Hwai-Jong Cheng

Title(s)Professor Emeritus, Pathology and Laboratory Medicine
SchoolSchool of Medicine
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    Neuronal Integration of Newborn Granule Cells in Aged Brains
    NIH R01AG054649Sep 15, 2017 - Mar 31, 2022
    Role: Co-Principal Investigator
    Development of a non-rodent model using light-activated channel technology to cur
    NIH R21EY020743Apr 1, 2010 - Mar 31, 2013
    Role: Principal Investigator
    NIH R01HD045757Sep 1, 2004 - Dec 29, 2010
    Role: Principal Investigator
    Development of Visual Pathways
    NIH R01EY011369Jul 1, 1996 - Jul 31, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Neurosphere culture derived from aged hippocampal dentate gyrus. bioRxiv. 2024 Mar 17. Vafaeva O, Namchaiw P, Murray K, Diaz E, Cheng HJ. PMID: 38559117; PMCID: PMC10980067.
      View in: PubMed   Mentions:
    2. Differential Requirement for Plexin-A3 and -A4 in Mediating Responses of Sensory and Sympathetic Neurons to Distinct Class 3 Semaphorins. Neuron. 2023 11 15; 111(22):3697. Yaron A, Huang PH, Cheng HJ, Tessier-Lavigne M. PMID: 37977660.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Involvement of a BH3-only apoptosis sensitizer gene Blm-s in hippocampus-mediated mood control. Transl Psychiatry. 2022 09 26; 12(1):411. Huang PH, Yang TY, Yeh CW, Huang SM, Chang HC, Hung YF, Chu WC, Cho KH, Lu TP, Kuo PH, Lee LJ, Kuo LW, Lien CC, Cheng HJ. PMID: 36163151; PMCID: PMC9512807.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis. eNeuro. 2020 May/Jun; 7(3). Murray KD, Liu XB, King AN, Luu JD, Cheng HJ. PMID: 32332082; PMCID: PMC7240290.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    5. Regulation of axon repulsion by MAX-1 SUMOylation and AP-3. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):E8236-E8245. Chen SY, Ho CT, Liu WW, Lucanic M, Shih HM, Huang PH, Cheng HJ. PMID: 30104385; PMCID: PMC6126772.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Monocular enucleation alters retinal waves in the surviving eye. Neural Dev. 2018 03 24; 13(1):4. Failor SW, Ng A, Cheng HJ. PMID: 29573745; PMCID: PMC5866508.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Increasing Spontaneous Retinal Activity before Eye Opening Accelerates the Development of Geniculate Receptive Fields. J Neurosci. 2015 Oct 28; 35(43):14612-23. Davis ZW, Chapman B, Cheng HJ. PMID: 26511250; PMCID: PMC4623229.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    8. Retinal waves regulate afferent terminal targeting in the early visual pathway. Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):E2957-66. Failor S, Chapman B, Cheng HJ. PMID: 26038569; PMCID: PMC4460437.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    9. Epibatidine blocks eye-specific segregation in ferret dorsal lateral geniculate nucleus during stage III retinal waves. PLoS One. 2015; 10(3):e0118783. Davis ZW, Sun C, Derieg B, Chapman B, Cheng HJ. PMID: 25794280; PMCID: PMC4368645.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Dual-Labeling Immuno-Electron Microscopic Method for Identifying Pre- and Postsynaptic Profiles in Mammalian Brain. . 2015 Jan 1; 115:21-33. Liu LX, Cheng CH. .
      View in: Publisher Site   Mentions:
    11. Eye-specific retinogeniculate segregation proceeds normally following disruption of patterned spontaneous retinal activity. Neural Dev. 2014 Nov 07; 9:25. Speer CM, Sun C, Liets LC, Stafford BK, Chapman B, Cheng HJ. PMID: 25377639; PMCID: PMC4289266.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. Blm-s, a BH3-only protein enriched in postmitotic immature neurons, is transcriptionally upregulated by p53 during DNA damage. Cell Rep. 2014 Oct 09; 9(1):166-179. Liu WW, Chen SY, Cheng CH, Cheng HJ, Huang PH. PMID: 25263558.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer. PLoS One. 2011 Apr 29; 6(4):e19396. Tseng CH, Murray KD, Jou MF, Hsu SM, Cheng HJ, Huang PH. PMID: 21559368; PMCID: PMC3084850.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    14. Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5861-6. Chen SY, Huang PH, Cheng HJ. PMID: 21422296; PMCID: PMC3078365.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    15. Emergence of lamina-specific retinal ganglion cell connectivity by axon arbor retraction and synapse elimination. J Neurosci. 2010 Dec 01; 30(48):16376-82. Cheng TW, Liu XB, Faulkner RL, Stephan AH, Barres BA, Huberman AD, Cheng HJ. PMID: 21123583; PMCID: PMC3073606.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    16. Guidance molecules in axon pruning and cell death. Cold Spring Harb Perspect Biol. 2010 Jun; 2(6):a001859. Vanderhaeghen P, Cheng HJ. PMID: 20516131; PMCID: PMC2869516.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    17. Functions of axon guidance molecules in synapse formation. Curr Opin Neurobiol. 2009 Oct; 19(5):471-8. Chen SY, Cheng HJ. PMID: 19828311; PMCID: PMC2812565.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    18. Deal breaker: semaphorin and specificity in the spinal stretch reflex circuit. Neuron. 2009 Jul 16; 63(1):8-11. Maro GS, Shen K, Cheng HJ. PMID: 19607788.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    19. A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans. PLoS Genet. 2008 Nov; 4(11):e1000269. Lucanic M, Cheng HJ. PMID: 19023419; PMCID: PMC2581894.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    20. Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14157-62. Faulkner RL, Jang MH, Liu XB, Duan X, Sailor KA, Kim JY, Ge S, Jones EG, Ming GL, Song H, Cheng HJ. PMID: 18780780; PMCID: PMC2544594.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    21. Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development. Dev Biol. 2008 Dec 01; 324(1):1-9. Schwarz Q, Waimey KE, Golding M, Takamatsu H, Kumanogoh A, Fujisawa H, Cheng HJ, Ruhrberg C. PMID: 18804103; PMCID: PMC2814064.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    22. Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling. Neural Dev. 2008 Aug 26; 3:21. Faulkner RL, Low LK, Liu XB, Coble J, Jones EG, Cheng HJ. PMID: 18727829; PMCID: PMC2532682.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    23. Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8136-41. Low LK, Liu XB, Faulkner RL, Coble J, Cheng HJ. PMID: 18523013; PMCID: PMC2430372.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    24. Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors. Dev Biol. 2008 Mar 15; 315(2):448-58. Waimey KE, Huang PH, Chen M, Cheng HJ. PMID: 18262512; PMCID: PMC2365924.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    25. Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell. 2007 Sep 21; 130(6):1146-58. Duan X, Chang JH, Ge S, Faulkner RL, Kim JY, Kitabatake Y, Liu XB, Yang CH, Jordan JD, Ma DK, Liu CY, Ganesan S, Cheng HJ, Ming GL, Lu B, Song H. PMID: 17825401; PMCID: PMC2002573.
      View in: PubMed   Mentions: 318     Fields:    Translation:AnimalsCells
    26. Semaphorin signaling facilitates cleft formation in the developing salivary gland. Development. 2007 Aug; 134(16):2935-45. Chung L, Yang TL, Huang HR, Hsu SM, Cheng HJ, Huang PH. PMID: 17626059.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    27. Axon pruning in the developing vertebrate hippocampus. Dev Neurosci. 2007; 29(1-2):6-13. Faulkner RL, Low LK, Cheng HJ. PMID: 17148945.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    28. The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance. Development. 2006 Nov; 133(22):4549-59. Lucanic M, Kiley M, Ashcroft N, L'etoile N, Cheng HJ. PMID: 17050621.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    29. Axon pruning and synaptic development: how are they per-plexin? Neuroscientist. 2006 Oct; 12(5):398-409. Waimey KE, Cheng HJ. PMID: 16957002.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    30. Axon pruning: an essential step underlying the developmental plasticity of neuronal connections. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29; 361(1473):1531-44. Low LK, Cheng HJ. PMID: 16939973; PMCID: PMC1664669.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    31. Stereotyped axon pruning via plexin signaling is associated with synaptic complex elimination in the hippocampus. J Neurosci. 2005 Oct 05; 25(40):9124-34. Liu XB, Low LK, Jones EG, Cheng HJ. PMID: 16207871; PMCID: PMC6725758.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    32. A little nip and tuck: axon refinement during development and axonal injury. Curr Opin Neurobiol. 2005 Oct; 15(5):549-56. Low LK, Cheng HJ. PMID: 16143509.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    33. Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins. Neuron. 2005 Feb 17; 45(4):513-23. Yaron A, Huang PH, Cheng HJ, Tessier-Lavigne M. PMID: 15721238.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    34. Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family. Cell. 2003 May 02; 113(3):285-99. Bagri A, Cheng HJ, Yaron A, Pleasure SJ, Tessier-Lavigne M. PMID: 12732138.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    35. MAX-1, a novel PH/MyTH4/FERM domain cytoplasmic protein implicated in netrin-mediated axon repulsion. Neuron. 2002 May 16; 34(4):563-76. Huang X, Cheng HJ, Tessier-Lavigne M, Jin Y. PMID: 12062040.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    36. Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. Neuron. 2001 Oct 25; 32(2):249-63. Cheng HJ, Bagri A, Yaron A, Stein E, Pleasure SJ, Tessier-Lavigne M. PMID: 11683995.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    37. Cloning and characterization of RTK ligands using receptor-alkaline phosphatase fusion proteins. Methods Mol Biol. 2001; 124:313-34. Cheng HJ, Flanagan JG. PMID: 11100484.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    38. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. J Biol Chem. 2000 Dec 01; 275(48):37815-23. Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ. PMID: 10980193.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    39. Alkaline phosphatase fusion proteins for molecular characterization and cloning of receptors and their ligands. Methods Enzymol. 2000; 327:198-210. Flanagan JG, Cheng HJ. PMID: 11044984.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    40. Alkaline phosphatase fusions of ligands or receptors as in situ probes for staining of cells, tissues, and embryos. Methods Enzymol. 2000; 327:19-35. Flanagan JG, Cheng HJ, Feldheim DA, Hattori M, Lu Q, Vanderhaeghen P. PMID: 11044971.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    41. Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell. 1996 Sep 06; 86(5):755-66. Nakamoto M, Cheng HJ, Friedman GC, McLaughlin T, Hansen MJ, Yoon CH, O'Leary DD, Flanagan JG. PMID: 8797822.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    42. ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol Cell Biol. 1995 Sep; 15(9):4921-9. Bergemann AD, Cheng HJ, Brambilla R, Klein R, Flanagan JG. PMID: 7651410; PMCID: PMC230738.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    43. Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell. 1995 Aug 11; 82(3):371-81. Cheng HJ, Nakamoto M, Bergemann AD, Flanagan JG. PMID: 7634327.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    44. Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell. 1994 Oct 07; 79(1):157-68. Cheng HJ, Flanagan JG. PMID: 7522971.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    45. Transmembrane kit ligand cleavage does not require a signal in the cytoplasmic domain and occurs at a site dependent on spacing from the membrane. Mol Biol Cell. 1994 Sep; 5(9):943-53. Cheng HJ, Flanagan JG. PMID: 7531036; PMCID: PMC301118.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    46. Macromolecular transport across arterial and venous endothelium in rats. Studies with Evans blue-albumin and horseradish peroxidase. Arteriosclerosis. 1990 Mar-Apr; 10(2):188-97. Chuang PT, Cheng HJ, Lin SJ, Jan KM, Lee MM, Chien S. PMID: 2180395.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
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