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Unlocking opioid neuropeptide dynamics with genetically encoded biosensors. Nat Neurosci. 2024 Sep; 27(9):1844-1857.
Dong C, Gowrishankar R, Jin Y, He XJ, Gupta A, Wang H, Sayar-Atasoy N, Flores RJ, Mahe K, Tjahjono N, Liang R, Marley A, Or Mizuno G, Lo DK, Sun Q, Whistler JL, Li B, Gomes I, Von Zastrow M, Tejeda HA, Atasoy D, Devi LA, Bruchas MR, Banghart MR, Tian L. PMID: 39009835; PMCID: PMC11374718.
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2 Fields:
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Nucleus accumbens sub-regions experience distinct dopamine release responses following acute and chronic morphine exposure. bioRxiv. 2024 Jul 02.
Gooding SW, Lewis E, Chau C, Sandhu S, Glienke J, Whistler JL. PMID: 39005415; PMCID: PMC11244850.
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Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic voluntary morphine. bioRxiv. 2024 Apr 17.
Sall I, Foxall R, Felth L, Maret S, Rosa Z, Gaur A, Calawa J, Pavlik N, Whistler JL, Whistler CA. PMID: 38659831; PMCID: PMC11042308.
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Deletion of arrestin-3 does not improve compulsive drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration. bioRxiv. 2024 Mar 22.
Gooding SW, Felth L, Foxall R, Rosa Z, Ireton K, Sall I, Gipoor J, Gaur A, King M, Dirks N, Whistler CA, Whistler JL. PMID: 38562752; PMCID: PMC10983877.
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A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy. Annu Rev Physiol. 2024 Feb 12; 86:1-25.
Gooding SW, Whistler JL. PMID: 38029388; PMCID: PMC10987332.
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HumansCells
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Arrestin-3 Agonism at Dopamine D3 Receptors Defines a Subclass of Second-Generation Antipsychotics That Promotes Drug Tolerance. Biol Psychiatry. 2023 10 01; 94(7):531-542.
Schamiloglu S, Lewis E, Keeshen CM, Hergarden AC, Bender KJ, Whistler JL. PMID: 36931452; PMCID: PMC10914650.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice. Neuropsychopharmacology. 2021 12; 46(13):2241-2249.
He L, Gooding SW, Lewis E, Felth LC, Gaur A, Whistler JL. PMID: 34257415; PMCID: PMC8581001.
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PubMed Mentions:
18 Fields:
Translation:
Animals
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"Don't Shoot, I Want to Grow Up": Findings of a Multi-City Youth-led Health Assessment. Prog Community Health Partnersh. 2021; 15(3):269-270.
Yan CT, McClay CJ, Maharaj M, Gray H, Muhammad N, Lewis SM, Ohaya U, Fallini G, Whistler J, Walker C, Patterson J, Miller R, Gonzales D, Ross T, Burch Z, Pendleton D, Sprague Martinez LS. PMID: 37934416.
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PubMed Mentions: Fields:
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"Don't Shoot, I Want to Grow Up": Findings of a Multicity Youth-led Health Assessment. Prog Community Health Partnersh. 2021; 15(3):297-318.
Yan CT, McClay CJ, Maharaj M, Gray H, Muhammad N, Lewis SM, Ohaya U, Fallini G, Whistler J, Walker C, Patterson J, Miller R, Gonzales D, Ross T, Burch Z, Pendleton D, Sprague Martinez LS. PMID: 37934419.
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TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning. Cell Rep. 2016 12 20; 17(12):3233-3245.
Luo SX, Timbang L, Kim JI, Shang Y, Sandoval K, Tang AA, Whistler JL, Ding JB, Huang EJ. PMID: 28009292; PMCID: PMC5312261.
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PubMed Mentions:
31 Fields:
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HumansAnimalsCells
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Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins. ACS Chem Neurosci. 2017 03 15; 8(3):473-485.
Johnson TA, Milan-Lobo L, Che T, Ferwerda M, Lambu E, McIntosh NL, Li F, He L, Lorig-Roach N, Crews P, Whistler JL. PMID: 27744679; PMCID: PMC5352491.
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PubMed Mentions:
17 Fields:
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HumansAnimalsCells
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Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. J Neurosci. 2016 07 27; 36(30):7925-35.
Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. PMID: 27466337; PMCID: PMC4961778.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment. Cell Rep. 2016 08 09; 16(6):1518-1526.
Yang S, Ben-Shalom R, Ahn M, Liptak AT, van Rijn RM, Whistler JL, Bender KJ. PMID: 27452469; PMCID: PMC5074334.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell Rep. 2016 Mar 29; 14(12):2774-83.
Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler JL, Bruchas MR, Kash TL. PMID: 26997280; PMCID: PMC4814306.
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PubMed Mentions:
85 Fields:
Translation:
Animals
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Trafficking of the D2 Dopamine Receptor Promotes Drug-Induced Changes in Neuronal and Behavioral Plasticity. . 2014 Jan 1; 97-98.
Tschische TP, Madhavan MA, Athiligam AJ, Milan-Lobo ML, Thompson TD, Wilbrecht WL, Whistler WJ. .
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Real-time trafficking and signaling of the glucagon-like peptide-1 receptor. Mol Cell Endocrinol. 2014 Feb 15; 382(2):938-49.
Roed SN, Wismann P, Underwood CR, Kulahin N, Iversen H, Cappelen KA, Schäffer L, Lehtonen J, Hecksher-Soerensen J, Secher A, Mathiesen JM, Bräuner-Osborne H, Whistler JL, Knudsen SM, Waldhoer M. PMID: 24275181.
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PubMed Mentions:
62 Fields:
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HumansAnimalsCells
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Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell. 2013 Aug 29; 154(5):1085-1099.
He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B. PMID: 23954414; PMCID: PMC4231430.
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PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
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Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area. J Neurosci. 2013 Jul 24; 33(30):12329-36.
Madhavan A, Argilli E, Bonci A, Whistler JL. PMID: 23884939; PMCID: PMC3721842.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Pharmacological traits of delta opioid receptors: pitfalls or opportunities? Psychopharmacology (Berl). 2013 Jul; 228(1):1-18.
van Rijn RM, Defriel JN, Whistler JL. PMID: 23649885; PMCID: PMC3679311.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
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Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. PLoS One. 2013; 8(3):e58362.
Milan-Lobo L, Enquist J, van Rijn RM, Whistler JL. PMID: 23554887; PMCID: PMC3598907.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling. Am J Pathol. 2013 Mar; 182(3):776-85.
Goldsmith JR, Perez-Chanona E, Yadav PN, Whistler J, Roth B, Jobin C. PMID: 23291213; PMCID: PMC3589074.
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PubMed Mentions:
19 Fields:
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AnimalsCells
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A FLIPR assay for evaluating agonists and antagonists of GPCR heterodimers. Methods Mol Biol. 2013; 995:43-54.
Harvey JH, van Rijn RM, Whistler JL. PMID: 23494371; PMCID: PMC6428067.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling. J Pharmacol Exp Ther. 2013 Jan; 344(1):179-88.
van Rijn RM, Harvey JH, Brissett DI, DeFriel JN, Whistler JL. PMID: 23097213; PMCID: PMC3533407.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers. ACS Med Chem Lett. 2012 Aug 09; 3(8):640-644.
Harvey JH, Long DH, England PM, Whistler JL. PMID: 23585918; PMCID: PMC3622216.
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13
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Chronic ethanol potentiates the effect of neuropeptide s in the basolateral amygdala and shows increased anxiolytic and anti-depressive effects. Neuropsychopharmacology. 2012 Oct; 37(11):2436-45.
Enquist J, Ferwerda M, Madhavan A, Hok D, Whistler JL. PMID: 22739468; PMCID: PMC3445991.
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PubMed Mentions:
11 Fields:
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Animals
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The chemoselective reactions of tyrosine-containing G-protein-coupled receptor peptides with [Cp*Rh(H2O)3](OTf)2, including 2D NMR structures and the biological consequences. J Am Chem Soc. 2012 Jun 27; 134(25):10321-4.
Albada HB, Wieberneit F, Dijkgraaf I, Harvey JH, Whistler JL, Stoll R, Metzler-Nolte N, Fish RH. PMID: 22671299.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55. Br J Pharmacol. 2012 Apr; 165(8):2611-9.
Kargl J, Balenga NA, Platzer W, Martini L, Whistler JL, Waldhoer M. PMID: 21718301; PMCID: PMC3366063.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2. PLoS One. 2012; 7(3):e33329.
Schröder R, Xue L, Konya V, Martini L, Kampitsch N, Whistler JL, Ulven T, Heinemann A, Pettipher R, Kostenis E. PMID: 22442685; PMCID: PMC3307725.
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PubMed Mentions:
7 Fields:
Translation:
HumansCellsCTClinical Trials
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Examining the role of mu opioid receptor endocytosis in the beneficial and side-effects of prolonged opioid use: from a symposium on new concepts in mu-opioid pharmacology. Drug Alcohol Depend. 2012 Mar 01; 121(3):189-204.
Whistler JL. PMID: 22226706; PMCID: PMC4224378.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimals
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Contribution of mu and delta opioid receptors to the pharmacological profile of kappa opioid receptor subtypes. Eur J Pain. 2012 Mar; 16(3):327-37.
Brissett DI, Whistler JL, van Rijn RM. PMID: 22337177; PMCID: PMC4086711.
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PubMed Mentions:
1 Fields:
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HumansAnimalsCells
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Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice. J Pharmacol Exp Ther. 2012 Feb; 340(2):386-92.
Enquist J, Ferwerda M, Milan-Lobo L, Whistler JL. PMID: 22062352; PMCID: PMC3263965.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Development of a bivalent dopamine D₂ receptor agonist. J Med Chem. 2011 Nov 24; 54(22):7911-9.
Kühhorn J, Götz A, Hübner H, Thompson D, Whistler J, Gmeiner P. PMID: 21999579.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Distinctive modulation of ethanol place preference by delta opioid receptor-selective agonists. Drug Alcohol Depend. 2012 Apr 01; 122(1-2):156-9.
van Rijn RM, Brissett DI, Whistler JL. PMID: 22018601; PMCID: PMC3279630.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Emergence of functional spinal delta opioid receptors after chronic ethanol exposure. Biol Psychiatry. 2012 Feb 01; 71(3):232-8.
van Rijn RM, Brissett DI, Whistler JL. PMID: 21889123; PMCID: PMC4086708.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Morphine-induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use. EMBO Mol Med. 2011 Jul; 3(7):385-97.
Berger AC, Whistler JL. PMID: 21656686; PMCID: PMC3394511.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
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Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis. PLoS One. 2011; 6(5):e19372.
He L, Whistler JL. PMID: 21602922; PMCID: PMC3094338.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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A novel knock-in mouse reveals mechanistically distinct forms of morphine tolerance. J Pharmacol Exp Ther. 2011 Aug; 338(2):633-40.
Enquist J, Kim JA, Bartlett S, Ferwerda M, Whistler JL. PMID: 21562138; PMCID: PMC3141896.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Trafficking properties of the D5 dopamine receptor. Traffic. 2011 May; 12(5):644-56.
Thompson D, Whistler JL. PMID: 21348911.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Heteromerization of the μ- and δ-opioid receptors produces ligand-biased antagonism and alters μ-receptor trafficking. J Pharmacol Exp Ther. 2011 Jun; 337(3):868-75.
Milan-Lobo L, Whistler JL. PMID: 21422164; PMCID: PMC3097170.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions. J Med Chem. 2011 Apr 14; 54(7):2477-91.
Tschammer N, Elsner J, Goetz A, Ehrlich K, Schuster S, Ruberg M, Kühhorn J, Thompson D, Whistler J, Hübner H, Gmeiner P. PMID: 21388142.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1. J Biol Chem. 2011 Jan 14; 286(2):1598-608.
Thompson D, Whistler JL. PMID: 21030592; PMCID: PMC3020768.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area. J Neurosci. 2010 Oct 20; 30(42):14029-35.
Madhavan A, Bonci A, Whistler JL. PMID: 20962224; PMCID: PMC3637958.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety. J Pharmacol Exp Ther. 2010 Oct; 335(1):133-9.
van Rijn RM, Brissett DI, Whistler JL. PMID: 20605909; PMCID: PMC2957775.
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PubMed Mentions:
36 Fields:
Translation:
Animals
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G protein-coupled receptor-associated sorting protein 1 regulates the postendocytic sorting of seven-transmembrane-spanning G protein-coupled receptors. Pharmacology. 2010; 86(1):22-9.
Moser E, Kargl J, Whistler JL, Waldhoer M, Tschische P. PMID: 20693822; PMCID: PMC2919430.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine. PLoS One. 2010 Jun 09; 5(6):e11038.
Thompson D, Martini L, Whistler JL. PMID: 20543951; PMCID: PMC2882949.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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How to design an opioid drug that causes reduced tolerance and dependence. Ann Neurol. 2010 May; 67(5):559-69.
Berger AC, Whistler JL. PMID: 20437553; PMCID: PMC2943346.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28. Traffic. 2010 May; 11(5):660-74.
Tschische P, Moser E, Thompson D, Vischer HF, Parzmair GP, Pommer V, Platzer W, Schwarzbraun T, Schaider H, Smit MJ, Martini L, Whistler JL, Waldhoer M. PMID: 20102549; PMCID: PMC2974616.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis. Biochem Pharmacol. 2010 Jul 01; 80(1):86-94.
Bonde MM, Yao R, Ma JN, Madabushi S, Haunsø S, Burstein ES, Whistler JL, Sheikh SP, Lichtarge O, Hansen JL. PMID: 20227396; PMCID: PMC2864232.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal. J Neurosci. 2010 Mar 03; 30(9):3276-86.
Madhavan A, He L, Stuber GD, Bonci A, Whistler JL. PMID: 20203187; PMCID: PMC2943338.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1. Neuropsychopharmacology. 2010 May; 35(6):1363-73.
Martini L, Thompson D, Kharazia V, Whistler JL. PMID: 20164830; PMCID: PMC2953419.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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GPR55 ligands promote receptor coupling to multiple signalling pathways. Br J Pharmacol. 2010 Jun; 160(3):604-14.
Henstridge CM, Balenga NA, Schröder R, Kargl JK, Platzer W, Martini L, Arthur S, Penman J, Whistler JL, Kostenis E, Waldhoer M, Irving AJ. PMID: 20136841; PMCID: PMC2931561.
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PubMed Mentions:
87 Fields:
Translation:
HumansCells
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Opioid-receptor-heteromer-specific trafficking and pharmacology. Curr Opin Pharmacol. 2010 Feb; 10(1):73-9.
van Rijn RM, Whistler JL, Waldhoer M. PMID: 19846340; PMCID: PMC2900797.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor. FASEB J. 2009 Dec; 23(12):4327-34.
He L, Kim JA, Whistler JL. PMID: 19679639; PMCID: PMC2812043.
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PubMed Mentions:
19 Fields:
Translation:
Animals
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The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake. Biol Psychiatry. 2009 Oct 15; 66(8):777-84.
van Rijn RM, Whistler JL. PMID: 19576572; PMCID: PMC2757485.
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PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
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Functional characterization of human variants of the mu-opioid receptor gene. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10811-6.
Ravindranathan A, Joslyn G, Robertson M, Schuckit MA, Whistler JL, White RL. PMID: 19528663; PMCID: PMC2705556.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Methadone antinociception is dependent on peripheral opioid receptors. J Pain. 2009 Apr; 10(4):369-79.
He L, Kim J, Ou C, McFadden W, van Rijn RM, Whistler JL. PMID: 19327642; PMCID: PMC2952445.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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PKCepsilon regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2. Neuropsychopharmacology. 2009 Jun; 34(7):1733-42.
Wallace MJ, Newton PM, McMahon T, Connolly J, Huibers A, Whistler J, Messing RO. PMID: 19158669; PMCID: PMC2680927.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers? Mol Interv. 2008 Dec; 8(6):277-80.
van Rijn RM, Whistler JL. PMID: 19144899.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. J Biol Chem. 2009 Jan 09; 284(2):1324-36.
Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E. PMID: 19010788.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence. Curr Biol. 2008 Jan 22; 18(2):129-35.
Kim JA, Bartlett S, He L, Nielsen CK, Chang AM, Kharazia V, Waldhoer M, Ou CJ, Taylor S, Ferwerda M, Cado D, Whistler JL. PMID: 18207746; PMCID: PMC2997702.
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PubMed Mentions:
56 Fields:
Translation:
Animals
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The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Curr Opin Neurobiol. 2007 Oct; 17(5):556-64.
Martini L, Whistler JL. PMID: 18068348.
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PubMed Mentions:
103 Fields:
Translation:
HumansAnimalsCells
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Changes in G protein-coupled receptor sorting protein affinity regulate postendocytic targeting of G protein-coupled receptors. J Biol Chem. 2007 Oct 05; 282(40):29178-85.
Thompson D, Pusch M, Whistler JL. PMID: 17635908.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Acute amphetamine exposure selectively desensitizes kappa-opioid receptors in the nucleus accumbens. Neuropsychopharmacology. 2008 Mar; 33(4):892-900.
Xia YF, He L, Whistler JL, Hjelmstad GO. PMID: 17551543; PMCID: PMC2268619.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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A molecular basis of analgesic tolerance to cannabinoids. J Neurosci. 2007 Apr 11; 27(15):4165-77.
Tappe-Theodor A, Agarwal N, Katona I, Rubino T, Martini L, Swiercz J, Mackie K, Monyer H, Parolaro D, Whistler J, Kuner T, Kuner R. PMID: 17428994; PMCID: PMC6672554.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice. Genes Brain Behav. 2007 Nov; 6(8):728-35.
Lasek AW, Janak PH, He L, Whistler JL, Heberlein U. PMID: 17428267.
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PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
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The biochemical analysis of methadone modulation on morphine-induced tolerance and dependence in the rat brain. Pharmacology. 2007; 79(4):193-202.
He L, Whistler JL. PMID: 17356311.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1. FASEB J. 2007 Mar; 21(3):802-11.
Martini L, Waldhoer M, Pusch M, Kharazia V, Fong J, Lee JH, Freissmuth C, Whistler JL. PMID: 17197383.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Kinins promote B2 receptor endocytosis and delay constitutive B1 receptor endocytosis. Mol Pharmacol. 2007 Feb; 71(2):494-507.
Enquist J, Skröder C, Whistler JL, Leeb-Lundberg LM. PMID: 17110500.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11521-6.
Bartlett SE, Enquist J, Hopf FW, Lee JH, Gladher F, Kharazia V, Waldhoer M, Mailliard WS, Armstrong R, Bonci A, Whistler JL. PMID: 16049099; PMCID: PMC1183554.
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PubMed Mentions:
88 Fields:
Translation:
HumansAnimalsCells
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An opiate cocktail that reduces morphine tolerance and dependence. Curr Biol. 2005 Jun 07; 15(11):1028-33.
He L, Whistler JL. PMID: 15936273.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):9050-5.
Waldhoer M, Fong J, Jones RM, Lunzer MM, Sharma SK, Kostenis E, Portoghese PS, Whistler JL. PMID: 15932946; PMCID: PMC1157030.
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A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity. J Pharmacol Exp Ther. 2005 Apr; 313(1):78-87.
Kostenis E, Martini L, Ellis J, Waldhoer M, Heydorn A, Rosenkilde MM, Norregaard PK, Jorgensen R, Whistler JL, Milligan G. PMID: 15615862.
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21 Fields:
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A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). J Biol Chem. 2004 Dec 24; 279(52):54291-303.
Heydorn A, Søndergaard BP, Ersbøll B, Holst B, Nielsen FC, Haft CR, Whistler J, Schwartz TW. PMID: 15452121.
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76 Fields:
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Opioid receptors. Annu Rev Biochem. 2004; 73:953-90.
Waldhoer M, Bartlett SE, Whistler JL. PMID: 15189164.
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242 Fields:
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HumansAnimals
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The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. J Biol Chem. 2003 May 23; 278(21):19473-82.
Waldhoer M, Casarosa P, Rosenkilde MM, Smit MJ, Leurs R, Whistler JL, Schwartz TW. PMID: 12646575.
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39 Fields:
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Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic. 2002 Dec; 3(12):866-77.
Whistler JL, Gerber BO, Meng EC, Baranski TJ, von Zastrow M, Bourne HR. PMID: 12453150.
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16 Fields:
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Modulation of postendocytic sorting of G protein-coupled receptors. Science. 2002 Jul 26; 297(5581):615-20.
Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M. PMID: 12142540.
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125 Fields:
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mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization. J Neurosci. 2002 Jul 01; 22(13):5769-76.
Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler JL, Von Zastrow M, Grandy DK, Williams JT. PMID: 12097530; PMCID: PMC6758217.
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76 Fields:
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The near-death experience of delta opioid receptors leads to new drug targets. Mol Interv. 2002 Jun; 2(3):134-6.
Bartlett SE, Whistler JL. PMID: 14993372.
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Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell. 2002 Jan 25; 108(2):271-82.
He L, Fong J, von Zastrow M, Whistler JL. PMID: 11832216.
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118 Fields:
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Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal. Neuron. 2001 Dec 06; 32(5):829-39.
Finn AK, Whistler JL. PMID: 11738029.
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109 Fields:
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A phosphorylation-regulated brake mechanism controls the initial endocytosis of opioid receptors but is not required for post-endocytic sorting to lysosomes. J Biol Chem. 2001 Sep 07; 276(36):34331-8.
Whistler JL, Tsao P, von Zastrow M. PMID: 11443128.
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25 Fields:
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Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature. 2001 May 31; 411(6837):583-7.
Ungless MA, Whistler JL, Malenka RC, Bonci A. PMID: 11385572.
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484 Fields:
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Tales from the crypt: evidence for heptahelical receptor signaling in the endocytic pathway. Sci STKE. 2000 Aug 29; 2000(47):pe1.
Whistler J, Beattie E, von Zastrow M. PMID: 11752604.
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Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction. J Biol Chem. 1999 Aug 27; 274(35):24575-8.
Whistler JL, von Zastrow M. PMID: 10455121.
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24 Fields:
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Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron. 1999 Aug; 23(4):737-46.
Whistler JL, Chuang HH, Chu P, Jan LY, von Zastrow M. PMID: 10482240.
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160 Fields:
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Morphine-activated opioid receptors elude desensitization by beta-arrestin. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9914-9.
Whistler JL, von Zastrow M. PMID: 9707575; PMCID: PMC21436.
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131 Fields:
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Ras2 and Ras1 protein phosphorylation in Saccharomyces cerevisiae. J Biol Chem. 1997 Jul 25; 272(30):18790-800.
Whistler JL, Rine J. PMID: 9228053.
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10 Fields:
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AnimalsCells