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Stephen C Noctor, PhD

Title(s)Associate Professor, Psychiatry And Behavioral Sciences
SchoolUniversity of California, Davis
Phone916-703-0435
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    Collapse Research 
    Collapse Research Activities and Funding
    Fetal Microglia and Neurogenesis
    NIH R21NS111313Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Developmental Origin and Trafficking of Microglial Cells
    NIH/NINDS R01NS109379Sep 30, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Congenital Zika Syndrome and Postnatal Outcomes in Nonhuman Primates
    NIH/NINDS R21NS103658Jun 15, 2017 - May 31, 2019
    Role: Co-Principal Investigator
    Leveraging Established Fetal Primate Models to Expedite ZIKV Investigations
    NIH R21OD023716Aug 1, 2016 - Jul 31, 2018
    Role: Co-Principal Investigator
    Microglia regulate development of the cerebral cortex
    NIH/NIMH R01MH101188Aug 1, 2013 - May 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Falcone C, Vakilzadeh G, Noctor SC, Martínez-Cerdeño V. The fundamental building blocks of cortical development are established in human exencephaly. Pediatr Res. 2019 Nov 29. PMID: 31783397.
      View in: PubMed
    2. Mota B, Dos Santos SE, Ventura-Antunes L, Jardim-Messeder D, Neves K, Kazu RS, Noctor S, Lambert K, Bertelsen MF, Manger PR, Sherwood CC, Kaas JH, Herculano-Houzel S. White matter volume and white/gray matter ratio in mammalian species as a consequence of the universal scaling of cortical folding. Proc Natl Acad Sci U S A. 2019 Jul 23; 116(30):15253-15261. PMID: 31285343.
      View in: PubMed
    3. Barger N, Keiter J, Kreutz A, Krishnamurthy A, Weidenthaler C, Martínez-Cerdeño V, Tarantal AF, Noctor SC. Microglia: An Intrinsic Component of the Proliferative Zones in the Fetal Rhesus Monkey (Macaca mulatta) Cerebral Cortex. Cereb Cortex. 2019 Jul 05; 29(7):2782-2796. PMID: 29992243.
      View in: PubMed
    4. Martínez-Cerdeño V, Noctor SC. Cortical Evolution Conference, 2018. J Comp Neurol. 2019 Jul 01; 527(10):1543-1544. PMID: 30740680.
      View in: PubMed
    5. Noctor SC, Penna E, Shepherd H, Chelson C, Barger N, Martínez-Cerdeño V, Tarantal AF. Periventricular microglial cells interact with dividing precursor cells in the nonhuman primate and rodent prenatal cerebral cortex. J Comp Neurol. 2019 Jul 01; 527(10):1598-1609. PMID: 30552670.
      View in: PubMed
    6. Falcone C, Wolf-Ochoa M, Amina S, Hong T, Vakilzadeh G, Hopkins WD, Hof PR, Sherwood CC, Manger PR, Noctor SC, Martínez-Cerdeño V. Cortical interlaminar astrocytes across the therian mammal radiation. J Comp Neurol. 2019 Jul 01; 527(10):1654-1674. PMID: 30552685.
      View in: PubMed
    7. Martínez Cerdeño V, Hong T, Amina S, Lechpammer M, Ariza J, Tassone F, Noctor SC, Hagerman P, Hagerman R. Microglial cell activation and senescence are characteristic of the pathology FXTAS. Mov Disord. 2018 12; 33(12):1887-1894. PMID: 30537011.
      View in: PubMed
    8. Martínez-Cerdeño V, Noctor SC. Neural Progenitor Cell Terminology. Front Neuroanat. 2018; 12:104. PMID: 30574073.
      View in: PubMed
    9. Martínez-Cerdeño V, Noctor SC. Cortical evolution 2018: Advantages of animal model species. J Comp Neurol. 2019 Jul 01; 527(10):1766-1768. PMID: 30394535.
      View in: PubMed
    10. Martínez-Cerdeño V, Camacho J, Ariza J, Rogers H, Horton-Sparks K, Kreutz A, Behringer R, Rasweiler JJ, Noctor SC. The Bat as a New Model of Cortical Development. Cereb Cortex. 2018 11 01; 28(11):3880-3893. PMID: 29136119.
      View in: PubMed
    11. Ibañez Rodriguez MP, Galiana MD, Rásmussen JA, Freites CL, Noctor SC, Muñoz EM. Differential response of pineal microglia to surgical versus pharmacological stimuli. J Comp Neurol. 2018 10 15; 526(15):2462-2481. PMID: 30246867.
      View in: PubMed
    12. Ariza J, Rogers H, Hashemi E, Noctor SC, Martínez-Cerdeño V. The Number of Chandelier and Basket Cells Are Differentially Decreased in Prefrontal Cortex in Autism. Cereb Cortex. 2018 02 01; 28(2):411-420. PMID: 28122807.
      View in: PubMed
    13. Hashemi E, Ariza J, Rogers H, Noctor SC, Martínez-Cerdeño V. The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Prefrontal Cortex in Autism. Cereb Cortex. 2018 02 01; 28(2):690. PMID: 28334402.
      View in: PubMed
    14. Jardim-Messeder D, Lambert K, Noctor S, Pestana FM, de Castro Leal ME, Bertelsen MF, Alagaili AN, Mohammad OB, Manger PR, Herculano-Houzel S. Dogs Have the Most Neurons, Though Not the Largest Brain: Trade-Off between Body Mass and Number of Neurons in the Cerebral Cortex of Large Carnivoran Species. Front Neuroanat. 2017; 11:118. PMID: 29311850.
      View in: PubMed
    15. Martínez-Cerdeño V, Lechpammer M, Noctor S, Ariza J, Hagerman P, Hagerman R. FMR1 premutation with Prader-Willi phenotype and fragile X-associated tremor/ataxia syndrome. Clin Case Rep. 2017 05; 5(5):625-629. PMID: 28469864.
      View in: PubMed
    16. Hashemi E, Ariza J, Rogers H, Noctor SC, Martínez-Cerdeño V. The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Prefrontal Cortex in Autism. Cereb Cortex. 2017 03 01; 27(3):1931-1943. PMID: 26922658.
      View in: PubMed
    17. Ibañez Rodriguez MP, Noctor SC, Muñoz EM. Cellular Basis of Pineal Gland Development: Emerging Role of Microglia as Phenotype Regulator. PLoS One. 2016; 11(11):e0167063. PMID: 27861587.
      View in: PubMed
    18. Hashemi E, Ariza J, Lechpammer M, Noctor SC, Martínez-Cerdeño V. Abnormal white matter tracts resembling pencil fibers involving prefrontal cortex (Brodmann area 47) in autism: a case report. J Med Case Rep. 2016 Aug 26; 10(1):237. PMID: 27562638.
      View in: PubMed
    19. Martínez-Cerdeño V, Noctor S. Cortical Evolution Conference 2015. J Comp Neurol. 2016 Feb 15; 524(3):431-2. PMID: 26745018.
      View in: PubMed
    20. Martínez-Cerdeño V, Noctor SC. Cortical evolution 2015: Discussion of neural progenitor cell nomenclature. J Comp Neurol. 2016 Feb 15; 524(3):704-9. PMID: 26439982.
      View in: PubMed
    21. Martínez-Cerdeño V, Cunningham CL, Camacho J, Keiter JA, Ariza J, Lovern M, Noctor SC. Evolutionary origin of Tbr2-expressing precursor cells and the subventricular zone in the developing cortex. J Comp Neurol. 2016 Feb 15; 524(3):433-47. PMID: 26267763.
      View in: PubMed
    22. Kim E, Camacho J, Combs Z, Ariza J, Lechpammer M, Noctor SC, Martínez-Cerdeño V. Preliminary findings suggest the number and volume of supragranular and infragranular pyramidal neurons are similar in the anterior superior temporal area of control subjects and subjects with autism. Neurosci Lett. 2015 Mar 04; 589:98-103. PMID: 25582788.
      View in: PubMed
    23. Martínez-Cerdeño V, Camacho J, Fox E, Miller E, Ariza J, Kienzle D, Plank K, Noctor SC, Van de Water J. Prenatal Exposure to Autism-Specific Maternal Autoantibodies Alters Proliferation of Cortical Neural Precursor Cells, Enlarges Brain, and Increases Neuronal Size in Adult Animals. Cereb Cortex. 2016 Jan; 26(1):374-383. PMID: 25535268.
      View in: PubMed
    24. Ariza J, Steward C, Rueckert F, Widdison M, Coffman R, Afjei A, Noctor SC, Hagerman R, Hagerman P, Martínez-Cerdeño V. Dysregulated iron metabolism in the choroid plexus in fragile X-associated tremor/ataxia syndrome. Brain Res. 2015 Feb 19; 1598:88-96. PMID: 25498860.
      View in: PubMed
    25. Clinton BK, Cunningham CL, Kriegstein AR, Noctor SC, Martínez-Cerdeño V. Radial glia in the proliferative ventricular zone of the embryonic and adult turtle, Trachemys scripta elegans. Neurogenesis (Austin). 2014; 1(1):e970905. PMID: 27504470.
      View in: PubMed
    26. Camacho J, Ejaz E, Ariza J, Noctor SC, Martínez-Cerdeño V. RELN-expressing neuron density in layer I of the superior temporal lobe is similar in human brains with autism and in age-matched controls. Neurosci Lett. 2014 Sep 05; 579:163-7. PMID: 25067827.
      View in: PubMed
    27. Martínez-Cerdeño V, Noctor SC. Cajal, Retzius, and Cajal-Retzius cells. Front Neuroanat. 2014; 8:48. PMID: 24987337.
      View in: PubMed
    28. Camacho J, Jones K, Miller E, Ariza J, Noctor S, de Water JV, Martínez-Cerdeño V. Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice. Behav Brain Res. 2014 Jun 01; 266:46-51. PMID: 24613242.
      View in: PubMed
    29. Pretto DI, Kumar M, Cao Z, Cunningham CL, Durbin-Johnson B, Qi L, Berman R, Noctor SC, Hagerman RJ, Pessah IN, Tassone F. Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome. Neurobiol Aging. 2014 May; 35(5):1189-97. PMID: 24332449.
      View in: PubMed
    30. Cunningham CL, Martínez-Cerdeño V, Noctor SC. Diversity of neural precursor cell types in the prenatal macaque cerebral cortex exists largely within the astroglial cell lineage. PLoS One. 2013; 8(5):e63848. PMID: 23724007.
      View in: PubMed
    31. Pretto DI, Hunsaker MR, Cunningham CL, Greco CM, Hagerman RJ, Noctor SC, Hall DA, Hagerman PJ, Tassone F. Intranuclear inclusions in a fragile X mosaic male. Transl Neurodegener. 2013 May 21; 2(1):10. PMID: 23692864.
      View in: PubMed
    32. Cunningham CL, Martínez-Cerdeño V, Noctor SC. Microglia regulate the number of neural precursor cells in the developing cerebral cortex. J Neurosci. 2013 Mar 06; 33(10):4216-33. PMID: 23467340.
      View in: PubMed
    33. Martínez-Cerdeño V, Cunningham CL, Camacho J, Antczak JL, Prakash AN, Cziep ME, Walker AI, Noctor SC. Comparative analysis of the subventricular zone in rat, ferret and macaque: evidence for an outer subventricular zone in rodents. PLoS One. 2012; 7(1):e30178. PMID: 22272298.
      View in: PubMed
    34. Noctor SC. Time-lapse imaging of fluorescently labeled live cells in the embryonic mammalian forebrain. Cold Spring Harb Protoc. 2011 Nov 01; 2011(11):1350-61. PMID: 22046042.
      View in: PubMed
    35. Fuentes P, Cánovas J, Berndt FA, Noctor SC, Kukuljan M. CoREST/LSD1 control the development of pyramidal cortical neurons. Cereb Cortex. 2012 Jun; 22(6):1431-41. PMID: 21878487.
      View in: PubMed
    36. Cunningham CL, Martínez Cerdeño V, Navarro Porras E, Prakash AN, Angelastro JM, Willemsen R, Hagerman PJ, Pessah IN, Berman RF, Noctor SC. Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development. Hum Mol Genet. 2011 Jan 01; 20(1):64-79. PMID: 20935171.
      View in: PubMed
    37. Martínez-Cerdeño V, Noctor SC, Espinosa A, Ariza J, Parker P, Orasji S, Daadi MM, Bankiewicz K, Alvarez-Buylla A, Kriegstein AR. Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats. Cell Stem Cell. 2010 Mar 05; 6(3):238-50. PMID: 20207227.
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    38. Milosevic A, Noctor SC, Martinez-Cerdeno V, Kriegstein AR, Goldman JE. Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation. Mol Cell Neurosci. 2008 Nov; 39(3):324-34. PMID: 18718868.
      View in: PubMed
    39. Noctor SC, Martínez-Cerdeño V, Kriegstein AR. Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis. J Comp Neurol. 2008 May 01; 508(1):28-44. PMID: 18288691.
      View in: PubMed
    40. Noctor SC, Martínez-Cerdeño V, Kriegstein AR. Contribution of intermediate progenitor cells to cortical histogenesis. Arch Neurol. 2007 May; 64(5):639-42. PMID: 17502462.
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    41. Noctor SC, Martinez-Cerdeño V, Kriegstein AR. Neural stem and progenitor cells in cortical development. Novartis Found Symp. 2007; 288:59-73; discussion 73-8, 96-8. PMID: 18494252.
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    42. Martínez-Cerdeño V, Noctor SC, Kriegstein AR. Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex. Eur J Neurosci. 2006 Dec; 24(12):3475-88. PMID: 17229096.
      View in: PubMed
    43. Kriegstein A, Noctor S, Martínez-Cerdeño V. Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion. Nat Rev Neurosci. 2006 Nov; 7(11):883-90. PMID: 17033683.
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    44. Martínez-Cerdeño V, Noctor SC, Kriegstein AR. The role of intermediate progenitor cells in the evolutionary expansion of the cerebral cortex. Cereb Cortex. 2006 Jul; 16 Suppl 1:i152-61. PMID: 16766701.
      View in: PubMed
    45. Butt SJ, Fuccillo M, Nery S, Noctor S, Kriegstein A, Corbin JG, Fishell G. The temporal and spatial origins of cortical interneurons predict their physiological subtype. Neuron. 2005 Nov 23; 48(4):591-604. PMID: 16301176.
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    46. Kriegstein AR, Noctor SC. Patterns of neuronal migration in the embryonic cortex. Trends Neurosci. 2004 Jul; 27(7):392-9. PMID: 15219738.
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    47. Jablonska B, Smith AL, Palmer SL, Noctor SC, Juliano SL. GABAA receptors reorganize when layer 4 in ferret somatosensory cortex is disrupted by methylazoxymethanol (MAM). Cereb Cortex. 2004 Apr; 14(4):432-40. PMID: 15028647.
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    48. Noctor SC, Martínez-Cerdeño V, Ivic L, Kriegstein AR. Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases. Nat Neurosci. 2004 Feb; 7(2):136-44. PMID: 14703572.
      View in: PubMed
    49. Weissman T, Noctor SC, Clinton BK, Honig LS, Kriegstein AR. Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration. Cereb Cortex. 2003 Jun; 13(6):550-9. PMID: 12764028.
      View in: PubMed
    50. Noctor SC, Flint AC, Weissman TA, Wong WS, Clinton BK, Kriegstein AR. Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia. J Neurosci. 2002 Apr 15; 22(8):3161-73. PMID: 11943818.
      View in: PubMed
    51. Noctor SC, Palmer SL, McLaughlin DF, Juliano SL. Disruption of layers 3 and 4 during development results in altered thalamocortical projections in ferret somatosensory cortex. J Neurosci. 2001 May 01; 21(9):3184-95. PMID: 11312303.
      View in: PubMed
    52. Palmer SL, Noctor SC, Jablonska B, Juliano SL. Laminar specific alterations of thalamocortical projections in organotypic cultures following layer 4 disruption in ferret somatosensory cortex. Eur J Neurosci. 2001 Apr; 13(8):1559-71. PMID: 11328350.
      View in: PubMed
    53. Noctor SC, Flint AC, Weissman TA, Dammerman RS, Kriegstein AR. Neurons derived from radial glial cells establish radial units in neocortex. Nature. 2001 Feb 08; 409(6821):714-20. PMID: 11217860.
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    54. Dammerman RS, Noctor SC, Kriegstein AR. Extrinsic GABAergic innervation of developing neocortical layer 1 in organotypic slice co-cultures. J Comp Neurol. 2000 Jul 17; 423(1):112-20. PMID: 10861540.
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    55. Dammerman RS, Flint AC, Noctor S, Kriegstein AR. An excitatory GABAergic plexus in developing neocortical layer 1. J Neurophysiol. 2000 Jul; 84(1):428-34. PMID: 10899216.
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    56. Hook VY, Noctor S, Sei CA, Toneff T, Yasothornsrikul S, Kang YH. Evidence for functional localization of the proenkephalin-processing enzyme, prohormone thiol protease, to secretory vesicles of chromaffin cells. Endocrinology. 1999 Aug; 140(8):3744-54. PMID: 10433235.
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    57. Noctor SC, Palmer SL, Hasling T, Juliano SL. Interference with the development of early generated neocortex results in disruption of radial glia and abnormal formation of neocortical layers. Cereb Cortex. 1999 Mar; 9(2):121-36. PMID: 10220225.
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    58. Noctor SC, Scholnicoff NJ, Juliano SL. Histogenesis of ferret somatosensory cortex. J Comp Neurol. 1997 Oct 20; 387(2):179-93. PMID: 9336222.
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    59. Juliano SL, Palmer SL, Sonty RV, Noctor S, Hill GF. Development of local connections in ferret somatosensory cortex. J Comp Neurol. 1996 Oct 14; 374(2):259-77. PMID: 8906498.
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    60. Tezapsidis N, Noctor S, Kannan R, Krieger TJ, Mende-Mueller L, Hook VY. Stimulation of "prohormone thiol protease" (PTP) and [Met]enkephalin by forskolin. Blockade of elevated [Met]enkephalin by a cysteine protease inhibitor of PTP. J Biol Chem. 1995 Jun 02; 270(22):13285-90. PMID: 7768928.
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    61. Guldenaar SE, Noctor SC, McCabe JT. Fos-like immunoreactivity in the brain of homozygous diabetes insipidus Brattleboro and normal Long-Evans rats. J Comp Neurol. 1992 Aug 15; 322(3):439-48. PMID: 1517486.
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