Maryam Afkarian

Title(s)	Professor, MED: Int Med Nephrology
School	School of Medicine
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Research

Research Activities and Funding

Molecular signatures of diabetic kidney disease
NIH R01DK104706Apr 25, 2015 - Oct 31, 2020
Role: Principal Investigator

Identifying urinary biomarkers for early type 2 diabetic nephropathy
NIH K23DK089017Sep 15, 2010 - Aug 31, 2016
Role: Principal Investigator

Bibliographic

Publications

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Urine complement proteins are associated with kidney disease progression of type 2 diabetes in Korean and American cohorts. medRxiv. 2024 Aug 17. Yun D, Bae S, Gao Y, Lopez L, Han D, Nicora CD, Kim TY, Moon KC, Kim DK, Fillmore TL, Kim YS, Rosenberg AZ, Wang W, Sarder P, Qian WJ, Afkarian M, Han SS. PMID: 39211860; PMCID: PMC11361241.

View in: PubMed Mentions:
Discovery and generalization of tissue structures from spatial omics data. Cell Rep Methods. 2024 Aug 19; 4(8):100838. Wu Z, Kondo A, McGrady M, Baker EAG, Chidester B, Wu E, Rahim MK, Bracey NA, Charu V, Cho RJ, Cheng JB, Afkarian M, Zou J, Mayer AT, Trevino AE. PMID: 39127044; PMCID: PMC11384092.

View in: PubMed Mentions: Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals
Spatial proteomics of human diabetic kidney disease, from health to class III. Diabetologia. 2024 Sep; 67(9):1962-1979. Kondo A, McGrady M, Nallapothula D, Ali H, Trevino AE, Lam A, Preska R, D'Angio HB, Wu Z, Lopez LN, Badhesha HK, Vargas CR, Ramesh A, Wiegley N, Han SS, Dall'Era M, Jen KY, Mayer AT, Afkarian M. PMID: 39037603.

View in: PubMed Mentions: 1 Fields:
End Endocrinology
Translation:Humans Cells
Comparative Analysis of Protein Quantification by the SomaScan Assay versus Orthogonal Methods in Urine from People with Diabetic Kidney Disease. J Proteome Res. 2024 Jul 05; 23(7):2598-2607. Lopez LN, Durbin-Johnson B, Vargas CR, Ruzinski J, Goodling A, Mehrotra R, Vaisar T, Rocke DM, Afkarian M. PMID: 38965919.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Translation:Humans
Single-cell spatial metabolomics with cell-type specific protein profiling for tissue systems biology. Nat Commun. 2023 Dec 13; 14(1):8260. Hu T, Allam M, Cai S, Henderson W, Yueh B, Garipcan A, Ievlev AV, Afkarian M, Beyaz S, Coskun AF. PMID: 38086839; PMCID: PMC10716522.

View in: PubMed Mentions: 20 Fields:
Bio Biology Sci Science
Translation:Humans
Understanding, and Reversing, Metabolic Memory Is Within Reach. Am J Kidney Dis. 2023 06; 81(6):728-731. Afkarian M. PMID: 36805076.

View in: PubMed Mentions: Fields:
Nep Nephrology
Deficiency of the Src homology phosphatase 2 in podocytes is associated with renoprotective effects in mice under hyperglycemia. Cell Mol Life Sci. 2022 Sep 14; 79(10):516. Hsu MF, Ito Y, Afkarian M, Haj FG. PMID: 36102977; PMCID: PMC10987040.

View in: PubMed Mentions: 1 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Diabetic kidney disease in children and adolescents: an update. Pediatr Nephrol. 2022 11; 37(11):2583-2597. Lopez LN, Wang W, Loomba L, Afkarian M, Butani L. PMID: 34913986; PMCID: PMC9489564.

View in: PubMed Mentions: 8 Fields:
Nep Nephrology Ped Pediatrics
Translation:Humans
Non-Alcoholic Steatohepatitis Severity Associates with FGF21 Level and Kidney Glucose Uptake. Metab Syndr Relat Disord. 2021 11; 19(9):491-497. Sarkar S, Chen S, Spencer B, Situ X, Afkarian M, Matsukuma K, Corwin MT, Wang G. PMID: 34448598; PMCID: PMC10027339.

View in: PubMed Mentions: 3 Fields:
Met Metabolism
Translation:Humans
Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes. N Engl J Med. 2020 06 25; 382(26):2493-2503. Doria A, Galecki AT, Spino C, Pop-Busui R, Cherney DZ, Lingvay I, Parsa A, Rossing P, Sigal RJ, Afkarian M, Aronson R, Caramori ML, Crandall JP, de Boer IH, Elliott TG, Goldfine AB, Haw JS, Hirsch IB, Karger AB, Maahs DM, McGill JB, Molitch ME, Perkins BA, Polsky S, Pragnell M, Robiner WN, Rosas SE, Senior P, Tuttle KR, Umpierrez GE, Wallia A, Weinstock RS, Wu C, Mauer M, PERL Study Group. PMID: 32579810; PMCID: PMC7375708.

View in: PubMed Mentions: 115 Fields:
Med Medicine (General)
Translation:Humans
Preventing Early Renal Loss in Diabetes (PERL) Study: A Randomized Double-Blinded Trial of Allopurinol-Rationale, Design, and Baseline Data. Diabetes Care. 2019 08; 42(8):1454-1463. Afkarian M, Polsky S, Parsa A, Aronson R, Caramori ML, Cherney DZ, Crandall JP, de Boer IH, Elliott TG, Galecki AT, Goldfine AB, Haw JS, Hirsch IB, Karger AB, Lingvay I, Maahs DM, McGill JB, Molitch ME, Perkins BA, Pop-Busui R, Pragnell M, Rosas SE, Rossing P, Senior P, Sigal RJ, Spino C, Tuttle KR, Umpierrez GE, Wallia A, Weinstock RS, Wu C, Mauer M, Doria A, PERL Study Group. PMID: 31186299; PMCID: PMC6647051.

View in: PubMed Mentions: 21 Fields:
End Endocrinology
Translation:Humans
Urinary Renin in Patients and Mice With Diabetic Kidney Disease. Hypertension. 2019 07; 74(1):83-94. Tang J, Wysocki J, Ye M, Vallés PG, Rein J, Shirazi M, Bader M, Gomez RA, Sequeira-Lopez MS, Afkarian M, Batlle D. PMID: 31079532; PMCID: PMC6561816.

View in: PubMed Mentions: 22 Fields:
Vas Vascular Diseases
Translation:Humans Animals
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science. 2019 04 12; 364(6436). Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW. PMID: 30975860; PMCID: PMC7580864.

View in: PubMed Mentions: 380 Fields:
Sci Science
Translation:Humans Cells
Erratum. Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes. Diabetes Care 2018;41:2361-2369. Diabetes Care. 2019 Jun; 42(6):1155. Vaisar T, Durbin-Johnson B, Whitlock K, Babenko I, Mehrotra R, Rocke DM, Afkarian M. PMID: 30936112; PMCID: PMC6609947.

View in: PubMed Mentions: Fields:
End Endocrinology
Co-occurrence of early diabetes-related complications in adolescents and young adults with type 1 diabetes: an observational cohort study. Lancet Child Adolesc Health. 2019 01; 3(1):35-43. Sauder KA, Stafford JM, Mayer-Davis EJ, Jensen ET, Saydah S, Mottl A, Dolan LM, Hamman RF, Lawrence JM, Pihoker C, Marcovina S, D'Agostino RB, Dabelea D, SEARCH for Diabetes in Youth Study Group. PMID: 30409691; PMCID: PMC6295346.

View in: PubMed Mentions: 23 Fields:
Ped Pediatrics
Translation:Humans
The early natural history of albuminuria in young adults with youth-onset type 1 and type 2 diabetes. J Diabetes Complications. 2018 Dec; 32(12):1160-1168. Kahkoska AR, Isom S, Divers J, Mayer-Davis EJ, Dolan L, Shah AS, Afkarian M, Pettitt DJ, Lawrence JM, Marcovina S, Saydah SH, Dabelea D, Maahs DM, Mottl AK, SEARCH for Diabetes in Youth Study Group. PMID: 30316542; PMCID: PMC6289668.

View in: PubMed Mentions: 9 Fields:
End Endocrinology
Translation:Humans
Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes. Diabetes Care. 2018 11; 41(11):2361-2369. Vaisar T, Durbin-Johnson B, Whitlock K, Babenko I, Mehrotra R, Rocke DM, Afkarian M. PMID: 30150236; PMCID: PMC6196831.

View in: PubMed Mentions: 16 Fields:
End Endocrinology
Translation:Humans
Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients. EBioMedicine. 2017 Dec; 26:68-77. Hallan S, Afkarian M, Zelnick LR, Kestenbaum B, Sharma S, Saito R, Darshi M, Barding G, Raftery D, Ju W, Kretzler M, Sharma K, de Boer IH. PMID: 29128444; PMCID: PMC5832558.

View in: PubMed Mentions: 64 Fields:
Gen Genetics Med Medicine (General)
Translation:Humans Cells
Identification, Confirmation, and Replication of Novel Urinary MicroRNA Biomarkers in Lupus Nephritis and Diabetic Nephropathy. Clin Chem. 2017 Sep; 63(9):1515-1526. Cardenas-Gonzalez M, Srivastava A, Pavkovic M, Bijol V, Rennke HG, Stillman IE, Zhang X, Parikh S, Rovin BH, Afkarian M, de Boer IH, Himmelfarb J, Waikar SS, Vaidya VS. PMID: 28667184; PMCID: PMC5610914.

View in: PubMed Mentions: 47 Fields:
Che Chemistry
Translation:Humans Cells
Vitamin D and Albuminuria in Youth with and without Type 1 Diabetes. Horm Res Paediatr. 2017; 87(6):385-395. Nandi-Munshi D, Afkarian M, Whitlock KB, Crandell JL, Bell RA, D'Agostino R, Saydah S, Mottl AK, Dabelea D, Black MH, Mayer-Davis EJ, Pihoker C. PMID: 28554178; PMCID: PMC5568007.

View in: PubMed Mentions: 1 Fields:
End Endocrinology Ped Pediatrics
Translation:Humans CTClinical Trials
Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F487-F494. Wysocki J, Goodling A, Burgaya M, Whitlock K, Ruzinski J, Batlle D, Afkarian M. PMID: 28468961; PMCID: PMC5582909.

View in: PubMed Mentions: 27 Fields:
Nep Nephrology Phy Physiology
Translation:Humans Animals Cells
Absolute Rates of Heart Failure, Coronary Heart Disease, and Stroke in Chronic Kidney Disease: An Analysis of 3 Community-Based Cohort Studies. JAMA Cardiol. 2017 03 01; 2(3):314-318. Bansal N, Katz R, Robinson-Cohen C, Odden MC, Dalrymple L, Shlipak MG, Sarnak MJ, Siscovick DS, Zelnick L, Psaty BM, Kestenbaum B, Correa A, Afkarian M, Young B, de Boer IH. PMID: 28002548; PMCID: PMC5832350.

View in: PubMed Mentions: 59 Fields:
Car Cardiology
Translation:Humans
Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood. JAMA. 2017 02 28; 317(8):825-835. Dabelea D, Stafford JM, Mayer-Davis EJ, D'Agostino R, Dolan L, Imperatore G, Linder B, Lawrence JM, Marcovina SM, Mottl AK, Black MH, Pop-Busui R, Saydah S, Hamman RF, Pihoker C, SEARCH for Diabetes in Youth Research Group. PMID: 28245334; PMCID: PMC5483855.

View in: PubMed Mentions: 270 Fields:
Med Medicine (General)
Translation:Humans
Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets. Am J Physiol Renal Physiol. 2017 04 01; 312(4):F716-F731. Pichler R, Afkarian M, Dieter BP, Tuttle KR. PMID: 27558558; PMCID: PMC6109808.

View in: PubMed Mentions: 116 Fields:
Nep Nephrology Phy Physiology
Translation:Humans Animals Cells
Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 1988-2014. JAMA. 2016 Aug 09; 316(6):602-10. Afkarian M, Zelnick LR, Hall YN, Heagerty PJ, Tuttle K, Weiss NS, de Boer IH. PMID: 27532915; PMCID: PMC5444809.

View in: PubMed Mentions: 387 Fields:
Med Medicine (General)
Translation:Humans
An Optimized Method for Protein Extraction from OCT-Embedded Human Kidney Tissue for Protein Quantification by LC-MS/MS Proteomics. Drug Metab Dispos. 2016 10; 44(10):1692-6. Vrana M, Goodling A, Afkarian M, Prasad B. PMID: 27481856; PMCID: PMC5034699.

View in: PubMed Mentions: 7 Fields:
Pha Pharmacology
Translation:Humans
Serum amyloid a and risk of death and end-stage renal disease in diabetic kidney disease. J Diabetes Complications. 2016 Nov - Dec; 30(8):1467-1472. Dieter BP, McPherson SM, Afkarian M, de Boer IH, Mehrotra R, Short R, Barbosa-Leiker C, Alicic RZ, Meek RL, Tuttle KR. PMID: 27522272; PMCID: PMC5435122.

View in: PubMed Mentions: 16 Fields:
End Endocrinology
Translation:Humans
Diabetes, Kidney Disease, and Cardiovascular Outcomes in the Jackson Heart Study. Clin J Am Soc Nephrol. 2016 08 08; 11(8):1384-1391. Afkarian M, Katz R, Bansal N, Correa A, Kestenbaum B, Himmelfarb J, de Boer IH, Young B. PMID: 27340284; PMCID: PMC4974894.

View in: PubMed Mentions: 27 Fields:
Nep Nephrology
Translation:Humans
Markers of kidney disease and risk of subclinical and clinical heart failure in African Americans: the Jackson Heart Study. Nephrol Dial Transplant. 2016 12; 31(12):2057-2064. Bansal N, Katz R, Himmelfarb J, Afkarian M, Kestenbaum B, de Boer IH, Young B. PMID: 27257276; PMCID: PMC5146707.

View in: PubMed Mentions: 4 Fields:
Nep Nephrology Tra Transplantation
Translation:Humans
Impaired Glucose and Insulin Homeostasis in Moderate-Severe CKD. J Am Soc Nephrol. 2016 09; 27(9):2861-71. de Boer IH, Zelnick L, Afkarian M, Ayers E, Curtin L, Himmelfarb J, Ikizler TA, Kahn SE, Kestenbaum B, Utzschneider K. PMID: 26823551; PMCID: PMC5004653.

View in: PubMed Mentions: 52 Fields:
Nep Nephrology
Translation:Humans
The Surging Tide of Diabetes: Implications for Nephrology. Am J Kidney Dis. 2016 Mar; 67(3):364-6. de Boer IH, Afkarian M, Tuttle KR. PMID: 26725312; PMCID: PMC5013824.

View in: PubMed Mentions: 1 Fields:
Nep Nephrology
Translation:Humans
Urine matrix metalloproteinase-7 and risk of kidney disease progression and mortality in type 2 diabetes. J Diabetes Complications. 2015 Nov-Dec; 29(8):1024-31. Afkarian M, Zelnick LR, Ruzinski J, Kestenbaum B, Himmelfarb J, de Boer IH, Mehrotra R. PMID: 26412030; PMCID: PMC5389898.

View in: PubMed Mentions: 15 Fields:
End Endocrinology
Translation:Humans Cells
A Cluster of Proteins Implicated in Kidney Disease Is Increased in High-Density Lipoprotein Isolated from Hemodialysis Subjects. J Proteome Res. 2015 Jul 02; 14(7):2792-806. Shao B, de Boer I, Tang C, Mayer PS, Zelnick L, Afkarian M, Heinecke JW, Himmelfarb J. PMID: 26011469; PMCID: PMC4636116.

View in: PubMed Mentions: 38 Fields:
Bio Biochemistry
Translation:Humans Cells
Renal outcomes in patients with type 1 diabetes and macroalbuminuria. J Am Soc Nephrol. 2014 Oct; 25(10):2342-50. de Boer IH, Afkarian M, Rue TC, Cleary PA, Lachin JM, Molitch ME, Steffes MW, Sun W, Zinman B, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (D. PMID: 24925722; PMCID: PMC4178441.

View in: PubMed Mentions: 42 Fields:
Nep Nephrology
Translation:Humans
Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease. Physiol Rep. 2014; 2(5):e12010. Afkarian M, Hirsch IB, Tuttle KR, Greenbaum C, Himmelfarb J, de Boer IH. PMID: 24793984; PMCID: PMC4098738.

View in: PubMed Mentions: 10 Fields:
Phy Physiology
Diabetic kidney disease in children and adolescents. Pediatr Nephrol. 2015 Jan; 30(1):65-74; quiz 70-1. Afkarian M. PMID: 24643739; PMCID: PMC4169353.

View in: PubMed Mentions: 21 Fields:
Nep Nephrology Ped Pediatrics
Translation:Humans
Albuminuria according to status of autoimmunity and insulin sensitivity among youth with type 1 and type 2 diabetes. Diabetes Care. 2013 Nov; 36(11):3633-8. Mottl AK, Lauer A, Dabelea D, Maahs DM, D'Agostino RB, Dolan LM, Gilliam LK, Lawrence JM, Rodriguez B, Marcovina SM, Imperatore G, Kanakatti Shankar R, Afkarian M, Reynolds K, Liese AD, Mauer M, Mayer-Davis EJ, SEARCH for Diabetes in Youth Study Group. PMID: 23846811; PMCID: PMC3816857.

View in: PubMed Mentions: 3 Fields:
End Endocrinology
Translation:Humans
Kidney disease and increased mortality risk in type 2 diabetes. J Am Soc Nephrol. 2013 Feb; 24(2):302-8. Afkarian M, Sachs MC, Kestenbaum B, Hirsch IB, Tuttle KR, Himmelfarb J, de Boer IH. PMID: 23362314; PMCID: PMC3559486.

View in: PubMed Mentions: 493 Fields:
Nep Nephrology
Translation:Humans
Diabetic Kidney Disease. . 2013 Jan 1; 547-560. Pichler PR, de Boer dI, Diaz DM, Afkarian AM. .

View in: Publisher Site Mentions:
Optimizing a proteomics platform for urine biomarker discovery. Mol Cell Proteomics. 2010 Oct; 9(10):2195-204. Afkarian M, Bhasin M, Dillon ST, Guerrero MC, Nelson RG, Knowler WC, Thadhani R, Libermann TA. PMID: 20511394; PMCID: PMC2957724.

View in: PubMed Mentions: 28 Fields:
Bio Biochemistry Cel Cell Biology Mol Molecular Biology
Translation:Humans
Klotho variants and chronic hemodialysis mortality. J Bone Miner Res. 2009 Nov; 24(11):1847-55. Friedman DJ, Afkarian M, Tamez H, Bhan I, Isakova T, Wolf M, Ankers E, Ye J, Tonelli M, Zoccali C, Kuro-o M, Moe O, Karumanchi SA, Thadhani R. PMID: 19419323; PMCID: PMC2765930.

View in: PubMed Mentions: 31 Fields:
Met Metabolism Ort Orthopedics
Translation:Humans
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells. Nat Immunol. 2002 Jun; 3(6):549-57. Afkarian M, Sedy JR, Yang J, Jacobson NG, Cereb N, Yang SY, Murphy TL, Murphy KM. PMID: 12006974.

View in: PubMed Mentions: 380 Fields:
All Allergy and Immunology
Translation:Animals Cells
Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human. J Immunol. 2002 May 01; 168(9):4268-71. Asnagli H, Afkarian M, Murphy KM. PMID: 11970965.

View in: PubMed Mentions: 42 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol. 2002 May; 22(9):3035-45. Nguyen A, Burack WR, Stock JL, Kortum R, Chaika OV, Afkarian M, Muller WJ, Murphy KM, Morrison DK, Lewis RE, McNeish J, Shaw AS. PMID: 11940661; PMCID: PMC133772.

View in: PubMed Mentions: 130 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Signaling and transcription in T helper development. Annu Rev Immunol. 2000; 18:451-94. Murphy KM, Ouyang W, Farrar JD, Yang J, Ranganath S, Asnagli H, Afkarian M, Murphy TL. PMID: 10837066.

View in: PubMed Mentions: 159 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
A rare cryptic translation product is presented by Kb major histocompatibility complex class I molecule to alloreactive T cells. J Exp Med. 1995 Dec 01; 182(6):1739-50. Malarkannan S, Afkarian M, Shastri N. PMID: 7500018; PMCID: PMC2192241.

View in: PubMed Mentions: 17 Fields:
All Allergy and Immunology Med Medicine (General)
Translation:Animals Cells