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Richard J Maddock

Title(s)Professor, Psychiatry and Behavioral Sciences
SchoolUniversity of California, Davis
Phone916-734-3286
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    Collapse Research 
    Collapse Research Activities and Funding
    MRS and fMRI Studies of Neurobiological Factors in Panic Disorder
    NIH/NIMH R21MH076988Jan 11, 2007 - Dec 31, 2009
    Role: Principal Investigator
    Brain Lactate and Photic Stimulation in Panic Disorder
    NIH/NIMH R21MH069699Jan 1, 2004 - Dec 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yoon JH, Maddock RJ, DongBo Cui E, Minzenberg MJ, Niendam TA, Lesh T, Solomon M, Ragland JD, Carter C. Reduced in vivo visual cortex GABA in schizophrenia, a replication in a recent onset sample. Schizophr Res. 2019 Nov 06. PMID: 31704157.
      View in: PubMed
    2. Lesh TA, Maddock RJ, Howell A, Wang H, Tanase C, Daniel Ragland J, Niendam TA, Carter CS. Extracellular free water and glutathione in first-episode psychosis-a multimodal investigation of an inflammatory model for psychosis. Mol Psychiatry. 2019 May 28. PMID: 31138893.
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    3. Fleming LM, Javitt DC, Carter CS, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Robinson J, Potter WZ, Carlson M, Wall MM, Choo TH, Grinband J, Lieberman J, Krystal JH, Corlett PR. A multicenter study of ketamine effects on functional connectivity: Large scale network relationships, hubs and symptom mechanisms. Neuroimage Clin. 2019; 22:101739. PMID: 30852397.
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    4. Maddock RJ, Caton MD, Ragland JD. Estimating glutamate and Glx from GABA-optimized MEGA-PRESS: Off-resonance but not difference spectra values correspond to PRESS values. Psychiatry Res Neuroimaging. 2018 09 30; 279:22-30. PMID: 30081290.
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    5. Javitt DC, Carter CS, Krystal JH, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Corlett PR, Rothman DL, Mason G, Qiu M, Robinson J, Potter WZ, Carlson M, Wall MM, Choo TH, Grinband J, Lieberman JA. Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial. JAMA Psychiatry. 2018 01 01; 75(1):11-19. PMID: 29167877.
      View in: PubMed
    6. Greenhouse I, King M, Noah S, Maddock RJ, Ivry RB. Individual Differences in Resting Corticospinal Excitability Are Correlated with Reaction Time and GABA Content in Motor Cortex. J Neurosci. 2017 03 08; 37(10):2686-2696. PMID: 28179557.
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    7. Yoon JH, Grandelis A, Maddock RJ. Dorsolateral Prefrontal Cortex GABA Concentration in Humans Predicts Working Memory Load Processing Capacity. J Neurosci. 2016 11 16; 36(46):11788-11794. PMID: 27852785.
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    8. Greenhouse I, Noah S, Maddock RJ, Ivry RB. Individual differences in GABA content are reliable but are not uniform across the human cortex. Neuroimage. 2016 Oct 01; 139:1-7. PMID: 27288552.
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    9. Maddock RJ, Casazza GA, Fernandez DH, Maddock MI. Acute Modulation of Cortical Glutamate and GABA Content by Physical Activity. J Neurosci. 2016 Feb 24; 36(8):2449-57. PMID: 26911692.
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    10. Buonocore MH, Maddock RJ. Magnetic resonance spectroscopy of the brain: a review of physical principles and technical methods. Rev Neurosci. 2015; 26(6):609-32. PMID: 26200810.
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    11. Maddock RJ. Glutamate changes in anterior cingulate cortex following CCK-4 infusion. Neuropsychopharmacology. 2014 Oct; 39(11):2706. PMID: 24939759.
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    12. Maddock R. The problem of spurious correlations between pairs of brain metabolite values measured in the same voxel with magnetic resonance spectroscopy. JAMA Psychiatry. 2014 Mar; 71(3):338-9. PMID: 24599243.
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    13. Maddock RJ, Buonocore MH, Miller AR, Yoon JH, Soosman SK, Unruh AM. Abnormal activity-dependent brain lactate and glutamate+glutamine responses in panic disorder. Biol Psychiatry. 2013 Jun 01; 73(11):1111-9. PMID: 23332354.
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    14. Maddock RJ, Buonocore MH. Comment regarding increased striatal glutamate in schizophrenia. Neuropsychopharmacology. 2012 Mar; 37(4):1067-8; author reply 1069. PMID: 22327901.
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    15. Maddock RJ, Buonocore MH. MR spectroscopic studies of the brain in psychiatric disorders. Curr Top Behav Neurosci. 2012; 11:199-251. PMID: 22294088.
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    16. Rokem A, Yoon JH, Ooms RE, Maddock RJ, Minzenberg MJ, Silver MA. Broader visual orientation tuning in patients with schizophrenia. Front Hum Neurosci. 2011; 5:127. PMID: 22069385.
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    17. Maddock RJ, Casazza GA, Buonocore MH, Tanase C. Vigorous exercise increases brain lactate and Glx (glutamate+glutamine): a dynamic 1H-MRS study. Neuroimage. 2011 Aug 15; 57(4):1324-30. PMID: 21640838.
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    18. Yoon JH, Maddock RJ, Rokem A, Silver MA, Minzenberg MJ, Ragland JD, Carter CS. GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression. J Neurosci. 2010 Mar 10; 30(10):3777-81. PMID: 20220012.
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    19. Esquivel G, Schruers KR, Maddock RJ, Colasanti A, Griez EJ. Acids in the brain: a factor in panic? J Psychopharmacol. 2010 May; 24(5):639-47. PMID: 19460873.
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    20. Maddock RJ, Buonocore MH, Copeland LE, Richards AL. Elevated brain lactate responses to neural activation in panic disorder: a dynamic 1H-MRS study. Mol Psychiatry. 2009 May; 14(5):537-45. PMID: 18180759.
      View in: PubMed
    21. Maddock RJ, Buonocore MH, Lavoie SP, Copeland LE, Kile SJ, Richards AL, Ryan JM. Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: a proton magnetic resonance spectroscopy study at 1.5 Tesla. Psychiatry Res. 2006 Nov 22; 148(1):47-54. PMID: 17020804.
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    22. Garrett AS, Maddock RJ. Separating subjective emotion from the perception of emotion-inducing stimuli: an fMRI study. Neuroimage. 2006 Oct 15; 33(1):263-74. PMID: 16908199.
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    23. Bourgeois JA, Maddock RJ, Rogers L, Greco CM, Mangrulkar RS, Saint S. Neurosarcoidosis and delirium. Psychosomatics. 2005 Mar-Apr; 46(2):148-50. PMID: 15774954.
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    24. Maddock RJ, Buonocore MH, Kile SJ, Garrett AS. Brain regions showing increased activation by threat-related words in panic disorder. Neuroreport. 2003 Mar 03; 14(3):325-8. PMID: 12634477.
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    25. Maddock RJ, Garrett AS, Buonocore MH. Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task. Hum Brain Mapp. 2003 Jan; 18(1):30-41. PMID: 12454910.
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    26. Hargrave R, Maddock RJ, Stone V. Impaired recognition of facial expressions of emotion in Alzheimer's disease. J Neuropsychiatry Clin Neurosci. 2002; 14(1):64-71. PMID: 11884657.
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    27. Davidson J, Pearlstein T, Londborg P, Brady KT, Rothbaum B, Bell J, Maddock R, Hegel MT, Farfel G. Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: results of a 28-week double-blind, placebo-controlled study. Am J Psychiatry. 2001 Dec; 158(12):1974-81. PMID: 11729012.
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    28. Garrett AS, Maddock RJ. Time course of the subjective emotional response to aversive pictures: relevance to fMRI studies. Psychiatry Res. 2001 Nov 05; 108(1):39-48. PMID: 11677066.
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    29. Londborg PD, Hegel MT, Goldstein S, Goldstein D, Himmelhoch JM, Maddock R, Patterson WM, Rausch J, Farfel GM. Sertraline treatment of posttraumatic stress disorder: results of 24 weeks of open-label continuation treatment. J Clin Psychiatry. 2001 May; 62(5):325-31. PMID: 11411812.
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    30. Maddock RJ, Garrett AS, Buonocore MH. Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval. Neuroscience. 2001; 104(3):667-76. PMID: 11440800.
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    31. Maddock RJ. The lactic acid response to alkalosis in panic disorder : an integrative review. J Neuropsychiatry Clin Neurosci. 2001; 13(1):22-34. PMID: 11207326.
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    32. Post RB, Chaderjian MR, Maddock RJ. Effects of alcohol on exogenous precueing of attention. J Stud Alcohol. 2000 Mar; 61(2):232-8. PMID: 10757133.
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    33. Maddock RJ. The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain. Trends Neurosci. 1999 Jul; 22(7):310-6. PMID: 10370255.
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    34. Wulsin LR, Maddock R, Beitman B, Dawaher R, Wells VE. Clonazepam treatment of panic disorder in patients with recurrent chest pain and normal coronary arteries. Int J Psychiatry Med. 1999; 29(1):97-105. PMID: 10376236.
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    35. Post RB, Tavano LA, Maddock RJ. Role of feedback in formation of acute tolerance to alcohol. J Stud Alcohol. 1998 Nov; 59(6):723-30. PMID: 9811094.
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    36. Maddock RJ. Acute effects of low-dose flumazenil in panic disorder. J Clin Psychopharmacol. 1998 Jun; 18(3):258-61. PMID: 9617991.
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    37. Carter CS, Maddock R, Chaderjian M, Post R. Attentional effects of single dose triazolam. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Feb; 22(2):279-92. PMID: 9608601.
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    38. Maddock RJ, Carter CS, Tavano-Hall L, Amsterdam EA. Hypocapnia associated with cardiac stress scintigraphy in chest pain patients with panic disorder. Psychosom Med. 1998 Jan-Feb; 60(1):52-5. PMID: 9492240.
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    39. Buonocore MH, Maddock RJ. Noise suppression digital filter for functional magnetic resonance imaging based on image reference data. Magn Reson Med. 1997 Sep; 38(3):456-69. PMID: 9339447.
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    40. Barbee JG, Todorov AA, Kuczmierczyk AR, Mancuso DM, Schwab JJ, Maddock RJ, Hoehn-Saric R, Kelley LA, Davidson JR. Explained and unexplained medical symptoms in generalized anxiety and panic disorder: relationship to the somatoform disorders. Ann Clin Psychiatry. 1997 Sep; 9(3):149-55. PMID: 9339880.
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    41. Maddock RJ, Buonocore MH. Activation of left posterior cingulate gyrus by the auditory presentation of threat-related words: an fMRI study. Psychiatry Res. 1997 Aug 08; 75(1):1-14. PMID: 9287369.
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    42. Post RB, Chaderjian MR, Maddock RJ, Lott LA. Effects of lorazepam on the distribution of spatial attention. Exp Clin Psychopharmacol. 1997 May; 5(2):143-9. PMID: 9234051.
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    43. Post RB, Lott LA, Maddock RJ, Beede JI. An effect of alcohol on the distribution of spatial attention. J Stud Alcohol. 1996 May; 57(3):260-6. PMID: 8709584.
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    44. Carter CS, Fawcett J, Hertzman M, Papp LA, Jones W, Patterson WM, Swinson RP, Weise CC, Maddock RJ, Denahan AQ. Adinazolam-SR in panic disorder with agoraphobia: relationship of daily dose to efficacy. J Clin Psychiatry. 1995 May; 56(5):202-10. PMID: 7737960.
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    45. Carter C, Maddock R, Zoglio M, Lutrin C, Jella S, Amsterdam E. Panic disorder and chest pain: a study of cardiac stress scintigraphy patients. Am J Cardiol. 1994 Aug 01; 74(3):296-8. PMID: 8037144.
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    46. Davidson JR, Beitman B, Greist JH, Maddock RJ, Lewis CP, Sheridan AQ, Carter C, Krishnan KR, Liebowitz MR, Haack DG. Adinazolam sustained-release treatment of panic disorder: a double-blind study. J Clin Psychopharmacol. 1994 Aug; 14(4):255-63. PMID: 7962681.
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    47. Post RB, Lott LA, Beede JI, Maddock RJ. The effect of alcohol on the vestibulo-ocular reflex and apparent concomitant motion. J Vestib Res. 1994 May-Jun; 4(3):181-7. PMID: 7921336.
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    48. Beitman BD, Beck NC, Deuser WE, Carter CS, Davidson JR, Maddock RJ. Patient Stage of Change predicts outcome in a panic disorder medication trial. Anxiety. 1994; 1(2):64-9. PMID: 9160550.
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    49. Maddock RJ, Casson EJ, Lott LA, Carter CS, Johnson CA. Benzodiazepine effects on flicker sensitivity: role of stimulus frequency and size. Prog Neuropsychopharmacol Biol Psychiatry. 1993 Nov; 17(6):955-70. PMID: 8278605.
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    50. Maddock RJ, Gietzen DW, Goodman TA. Decreased lymphocyte beta-adrenoreceptor function correlates with less agoraphobia and better outcome in panic disorder. J Affect Disord. 1993 Sep; 29(1):27-32. PMID: 8254140.
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    51. Maddock RJ, Carter CS, Magliozzi JR, Gietzen DW. Evidence that decreased function of lymphocyte beta adrenoreceptors reflects regulatory and adaptive processes in panic disorder with agoraphobia. Am J Psychiatry. 1993 Aug; 150(8):1219-25. PMID: 8392297.
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    52. Magliozzi JR, Maddock RJ, Gold AS, Gietzen DW. Relationships between thyroid indices and symptoms of anxiety in depressed outpatients. Ann Clin Psychiatry. 1993 Jun; 5(2):111-6. PMID: 8348202.
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    53. Maddock RJ, Carter CS, Blacker KH, Beitman BD, Krishnan KR, Jefferson JW, Lewis CP, Liebowitz MR. Relationship of past depressive episodes to symptom severity and treatment response in panic disorder with agoraphobia. J Clin Psychiatry. 1993 Mar; 54(3):88-95. PMID: 8468314.
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    54. Logue MB, Thomas AM, Barbee JG, Hoehn-Saric R, Maddock RJ, Schwab J, Smith RD, Sullivan M, Beitman BD. Generalized anxiety disorder patients seek evaluation for cardiological symptoms at the same frequency as patients with panic disorder. J Psychiatr Res. 1993 Jan-Mar; 27(1):55-9. PMID: 8515389.
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    55. Roth WT, Margraf J, Ehlers A, Taylor CB, Maddock RJ, Davies S, Agras WS. Stress test reactivity in panic disorder. Arch Gen Psychiatry. 1992 Apr; 49(4):301-10. PMID: 1558464.
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    56. Carter CS, Maddock RJ, Magliozzi J. Patterns of abnormal processing of emotional information in panic disorder and major depression. Psychopathology. 1992; 25(2):65-70. PMID: 1502294.
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    57. Roth WT, Margraf J, Ehlers A, Haddad JM, Maddock RJ, Agras WS, Taylor CB. Imipramine and alprazolam effects on stress test reactivity in panic disorder. Biol Psychiatry. 1992 Jan 01; 31(1):35-51. PMID: 1543796.
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    58. Carter CS, Maddock RJ. Chest pain in generalized anxiety disorder. Int J Psychiatry Med. 1992; 22(3):291-8. PMID: 1487393.
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    59. Carter C, Maddock R, Amsterdam E, McCormick S, Waters C, Billett J. Panic disorder and chest pain in the coronary care unit. Psychosomatics. 1992; 33(3):302-9. PMID: 1410204.
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    60. Maddock RJ, Carter CS, Gietzen DW. Elevated serum lactate associated with panic attacks induced by hyperventilation. Psychiatry Res. 1991 Sep; 38(3):301-11. PMID: 1754640.
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    61. Gietzen DW, Goodman TA, Weiler PG, Graf K, Fregeau DR, Magliozzi JR, Doran AR, Maddock RJ. Beta receptor density in human lymphocyte membranes: changing with aging? J Gerontol. 1991 Jul; 46(4):B130-4. PMID: 1677018.
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    62. Maddock RJ, Carter CS. Hyperventilation-induced panic attacks in panic disorder with agoraphobia. Biol Psychiatry. 1991 May 01; 29(9):843-54. PMID: 1904781.
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    63. Maddock RJ, Blacker KH. Response to treatment in panic disorder with associated depression. Psychopathology. 1991; 24(1):1-6. PMID: 2023978.
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    64. Taylor CB, Hayward C, King R, Ehlers A, Margraf J, Maddock R, Clark D, Roth WT, Agras WS. Cardiovascular and symptomatic reduction effects of alprazolam and imipramine in patients with panic disorder: results of a double-blind, placebo-controlled trial. J Clin Psychopharmacol. 1990 Apr; 10(2):112-8. PMID: 2187912.
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    65. Maddock RJ, Mateo-Bermudez J. Elevated serum lactate following hyperventilation during glucose infusion in panic disorder. Biol Psychiatry. 1990 Feb 15; 27(4):411-8. PMID: 2310796.
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    66. Magliozzi JR, Gietzen D, Maddock RJ, Haack D, Doran AR, Goodman T, Weiler PG. Lymphocyte beta-adrenoreceptor density in patients with unipolar depression and normal controls. Biol Psychiatry. 1989 May; 26(1):15-25. PMID: 2541807.
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    67. Maddock R. Panic disorder and phobic avoidance. Am J Psychiatry. 1987 Dec; 144(12):1625-6. PMID: 3688298.
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    68. Maddock RJ, Moses JA, Roth WT, King R, Murchison A, Berger PA. Serum phosphate and anxiety in major depression. Psychiatry Res. 1987 Sep; 22(1):29-36. PMID: 3659218.
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    69. Taylor CB, Sheikh J, Agras WS, Roth WT, Margraf J, Ehlers A, Maddock RJ, Gossard D. Ambulatory heart rate changes in patients with panic attacks. Am J Psychiatry. 1986 Apr; 143(4):478-82. PMID: 3953890.
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    70. Ehlers A, Margraf J, Roth WT, Taylor CB, Maddock RJ, Sheikh J, Kopell ML, McClenahan KL, Gossard D, Blowers GH. Lactate infusions and panic attacks: do patients and controls respond differently? Psychiatry Res. 1986 Apr; 17(4):295-308. PMID: 3714912.
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    71. Maddock RJ, Millodot M, Leat S, Johnson CA. Accommodation responses and refractive error. Invest Ophthalmol Vis Sci. 1981 Mar; 20(3):387-91. PMID: 7203882.
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