Jennifer L Whistler

Title(s)Professor, MED: Physiology & Membrane Biol
SchoolSchool of Medicine
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    The Microbiome in opioid use and abuse
    NIH R21DA049565Jun 1, 2020 - May 31, 2022
    Role: Principal Investigator
    Genetic Variation in the Neuropeptide S Receptor and Opioid Abuse Liability
    NIH R21DA043816Nov 1, 2017 - Aug 31, 2020
    Role: Principal Investigator
    Molecular and circuit mechanisms of antipsychotics
    NIH R01MH112729Apr 10, 2017 - Feb 28, 2022
    Role: Co-Principal Investigator
    Dopamine receptor trafficking in drug sensitization and behavioral flexibility
    NIH R01DA037963Sep 15, 2015 - Jun 30, 2021
    Role: Principal Investigator
    Neuropeptide S receptors in ethanol abuse and anxiety
    NIH R21AA023231Sep 10, 2015 - Aug 31, 2019
    Role: Principal Investigator
    Receptor trafficking profiles of clinically important dopaminergic drugs
    NIH R21MH096058Mar 1, 2012 - Feb 28, 2015
    Role: Principal Investigator
    Selectively targeting delta opioid receptor subtypes to control drinking behavior
    NIH R01AA020401Aug 1, 2011 - Jun 30, 2018
    Role: Principal Investigator
    Selectively Targeting Opioid Receptor Heterodimers
    NIH R21DA031574Feb 15, 2011 - Jan 31, 2015
    Role: Principal Investigator
    Role of opioid receptor trafficking in tolerance and dependence
    NIH R01DA019958May 1, 2007 - Mar 31, 2014
    Role: Principal Investigator
    GASP and Trafficking of the Dopamine Receptors
    NIH R01MH068442Jul 1, 2003 - Apr 30, 2009
    Role: Principal Investigator
    Trafficking and signaling of opioid receptor subtypes and heterodimers
    NIH R01DA015232Apr 1, 2002 - Jul 31, 2011
    Role: Principal Investigator
    REGULATION OF OPIOID RECEPTOR FUNCTION
    NIH F32DA005844Mar 25, 1998
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Unlocking opioid neuropeptide dynamics with genetically encoded biosensors. Nat Neurosci. 2024 Sep; 27(9):1844-1857. Dong C, Gowrishankar R, Jin Y, He XJ, Gupta A, Wang H, Sayar-Atasoy N, Flores RJ, Mahe K, Tjahjono N, Liang R, Marley A, Or Mizuno G, Lo DK, Sun Q, Whistler JL, Li B, Gomes I, Von Zastrow M, Tejeda HA, Atasoy D, Devi LA, Bruchas MR, Banghart MR, Tian L. PMID: 39009835; PMCID: PMC11374718.
      View in: PubMed   Mentions: 2     Fields:    
    2. Nucleus accumbens sub-regions experience distinct dopamine release responses following acute and chronic morphine exposure. bioRxiv. 2024 Jul 02. Gooding SW, Lewis E, Chau C, Sandhu S, Glienke J, Whistler JL. PMID: 39005415; PMCID: PMC11244850.
      View in: PubMed   Mentions:
    3. Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic voluntary morphine. bioRxiv. 2024 Apr 17. Sall I, Foxall R, Felth L, Maret S, Rosa Z, Gaur A, Calawa J, Pavlik N, Whistler JL, Whistler CA. PMID: 38659831; PMCID: PMC11042308.
      View in: PubMed   Mentions:
    4. Deletion of arrestin-3 does not improve compulsive drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration. bioRxiv. 2024 Mar 22. Gooding SW, Felth L, Foxall R, Rosa Z, Ireton K, Sall I, Gipoor J, Gaur A, King M, Dirks N, Whistler CA, Whistler JL. PMID: 38562752; PMCID: PMC10983877.
      View in: PubMed   Mentions:
    5. A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy. Annu Rev Physiol. 2024 Feb 12; 86:1-25. Gooding SW, Whistler JL. PMID: 38029388; PMCID: PMC10987332.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Arrestin-3 Agonism at Dopamine D3 Receptors Defines a Subclass of Second-Generation Antipsychotics That Promotes Drug Tolerance. Biol Psychiatry. 2023 10 01; 94(7):531-542. Schamiloglu S, Lewis E, Keeshen CM, Hergarden AC, Bender KJ, Whistler JL. PMID: 36931452; PMCID: PMC10914650.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    7. Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice. Neuropsychopharmacology. 2021 12; 46(13):2241-2249. He L, Gooding SW, Lewis E, Felth LC, Gaur A, Whistler JL. PMID: 34257415; PMCID: PMC8581001.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    8. "Don't Shoot, I Want to Grow Up": Findings of a Multi-City Youth-led Health Assessment. Prog Community Health Partnersh. 2021; 15(3):269-270. Yan CT, McClay CJ, Maharaj M, Gray H, Muhammad N, Lewis SM, Ohaya U, Fallini G, Whistler J, Walker C, Patterson J, Miller R, Gonzales D, Ross T, Burch Z, Pendleton D, Sprague Martinez LS. PMID: 37934416.
      View in: PubMed   Mentions:    Fields:    
    9. "Don't Shoot, I Want to Grow Up": Findings of a Multicity Youth-led Health Assessment. Prog Community Health Partnersh. 2021; 15(3):297-318. Yan CT, McClay CJ, Maharaj M, Gray H, Muhammad N, Lewis SM, Ohaya U, Fallini G, Whistler J, Walker C, Patterson J, Miller R, Gonzales D, Ross T, Burch Z, Pendleton D, Sprague Martinez LS. PMID: 37934419.
      View in: PubMed   Mentions:    Fields:    
    10. TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning. Cell Rep. 2016 12 20; 17(12):3233-3245. Luo SX, Timbang L, Kim JI, Shang Y, Sandoval K, Tang AA, Whistler JL, Ding JB, Huang EJ. PMID: 28009292; PMCID: PMC5312261.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    11. Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins. ACS Chem Neurosci. 2017 03 15; 8(3):473-485. Johnson TA, Milan-Lobo L, Che T, Ferwerda M, Lambu E, McIntosh NL, Li F, He L, Lorig-Roach N, Crews P, Whistler JL. PMID: 27744679; PMCID: PMC5352491.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    12. Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. J Neurosci. 2016 07 27; 36(30):7925-35. Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. PMID: 27466337; PMCID: PMC4961778.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    13. β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment. Cell Rep. 2016 08 09; 16(6):1518-1526. Yang S, Ben-Shalom R, Ahn M, Liptak AT, van Rijn RM, Whistler JL, Bender KJ. PMID: 27452469; PMCID: PMC5074334.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    14. Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell Rep. 2016 Mar 29; 14(12):2774-83. Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler JL, Bruchas MR, Kash TL. PMID: 26997280; PMCID: PMC4814306.
      View in: PubMed   Mentions: 85     Fields:    Translation:Animals
    15. Trafficking of the D2 Dopamine Receptor Promotes Drug-Induced Changes in Neuronal and Behavioral Plasticity. . 2014 Jan 1; 97-98. Tschische TP, Madhavan MA, Athiligam AJ, Milan-Lobo ML, Thompson TD, Wilbrecht WL, Whistler WJ. .
      View in: Publisher Site   Mentions:
    16. Real-time trafficking and signaling of the glucagon-like peptide-1 receptor. Mol Cell Endocrinol. 2014 Feb 15; 382(2):938-49. Roed SN, Wismann P, Underwood CR, Kulahin N, Iversen H, Cappelen KA, Schäffer L, Lehtonen J, Hecksher-Soerensen J, Secher A, Mathiesen JM, Bräuner-Osborne H, Whistler JL, Knudsen SM, Waldhoer M. PMID: 24275181.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    17. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell. 2013 Aug 29; 154(5):1085-1099. He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B. PMID: 23954414; PMCID: PMC4231430.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    18. Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area. J Neurosci. 2013 Jul 24; 33(30):12329-36. Madhavan A, Argilli E, Bonci A, Whistler JL. PMID: 23884939; PMCID: PMC3721842.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    19. Pharmacological traits of delta opioid receptors: pitfalls or opportunities? Psychopharmacology (Berl). 2013 Jul; 228(1):1-18. van Rijn RM, Defriel JN, Whistler JL. PMID: 23649885; PMCID: PMC3679311.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    20. Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. PLoS One. 2013; 8(3):e58362. Milan-Lobo L, Enquist J, van Rijn RM, Whistler JL. PMID: 23554887; PMCID: PMC3598907.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    21. Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling. Am J Pathol. 2013 Mar; 182(3):776-85. Goldsmith JR, Perez-Chanona E, Yadav PN, Whistler J, Roth B, Jobin C. PMID: 23291213; PMCID: PMC3589074.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    22. A FLIPR assay for evaluating agonists and antagonists of GPCR heterodimers. Methods Mol Biol. 2013; 995:43-54. Harvey JH, van Rijn RM, Whistler JL. PMID: 23494371; PMCID: PMC6428067.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling. J Pharmacol Exp Ther. 2013 Jan; 344(1):179-88. van Rijn RM, Harvey JH, Brissett DI, DeFriel JN, Whistler JL. PMID: 23097213; PMCID: PMC3533407.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers. ACS Med Chem Lett. 2012 Aug 09; 3(8):640-644. Harvey JH, Long DH, England PM, Whistler JL. PMID: 23585918; PMCID: PMC3622216.
      View in: PubMed   Mentions: 13  
    25. Chronic ethanol potentiates the effect of neuropeptide s in the basolateral amygdala and shows increased anxiolytic and anti-depressive effects. Neuropsychopharmacology. 2012 Oct; 37(11):2436-45. Enquist J, Ferwerda M, Madhavan A, Hok D, Whistler JL. PMID: 22739468; PMCID: PMC3445991.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    26. The chemoselective reactions of tyrosine-containing G-protein-coupled receptor peptides with [Cp*Rh(H2O)3](OTf)2, including 2D NMR structures and the biological consequences. J Am Chem Soc. 2012 Jun 27; 134(25):10321-4. Albada HB, Wieberneit F, Dijkgraaf I, Harvey JH, Whistler JL, Stoll R, Metzler-Nolte N, Fish RH. PMID: 22671299.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    27. The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55. Br J Pharmacol. 2012 Apr; 165(8):2611-9. Kargl J, Balenga NA, Platzer W, Martini L, Whistler JL, Waldhoer M. PMID: 21718301; PMCID: PMC3366063.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2. PLoS One. 2012; 7(3):e33329. Schröder R, Xue L, Konya V, Martini L, Kampitsch N, Whistler JL, Ulven T, Heinemann A, Pettipher R, Kostenis E. PMID: 22442685; PMCID: PMC3307725.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsCTClinical Trials
    29. Examining the role of mu opioid receptor endocytosis in the beneficial and side-effects of prolonged opioid use: from a symposium on new concepts in mu-opioid pharmacology. Drug Alcohol Depend. 2012 Mar 01; 121(3):189-204. Whistler JL. PMID: 22226706; PMCID: PMC4224378.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    30. Contribution of mu and delta opioid receptors to the pharmacological profile of kappa opioid receptor subtypes. Eur J Pain. 2012 Mar; 16(3):327-37. Brissett DI, Whistler JL, van Rijn RM. PMID: 22337177; PMCID: PMC4086711.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    31. Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice. J Pharmacol Exp Ther. 2012 Feb; 340(2):386-92. Enquist J, Ferwerda M, Milan-Lobo L, Whistler JL. PMID: 22062352; PMCID: PMC3263965.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    32. Development of a bivalent dopamine D₂ receptor agonist. J Med Chem. 2011 Nov 24; 54(22):7911-9. Kühhorn J, Götz A, Hübner H, Thompson D, Whistler J, Gmeiner P. PMID: 21999579.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    33. Distinctive modulation of ethanol place preference by delta opioid receptor-selective agonists. Drug Alcohol Depend. 2012 Apr 01; 122(1-2):156-9. van Rijn RM, Brissett DI, Whistler JL. PMID: 22018601; PMCID: PMC3279630.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    34. Emergence of functional spinal delta opioid receptors after chronic ethanol exposure. Biol Psychiatry. 2012 Feb 01; 71(3):232-8. van Rijn RM, Brissett DI, Whistler JL. PMID: 21889123; PMCID: PMC4086708.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    35. Morphine-induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use. EMBO Mol Med. 2011 Jul; 3(7):385-97. Berger AC, Whistler JL. PMID: 21656686; PMCID: PMC3394511.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    36. Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis. PLoS One. 2011; 6(5):e19372. He L, Whistler JL. PMID: 21602922; PMCID: PMC3094338.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    37. A novel knock-in mouse reveals mechanistically distinct forms of morphine tolerance. J Pharmacol Exp Ther. 2011 Aug; 338(2):633-40. Enquist J, Kim JA, Bartlett S, Ferwerda M, Whistler JL. PMID: 21562138; PMCID: PMC3141896.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    38. Trafficking properties of the D5 dopamine receptor. Traffic. 2011 May; 12(5):644-56. Thompson D, Whistler JL. PMID: 21348911.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    39. Heteromerization of the μ- and δ-opioid receptors produces ligand-biased antagonism and alters μ-receptor trafficking. J Pharmacol Exp Ther. 2011 Jun; 337(3):868-75. Milan-Lobo L, Whistler JL. PMID: 21422164; PMCID: PMC3097170.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    40. Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions. J Med Chem. 2011 Apr 14; 54(7):2477-91. Tschammer N, Elsner J, Goetz A, Ehrlich K, Schuster S, Ruberg M, Kühhorn J, Thompson D, Whistler J, Hübner H, Gmeiner P. PMID: 21388142.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    41. Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1. J Biol Chem. 2011 Jan 14; 286(2):1598-608. Thompson D, Whistler JL. PMID: 21030592; PMCID: PMC3020768.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    42. Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area. J Neurosci. 2010 Oct 20; 30(42):14029-35. Madhavan A, Bonci A, Whistler JL. PMID: 20962224; PMCID: PMC3637958.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    43. Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety. J Pharmacol Exp Ther. 2010 Oct; 335(1):133-9. van Rijn RM, Brissett DI, Whistler JL. PMID: 20605909; PMCID: PMC2957775.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    44. G protein-coupled receptor-associated sorting protein 1 regulates the postendocytic sorting of seven-transmembrane-spanning G protein-coupled receptors. Pharmacology. 2010; 86(1):22-9. Moser E, Kargl J, Whistler JL, Waldhoer M, Tschische P. PMID: 20693822; PMCID: PMC2919430.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    45. Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine. PLoS One. 2010 Jun 09; 5(6):e11038. Thompson D, Martini L, Whistler JL. PMID: 20543951; PMCID: PMC2882949.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    46. How to design an opioid drug that causes reduced tolerance and dependence. Ann Neurol. 2010 May; 67(5):559-69. Berger AC, Whistler JL. PMID: 20437553; PMCID: PMC2943346.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    47. The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28. Traffic. 2010 May; 11(5):660-74. Tschische P, Moser E, Thompson D, Vischer HF, Parzmair GP, Pommer V, Platzer W, Schwarzbraun T, Schaider H, Smit MJ, Martini L, Whistler JL, Waldhoer M. PMID: 20102549; PMCID: PMC2974616.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    48. An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis. Biochem Pharmacol. 2010 Jul 01; 80(1):86-94. Bonde MM, Yao R, Ma JN, Madabushi S, Haunsø S, Burstein ES, Whistler JL, Sheikh SP, Lichtarge O, Hansen JL. PMID: 20227396; PMCID: PMC2864232.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    49. micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal. J Neurosci. 2010 Mar 03; 30(9):3276-86. Madhavan A, He L, Stuber GD, Bonci A, Whistler JL. PMID: 20203187; PMCID: PMC2943338.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    50. Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1. Neuropsychopharmacology. 2010 May; 35(6):1363-73. Martini L, Thompson D, Kharazia V, Whistler JL. PMID: 20164830; PMCID: PMC2953419.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    51. GPR55 ligands promote receptor coupling to multiple signalling pathways. Br J Pharmacol. 2010 Jun; 160(3):604-14. Henstridge CM, Balenga NA, Schröder R, Kargl JK, Platzer W, Martini L, Arthur S, Penman J, Whistler JL, Kostenis E, Waldhoer M, Irving AJ. PMID: 20136841; PMCID: PMC2931561.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    52. Opioid-receptor-heteromer-specific trafficking and pharmacology. Curr Opin Pharmacol. 2010 Feb; 10(1):73-9. van Rijn RM, Whistler JL, Waldhoer M. PMID: 19846340; PMCID: PMC2900797.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    53. Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor. FASEB J. 2009 Dec; 23(12):4327-34. He L, Kim JA, Whistler JL. PMID: 19679639; PMCID: PMC2812043.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    54. The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake. Biol Psychiatry. 2009 Oct 15; 66(8):777-84. van Rijn RM, Whistler JL. PMID: 19576572; PMCID: PMC2757485.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    55. Functional characterization of human variants of the mu-opioid receptor gene. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10811-6. Ravindranathan A, Joslyn G, Robertson M, Schuckit MA, Whistler JL, White RL. PMID: 19528663; PMCID: PMC2705556.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    56. Methadone antinociception is dependent on peripheral opioid receptors. J Pain. 2009 Apr; 10(4):369-79. He L, Kim J, Ou C, McFadden W, van Rijn RM, Whistler JL. PMID: 19327642; PMCID: PMC2952445.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    57. PKCepsilon regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2. Neuropsychopharmacology. 2009 Jun; 34(7):1733-42. Wallace MJ, Newton PM, McMahon T, Connolly J, Huibers A, Whistler J, Messing RO. PMID: 19158669; PMCID: PMC2680927.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    58. The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers? Mol Interv. 2008 Dec; 8(6):277-80. van Rijn RM, Whistler JL. PMID: 19144899.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    59. The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. J Biol Chem. 2009 Jan 09; 284(2):1324-36. Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E. PMID: 19010788.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    60. Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence. Curr Biol. 2008 Jan 22; 18(2):129-35. Kim JA, Bartlett S, He L, Nielsen CK, Chang AM, Kharazia V, Waldhoer M, Ou CJ, Taylor S, Ferwerda M, Cado D, Whistler JL. PMID: 18207746; PMCID: PMC2997702.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    61. The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Curr Opin Neurobiol. 2007 Oct; 17(5):556-64. Martini L, Whistler JL. PMID: 18068348.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    62. Changes in G protein-coupled receptor sorting protein affinity regulate postendocytic targeting of G protein-coupled receptors. J Biol Chem. 2007 Oct 05; 282(40):29178-85. Thompson D, Pusch M, Whistler JL. PMID: 17635908.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    63. Acute amphetamine exposure selectively desensitizes kappa-opioid receptors in the nucleus accumbens. Neuropsychopharmacology. 2008 Mar; 33(4):892-900. Xia YF, He L, Whistler JL, Hjelmstad GO. PMID: 17551543; PMCID: PMC2268619.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    64. A molecular basis of analgesic tolerance to cannabinoids. J Neurosci. 2007 Apr 11; 27(15):4165-77. Tappe-Theodor A, Agarwal N, Katona I, Rubino T, Martini L, Swiercz J, Mackie K, Monyer H, Parolaro D, Whistler J, Kuner T, Kuner R. PMID: 17428994; PMCID: PMC6672554.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
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