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Sumathi Sankaran-Walters

Title(s)Associate Adjunct Professor, Medical Microbiology and Immunology
SchoolUniversity of California, Davis
Phone530-752-3542
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Crakes KR, Santos Rocha C, Grishina I, Hirao LA, Napoli E, Gaulke CA, Fenton A, Datta S, Arredondo J, Marco ML, Sankaran-Walters S, Cortopassi G, Giulivi C, Dandekar S. PPARa-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection. Proc Natl Acad Sci U S A. 2019 Nov 18. PMID: 31740620.
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    2. Gaulke CA, Porter M, Han YH, Sankaran-Walters S, Grishina I, George MD, Dang AT, Ding SW, Jiang G, Korf I, Dandekar S. Correction for Gaulke et al., "Intestinal Epithelial Barrier Disruption through Altered Mucosal MicroRNA Expression in Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections". J Virol. 2018 06 15; 92(12). PMID: 29844248.
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    3. Sankaran-Walters S, Hart R, Dills C. Guardians of the Gut: Enteric Defensins. Front Microbiol. 2017; 8:647. PMID: 28469609.
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    4. Sena AA, Glavan T, Jiang G, Sankaran-Walters S, Grishina I, Dandekar S, Goulart LR. Divergent Annexin A1 expression in periphery and gut is associated with systemic immune activation and impaired gut immune response during SIV infection. Sci Rep. 2016 08 03; 6:31157. PMID: 27484833.
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    5. Kis O, Sankaran-Walters S, Hoque MT, Walmsley SL, Dandekar S, Bendayan R. HIV-1 Alters Intestinal Expression of Drug Transporters and Metabolic Enzymes: Implications for Antiretroviral Drug Disposition. Antimicrob Agents Chemother. 2016 05; 60(5):2771-81. PMID: 26902756.
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    6. Glavan TW, Gaulke CA, Santos Rocha C, Sankaran-Walters S, Hirao LA, Raffatellu M, Jiang G, Bäumler AJ, Goulart LR, Dandekar S. Gut immune dysfunction through impaired innate pattern recognition receptor expression and gut microbiota dysbiosis in chronic SIV infection. Mucosal Immunol. 2016 05; 9(3):677-88. PMID: 26376368.
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    7. Glavan TW, Gaulke CA, Hirao LA, Sankaran-Walters S, Dandekar S. SIV-infection-driven changes of pattern recognition receptor expression in mesenteric lymph nodes and gut microbiota dysbiosis. J Med Primatol. 2015 Oct; 44(5):241-52. PMID: 26275157.
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    8. George MD, Hu W, Billingsley JM, Reeves RK, Sankaran-Walters S, Johnson RP, Dandekar S. Transcriptional profiling of peripheral CD8+T cell responses to SIV?nef and SIVmac251 challenge reveals a link between protective immunity and induction of systemic immunoregulatory mechanisms. Virology. 2014 Nov; 468-470:581-591. PMID: 25282469.
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    9. Hirao LA, Grishina I, Bourry O, Hu WK, Somrit M, Sankaran-Walters S, Gaulke CA, Fenton AN, Li JA, Crawford RW, Chuang F, Tarara R, Marco ML, Bäumler AJ, Cheng H, Dandekar S. Early mucosal sensing of SIV infection by paneth cells induces IL-1ß production and initiates gut epithelial disruption. PLoS Pathog. 2014 Aug; 10(8):e1004311. PMID: 25166758.
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    10. Jiang G, Mendes EA, Kaiser P, Sankaran-Walters S, Tang Y, Weber MG, Melcher GP, Thompson GR, Tanuri A, Pianowski LF, Wong JK, Dandekar S. Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cd-NF-?B signaling. AIDS. 2014 Jul 17; 28(11):1555-66. PMID: 24804860.
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    11. Grishina I, Fenton A, Sankaran-Walters S. Gender differences, aging and hormonal status in mucosal injury and repair. Aging Dis. 2014 Apr; 5(2):160-9. PMID: 24729941.
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    12. Gaulke CA, Porter M, Han YH, Sankaran-Walters S, Grishina I, George MD, Dang AT, Ding SW, Jiang G, Korf I, Dandekar S. Intestinal epithelial barrier disruption through altered mucosal microRNA expression in human immunodeficiency virus and simian immunodeficiency virus infections. J Virol. 2014 Jun; 88(11):6268-80. PMID: 24672033.
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    13. Verhoeven D, George MD, Hu W, Dang AT, Smit-McBride Z, Reay E, Macal M, Fenton A, Sankaran-Walters S, Dandekar S. Enhanced innate antiviral gene expression, IFN-a, and cytolytic responses are predictive of mucosal immune recovery during simian immunodeficiency virus infection. J Immunol. 2014 Apr 01; 192(7):3308-18. PMID: 24610016.
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    14. Ocon S, Murphy C, Dang AT, Sankaran-Walters S, Li CS, Tarara R, Borujerdpur N, Dandekar S, Paster BJ, George MD. Transcription profiling reveals potential mechanisms of dysbiosis in the oral microbiome of rhesus macaques with chronic untreated SIV infection. PLoS One. 2013; 8(11):e80863. PMID: 24312248.
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    15. Sena A, Grishina I, Thai A, Goulart L, Macal M, Fenton A, Li J, Prindiville T, Oliani SM, Dandekar S, Goulart L, Sankaran-Walters S. Dysregulation of anti-inflammatory annexin A1 expression in progressive Crohns Disease. PLoS One. 2013; 8(10):e76969. PMID: 24130820.
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    16. Nagy LH, Grishina I, Macal M, Hirao LA, Hu WK, Sankaran-Walters S, Gaulke CA, Pollard R, Brown J, Suni M, Baumler AJ, Ghanekar S, Marco ML, Dandekar S. Chronic HIV infection enhances the responsiveness of antigen presenting cells to commensal Lactobacillus. PLoS One. 2013; 8(8):e72789. PMID: 24023646.
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    17. Roodgar M, Lackner A, Kaushal D, Sankaran S, Dandekar S, Trask JS, Drake C, Smith DG. Expression levels of 10 candidate genes in lung tissue of vaccinated and TB-infected cynomolgus macaques. J Med Primatol. 2013 Jun; 42(3):161-4. PMID: 23802315.
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    18. Sankaran-Walters S, Macal M, Grishina I, Nagy L, Goulart L, Coolidge K, Li J, Fenton A, Williams T, Miller MK, Flamm J, Prindiville T, George M, Dandekar S. Sex differences matter in the gut: effect on mucosal immune activation and inflammation. Biol Sex Differ. 2013 May 07; 4(1):10. PMID: 23651648.
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    19. Dang AT, Cotton S, Sankaran-Walters S, Li CS, Lee CY, Dandekar S, Paster BJ, George MD. Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patients. BMC Microbiol. 2012 Jul 28; 12:153. PMID: 22838383.
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    20. Lerner P, Guadalupe M, Donovan R, Hung J, Flamm J, Prindiville T, Sankaran-Walters S, Syvanen M, Wong JK, George MD, Dandekar S. The gut mucosal viral reservoir in HIV-infected patients is not the major source of rebound plasma viremia following interruption of highly active antiretroviral therapy. J Virol. 2011 May; 85(10):4772-82. PMID: 21345945.
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    21. Zaragoza MM, Sankaran-Walters S, Canfield DR, Hung JK, Martinez E, Ouellette AJ, Dandekar S. Persistence of gut mucosal innate immune defenses by enteric a-defensin expression in the simian immunodeficiency virus model of AIDS. J Immunol. 2011 Feb 01; 186(3):1589-97. PMID: 21178012.
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    22. Sankaran-Walters S, Ransibrahmanakul K, Grishina I, Hung J, Martinez E, Prindiville T, Dandekar S. Epstein-Barr virus replication linked to B cell proliferation in inflamed areas of colonic mucosa of patients with inflammatory bowel disease. J Clin Virol. 2011 Jan; 50(1):31-6. PMID: 21035384.
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    23. Wong JK, Strain MC, Porrata R, Reay E, Sankaran-Walters S, Ignacio CC, Russell T, Pillai SK, Looney DJ, Dandekar S. In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells. PLoS Pathog. 2010 Jan 29; 6(1):e1000748. PMID: 20126442.
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    24. Paixão TA, Roux CM, den Hartigh AB, Sankaran-Walters S, Dandekar S, Santos RL, Tsolis RM. Establishment of systemic Brucella melitensis infection through the digestive tract requires urease, the type IV secretion system, and lipopolysaccharide O antigen. Infect Immun. 2009 Oct; 77(10):4197-208. PMID: 19651862.
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    25. Shen R, Richter HE, Clements RH, Novak L, Huff K, Bimczok D, Sankaran-Walters S, Dandekar S, Clapham PR, Smythies LE, Smith PD. Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection. J Virol. 2009 Apr; 83(7):3258-67. PMID: 19153236.
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    26. George MD, Verhoeven D, Sankaran S, Glavan T, Reay E, Dandekar S. Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques. Clin Vaccine Immunol. 2009 Feb; 16(2):277-81. PMID: 19091994.
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    27. George MD, Verhoeven D, Sankaran S, Dang AT, Dandekar S. Loss of growth factor receptor signaling in the oral mucosa during primary SIV infection may enhance apoptosis and promote pathogenesis. J Med Primatol. 2008 Dec; 37 Suppl 2:55-61. PMID: 19187431.
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    28. Macal M, Sankaran S, Chun TW, Reay E, Flamm J, Prindiville TJ, Dandekar S. Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses. Mucosal Immunol. 2008 Nov; 1(6):475-88. PMID: 19079215.
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    29. Raffatellu M, Santos RL, Verhoeven DE, George MD, Wilson RP, Winter SE, Godinez I, Sankaran S, Paixao TA, Gordon MA, Kolls JK, Dandekar S, Bäumler AJ. Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat Med. 2008 Apr; 14(4):421-8. PMID: 18376406.
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    30. Verhoeven D, Sankaran S, Silvey M, Dandekar S. Antiviral therapy during primary simian immunodeficiency virus infection fails to prevent acute loss of CD4+ T cells in gut mucosa but enhances their rapid restoration through central memory T cells. J Virol. 2008 Apr; 82(8):4016-27. PMID: 18272585.
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    31. Sankaran S, George MD, Reay E, Guadalupe M, Flamm J, Prindiville T, Dandekar S. Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration. J Virol. 2008 Jan; 82(1):538-45. PMID: 17959677.
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    32. Agarwal A, Sankaran S, Vajpayee M, Sreenivas V, Seth P, Dandekar S. Correlation of immune activation with HIV-1 RNA levels assayed by real-time RT-PCR in HIV-1 subtype C infected patients in Northern India. J Clin Virol. 2007 Dec; 40(4):301-6. PMID: 17962068.
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    33. Verhoeven D, Sankaran S, Dandekar S. Simian immunodeficiency virus infection induces severe loss of intestinal central memory T cells which impairs CD4+ T-cell restoration during antiretroviral therapy. J Med Primatol. 2007 Aug; 36(4-5):219-27. PMID: 17669210.
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    34. Guadalupe M, Sankaran S, George MD, Reay E, Verhoeven D, Shacklett BL, Flamm J, Wegelin J, Prindiville T, Dandekar S. Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection. J Virol. 2006 Aug; 80(16):8236-47. PMID: 16873279.
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    35. Nguyen H, Sankaran S, Dandekar S. Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes. Virology. 2006 Oct 10; 354(1):58-68. PMID: 16876223.
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    36. Sankaran S, Guadalupe M, Reay E, George MD, Flamm J, Prindiville T, Dandekar S. Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9860-5. PMID: 15980151.
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    37. George MD, Reay E, Sankaran S, Dandekar S. Early antiretroviral therapy for simian immunodeficiency virus infection leads to mucosal CD4+ T-cell restoration and enhanced gene expression regulating mucosal repair and regeneration. J Virol. 2005 Mar; 79(5):2709-19. PMID: 15708990.
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    38. Guadalupe M, Reay E, Sankaran S, Prindiville T, Flamm J, McNeil A, Dandekar S. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J Virol. 2003 Nov; 77(21):11708-17. PMID: 14557656.
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    39. George MD, Sankaran S, Reay E, Gelli AC, Dandekar S. High-throughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection. Virology. 2003 Jul 20; 312(1):84-94. PMID: 12890623.
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