Brian Leonard

Title(s)Associate Professor, VM: Surgery/Radiology Science
SchoolSchool of Veterinary Medicine
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    Defining a new model of evaporative dry eye disease
    NIH R21EY037056May 1, 2025 - Apr 30, 2028
    Role: Principal Investigator
    Modulation of Hsp90 signaling to limit corneal fibrosis and improve ocular drug penetration
    NIH K08EY028199Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Limited Efficacy of Autologous Mesenchymal Stromal Cell Injections in Immunomodulatory-Dependent Dogs With Aqueous Deficient Dry Eye Disease. Vet Ophthalmol. 2026 Sep; 29(5):e70233. Leonard BC, Park SA, Kim SY, Hayashi K, Thomasy SM, Rozo V, Motta MJ, Borjesson DL, Murphy CJ, Good KL. PMID: 42487272; PMCID: PMC13392327.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Interplay between ferroptosis and guttae in an early-onset murine model of Fuchs' endothelial corneal dystrophy (FECD). bioRxiv. 2026 Jul 10. Handel KW, Lim J, Iwashita H, Khan S, Shevalye H, Park S, Echeverria N, Ferneding M, Khan MJ, Roszak KP, Donovan GL, Iwamoto M, Shim J, Young LJ, Ardon M, Le S, Leonard BC, Skeie JM, Greiner MA, Thomasy SM. PMID: 42465516; PMCID: PMC13370965.
      View in: PubMed   Mentions:
    3. Rhesus macaques with an OPA1 mutation demonstrate features of autosomal dominant optic atrophy. Proc Natl Acad Sci U S A. 2026 Apr 21; 123(16):e2509165123. Jaggers TN, Ripolles-Garcia A, Moshiri A, Story BD, Wang J, Chen R, Moore LG, Teixeira LBC, Shim J, Raposo AC, Casanova MI, Le SM, Park S, Young LJ, Kim S, Roszak KP, Ureno V, Karpinen PM, Echeverria N, Ardon M, Leonard BC, Knipe M, Bliss-Moreau E, Fortune B, Stout JT, Rogers J, Marsh-Armstrong N, Thomasy SM. PMID: 41984835; PMCID: PMC13099570.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Zfp503 haploinsufficiency causes optic nerve coloboma in mice. Exp Eye Res. 2026 Jun; 267:110985. Wong-Fortunato J, Yang B, Lanoue L, Jacobo Lopez A, Luxardi G, Kasiri N, Minella A, Imai DM, Thomasy SM, Ren Y, Bacha T, Sadegh C, Boobalan E, Brooks BP, Lloyd KK, Leonard BC, Moshiri A. PMID: 41887347.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. Topical Application of a Novel Harderian-Derived Nonpolar Lipid Prolongs Tear Film Breakup Time in Normal Beagle Dogs. J Ocul Pharmacol Ther. 2026 Jan-Feb; 42(1):38-44. Lantyer-Araujo NL, Park S, Hisey EA, Thomasy SM, Murphy CJ, Albert DM, O'Neill CA, Gadek TR, Parikh AN, Leonard BC. PMID: 40986539; PMCID: PMC13102128.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. TAZ (Wwtr1) deficiency leads to ER stress and mitochondrial dysfunction in a mouse model of Fuchs' endothelial corneal dystrophy. bioRxiv. 2026 Feb 19. Park S, Ramarapu R, Lim J, Khan S, Khan MJ, Stoehr WR, Leonard BC, Thomasy SM. PMID: 41756894; PMCID: PMC12934714.
      View in: PubMed   Mentions:
    7. The role of epithelial membrane-associated mucin 4 in ocular surface health and corneal wound healing. Front Med (Lausanne). 2025; 12:1720986. Adelman SA, Hisey EA, Park S, Lantyer-Araujo N, Quan MM, Sandberg K, Khan S, Khan M, Dreyer CA, Thomasy SM, Carraway KL, Morgan JT, Leonard BC. PMID: 41608418; PMCID: PMC12835331.
      View in: PubMed   Mentions: 1  
    8. Regulation, responsibility, and resource complexity: A qualitative evaluation of stakeholder perspectives on Ireland's Nitrates Action Programme for dairy farms. J Dairy Sci. 2025 Nov 27. Kelly E, Leonard B, McCormack M, Mulkerrins D. PMID: 41317856.
      View in: PubMed   Mentions:    Fields:    
    9. Pipeline: Pharmacotherapy of dry eye disease in vertebrates. Ocul Surf. 2026 Jan; 39:79-81. Novack GD, Thomasy SM, Leonard B. PMID: 41205650.
      View in: PubMed   Mentions:    Fields:    
    10. Risk Factors and Treatment Outcomes for Canine Spontaneous Chronic Corneal Epithelial Defects (SCCED): 335 Cases Within a Reference Population. Vet Ophthalmol. 2026 Mar; 29(2):e70059. Bromberg RB, Roszak K, Ripolles-Garcia A, Brady RV, Blandino A, Leonard BC, Martins BC, Good KL, Kim S, Thomasy SM. PMID: 40814849.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes. Invest Ophthalmol Vis Sci. 2025 06 02; 66(6):64. Hang A, Shao A, Shea M, Roux MJ, Imai-Leonard DM, Adams DJ, Amano T, Amarie OV, Berberovic Z, Bour R, Bower L, Leonard BC, Brown SD, Cho SY, Clementson-Mobbs S, D'Souza AJ, Dickinson M, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Heaney J, Hérault Y, Hrabe de Angelis M, Hsu CW, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Salazar J, Seavitt JR, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Sorg T, Stewart M, Tamura M, Tolentino H, Udensi U, Wells S, Wurst W, Yoshiki A, Meziane H, Yiu G, Sieving PA, Lanoue L, Lloyd KCK, McKerlie C, Moshiri A, International Mouse Phenotyping Consortium (IMPC). PMID: 40548636; PMCID: PMC12186831.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    12. Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies. Invest Ophthalmol Vis Sci. 2025 May 01; 66(5):7. Briere A, Vo P, Yang B, Adams D, Amano T, Amarie O, Berberovic Z, Bower L, Brown SDM, Burrill S, Cho SY, Clementson-Mobbs S, D'souza A, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Hérault Y, Hrabe de Angelis M, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Meziane H, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Salazar J, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Stewart M, Svenson K, Tamura M, Tolentino H, Wells S, Wurst W, Yoshiki A, Lanoue L, Lloyd KCK, Leonard BC, Roux MJ, McKerlie C, Moshiri A, International Mouse Phenotyping Consortium. PMID: 40323269; PMCID: PMC12060066.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. Clic6 Deficiency Triggers Aberrant Apical Microvilli in RPE. Invest Ophthalmol Vis Sci. 2025 May 01; 66(5):44. Park S, Suvarnpradip N, Kasiri N, Yiu G, Thomasy SM, Imai DM, Lloyd KCK, Leonard BC, Moshiri A. PMID: 40434344; PMCID: PMC12126129.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    14. Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes. BMC Genomics. 2025 Jan 20; 26(1):48. Vo P, Imai-Leonard DM, Yang B, Briere A, Shao A, Casanova MI, Adams D, Amano T, Amarie O, Berberovic Z, Bower L, Braun R, Brown S, Burrill S, Cho SY, Clementson-Mobbs S, D'Souza A, Dickinson M, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Heaney J, Hérault Y, Angelis MH, Hsu CW, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Meziane H, Murray S, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Ryan J, Salazar J, Seavey Z, Seavitt JR, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Stewart M, Svenson K, Tamura M, Tolentino H, Udensi U, Wells S, White J, Willett A, Wotton J, Wurst W, Yoshiki A, International Mouse Phenotyping Consortium, Lanoue L, Lloyd KCK, Leonard BC, Roux MJ, McKerlie C, Moshiri A. PMID: 39833678; PMCID: PMC11744888.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    15. Application of OSA-VET® and qualiquantitative tear tests in brachycephalic dogs with and without keratoconjunctivitis sicca. Vet Res Commun. 2024 Nov 26; 49(1):40. Voitena JN, Brito FLC, Marinho TOC, Montiani-Ferreira F, Cremonini DN, Chiurciu JLV, Jesus NS, Leonard BC, da Cunha O. PMID: 39589642.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    16. Meibomian gland lipid alterations and ocular surface sequela in Awat2 knockout murine model of meibomian gland dysfunction and evaporative dry eye disease. Ocul Surf. 2024 10; 34:489-503. Hisey EA, Wong S, Park S, Gamarra KA, Adelman SA, Knickelbein KE, Quan M, Ferneding MH, McCorkell M, Daley N, Ureno V, Le S, Ardon M, Williams L, Puentes B, Bowman M, Motta MJ, Pham HQH, Wilkerson A, Yuksel S, Jester JV, Thomasy SM, Morgan JT, Butovich IA, Leonard BC. PMID: 39414024; PMCID: PMC11879417.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    17. Contrast computed tomography dacryocystorhinography identifies nasolacrimal duct obstruction secondary to chronic dental disease in two chinchilla langeria. Vet Ophthalmol. 2025 Nov; 28(6):983-989. Hisey EA, Rodriguez P, Tarbert DK, Paul-Murphy JR, Hendrickson C, Brust K, Maggs DJ, Leonard BC. PMID: 39331564; PMCID: PMC11946921.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    18. The effects of age and dysfunction on meibomian gland population dynamics. Ocul Surf. 2024 10; 34:194-209. Wiedemann J, Kashgari G, Lane S, Leonard BC, Knickelbein KE, Andersen B, Jester JV. PMID: 39122180; PMCID: PMC11884644.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    19. Development and validation of a method to generate phenol red thread tests. Ocul Surf. 2024 10; 34:262-266. Puentes B, Hisey EA, Ferneding M, Ureno VN, Do MAH, Karpinen PM, Luo CC, Thomasy SM, Leonard BC. PMID: 39127389; PMCID: PMC11913062.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    20. Biomechanic, proteomic and miRNA transcriptional changes in the trabecular meshwork of primates injected with intravitreal triamcinolone. Vision Res. 2024 09; 222:108456. Park S, Raghunathan VK, Ramarapu R, Moshiri A, Yiu G, Casanova MI, Cosert K, McCorkell M, Leonard BC, Thomasy SM. PMID: 38991466; PMCID: PMC12861077.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    21. Topical netarsudil for the treatment of primary corneal endothelial degeneration in dogs. Sci Rep. 2024 03 14; 14(1):6238. Casanova MI, Park S, Mayes MA, Roszak K, Ferneding M, Echeverria N, Bowman MAW, Michalak SR, Ardon M, Wong S, Le SM, Daley N, Leonard BC, Good KL, Li JY, Thomasy SM. PMID: 38485975; PMCID: PMC10940293.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    22. Concerns About a Dog Model of Dry Eye Disease. Transl Vis Sci Technol. 2024 03 01; 13(3):28. Ofri R, Millichamp NJ, Keller C, McLellan GJ, Komáromy AM, Morton D, Matas M, Michau TM, Coall S, Sansom J, Leonard BC. PMID: 38547120; PMCID: PMC10981438.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    23. Squishy matters - Corneal mechanobiology in health and disease. Prog Retin Eye Res. 2024 03; 99:101234. Thomasy SM, Leonard BC, Greiner MA, Skeie JM, Raghunathan VK. PMID: 38176611; PMCID: PMC11193890.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    24. Preliminary evaluation of safety and migration of immune activated mesenchymal stromal cells administered by subconjunctival injection for equine recurrent uveitis. Front Vet Sci. 2023; 10:1293199. Cassano JM, Leonard BC, Martins BC, Vapniarsky N, Morgan JT, Dow SW, Wotman KL, Pezzanite LM. PMID: 38162475; PMCID: PMC10757620.
      View in: PubMed   Mentions: 4  
    25. Safety and Efficacy of Adeno-Associated Viral Gene Therapy in Patients With Retinal Degeneration: A Systematic Review and Meta-Analysis. Transl Vis Sci Technol. 2023 11 01; 12(11):24. Sobh M, Lagali PS, Ghiasi M, Montroy J, Dollin M, Hurley B, Leonard BC, Dimopoulos I, Lafreniere M, Fergusson DA, Lalu MM, Tsilfidis C. PMID: 37982768; PMCID: PMC10668613.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    26. Oculosystemic pneumocystosis in 2 sibling Chihuahuas. J Vet Intern Med. 2023 May-Jun; 37(3):1179-1185. Johnson LR, Hulsebosch SE, Viall AK, Danesi P, Woolard KD, Cook SE, Maggs DJ, Leonard BC. PMID: 37134072; PMCID: PMC10229366.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    27. Veterinary Ophthalmology-Ocular Surface Diseases. Vet Ophthalmol. 2023 04; 26 Suppl 1:4. Leonard BC, Sebbag L. PMID: 37096793.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    28. Mice Deficient in TAZ (Wwtr1) Demonstrate Clinical Features of Late-Onset Fuchs' Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci. 2023 04 03; 64(4):22. Leonard BC, Park S, Kim S, Young LJ, Jalilian I, Cosert K, Zhang X, Skeie JM, Shevalye H, Echeverria N, Rozo V, Gong X, Xing C, Murphy CJ, Greiner MA, Mootha VV, Raghunathan VK, Thomasy SM. PMID: 37074694; PMCID: PMC10132321.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    29. COVID-19 as a polymorphic inflammatory spectrum of diseases: a review with focus on the brain. Acta Neuropsychiatr. 2023 Oct; 35(5):248-269. Tang SW, Helmeste DM, Leonard BE. PMID: 36861428.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    30. Effect of graphene-based nanomaterials on corneal wound healing in vitro. Exp Eye Res. 2023 04; 229:109419. Fukuto A, Kang J, Gates BL, Sannajust K, Pinkerton KE, Van Winkle LS, Kiuchi Y, Leonard BC, Thomasy SM. PMID: 36806671; PMCID: PMC10131158.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    31. A comparative review of evaporative dry eye disease and meibomian gland dysfunction in dogs and humans. Vet Ophthalmol. 2023 Apr; 26 Suppl 1:16-30. Hisey EA, Galor A, Leonard BC. PMID: 36786010; PMCID: PMC10175238.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    32. A review of diagnostic tests for qualitative and quantitative tear film deficiency in dogs. Vet Ophthalmol. 2023 Apr; 26 Suppl 1:5-15. Iwashita H, Sebbag L, Leonard BC, Saito A. PMID: 36575128.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    33. Identification of putative orthologs of clinically relevant antimicrobial peptides in the equine ocular surface and amniotic membrane. Vet Ophthalmol. 2023 Apr; 26 Suppl 1:125-133. Hisey EA, Martins BC, Donnelly CG, Cassano JM, Katzman SA, Murphy CJ, Thomasy SM, Leonard BC. PMID: 36478371; PMCID: PMC10175123.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    34. The TGM2 inhibitor cysteamine hydrochloride does not impact corneal epithelial and stromal wound healing in vitro and in vivo. Exp Eye Res. 2023 01; 226:109338. Minella AL, Casanova MI, Chokshi TJ, Kang J, Cosert K, Gragg MM, Bowman MA, Mccorkell ME, Daley NL, Leonard BC, Murphy CJ, Raghunathan VK, Thomasy SM. PMID: 36470430; PMCID: PMC10120528.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    35. Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility. Sci Rep. 2022 11 08; 12(1):18980. Park S, Casanova MI, Bannasch DL, Daley NL, Kim S, Kuchtey J, Gomes FE, Leonard BC, Good KL, Martins BDC, Murphy CJ, Thomasy SM. PMID: 36348026; PMCID: PMC9643544.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    36. Andrographolide Inhibits Corneal Fibroblast to Myofibroblast Differentiation In Vitro. Biomolecules. 2022 Oct 09; 12(10). Rozo V, Quan M, Aung T, Kang J, Thomasy SM, Leonard BC. PMID: 36291655; PMCID: PMC9599903.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    37. Normal Corneal Thickness and Endothelial Cell Density in Rhesus Macaques (Macaca mulatta). Transl Vis Sci Technol. 2022 09 01; 11(9):23. Casanova MI, Young LJ, Park S, Kim S, Roszak K, Leonard BC, Blandino A, Motta MJ, Yiu G, Li JY, Moshiri A, Thomasy SM. PMID: 36156731; PMCID: PMC9526363.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    38. Topical Ripasudil for the Treatment of Primary Corneal Endothelial Degeneration in Dogs. Transl Vis Sci Technol. 2022 09 01; 11(9):2. Michalak SR, Kim S, Park S, Casanova MI, Bowman MAW, Ferneding M, Leonard BC, Good KL, Li JY, Thomasy SM. PMID: 36048012; PMCID: PMC9440609.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    39. Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death. Dis Model Mech. 2022 07 01; 15(7). Shao A, Lopez AJ, Chen J, Tham A, Javier S, Quiroz A, Frick S, Levine EM, Lloyd KCK, Leonard BC, Murphy CJ, Glaser TM, Moshiri A. PMID: 35758026; PMCID: PMC9346516.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    40. Antimicrobial Peptide Expression at the Ocular Surface and Their Therapeutic Use in the Treatment of Microbial Keratitis. Front Microbiol. 2022; 13:857735. Shannon AH, Adelman SA, Hisey EA, Potnis SS, Rozo V, Yung MW, Li JY, Murphy CJ, Thomasy SM, Leonard BC. PMID: 35722307; PMCID: PMC9201425.
      View in: PubMed   Mentions: 8  
    41. Metallic Engineered Nanomaterials and Ocular Toxicity: A Current Perspective. Pharmaceutics. 2022 May 03; 14(5). Cosert KM, Kim S, Jalilian I, Chang M, Gates BL, Pinkerton KE, Van Winkle LS, Raghunathan VK, Leonard BC, Thomasy SM. PMID: 35631569; PMCID: PMC9145553.
      View in: PubMed   Mentions: 7  
    42. Multimodal ocular imaging of known and novel corneal stromal disorders in dogs. BMC Vet Res. 2022 Mar 26; 18(1):117. Park S, Sebbag L, Moore BA, Casanova MI, Leonard BC, Daley NL, Steele KA, Li JY, Murphy CJ, Thomasy SM. PMID: 35346188; PMCID: PMC8962188.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    43. Long COVID, neuropsychiatric disorders, psychotropics, present and future. Acta Neuropsychiatr. 2022 Jun; 34(3):109-126. Tang SW, Leonard BE, Helmeste DM. PMID: 35144718.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansPHPublic Health
    44. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci. 2022 02 01; 63(2):12. McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. PMID: 35129590; PMCID: PMC8842499.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    45. Canine endotheliitis: Clinical characteristics, advanced imaging features, and treatment. Vet Ophthalmol. 2022 May; 25 Suppl 1:185-192. Mayes MA, Casanova MI, Park S, Steele K, Linton L, Kim S, Good KL, Moore BA, Newbold GM, Leonard BC, Li JY, Thomasy SM. PMID: 34971485; PMCID: PMC9243184.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    46. Treatment-induced mood switching in affective disorders. Acta Neuropsychiatr. 2022 Apr; 34(2):55-68. Tang SW, Tang WH, Leonard BE. PMID: 34955101.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    47. Comparison of intraocular pressures estimated by rebound and applanation tonometry in dogs with lens instability: 66 cases (2012-2018). J Am Vet Med Assoc. 2021 11 01; 259(9):1025-1031. Schlesener BN, Leonard BC, Miller PE, Kass PH, Hollingsworth SR, Cooper AE, Maggs DJ. PMID: 34647480.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    48. Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation. Transl Vis Sci Technol. 2021 10 04; 10(12):23. Fukuto A, Kim S, Kang J, Gates BL, Chang MW, Pinkerton KE, Van Winkle LS, Kiuchi Y, Murphy CJ, Leonard BC, Thomasy SM. PMID: 34661622; PMCID: PMC8525860.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    49. Novel Lipids of the Rabbit Harderian Gland Improve Tear Stability in an Animal Model of Dry Eye Disease. J Ocul Pharmacol Ther. 2021 12; 37(10):545-555. Butovich IA, Yuksel S, Leonard B, Gadek T, Polans AS, Albert DM. PMID: 34590914; PMCID: PMC8713569.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    50. Transcorneal delivery of topically applied silver nanoparticles does not delay epithelial wound healing. NanoImpact. 2021 10; 24:100352. Kim S, Gates BL, Chang M, Pinkerton KE, Van Winkle L, Murphy CJ, Leonard BC, Demokritou P, Thomasy SM. PMID: 35559825.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    51. Retinal degeneration in mice and humans with neuronal ceroid lipofuscinosis type 8. Ann Transl Med. 2021 Aug; 9(15):1274. Salpeter EM, Leonard BC, Lopez AJ, Murphy CJ, Thomasy S, Imai DM, Grimsrud K, Lloyd KCK, Yan J, Sanchez Russo R, Shankar SP, Moshiri A. PMID: 34532411; PMCID: PMC8421982.
      View in: PubMed   Mentions: 3  
    52. Animal models of corneal endothelial dysfunction to facilitate development of novel therapies. Ann Transl Med. 2021 Aug; 9(15):1271. Park S, Leonard BC, Raghunathan VK, Kim S, Li JY, Mannis MJ, Murphy CJ, Thomasy SM. PMID: 34532408; PMCID: PMC8421955.
      View in: PubMed   Mentions: 16  
    53. Correlations between clinical signs and corneal cytology in feline eosinophilic keratoconjunctivitis. Vet Ophthalmol. 2021 Nov; 24(6):620-626. Lucyshyn DR, Vernau W, Maggs DJ, Murphy CJ, Leonard BC. PMID: 34184388; PMCID: PMC9291071.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    54. A Retrospective Study of Corneal Endothelial Dystrophy in Dogs (1991-2014). Cornea. 2021 May 01; 40(5):578-583. Leonard BC, Kermanian CS, Michalak SR, Kass PH, Hollingsworth SR, Good KL, Maggs DJ, Thomasy SM. PMID: 32947393; PMCID: PMC7960559.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    55. Two-Dimensional 2M-WS2 Nanolayers for Superconductivity. ACS Omega. 2021 Feb 02; 6(4):2966-2972. Samarawickrama P, Dulal R, Fu Z, Erugu U, Wang W, Ackerman J, Leonard B, Tang J, Chien T, Tian J. PMID: 33553915; PMCID: PMC7860099.
      View in: PubMed   Mentions: 3  
    56. Biallelic UBE4A loss-of-function variants cause intellectual disability and global developmental delay. Genet Med. 2021 04; 23(4):661-668. Melo US, Bonner D, Kent Lloyd KC, Moshiri A, Willis B, Lanoue L, Bower L, Leonard BC, Martins DJ, Gomes F, de Souza Leite F, Oliveira D, Kitajima JP, Monteiro FP, Zatz M, Menck CFM, Wheeler MT, Bernstein JA, Dumas K, Spiteri E, Di Donato N, Jahn A, Hashem M, Alsaif HS, Chedrawi A, Alkuraya FS, Kok F, Byers HM. PMID: 33420346.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    57. Differential effects of Hsp90 inhibition on corneal cells in vitro and in vivo. Exp Eye Res. 2021 01; 202:108362. Raghunathan V, Edwards SG, Leonard BC, Kim S, Evashenk AT, Song Y, Rewinski E, Marangakis Price A, Hoehn A, Chang C, Reilly CM, Muppala S, Murphy CJ, Thomasy SM. PMID: 33220237; PMCID: PMC7856234.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    58. Subcutaneous administration of triamcinolone as part of the management of feline eosinophilic keratoconjunctivitis. J Feline Med Surg. 2021 Jun; 23(6):575-583. Lucyshyn DR, Good KL, Knickelbein KE, Chang MW, Strøm AR, Hollingsworth SR, Thomasy SM, Leonard BC, Sebbag L, Wiggans KT, Maggs DJ. PMID: 33140999; PMCID: PMC10741297.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    59. Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models. Pharmacol Biochem Behav. 2020 06; 193:172928. de Abreu MS, Giacomini ACVV, Genario R, Rech N, Carboni J, Lakstygal AM, Amstislavskaya TG, Demin KA, Leonard BE, Vlok M, Harvey BH, Piato A, Barcellos LJG, Kalueff AV. PMID: 32289330.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    60. Cross-species Analyses of Intra-species Behavioral Differences in Mammals and Fish. Neuroscience. 2020 03 01; 429:33-45. Demin KA, Lakstygal AM, Volgin AD, de Abreu MS, Genario R, Alpyshov ET, Serikuly N, Wang D, Wang J, Yan D, Wang M, Yang L, Hu G, Bytov M, Zabegalov KN, Zhdanov A, Harvey BH, Costa F, Rosemberg DB, Leonard BE, Fontana BD, Cleal M, Parker MO, Wang J, Song C, Amstislavskaya TG, Kalueff AV. PMID: 31931109.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    61. Stromal Collagen Arrangement Correlates with Stiffness of the Canine Cornea. Bioengineering (Basel). 2019 Dec 25; 7(1). Leonard BC, Cosert K, Winkler M, Marangakis A, Thomasy SM, Murphy CJ, Jester JV, Raghunathan VK. PMID: 31881719; PMCID: PMC7175282.
      View in: PubMed   Mentions: 6  
    62. Engineered metal oxide nanomaterials inhibit corneal epithelial wound healing in vitro and in vivo. NanoImpact. 2020 Jan; 17. Kim S, Gates B, Leonard BC, Gragg M, Pinkerton KE, Winkle LV, Murphy CJ, Pyrgiotakis G, Zhang Z, Demokritou P, Thomasy SM. PMID: 32154443; PMCID: PMC7062360.
      View in: PubMed   Mentions: 10     Fields:    
    63. Comprehensive Clinical, Diagnostic, and Advanced Imaging Characterization of the Ocular Surface in Spontaneous Aqueous Deficient Dry Eye Disease in Dogs. Cornea. 2019 Dec; 38(12):1568-1575. Leonard BC, Stewart KA, Shaw GC, Hoehn AL, Stanley AA, Murphy CJ, Thomasy SM. PMID: 31369464; PMCID: PMC7217326.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    64. Acremonium and trichosporon fungal keratoconjunctivitis in a Leopard Gecko (Eublepharis macularius). Vet Ophthalmol. 2019 Nov; 22(6):928-932. Munevar C, Moore BA, Gleeson MD, Ozawa SM, Murphy CJ, Paul-Murphy JR, Leonard BC. PMID: 31339654.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    65. Inflammation, insulin resistance and neuroprogression in depression. Acta Neuropsychiatr. 2020 Feb; 32(1):1-9. Leonard BE, Wegener G. PMID: 31186075.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    66. Identification of genes required for eye development by high-throughput screening of mouse knockouts. Commun Biol. 2018; 1:236. Moore BA, Leonard BC, Sebbag L, Edwards SG, Cooper A, Imai DM, Straiton E, Santos L, Reilly C, Griffey SM, Bower L, Clary D, Mason J, Roux MJ, Meziane H, Herault Y, International Mouse Phenotyping Consortium, McKerlie C, Flenniken AM, Nutter LMJ, Berberovic Z, Owen C, Newbigging S, Adissu H, Eskandarian M, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gallegos JJ, Seavitt JR, Heaney JD, Beaudet AL, Dickinson ME, Justice MJ, Philip V, Kumar V, Svenson KL, Braun RE, Wells S, Cater H, Stewart M, Clementson-Mobbs S, Joynson R, Gao X, Suzuki T, Wakana S, Smedley D, Seong JK, Tocchini-Valentini G, Moore M, Fletcher C, Karp N, Ramirez-Solis R, White JK, de Angelis MH, Wurst W, Thomasy SM, Flicek P, Parkinson H, Brown SDM, Meehan TF, Nishina PM, Murray SA, Krebs MP, Mallon AM, Lloyd KCK, Murphy CJ, Moshiri A. PMID: 30588515; PMCID: PMC6303268.
      View in: PubMed   Mentions: 30  
    67. Biomechanical changes to Descemet's membrane precede endothelial cell loss in an early-onset murine model of Fuchs endothelial corneal dystrophy. Exp Eye Res. 2019 03; 180:18-22. Leonard BC, Jalilian I, Raghunathan VK, Wang W, Jun AS, Murphy CJ, Thomasy SM. PMID: 30471280; PMCID: PMC6389414.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    68. A multidisciplinary, minimally invasive approach combining lacrimoscopy and fluoroscopically guided stenting for management of nasolacrimal apparatus obstruction in dogs. J Am Vet Med Assoc. 2018 Jun 15; 252(12):1527-1537. Strom AR, Culp WTN, Leonard BC, Dear JD, Wisner ER, Johnson LR, Maggs DJ. PMID: 29889638.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    69. Medical management of deep ulcerative keratitis in cats: 13 cases. J Feline Med Surg. 2019 04; 21(4):387-393. Martin de Bustamante MG, Good KL, Leonard BC, Hollingsworth SR, Edwards SG, Knickelbein KE, Cooper AE, Thomasy SM, Maggs DJ. PMID: 29767565; PMCID: PMC10814642.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    70. A Population Study of Common Ocular Abnormalities in C57BL/6N rd8 Mice. Invest Ophthalmol Vis Sci. 2018 05 01; 59(6):2252-2261. Moore BA, Roux MJ, Sebbag L, Cooper A, Edwards SG, Leonard BC, Imai DM, Griffey S, Bower L, Clary D, Lloyd KCK, Hérault Y, Thomasy SM, Murphy CJ, Moshiri A. PMID: 29847629; PMCID: PMC5935295.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    71. Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor. J Pharmacol Exp Ther. 2018 05; 365(2):237-248. Kratochwil NA, Triyatni M, Mueller MB, Klammers F, Leonard B, Turley D, Schmaler J, Ekiciler A, Molitor B, Walter I, Gonsard PA, Tournillac CA, Durrwell A, Marschmann M, Jones R, Ullah M, Boess F, Ottaviani G, Jin Y, Parrott NJ, Fowler S. PMID: 29453199.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    72. Animal inflammation-based models of depression and their application to drug discovery. Expert Opin Drug Discov. 2017 10; 12(10):995-1009. Ma L, Demin KA, Kolesnikova TO, Khatsko SL, Zhu X, Yuan X, Song C, Meshalkina DA, Leonard BE, Tian L, Kalueff AV. PMID: 28816544.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    73. Herbal medicine for psychiatric disorders: Psychopharmacology and neuroscience-based nomenclature. World J Biol Psychiatry. 2019 10; 20(8):586-604. Tang SW, Tang WH, Leonard BE. PMID: 28649903.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    74. Managing interactions between cognitive enhancers and other psychotropics. Int Clin Psychopharmacol. 2017 07; 32(4):175-183. Tang SW, Tang WH, Leonard BE. PMID: 28234656.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    75. Patients on psychotropic medications and herbal supplement combinations: clinical considerations. Int Clin Psychopharmacol. 2017 03; 32(2):63-71. Tang SW, Tang W, Leonard BE. PMID: 27902536.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    76. Arap1 Deficiency Causes Photoreceptor Degeneration in Mice. Invest Ophthalmol Vis Sci. 2017 03 01; 58(3):1709-1718. Moshiri A, Humpal D, Leonard BC, Imai DM, Tham A, Bower L, Clary D, Glaser TM, Lloyd KC, Murphy CJ. PMID: 28324111; PMCID: PMC5361582.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    77. Species variation and spatial differences in mucin expression from corneal epithelial cells. Exp Eye Res. 2016 11; 152:43-48. Leonard BC, Yañez-Soto B, Raghunathan VK, Abbott NL, Murphy CJ. PMID: 27614208; PMCID: PMC6697374.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    78. Effect of Stratification on Surface Properties of Corneal Epithelial Cells. Invest Ophthalmol Vis Sci. 2015 Dec; 56(13):8340-8. Yáñez-Soto B, Leonard BC, Raghunathan VK, Abbott NL, Murphy CJ. PMID: 26747762; PMCID: PMC4699408.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    79. The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 04; 64:277-84. Kim YK, Na KS, Myint AM, Leonard BE. PMID: 26111720.
      View in: PubMed   Mentions: 255     Fields:    Translation:HumansAnimals
    80. Interfacial phenomena and the ocular surface. Ocul Surf. 2014 Jul; 12(3):178-201. Yañez-Soto B, Mannis MJ, Schwab IR, Li JY, Leonard BC, Abbott NL, Murphy CJ. PMID: 24999101.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    81. Impact of inflammation on neurotransmitter changes in major depression: an insight into the action of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 03; 48:261-7. Leonard BE. PMID: 24189118.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    82. Visceral smooth muscle α-actin deficiency associated with chronic intestinal pseudo-obstruction in a Bengal cat (Felis catus x Prionailurus bengalensis). Vet Pathol. 2014 May; 51(3):612-8. Imai DM, Miller JL, Leonard BC, Bach J, Drees R, Steinberg H, Teixeira LB. PMID: 23774747.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    83. Inflammation as the cause of the metabolic syndrome in depression. Mod Trends Pharmacopsychiatry. 2013; 28:117-26. Leonard BE. PMID: 25224895.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    84. Controlled release of bevacizumab through nanospheres for extended treatment of age-related macular degeneration. Open Ophthalmol J. 2012; 6:54-8. Li F, Hurley B, Liu Y, Leonard B, Griffith M. PMID: 22798970; PMCID: PMC3394187.
      View in: PubMed   Mentions: 31  
    85. Antimicrobial peptides: agents of border protection for companion animals. Vet Dermatol. 2012 Jun; 23(3):177-e36. Leonard BC, Affolter VK, Bevins CL. PMID: 22409270; PMCID: PMC3467306.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    86. Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: antimicrobial peptide and protein responses. Pediatr Res. 2012 May; 71(5):546-51. Underwood MA, Kananurak A, Coursodon CF, Adkins-Reick CK, Chu H, Bennett SH, Wehkamp J, Castillo PA, Leonard BC, Tancredi DJ, Sherman MP, Dvorak B, Bevins CL. PMID: 22322385; PMCID: PMC3619207.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    87. Activity, expression and genetic variation of canine β-defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs. J Innate Immun. 2012; 4(3):248-59. Leonard BC, Marks SL, Outerbridge CA, Affolter VK, Kananurak A, Young A, Moore PF, Bannasch DL, Bevins CL. PMID: 22261569; PMCID: PMC3357142.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    88. Skeletogenic phenotype of human Marfan embryonic stem cells faithfully phenocopied by patient-specific induced-pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):215-20. Quarto N, Leonard B, Li S, Marchand M, Anderson E, Behr B, Francke U, Reijo-Pera R, Chiao E, Longaker MT. PMID: 22178754; PMCID: PMC3252902.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    89. Expression and activity of a novel cathelicidin from domestic cats. PLoS One. 2011 Apr 12; 6(4):e18756. Leonard BC, Chu H, Johns JL, Gallo RL, Moore PF, Marks SL, Bevins CL. PMID: 21533281; PMCID: PMC3075274.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    90. Association of high-sensitivity C-reactive protein with de novo major depression. Br J Psychiatry. 2010 Nov; 197(5):372-7. Pasco JA, Nicholson GC, Williams LJ, Jacka FN, Henry MJ, Kotowicz MA, Schneider HG, Leonard BE, Berk M. PMID: 21037214.
      View in: PubMed   Mentions: 141     Fields:    Translation:Humans
    91. Catalyst supports for polymer electrolyte fuel cells. Philos Trans A Math Phys Eng Sci. 2010 Jul 28; 368(1923):3243-53. Subban C, Zhou Q, Leonard B, Ranjan C, Edvenson HM, Disalvo FJ, Munie S, Hunting J. PMID: 20566509.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    92. Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression. Neuroimmunomodulation. 2007; 14(2):65-71. Myint AM, Steinbusch HW, Goeghegan L, Luchtman D, Kim YK, Leonard BE. PMID: 17713352.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    93. New component of the limbic system: Marginal division of the neostriatum that links the limbic system to the basal nucleus of Meynert. J Neurosci Res. 2003 Mar 01; 71(5):751-7. Shu SY, Bao XM, Ning Q, Wu YM, Wang J, Leonard BE. PMID: 12584733.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    94. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15101-6. Wiemels JL, Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR. PMID: 12415113; PMCID: PMC137550.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
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