Richart W Harper

Title(s)Professor, MED: Int Med Pulmonary, Critical Care, and Sleep Medicine
SchoolSchool of Medicine
AddressPSSB/UCDMC
CA 95817
Phone916-734-3564
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    Other Positions
    Title(s)Professor in Residence, MED: Int Med Pulmonary, Critical Care, and Sleep Medicine


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Defining VOC signatures of airway epithelial cells with PM2.5 exposure. Toxicol Sci. 2025 Jan 01; 203(1):88-95. Linderholm AL, Borras E, Aribindi K, Jones LL, Rojas DE, Bein K, McCartney MM, Davis CE, Harper RW, Kenyon NJ. PMID: 39475431; PMCID: PMC11664101.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Bioreactor contamination monitoring using off-gassed volatile organic compounds (VOCs). Anal Bioanal Chem. 2024 Dec 26. Linderholm AL, Bhandari MP, Borras E, Kwon A, Herve FM, McCartney MM, Harper RW, Kenyon NJ, Davis CE. PMID: 39724424.
      View in: PubMed   Mentions:    Fields:    
    3. Using the ROX Index to Predict Treatment Outcome for High-Flow Nasal Cannula and/or Noninvasive Ventilation in Patients With COPD Exacerbations. Respir Care. 2024 08 24; 69(9):1100-1107. Schaeffer BZ, Fazio SA, Stocking JC, Adams JY, Liu A, Black HB, Harper RW, Cortes-Puch I, Albertson TE, Kuhn BT. PMID: 38653556; PMCID: PMC11349586.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Oxylipin concentration shift in exhaled breath condensate (EBC) of SARS-CoV-2 infected patients. J Breath Res. 2023 08 07; 17(4). Borras E, McCartney MM, Rojas DE, Hicks TL, Tran NK, Tham T, Juarez MM, Franzi L, Harper RW, Davis CE, Kenyon NJ. PMID: 37489864; PMCID: PMC10446499.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    5. Work of Breathing During Proportional Assist Ventilation as a Predictor of Extubation Failure. Respir Care. 2023 08; 68(8):1049-1057. Fazio SA, Lin G, Cortés-Puch I, Stocking JC, Tokeshi B, Kuhn BT, Adams JY, Harper R. PMID: 37160340; PMCID: PMC10353166.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Interstitial lung disease progression after genomic usual interstitial pneumonia testing. Eur Respir J. 2023 04; 61(4). Chaudhary S, Weigt SS, Ribeiro Neto ML, Benn BS, Pugashetti JV, Keith R, Chand A, Oh S, Kheir F, Ramalingam V, Solomon JJ, Harper R, Lasky JA, Oldham JM. PMID: 36549706; PMCID: PMC10288658.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. The pharmacotherapeutics of sarcoidosis. Expert Rev Clin Pharmacol. 2022 Jan; 15(1):51-64. Mangialardi P, Harper R, Albertson TE. PMID: 35057691.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Inactivation of SARS-CoV-2 in clinical exhaled breath condensate samples for metabolomic analysis. J Breath Res. 2021 12 20; 16(1). Hu S, McCartney MM, Arredondo J, Sankaran-Walters S, Borras E, Harper RW, Schivo M, Davis CE, Kenyon NJ, Dandekar S. PMID: 34852327; PMCID: PMC9809239.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Predicting Influenza and Rhinovirus Infections in Airway Cells Utilizing Volatile Emissions. J Infect Dis. 2021 11 22; 224(10):1742-1750. McCartney MM, Linderholm AL, Yamaguchi MS, Falcon AK, Harper RW, Thompson GR, Ebeler SE, Kenyon NJ, Davis CE, Schivo M. PMID: 33858010; PMCID: PMC9010222.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    10. A 70-Year-Old Woman With Refractory Hypoxemia. Chest. 2021 09; 160(3):e265-e268. Manoukian MAC, Corbett RL, Mumma BE, Darrow MA, Harper RW. PMID: 34488965.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Role of Dual Oxidases in Ventilator-induced Lung Injury. Am J Respir Cell Mol Biol. 2021 02; 64(2):208-215. Cagle L, Linderholm A, Franzi L, Hoehne S, Last J, Kenyon N, Illek B, Harper R. PMID: 33253594; PMCID: PMC7874397.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Volatile organic compound (VOC) emissions of CHO and T cells correlate to their expansion in bioreactors. J Breath Res. 2019 10 21; 14(1):016002. McCartney MM, Yamaguchi MS, Bowles PA, Gratch YS, Iyer RK, Linderholm AL, Ebeler SE, Kenyon NJ, Schivo M, Harper RW, Goodwin P, Davis CE. PMID: 31430743; PMCID: PMC9770099.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Modeling cellular metabolomic effects of oxidative stress impacts from hydrogen peroxide and cigarette smoke on human lung epithelial cells. J Breath Res. 2019 06 19; 13(3):036014. Yamaguchi MS, McCartney MM, Falcon AK, Linderholm AL, Ebeler SE, Kenyon NJ, Harper RH, Schivo M, Davis CE. PMID: 31063985; PMCID: PMC9798928.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD. Int J Chron Obstruct Pulmon Dis. 2019; 14:1251-1265. Albertson TE, Bowman WS, Harper RW, Godbout RM, Murin S. PMID: 31239659; PMCID: PMC6559138.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. The Club Cell Marker SCGB1A1 Downstream of FOXA2 is Reduced in Asthma. Am J Respir Cell Mol Biol. 2019 06; 60(6):695-704. Zhu L, An L, Ran D, Lizarraga R, Bondy C, Zhou X, Harper RW, Liao SY, Chen Y. PMID: 30576223; PMCID: PMC6543749.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    16. Airway transcriptomic profiling after bronchial thermoplasty. ERJ Open Res. 2019 Feb; 5(1). Liao SY, Linderholm AL, Yoneda KY, Kenyon NJ, Harper RW. PMID: 30792984; PMCID: PMC6378341.
      View in: PubMed   Mentions: 8  
    17. Weight loss as a predictor of mortality in patients with interstitial lung disease. Eur Respir J. 2018 09; 52(3). Pugashetti J, Graham J, Boctor N, Mendez C, Foster E, Juarez M, Harper R, Morrissey B, Kadoch M, Oldham JM. PMID: 30072505; PMCID: PMC6643265.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    18. Biological responses to asbestos inhalation and pathogenesis of asbestos-related benign and malignant disease. J Investig Med. 2018 04; 66(4):721-727. Solbes E, Harper RW. PMID: 29306869.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic Health
    19. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model. PLoS One. 2017; 12(11):e0187419. Cagle LA, Franzi LM, Linderholm AL, Last JA, Adams JY, Harper RW, Kenyon NJ. PMID: 29112971; PMCID: PMC5675408.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    20. Partners in Crime: Epithelial Priming of Macrophages during Viral Infection. Am J Respir Cell Mol Biol. 2017 08; 57(2):145-146. Harper RW. PMID: 28762773.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    21. Early Life Wildfire Smoke Exposure Is Associated with Immune Dysregulation and Lung Function Decrements in Adolescence. Am J Respir Cell Mol Biol. 2017 05; 56(5):657-666. Black C, Gerriets JE, Fontaine JH, Harper RW, Kenyon NJ, Tablin F, Schelegle ES, Miller LA. PMID: 28208028; PMCID: PMC5449494.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCellsPHPublic Health
    22. Parsimony or poor luck: Concurrent Birt-Hogg- Dubé Syndrome and sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2017; 34(2):194-196. Kuhn B, Teckchandani P, Harper R. PMID: 32476844; PMCID: PMC7170139.
      View in: PubMed   Mentions:    Fields:    
    23. Acute Fibrinous and Organizing Pneumonia Associated With Allogenic Hematopoietic Stem Cell Transplant Successfully Treated With Corticosteroids: A Two-Patient Case Series. J Investig Med High Impact Case Rep. 2016 Apr-Jun; 4(2):2324709616643990. Nguyen LP, Ahdoot S, Sriratanaviriyakul N, Zhang Y, Stollenwerk N, Schivo M, Harper R. PMID: 27152316; PMCID: PMC4843051.
      View in: PubMed   Mentions: 12     Fields:    
    24. DUOX-Mediated Signaling Is Not Required for LPS-Induced Neutrophilic Response in the Airways. PLoS One. 2015; 10(7):e0131810. Chang S, Linderholm A, Harper R. PMID: 26148206; PMCID: PMC4493023.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. Patient considerations in the treatment of COPD: focus on the new combination inhaler umeclidinium/vilanterol. Patient Prefer Adherence. 2015; 9:235-42. Albertson TE, Harper R, Murin S, Sandrock C. PMID: 25673975; PMCID: PMC4321647.
      View in: PubMed   Mentions: 7  
    26. Critical asthma syndrome in the ICU. Clin Rev Allergy Immunol. 2015 Feb; 48(1):31-44. Schivo M, Phan C, Louie S, Harper RW. PMID: 25759905.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    27. Immunobiology of the critical asthma syndrome. Clin Rev Allergy Immunol. 2015 Feb; 48(1):54-65. Harper RW, Zeki AA. PMID: 24399247; PMCID: PMC6018052.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    28. Volatile emanations from in vitro airway cells infected with human rhinovirus. J Breath Res. 2014 Sep; 8(3):037110. Schivo M, Aksenov AA, Linderholm AL, McCartney MM, Simmons J, Harper RW, Davis CE. PMID: 25189196; PMCID: PMC4182727.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    29. Cellular scent of influenza virus infection. Chembiochem. 2014 May 05; 15(7):1040-8. Aksenov AA, Sandrock CE, Zhao W, Sankaran S, Schivo M, Harper R, Cardona CJ, Xing Z, Davis CE. PMID: 24719290; PMCID: PMC4104277.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    30. DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid. Inflamm Bowel Dis. 2014 Mar; 20(3):514-24. MacFie TS, Poulsom R, Parker A, Warnes G, Boitsova T, Nijhuis A, Suraweera N, Poehlmann A, Szary J, Feakins R, Jeffery R, Harper RW, Jubb AM, Lindsay JO, Silver A. PMID: 24492313.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    31. Critical Asthma Syndrome in the ICU. Clin Rev Allergy Immunol. 2013 Nov 15. Schivo M, Phan C, Louie S, Harper RW. PMID: 24234835.
      View in: PubMed   Mentions: 1     Fields:    
    32. Dual oxidase regulates neutrophil recruitment in allergic airways. Free Radic Biol Med. 2013 Dec; 65:38-46. Chang S, Linderholm A, Franzi L, Kenyon N, Grasberger H, Harper R. PMID: 23770197; PMCID: PMC3859817.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    33. Progressive cervical myelopathy as presentation of sarcoidosis. J Gen Intern Med. 2013 Jun; 28(6):855-6. Price D, Harper R, Henderson MC. PMID: 23371382; PMCID: PMC3663948.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Sarcoidosis. . 2013 Jan 1; 89-105. Sebat SC, Harper HR. .
      View in: Publisher Site   Mentions:
    35. Cigarette smoke induces MUC5AC protein expression through the activation of Sp1. J Biol Chem. 2012 Aug 10; 287(33):27948-58. Di YP, Zhao J, Harper R. PMID: 22700966; PMCID: PMC3431669.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCellsCTClinical Trials
    36. Dual oxidase 2 bidirectional promoter polymorphisms confer differential immune responses in airway epithelia. Am J Respir Cell Mol Biol. 2012 Oct; 47(4):484-90. Xu C, Linderholm A, Grasberger H, Harper RW. PMID: 22592922; PMCID: PMC3488619.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    37. All-trans retinoic acid mediates DUOX2 expression and function in respiratory tract epithelium. Am J Physiol Lung Cell Mol Physiol. 2010 Aug; 299(2):L215-21. Linderholm AL, Onitsuka J, Xu C, Chiu M, Lee WM, Harper RW. PMID: 20511343; PMCID: PMC2928607.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    38. IFNgamma mediates DUOX2 expression via a STAT-independent signaling pathway. Biochem Biophys Res Commun. 2010 Apr 30; 395(2):270-4. Hill T, Xu C, Harper RW. PMID: 20381453; PMCID: PMC2868382.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    39. Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cells. Am J Respir Cell Mol Biol. 2011 Jan; 44(1):24-33. Xing Z, Harper R, Anunciacion J, Yang Z, Gao W, Qu B, Guan Y, Cardona CJ. PMID: 20118223; PMCID: PMC3159084.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    40. Bench-to-bedside review: rare and common viral infections in the intensive care unit--linking pathophysiology to clinical presentation. Crit Care. 2008; 12(4):219. Stollenwerk N, Harper RW, Sandrock CE. PMID: 18671826; PMCID: PMC2575602.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    41. TRX-ASK1-JNK signaling regulation of cell density-dependent cytotoxicity in cigarette smoke-exposed human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5):L921-31. Lee YC, Chuang CY, Lee PK, Lee JS, Harper RW, Buckpitt AB, Wu R, Oslund K. PMID: 18281606.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsPHPublic Health
    42. Identification of multiple MAPK-mediated transcription factors regulated by tobacco smoke in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L480-90. Zhao J, Harper R, Barchowsky A, Di YP. PMID: 17496060; PMCID: PMC3287033.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    43. Posttranslational nitrotyrosination of alpha-tubulin induces cell cycle arrest and inhibits proliferation of vascular smooth muscle cells. Eur J Cell Biol. 2006 Dec; 85(12):1241-52. Phung AD, Soucek K, Kubala L, Harper RW, Chloë Bulinski J, Eiserich JP. PMID: 17118269.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    44. Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium. FEBS Lett. 2006 Oct 02; 580(22):5150-4. Harper RW, Xu C, McManus M, Heidersbach A, Eiserich JP. PMID: 16970942.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    45. Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications. Prostate. 2006 Jun 15; 66(9):954-65. Soucek K, Kamaid A, Phung AD, Kubala L, Bulinski JC, Harper RW, Eiserich JP. PMID: 16541425.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    46. A 25-year-old patient with spontaneous hemothorax. Chest. 2005 Oct; 128(4):3080-1, 3082-3. Black H, Sigal D, Barnes D, Felisky C, Follette D, Harper R. PMID: 16236990.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    47. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Lett. 2005 Aug 29; 579(21):4911-7. Harper RW, Xu C, Eiserich JP, Chen Y, Kao CY, Thai P, Setiadi H, Wu R. PMID: 16111680.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    48. A reappraisal of the genomic organization of human Nox1 and its splice variants. Arch Biochem Biophys. 2005 Mar 15; 435(2):323-30. Harper RW, Xu C, Soucek K, Setiadi H, Eiserich JP. PMID: 15708375.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    49. Identification of a novel MAGE D2 antisense RNA transcript in human tissues. Biochem Biophys Res Commun. 2004 Nov 05; 324(1):199-204. Harper R, Xu C, Di P, Chen Y, Privalsky M, Wu R. PMID: 15465002.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    50. An evaluation of a blind rotational technique for selective mainstem intubation. Acad Emerg Med. 2004 Oct; 11(10):1105-7. Bair AE, Doherty MJ, Harper R, Albertson TE. PMID: 15466157.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    51. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J Immunol. 2004 Sep 01; 173(5):3482-91. Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R. PMID: 15322213.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    52. Bronchiectasis: sex and gender considerations. Clin Chest Med. 2004 Jun; 25(2):361-72. Morrissey BM, Harper RW. PMID: 15099895.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    53. Severe chronic obstructive pulmonary disease. Clin Rev Allergy Immunol. 2003 Oct; 25(2):151-63. Yoneda KY, Harper RW, Louie S. PMID: 14573882.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    54. Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts. J Biol Chem. 2003 Jan 10; 278(2):1165-73. Di YP, Harper R, Zhao Y, Pahlavan N, Finkbeiner W, Wu R. PMID: 12409287.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    55. Regulation of thioredoxin gene expression by vitamin A in human airway epithelial cells. Am J Respir Cell Mol Biol. 2002 May; 26(5):627-35. Chang WH, Reddy SP, Di YP, Yoneda K, Harper R, Wu R. PMID: 11970916.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    56. Activation of nuclear factor-kappa b transcriptional activity in airway epithelial cells by thioredoxin but not by N-acetyl-cysteine and glutathione. Am J Respir Cell Mol Biol. 2001 Aug; 25(2):178-85. Harper R, Wu K, Chang MM, Yoneda K, Pan R, Reddy SP, Wu R. PMID: 11509327.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    57. A novel mechanism of retinoic acid-enhanced interleukin-8 gene expression in airway epithelium. Am J Respir Cell Mol Biol. 2000 Apr; 22(4):502-10. Chang MM, Harper R, Hyde DM, Wu R. PMID: 10745031.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    58. Recurrent pulmonary embolism associated with Klippel-Trenaunay-Weber syndrome. Chest. 1999 Apr; 115(4):1199-201. Gianlupi A, Harper RW, Dwyre DM, Marelich GP. PMID: 10208231.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
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