Maryam Afkarian

Title(s)Professor, Nephrology
SchoolUniversity of California, Davis
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    Molecular signatures of diabetic kidney disease
    NIH R01DK104706Apr 25, 2015 - Oct 31, 2020
    Role: Principal Investigator
    Identifying urinary biomarkers for early type 2 diabetic nephropathy
    NIH K23DK089017Sep 15, 2010 - Aug 31, 2016
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Diabetic kidney disease in children and adolescents: an update. Pediatr Nephrol. 2021 Dec 16. Lopez LN, Wang W, Loomba L, Afkarian M, Butani L. PMID: 34913986.
      View in: PubMed   Mentions:
    2. Non-Alcoholic Steatohepatitis Severity Associates with FGF21 Level and Kidney Glucose Uptake. Metab Syndr Relat Disord. 2021 11; 19(9):491-497. Sarkar S, Chen S, Spencer B, Situ X, Afkarian M, Matsukuma K, Corwin MT, Wang G. PMID: 34448598.
      View in: PubMed   Mentions:    Fields:    
    3. Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes. N Engl J Med. 2020 06 25; 382(26):2493-2503. Doria A, Galecki AT, Spino C, Pop-Busui R, Cherney DZ, Lingvay I, Parsa A, Rossing P, Sigal RJ, Afkarian M, Aronson R, Caramori ML, Crandall JP, de Boer IH, Elliott TG, Goldfine AB, Haw JS, Hirsch IB, Karger AB, Maahs DM, McGill JB, Molitch ME, Perkins BA, Polsky S, Pragnell M, Robiner WN, Rosas SE, Senior P, Tuttle KR, Umpierrez GE, Wallia A, Weinstock RS, Wu C, Mauer M, PERL Study Group. PMID: 32579810; PMCID: PMC7375708.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    4. Preventing Early Renal Loss in Diabetes (PERL) Study: A Randomized Double-Blinded Trial of Allopurinol-Rationale, Design, and Baseline Data. Diabetes Care. 2019 08; 42(8):1454-1463. Afkarian M, Polsky S, Parsa A, Aronson R, Caramori ML, Cherney DZ, Crandall JP, de Boer IH, Elliott TG, Galecki AT, Goldfine AB, Haw JS, Hirsch IB, Karger AB, Lingvay I, Maahs DM, McGill JB, Molitch ME, Perkins BA, Pop-Busui R, Pragnell M, Rosas SE, Rossing P, Senior P, Sigal RJ, Spino C, Tuttle KR, Umpierrez GE, Wallia A, Weinstock RS, Wu C, Mauer M, Doria A, PERL Study Group. PMID: 31186299; PMCID: PMC6647051.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    5. Urinary Renin in Patients and Mice With Diabetic Kidney Disease. Hypertension. 2019 07; 74(1):83-94. Tang J, Wysocki J, Ye M, Vallés PG, Rein J, Shirazi M, Bader M, Gomez RA, Sequeira-Lopez MS, Afkarian M, Batlle D. PMID: 31079532; PMCID: PMC6561816.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    6. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science. 2019 04 12; 364(6436). Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW. PMID: 30975860; PMCID: PMC7580864.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    7. Erratum. Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes. Diabetes Care 2018;41:2361-2369. Diabetes Care. 2019 Jun; 42(6):1155. Vaisar T, Durbin-Johnson B, Whitlock K, Babenko I, Mehrotra R, Rocke DM, Afkarian M. PMID: 30936112; PMCID: PMC6609947.
      View in: PubMed   Mentions:    Fields:    
    8. Co-occurrence of early diabetes-related complications in adolescents and young adults with type 1 diabetes: an observational cohort study. Lancet Child Adolesc Health. 2019 01; 3(1):35-43. Sauder KA, Stafford JM, Mayer-Davis EJ, Jensen ET, Saydah S, Mottl A, Dolan LM, Hamman RF, Lawrence JM, Pihoker C, Marcovina S, D'Agostino RB, Dabelea D, SEARCH for Diabetes in Youth Study Group. PMID: 30409691; PMCID: PMC6295346.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    9. The early natural history of albuminuria in young adults with youth-onset type 1 and type 2 diabetes. J Diabetes Complications. 2018 Dec; 32(12):1160-1168. Kahkoska AR, Isom S, Divers J, Mayer-Davis EJ, Dolan L, Shah AS, Afkarian M, Pettitt DJ, Lawrence JM, Marcovina S, Saydah SH, Dabelea D, Maahs DM, Mottl AK, SEARCH for Diabetes in Youth Study Group. PMID: 30316542; PMCID: PMC6289668.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes. Diabetes Care. 2018 11; 41(11):2361-2369. Vaisar T, Durbin-Johnson B, Whitlock K, Babenko I, Mehrotra R, Rocke DM, Afkarian M. PMID: 30150236; PMCID: PMC6196831.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients. EBioMedicine. 2017 Dec; 26:68-77. Hallan S, Afkarian M, Zelnick LR, Kestenbaum B, Sharma S, Saito R, Darshi M, Barding G, Raftery D, Ju W, Kretzler M, Sharma K, de Boer IH. PMID: 29128444; PMCID: PMC5832558.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    12. Identification, Confirmation, and Replication of Novel Urinary MicroRNA Biomarkers in Lupus Nephritis and Diabetic Nephropathy. Clin Chem. 2017 Sep; 63(9):1515-1526. Cardenas-Gonzalez M, Srivastava A, Pavkovic M, Bijol V, Rennke HG, Stillman IE, Zhang X, Parikh S, Rovin BH, Afkarian M, de Boer IH, Himmelfarb J, Waikar SS, Vaidya VS. PMID: 28667184; PMCID: PMC5610914.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    13. Vitamin D and Albuminuria in Youth with and without Type 1 Diabetes. Horm Res Paediatr. 2017; 87(6):385-395. Nandi-Munshi D, Afkarian M, Whitlock KB, Crandell JL, Bell RA, D'Agostino R, Saydah S, Mottl AK, Dabelea D, Black MH, Mayer-Davis EJ, Pihoker C. PMID: 28554178; PMCID: PMC5568007.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    14. Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F487-F494. Wysocki J, Goodling A, Burgaya M, Whitlock K, Ruzinski J, Batlle D, Afkarian M. PMID: 28468961; PMCID: PMC5582909.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    15. Absolute Rates of Heart Failure, Coronary Heart Disease, and Stroke in Chronic Kidney Disease: An Analysis of 3 Community-Based Cohort Studies. JAMA Cardiol. 2017 03 01; 2(3):314-318. Bansal N, Katz R, Robinson-Cohen C, Odden MC, Dalrymple L, Shlipak MG, Sarnak MJ, Siscovick DS, Zelnick L, Psaty BM, Kestenbaum B, Correa A, Afkarian M, Young B, de Boer IH. PMID: 28002548; PMCID: PMC5832350.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    16. Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood. JAMA. 2017 02 28; 317(8):825-835. Dabelea D, Stafford JM, Mayer-Davis EJ, D'Agostino R, Dolan L, Imperatore G, Linder B, Lawrence JM, Marcovina SM, Mottl AK, Black MH, Pop-Busui R, Saydah S, Hamman RF, Pihoker C, SEARCH for Diabetes in Youth Research Group. PMID: 28245334; PMCID: PMC5483855.
      View in: PubMed   Mentions: 124     Fields:    Translation:Humans
    17. Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets. Am J Physiol Renal Physiol. 2017 04 01; 312(4):F716-F731. Pichler R, Afkarian M, Dieter BP, Tuttle KR. PMID: 27558558; PMCID: PMC6109808.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    18. Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 1988-2014. JAMA. 2016 Aug 09; 316(6):602-10. Afkarian M, Zelnick LR, Hall YN, Heagerty PJ, Tuttle K, Weiss NS, de Boer IH. PMID: 27532915; PMCID: PMC5444809.
      View in: PubMed   Mentions: 171     Fields:    Translation:Humans
    19. An Optimized Method for Protein Extraction from OCT-Embedded Human Kidney Tissue for Protein Quantification by LC-MS/MS Proteomics. Drug Metab Dispos. 2016 10; 44(10):1692-6. Vrana M, Goodling A, Afkarian M, Prasad B. PMID: 27481856; PMCID: PMC5034699.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    20. Serum amyloid a and risk of death and end-stage renal disease in diabetic kidney disease. J Diabetes Complications. 2016 Nov - Dec; 30(8):1467-1472. Dieter BP, McPherson SM, Afkarian M, de Boer IH, Mehrotra R, Short R, Barbosa-Leiker C, Alicic RZ, Meek RL, Tuttle KR. PMID: 27522272; PMCID: PMC5435122.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    21. Diabetes, Kidney Disease, and Cardiovascular Outcomes in the Jackson Heart Study. Clin J Am Soc Nephrol. 2016 08 08; 11(8):1384-91. Afkarian M, Katz R, Bansal N, Correa A, Kestenbaum B, Himmelfarb J, de Boer IH, Young B. PMID: 27340284; PMCID: PMC4974894.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    22. Markers of kidney disease and risk of subclinical and clinical heart failure in African Americans: the Jackson Heart Study. Nephrol Dial Transplant. 2016 12; 31(12):2057-2064. Bansal N, Katz R, Himmelfarb J, Afkarian M, Kestenbaum B, de Boer IH, Young B. PMID: 27257276; PMCID: PMC5146707.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Impaired Glucose and Insulin Homeostasis in Moderate-Severe CKD. J Am Soc Nephrol. 2016 09; 27(9):2861-71. de Boer IH, Zelnick L, Afkarian M, Ayers E, Curtin L, Himmelfarb J, Ikizler TA, Kahn SE, Kestenbaum B, Utzschneider K. PMID: 26823551; PMCID: PMC5004653.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    24. The Surging Tide of Diabetes: Implications for Nephrology. Am J Kidney Dis. 2016 Mar; 67(3):364-6. de Boer IH, Afkarian M, Tuttle KR. PMID: 26725312; PMCID: PMC5013824.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Urine matrix metalloproteinase-7 and risk of kidney disease progression and mortality in type 2 diabetes. J Diabetes Complications. 2015 Nov-Dec; 29(8):1024-31. Afkarian M, Zelnick LR, Ruzinski J, Kestenbaum B, Himmelfarb J, de Boer IH, Mehrotra R. PMID: 26412030; PMCID: PMC5389898.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    26. A Cluster of Proteins Implicated in Kidney Disease Is Increased in High-Density Lipoprotein Isolated from Hemodialysis Subjects. J Proteome Res. 2015 Jul 02; 14(7):2792-806. Shao B, de Boer I, Tang C, Mayer PS, Zelnick L, Afkarian M, Heinecke JW, Himmelfarb J. PMID: 26011469; PMCID: PMC4636116.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    27. Renal outcomes in patients with type 1 diabetes and macroalbuminuria. J Am Soc Nephrol. 2014 Oct; 25(10):2342-50. de Boer IH, Afkarian M, Rue TC, Cleary PA, Lachin JM, Molitch ME, Steffes MW, Sun W, Zinman B, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (D. PMID: 24925722; PMCID: PMC4178441.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    28. Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease. Physiol Rep. 2014; 2(5):e12010. Afkarian M, Hirsch IB, Tuttle KR, Greenbaum C, Himmelfarb J, de Boer IH. PMID: 24793984; PMCID: PMC4098738.
      View in: PubMed   Mentions: 6     Fields:    
    29. Diabetic kidney disease in children and adolescents. Pediatr Nephrol. 2015 Jan; 30(1):65-74; quiz 70-1. Afkarian M. PMID: 24643739; PMCID: PMC4169353.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    30. Albuminuria according to status of autoimmunity and insulin sensitivity among youth with type 1 and type 2 diabetes. Diabetes Care. 2013 Nov; 36(11):3633-8. Mottl AK, Lauer A, Dabelea D, Maahs DM, D'Agostino RB, Dolan LM, Gilliam LK, Lawrence JM, Rodriguez B, Marcovina SM, Imperatore G, Kanakatti Shankar R, Afkarian M, Reynolds K, Liese AD, Mauer M, Mayer-Davis EJ, SEARCH for Diabetes in Youth Study Group. PMID: 23846811; PMCID: PMC3816857.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. Kidney disease and increased mortality risk in type 2 diabetes. J Am Soc Nephrol. 2013 Feb; 24(2):302-8. Afkarian M, Sachs MC, Kestenbaum B, Hirsch IB, Tuttle KR, Himmelfarb J, de Boer IH. PMID: 23362314; PMCID: PMC3559486.
      View in: PubMed   Mentions: 264     Fields:    Translation:Humans
    32. Diabetic Kidney Disease. . 2013 Jan 1; 547-560. Pichler PR, de Boer dI, Diaz DM, Afkarian AM. .
      View in: Publisher Site   Mentions:
    33. Optimizing a proteomics platform for urine biomarker discovery. Mol Cell Proteomics. 2010 Oct; 9(10):2195-204. Afkarian M, Bhasin M, Dillon ST, Guerrero MC, Nelson RG, Knowler WC, Thadhani R, Libermann TA. PMID: 20511394; PMCID: PMC2957724.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    34. Klotho variants and chronic hemodialysis mortality. J Bone Miner Res. 2009 Nov; 24(11):1847-55. Friedman DJ, Afkarian M, Tamez H, Bhan I, Isakova T, Wolf M, Ankers E, Ye J, Tonelli M, Zoccali C, Kuro-o M, Moe O, Karumanchi SA, Thadhani R. PMID: 19419323; PMCID: PMC2765930.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    35. T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells. Nat Immunol. 2002 Jun; 3(6):549-57. Afkarian M, Sedy JR, Yang J, Jacobson NG, Cereb N, Yang SY, Murphy TL, Murphy KM. PMID: 12006974.
      View in: PubMed   Mentions: 323     Fields:    Translation:AnimalsCells
    36. Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human. J Immunol. 2002 May 01; 168(9):4268-71. Asnagli H, Afkarian M, Murphy KM. PMID: 11970965.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    37. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol. 2002 May; 22(9):3035-45. Nguyen A, Burack WR, Stock JL, Kortum R, Chaika OV, Afkarian M, Muller WJ, Murphy KM, Morrison DK, Lewis RE, McNeish J, Shaw AS. PMID: 11940661; PMCID: PMC133772.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    38. Signaling and transcription in T helper development. Annu Rev Immunol. 2000; 18:451-94. Murphy KM, Ouyang W, Farrar JD, Yang J, Ranganath S, Asnagli H, Afkarian M, Murphy TL. PMID: 10837066.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    39. A rare cryptic translation product is presented by Kb major histocompatibility complex class I molecule to alloreactive T cells. J Exp Med. 1995 Dec 01; 182(6):1739-50. Malarkannan S, Afkarian M, Shastri N. PMID: 7500018; PMCID: PMC2192241.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
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