-associated gastric cancer. Gut Microbes. 2013 Nov-Dec; 4(6):532-40. PMID: 23851317.
      View in: PubMed
    21. Barrozo RM, Cooke CL, Hansen LM, Lam AM, Gaddy JA, Johnson EM, Cariaga TA, Suarez G, Peek RM, Cover TL, Solnick J. Functional plasticity in the type IV secretion system of Helicobacter pylori. PLoS Pathog. 2013 Feb; 9(2):e1003189. PMID: 23468628; PMCID: PMC3585145.
    22. Martin ME, Dieter JA, Luo Z, Baumgarth N, Solnick J. Predicting the outcome of infectious diseases: variability among inbred mice as a new and powerful tool for biomarker discovery. MBio. 2012 Oct 16; 3(5):e00199-12. PMID: 23073762; PMCID: PMC3470649.
    23. Gyorke CE, Wang S, Leslie JL, Cohen SH, Solnick J, Polage CR. Evaluation of Clostridium difficile fecal load and limit of detection during a prospective comparison of two molecular tests, the illumigene C. difficile and Xpert C. difficile/Epi tests. J Clin Microbiol. 2013 Jan; 51(1):278-80. PMID: 23052320; PMCID: PMC3536201.
    24. Polage CR, Chin DL, Leslie JL, Tang J, Cohen SH, Solnick J. Outcomes in patients tested for Clostridium difficile toxins. Diagn Microbiol Infect Dis. 2012 Dec; 74(4):369-73. PMID: 23009731; PMCID: PMC3496840.
    25. Polage CR, Solnick J, Cohen SH. Nosocomial diarrhea: evaluation and treatment of causes other than Clostridium difficile. Clin Infect Dis. 2012 Oct; 55(7):982-9. PMID: 22700831; PMCID: PMC3657522.
    26. Gardner MB, Baumgarth N, Fell A, McSorley SJ, Solnick J, Bevins CL. Meeting report: a symposium on the evolution of common molecular pathways underlying innate immunity. Microbes Infect. 2012 Aug; 14(9):667-71. PMID: 22580093.
      View in: PubMed
    27. Ta LH, Hansen LM, Sause WE, Shiva O, Millstein A, Ottemann KM, Castillo AR, Solnick J. Conserved transcriptional unit organization of the cag pathogenicity island among Helicobacter pylori strains. Front Cell Infect Microbiol. 2012; 2:46. PMID: 22919637; PMCID: PMC3417554.
    28. Avilés-Jiménez F, Reyes-Leon A, Nieto-Patlán E, Hansen LM, Burgueño J, Ramos IP, Camorlinga-Ponce M, Bermúdez H, Blancas JM, Cabrera L, Ribas-Aparicio RM, Solnick J, Torres-López J. In vivo expression of Helicobacter pylori virulence genes in patients with gastritis, ulcer, and gastric cancer. Infect Immun. 2012 Feb; 80(2):594-601. PMID: 22124657; PMCID: PMC3264312.
    29. Müller A, Solnick J. Inflammation, immunity, and vaccine development for Helicobacter pylori. Helicobacter. 2011 Sep; 16 Suppl 1:26-32. PMID: 21896082.
      View in: PubMed
    30. Goldman CG, Matteo MJ, Loureiro JD, Almuzara M, Barberis C, Vay C, Catalano M, Heredia SR, Mantero P, Boccio JR, Zubillaga MB, Cremaschi GA, Solnick J, Perez-Perez GI, Blaser MJ. Novel gastric helicobacters and oral campylobacters are present in captive and wild cetaceans. Vet Microbiol. 2011 Aug 26; 152(1-2):138-45. PMID: 21592686; PMCID: PMC3142288.
    31. Moore ME, Borén T, Solnick J. Life at the margins: modulation of attachment proteins in Helicobacter pylori. Gut Microbes. 2011 Jan-Feb; 2(1):42-6. PMID: 21637017; PMCID: PMC3225796.
    32. Styer CM, Hansen LM, Cooke CL, Gundersen AM, Choi SS, Berg DE, Benghezal M, Marshall BJ, Peek RM, Borén T, Solnick J. Expression of the BabA adhesin during experimental infection with Helicobacter pylori. Infect Immun. 2010 Apr; 78(4):1593-600. PMID: 20123715; PMCID: PMC2849406.
    33. Perry S, de Jong BC, Solnick J, de la Luz Sanchez M, Yang S, Lin PL, Hansen LM, Talat N, Hill PC, Hussain R, Adegbola RA, Flynn J, Canfield D, Parsonnet J. Infection with Helicobacter pylori is associated with protection against tuberculosis. PLoS One. 2010 Jan 20; 5(1):e8804. PMID: 20098711; PMCID: PMC2808360.
    34. Axsen WS, Styer CM, Solnick J. Inhibition of heat shock protein expression by Helicobacter pylori. Microb Pathog. 2009 Oct; 47(4):231-6. PMID: 19683049.
      View in: PubMed
    35. Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA, Butler BP, Chu H, Santos RL, Berger T, Mak TW, Tsolis RM, Bevins CL, Solnick J, Dandekar S, Bäumler AJ. Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe. 2009 May 08; 5(5):476-86. PMID: 19454351; PMCID: PMC2768556.
    36. Cooke CL, An HJ, Kim J, Canfield DR, Torres J, Lebrilla CB, Solnick J. Modification of gastric mucin oligosaccharide expression in rhesus macaques after infection with Helicobacter pylori. Gastroenterology. 2009 Sep; 137(3):1061-71, 1071.e1-8. PMID: 19375420.
      View in: PubMed
    37. Tsolis RM, Young GM, Solnick J, Bäumler AJ. From bench to bedside: stealth of enteroinvasive pathogens. Nat Rev Microbiol. 2008 Dec; 6(12):883-92. PMID: 18955984.
      View in: PubMed
    38. Amundsen SK, Fero J, Hansen LM, Cromie GA, Solnick J, Smith GR, Salama NR. Helicobacter pylori AddAB helicase-nuclease and RecA promote recombination-related DNA repair and survival during stomach colonization. Mol Microbiol. 2008 Aug; 69(4):994-1007. PMID: 18573180; PMCID: PMC2680919.
    39. Hornsby MJ, Huff JL, Kays RJ, Canfield DR, Bevins CL, Solnick J. Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity island-dependent manner. Gastroenterology. 2008 Apr; 134(4):1049-57. PMID: 18395086; PMCID: PMC2386437.
    40. Cooke CL, An HJ, Kim J, Solnick J, Lebrilla CB. Method for profiling mucin oligosaccharides from gastric biopsies of rhesus monkeys with and without Helicobacter pylori infection. Anal Chem. 2007 Nov 01; 79(21):8090-7. PMID: 17918860.
      View in: PubMed
    41. Taylor JM, Ziman ME, Canfield DR, Vajdy M, Solnick J. Effects of a Th1- versus a Th2-biased immune response in protection against Helicobacter pylori challenge in mice. Microb Pathog. 2008 Jan; 44(1):20-7. PMID: 17683897; PMCID: PMC2234601.
    42. Taylor JM, Ziman ME, Fong J, Solnick J, Vajdy M. Possible correlates of long-term protection against Helicobacter pylori following systemic or combinations of mucosal and systemic immunizations. Infect Immun. 2007 Jul; 75(7):3462-9. PMID: 17502399; PMCID: PMC1932914.
    43. Solnick J, Fong J, Hansen LM, Chang K, Canfield DR, Parsonnet J. Acquisition of Helicobacter pylori infection in rhesus macaques is most consistent with oral-oral transmission. J Clin Microbiol. 2006 Oct; 44(10):3799-803. PMID: 17021115; PMCID: PMC1594807.
    44. Solnick J, Franceschi F, Roccarina D, Gasbarrini A. Extragastric manifestations of Helicobacter pylori infection--other Helicobacter species. Helicobacter. 2006 Oct; 11 Suppl 1:46-51. PMID: 16925612.
      View in: PubMed
    45. Solnick J. Treatment with moxifloxacin versus standard therapy for community-acquired pneumonia. Clin Infect Dis. 2006 Jul 01; 43(1):109; author reply 110-1. PMID: 16758427.
      View in: PubMed
    46. Colbeck JC, Hansen LM, Fong JM, Solnick J. Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori. Infect Immun. 2006 Jul; 74(7):4375-8. PMID: 16790815; PMCID: PMC1489689.
    47. Taylor JM, Ziman ME, Huff JL, Moroski NM, Vajdy M, Solnick J. Helicobacter pylori lipopolysaccharide promotes a Th1 type immune response in immunized mice. Vaccine. 2006 Jun 05; 24(23):4987-94. PMID: 16621176.
      View in: PubMed
    48. Boonjakuakul JK, Canfield DR, Solnick J. Comparison of Helicobacter pylori virulence gene expression in vitro and in the Rhesus macaque. Infect Immun. 2005 Aug; 73(8):4895-904. PMID: 16041003; PMCID: PMC1201232.
    49. Cooke CL, Huff JL, Solnick J. The role of genome diversity and immune evasion in persistent infection with Helicobacter pylori. FEMS Immunol Med Microbiol. 2005 Jul 01; 45(1):11-23. PMID: 15949928.
      View in: PubMed
    50. O'Rourke JL, Solnick J, Neilan BA, Seidel K, Hayter R, Hansen LM, Lee A. Description of 'Candidatus Helicobacter heilmannii' based on DNA sequence analysis of 16S rRNA and urease genes. Int J Syst Evol Microbiol. 2004 Nov; 54(Pt 6):2203-11. PMID: 15545459.
      View in: PubMed
    51. Huff JL, Hansen LM, Solnick J. Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque. Infect Immun. 2004 Sep; 72(9):5216-26. PMID: 15322016; PMCID: PMC517414.
    52. Ayala G, Chihu L, Perales G, Fierros-Zárate G, Hansen LM, Solnick J, Sánchez J. Quantitation of H. pylori cytotoxin mRNA by real-time RT-PCR shows a wide expression range that does not correlate with promoter sequences. Microb Pathog. 2004 Sep; 37(3):163-7. PMID: 15351040.
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    53. Boonjakuakul JK, Syvanen M, Suryaprasad A, Bowlus CL, Solnick J. Transcription profile of Helicobacter pylori in the human stomach reflects its physiology in vivo. J Infect Dis. 2004 Sep 01; 190(5):946-56. PMID: 15295700.
      View in: PubMed
    54. Solnick J, Hansen LM, Salama NR, Boonjakuakul JK, Syvanen M. Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2106-11. PMID: 14762173.
      View in: PubMed
    55. Solnick J, Chang K, Canfield DR, Parsonnet J. Natural acquisition of Helicobacter pylori infection in newborn rhesus macaques. J Clin Microbiol. 2003 Dec; 41(12):5511-6. PMID: 14662932; PMCID: PMC309038.
    56. Dandekar S, Reay E, Taylor JM, Solnick J. Apoptosis of gastric lymphocytes in Helicobacter pylori-infected rhesus macaques. Dig Dis Sci. 2003 Jun; 48(6):1073-80. PMID: 12822865.
      View in: PubMed
    57. Solnick J. Clinical significance of Helicobacter species other than Helicobacter pylori. Clin Infect Dis. 2003 Feb 01; 36(3):349-54. PMID: 12539077.
      View in: PubMed
    58. Fernandez KR, Hansen LM, Vandamme P, Beaman BL, Solnick J. Captive rhesus monkeys (Macaca mulatta) are commonly infected with Helicobacter cinaedi. J Clin Microbiol. 2002 Jun; 40(6):1908-12. PMID: 12037042; PMCID: PMC130736.
    59. Solnick J, Hansen LM, Canfield DR. [14C]Urea breath test is not sensitive for detection of acute Helicobacter pylori infection in rhesus monkeys (Macaca mulatta). Dig Dis Sci. 2002 Feb; 47(2):298-303. PMID: 11855544.
      View in: PubMed
    60. Solnick J, Hansen LM, Canfield DR, Parsonnet J. Determination of the infectious dose of Helicobacter pylori during primary and secondary infection in rhesus monkeys (Macaca mulatta). Infect Immun. 2001 Nov; 69(11):6887-92. PMID: 11598063; PMCID: PMC100068.
    61. Solnick J, Schauer DB. Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases. Clin Microbiol Rev. 2001 Jan; 14(1):59-97. PMID: 11148003; PMCID: PMC88962.
    62. Solnick J, Canfield DR, Hansen LM, Torabian SZ. Immunization with recombinant Helicobacter pylori urease in specific-pathogen-free rhesus monkeys (Macaca mulatta). Infect Immun. 2000 May; 68(5):2560-5. PMID: 10768944; PMCID: PMC97459.
    63. Solnick J, Hansen LM, Syvanen M. The major sigma factor (RpoD) from Helicobacter pylori and other gram-negative bacteria shows an enhanced rate of divergence. J Bacteriol. 1997 Oct; 179(19):6196-200. PMID: 9324272; PMCID: PMC179528.