Jennifer L Whistler

InstitutionUniversity of California Davis
DepartmentPhysiology and Membrane Biology
Address1275 Med Sci Drive
CA 95616
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    Collapse Research 
    Collapse Research Activities and Funding
    Genetic Variation in the Neuropeptide S Receptor and Opioid Abuse Liability
    NIH/NIDA R21DA043816Sep 1, 2017 - Aug 31, 2019
    Role: Principal Investigator
    Molecular and circuit mechanisms of antipsychotics
    NIH/NIMH R01MH112729Apr 10, 2017 - Feb 28, 2022
    Role: Co-Principal Investigator
    Dopamine receptor trafficking in drug sensitization and behavioral flexibility
    NIH/NIDA R01DA037963Sep 15, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Neuropeptide S receptors in ethanol abuse and anxiety
    NIH/NIAAA R21AA023231Sep 10, 2015 - Aug 31, 2018
    Role: Principal Investigator
    Receptor trafficking profiles of clinically important dopaminergic drugs
    NIH/NIMH R21MH096058Mar 1, 2012 - Feb 28, 2014
    Role: Principal Investigator
    Selectively targeting delta opioid receptor subtypes to control drinking behavior
    NIH/NIAAA R01AA020401Aug 1, 2011 - Jun 30, 2018
    Role: Principal Investigator
    Selectively Targeting Opioid Receptor Heterodimers
    NIH/NIDA R21DA031574Feb 15, 2011 - Jan 31, 2014
    Role: Principal Investigator
    Role of opioid receptor trafficking in tolerance and dependence
    NIH/NIDA R01DA019958May 1, 2007 - Mar 31, 2014
    Role: Principal Investigator
    GASP and Trafficking of the Dopamine Receptors
    NIH/NIMH R01MH068442Jul 1, 2003 - Apr 30, 2009
    Role: Principal Investigator
    Trafficking and signaling of opioid receptor subtypes and heterodimers
    NIH/NIDA R01DA015232Apr 1, 2002 - Jul 31, 2011
    Role: Principal Investigator
    NIH/NIDA F32DA005844Mar 25, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Luo SX, Timbang L, Kim JI, Shang Y, Sandoval K, Tang AA, Whistler JL, Ding JB, Huang EJ. TGF-ß Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning. Cell Rep. 2016 12 20; 17(12):3233-3245. PMID: 28009292.
      View in: PubMed
    2. Johnson TA, Milan-Lobo L, Che T, Ferwerda M, Lambu E, McIntosh NL, Li F, He L, Lorig-Roach N, Crews P, Whistler JL. Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins. ACS Chem Neurosci. 2017 03 15; 8(3):473-485. PMID: 27744679.
      View in: PubMed
    3. Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. J Neurosci. 2016 07 27; 36(30):7925-35. PMID: 27466337; PMCID: PMC4961778 [Available on 01/27/17].
    4. Yang S, Ben-Shalom R, Ahn M, Liptak AT, van Rijn RM, Whistler JL, Bender KJ. ß-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment. Cell Rep. 2016 08 09; 16(6):1518-1526. PMID: 27452469.
      View in: PubMed
    5. Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler JL, Bruchas MR, Kash TL. Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell Rep. 2016 Mar 29; 14(12):2774-83. PMID: 26997280; PMCID: PMC4814306.
    6. Roed SN, Wismann P, Underwood CR, Kulahin N, Iversen H, Cappelen KA, Schäffer L, Lehtonen J, Hecksher-Soerensen J, Secher A, Mathiesen JM, Bräuner-Osborne H, Whistler JL, Knudsen SM, Waldhoer M. Real-time trafficking and signaling of the glucagon-like peptide-1 receptor. Mol Cell Endocrinol. 2014 Feb 15; 382(2):938-49. PMID: 24275181.
      View in: PubMed
    7. He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell. 2013 Aug 29; 154(5):1085-1099. PMID: 23954414.
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    8. Madhavan A, Argilli E, Bonci A, Whistler JL. Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area. J Neurosci. 2013 Jul 24; 33(30):12329-36. PMID: 23884939; PMCID: PMC3721842.
    9. van Rijn RM, Defriel JN, Whistler JL. Pharmacological traits of delta opioid receptors: pitfalls or opportunities? Psychopharmacology (Berl). 2013 Jul; 228(1):1-18. PMID: 23649885; PMCID: PMC3679311.
    10. Milan-Lobo L, Enquist J, van Rijn RM, Whistler JL. Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. PLoS One. 2013; 8(3):e58362. PMID: 23554887; PMCID: PMC3598907.
    11. Goldsmith JR, Perez-Chanona E, Yadav PN, Whistler J, Roth B, Jobin C. Intestinal epithelial cell-derived µ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling. Am J Pathol. 2013 Mar; 182(3):776-85. PMID: 23291213; PMCID: PMC3589074.
    12. Harvey JH, van Rijn RM, Whistler JL. A FLIPR assay for evaluating agonists and antagonists of GPCR heterodimers. Methods Mol Biol. 2013; 995:43-54. PMID: 23494371.
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    13. van Rijn RM, Harvey JH, Brissett DI, DeFriel JN, Whistler JL. Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling. J Pharmacol Exp Ther. 2013 Jan; 344(1):179-88. PMID: 23097213; PMCID: PMC3533407.
    14. Harvey JH, Long DH, England PM, Whistler JL. Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers. ACS Med Chem Lett. 2012 Aug 09; 3(8):640-644. PMID: 23585918.
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    15. Enquist J, Ferwerda M, Madhavan A, Hok D, Whistler JL. Chronic ethanol potentiates the effect of neuropeptide s in the basolateral amygdala and shows increased anxiolytic and anti-depressive effects. Neuropsychopharmacology. 2012 Oct; 37(11):2436-45. PMID: 22739468; PMCID: PMC3445991.
    16. Albada HB, Wieberneit F, Dijkgraaf I, Harvey JH, Whistler JL, Stoll R, Metzler-Nolte N, Fish RH. The chemoselective reactions of tyrosine-containing G-protein-coupled receptor peptides with [Cp*Rh(H2O)3](OTf)2, including 2D NMR structures and the biological consequences. J Am Chem Soc. 2012 Jun 27; 134(25):10321-4. PMID: 22671299.
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    17. Schröder R, Xue L, Konya V, Martini L, Kampitsch N, Whistler JL, Ulven T, Heinemann A, Pettipher R, Kostenis E. PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2. PLoS One. 2012; 7(3):e33329. PMID: 22442685; PMCID: PMC3307725.
    18. Whistler JL. Examining the role of mu opioid receptor endocytosis in the beneficial and side-effects of prolonged opioid use: from a symposium on new concepts in mu-opioid pharmacology. Drug Alcohol Depend. 2012 Mar 01; 121(3):189-204. PMID: 22226706; PMCID: PMC4224378.
    19. Enquist J, Ferwerda M, Milan-Lobo L, Whistler JL. Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice. J Pharmacol Exp Ther. 2012 Feb; 340(2):386-92. PMID: 22062352; PMCID: PMC3263965.
    20. Kühhorn J, Götz A, Hübner H, Thompson D, Whistler J, Gmeiner P. Development of a bivalent dopamine D2 receptor agonist. J Med Chem. 2011 Nov 24; 54(22):7911-9. PMID: 21999579.
      View in: PubMed
    21. van Rijn RM, Brissett DI, Whistler JL. Distinctive modulation of ethanol place preference by delta opioid receptor-selective agonists. Drug Alcohol Depend. 2012 Apr 01; 122(1-2):156-9. PMID: 22018601; PMCID: PMC3279630.
    22. van Rijn RM, Brissett DI, Whistler JL. Emergence of functional spinal delta opioid receptors after chronic ethanol exposure. Biol Psychiatry. 2012 Feb 01; 71(3):232-8. PMID: 21889123; PMCID: PMC4086708.
    23. Berger AC, Whistler JL. Morphine-induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use. EMBO Mol Med. 2011 Jul; 3(7):385-97. PMID: 21656686; PMCID: PMC3394511.
    24. He L, Whistler JL. Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis. PLoS One. 2011; 6(5):e19372. PMID: 21602922; PMCID: PMC3094338.
    25. Enquist J, Kim JA, Bartlett S, Ferwerda M, Whistler JL. A novel knock-in mouse reveals mechanistically distinct forms of morphine tolerance. J Pharmacol Exp Ther. 2011 Aug; 338(2):633-40. PMID: 21562138; PMCID: PMC3141896.
    26. Thompson D, Whistler JL. Trafficking properties of the D5 dopamine receptor. Traffic. 2011 May; 12(5):644-56. PMID: 21348911.
      View in: PubMed
    27. Milan-Lobo L, Whistler JL. Heteromerization of the µ- and d-opioid receptors produces ligand-biased antagonism and alters µ-receptor trafficking. J Pharmacol Exp Ther. 2011 Jun; 337(3):868-75. PMID: 21422164; PMCID: PMC3097170.
    28. Tschammer N, Elsner J, Goetz A, Ehrlich K, Schuster S, Ruberg M, Kühhorn J, Thompson D, Whistler J, Hübner H, Gmeiner P. Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions. J Med Chem. 2011 Apr 14; 54(7):2477-91. PMID: 21388142.
      View in: PubMed
    29. Thompson D, Whistler JL. Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1. J Biol Chem. 2011 Jan 14; 286(2):1598-608. PMID: 21030592; PMCID: PMC3020768.
    30. Madhavan A, Bonci A, Whistler JL. Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area. J Neurosci. 2010 Oct 20; 30(42):14029-35. PMID: 20962224; PMCID: PMC3637958.
    31. van Rijn RM, Brissett DI, Whistler JL. Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety. J Pharmacol Exp Ther. 2010 Oct; 335(1):133-9. PMID: 20605909; PMCID: PMC2957775.
    32. Moser E, Kargl J, Whistler JL, Waldhoer M, Tschische P. G protein-coupled receptor-associated sorting protein 1 regulates the postendocytic sorting of seven-transmembrane-spanning G protein-coupled receptors. Pharmacology. 2010; 86(1):22-9. PMID: 20693822; PMCID: PMC2919430.
    33. Thompson D, Martini L, Whistler JL. Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine. PLoS One. 2010 Jun 09; 5(6):e11038. PMID: 20543951; PMCID: PMC2882949.
    34. Berger AC, Whistler JL. How to design an opioid drug that causes reduced tolerance and dependence. Ann Neurol. 2010 May; 67(5):559-69. PMID: 20437553; PMCID: PMC2943346.
    35. Tschische P, Moser E, Thompson D, Vischer HF, Parzmair GP, Pommer V, Platzer W, Schwarzbraun T, Schaider H, Smit MJ, Martini L, Whistler JL, Waldhoer M. The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28. Traffic. 2010 May; 11(5):660-74. PMID: 20102549; PMCID: PMC2974616.
    36. Bonde MM, Yao R, Ma JN, Madabushi S, Haunsø S, Burstein ES, Whistler JL, Sheikh SP, Lichtarge O, Hansen JL. An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis. Biochem Pharmacol. 2010 Jul 01; 80(1):86-94. PMID: 20227396; PMCID: PMC2864232.
    37. Madhavan A, He L, Stuber GD, Bonci A, Whistler JL. micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal. J Neurosci. 2010 Mar 03; 30(9):3276-86. PMID: 20203187; PMCID: PMC2943338.
    38. Martini L, Thompson D, Kharazia V, Whistler JL. Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1. Neuropsychopharmacology. 2010 May; 35(6):1363-73. PMID: 20164830; PMCID: PMC2953419.
    39. Henstridge CM, Balenga NA, Schröder R, Kargl JK, Platzer W, Martini L, Arthur S, Penman J, Whistler JL, Kostenis E, Waldhoer M, Irving AJ. GPR55 ligands promote receptor coupling to multiple signalling pathways. Br J Pharmacol. 2010 Jun; 160(3):604-14. PMID: 20136841; PMCID: PMC2931561.
    40. van Rijn RM, Whistler JL, Waldhoer M. Opioid-receptor-heteromer-specific trafficking and pharmacology. Curr Opin Pharmacol. 2010 Feb; 10(1):73-9. PMID: 19846340; PMCID: PMC2900797.
    41. He L, Kim JA, Whistler JL. Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor. FASEB J. 2009 Dec; 23(12):4327-34. PMID: 19679639; PMCID: PMC2812043.
    42. van Rijn RM, Whistler JL. The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake. Biol Psychiatry. 2009 Oct 15; 66(8):777-84. PMID: 19576572; PMCID: PMC2757485.
    43. Ravindranathan A, Joslyn G, Robertson M, Schuckit MA, Whistler JL, White RL. Functional characterization of human variants of the mu-opioid receptor gene. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10811-6. PMID: 19528663; PMCID: PMC2705556.
    44. He L, Kim J, Ou C, McFadden W, van Rijn RM, Whistler JL. Methadone antinociception is dependent on peripheral opioid receptors. J Pain. 2009 Apr; 10(4):369-79. PMID: 19327642; PMCID: PMC2952445.
    45. Wallace MJ, Newton PM, McMahon T, Connolly J, Huibers A, Whistler J, Messing RO. PKCepsilon regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2. Neuropsychopharmacology. 2009 Jun; 34(7):1733-42. PMID: 19158669; PMCID: PMC2680927.
    46. van Rijn RM, Whistler JL. The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers? Mol Interv. 2008 Dec; 8(6):277-80. PMID: 19144899.
      View in: PubMed
    47. Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E. The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. J Biol Chem. 2009 Jan 09; 284(2):1324-36. PMID: 19010788.
      View in: PubMed
    48. Kim JA, Bartlett S, He L, Nielsen CK, Chang AM, Kharazia V, Waldhoer M, Ou CJ, Taylor S, Ferwerda M, Cado D, Whistler JL. Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence. Curr Biol. 2008 Jan 22; 18(2):129-35. PMID: 18207746; PMCID: PMC2997702.
    49. Martini L, Whistler JL. The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Curr Opin Neurobiol. 2007 Oct; 17(5):556-64. PMID: 18068348.
      View in: PubMed
    50. Thompson D, Pusch M, Whistler JL. Changes in G protein-coupled receptor sorting protein affinity regulate postendocytic targeting of G protein-coupled receptors. J Biol Chem. 2007 Oct 05; 282(40):29178-85. PMID: 17635908.
      View in: PubMed
    51. Xia YF, He L, Whistler JL, Hjelmstad GO. Acute amphetamine exposure selectively desensitizes kappa-opioid receptors in the nucleus accumbens. Neuropsychopharmacology. 2008 Mar; 33(4):892-900. PMID: 17551543; PMCID: PMC2268619.
    52. Tappe-Theodor A, Agarwal N, Katona I, Rubino T, Martini L, Swiercz J, Mackie K, Monyer H, Parolaro D, Whistler J, Kuner T, Kuner R. A molecular basis of analgesic tolerance to cannabinoids. J Neurosci. 2007 Apr 11; 27(15):4165-77. PMID: 17428994.
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    53. He L, Whistler JL. The biochemical analysis of methadone modulation on morphine-induced tolerance and dependence in the rat brain. Pharmacology. 2007; 79(4):193-202. PMID: 17356311.
      View in: PubMed
    54. Martini L, Waldhoer M, Pusch M, Kharazia V, Fong J, Lee JH, Freissmuth C, Whistler JL. Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1. FASEB J. 2007 Mar; 21(3):802-11. PMID: 17197383.
      View in: PubMed
    55. Enquist J, Skröder C, Whistler JL, Leeb-Lundberg LM. Kinins promote B2 receptor endocytosis and delay constitutive B1 receptor endocytosis. Mol Pharmacol. 2007 Feb; 71(2):494-507. PMID: 17110500.
      View in: PubMed
    56. Bartlett SE, Enquist J, Hopf FW, Lee JH, Gladher F, Kharazia V, Waldhoer M, Mailliard WS, Armstrong R, Bonci A, Whistler JL. Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11521-6. PMID: 16049099; PMCID: PMC1183554.
    57. He L, Whistler JL. An opiate cocktail that reduces morphine tolerance and dependence. Curr Biol. 2005 Jun 07; 15(11):1028-33. PMID: 15936273.
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    58. Waldhoer M, Fong J, Jones RM, Lunzer MM, Sharma SK, Kostenis E, Portoghese PS, Whistler JL. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):9050-5. PMID: 15932946; PMCID: PMC1157030.
    59. Kostenis E, Martini L, Ellis J, Waldhoer M, Heydorn A, Rosenkilde MM, Norregaard PK, Jorgensen R, Whistler JL, Milligan G. A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity. J Pharmacol Exp Ther. 2005 Apr; 313(1):78-87. PMID: 15615862.
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    60. Heydorn A, Søndergaard BP, Ersbøll B, Holst B, Nielsen FC, Haft CR, Whistler J, Schwartz TW. A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). J Biol Chem. 2004 Dec 24; 279(52):54291-303. PMID: 15452121.
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    61. Waldhoer M, Bartlett SE, Whistler JL. Opioid receptors. Annu Rev Biochem. 2004; 73:953-90. PMID: 15189164.
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    62. Waldhoer M, Casarosa P, Rosenkilde MM, Smit MJ, Leurs R, Whistler JL, Schwartz TW. The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. J Biol Chem. 2003 May 23; 278(21):19473-82. PMID: 12646575.
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    63. Whistler JL, Gerber BO, Meng EC, Baranski TJ, von Zastrow M, Bourne HR. Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic. 2002 Dec; 3(12):866-77. PMID: 12453150.
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    64. Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M. Modulation of postendocytic sorting of G protein-coupled receptors. Science. 2002 Jul 26; 297(5581):615-20. PMID: 12142540.
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    65. Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler JL, Von Zastrow M, Grandy DK, Williams JT. mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization. J Neurosci. 2002 Jul 01; 22(13):5769-76. PMID: 12097530.
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    66. Bartlett SE, Whistler JL. The near-death experience of delta opioid receptors leads to new drug targets. Mol Interv. 2002 Jun; 2(3):134-6. PMID: 14993372.
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    67. He L, Fong J, von Zastrow M, Whistler JL. Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell. 2002 Jan 25; 108(2):271-82. PMID: 11832216.
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