Michael A Savageau

Title(s)Professor Emeritus, Biomedical Engineering
SchoolCollege of Biological Sciences
Address228 Briggs Hall
CA 95616
Phone530-752-3047
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    Collapse Research 
    Collapse Research Activities and Funding
    International Conference on Molecular Systems Biology
    NIH/NIGMS R13GM071521Aug 1, 2004 - Jul 31, 2005
    Role: Principal Investigator
    Cellular Biotechnology Training Program (CBTP)
    NIH/NIGMS T32GM008353Jul 1, 1991 - Jun 30, 2022
    Role: Co-Principal Investigator
    Analysis of Molecular Networks and Control Systems
    NIH/NIGMS R01GM030054Apr 1, 1982 - Apr 30, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phenotype-centric modeling for rational metabolic engineering. Metab Eng. 2022 07; 72:365-375. Valderrama-Gómez MÁ, Savageau MA. PMID: 35537663.
      View in: PubMed   Mentions:    Fields:    
    2. TaxisPy: A Python-based software for the quantitative analysis of bacterial chemotaxis. J Microbiol Methods. 2020 08; 175:105918. Valderrama-Gómez MÁ, Schomer RA, Savageau MA, Parales RE. PMID: 32512119.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Mechanistic Modeling of Biochemical Systems without A Priori Parameter Values Using the Design Space Toolbox v.3.0. iScience. 2020 Jun 26; 23(6):101200. Valderrama-Gómez MÁ, Lomnitz JG, Fasani RA, Savageau MA. PMID: 32531747; PMCID: PMC7287267.
      View in: PubMed   Mentions:
    4. Molecular Mechanisms Driving Switch Behavior in Xylem Cell Differentiation. Cell Rep. 2019 07 09; 28(2):342-351.e4. Turco GM, Rodriguez-Medina J, Siebert S, Han D, Valderrama-Gómez MÁ, Vahldick H, Shulse CN, Cole BJ, Juliano CE, Dickel DE, Savageau MA, Brady SM. PMID: 31291572.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    5. Phenotype-centric modeling for elucidation of biological design principles. J Theor Biol. 2018 10 14; 455:281-292. Valderrama-Gómez MA, Parales RE, Savageau MA. PMID: 30036529.
      View in: PubMed   Mentions: 1     Fields:    
    6. Rapid Discrimination Among Putative Mechanistic Models of Biochemical Systems. Sci Rep. 2016 08 31; 6:32375. Lomnitz JG, Savageau MA. PMID: 27578053; PMCID: PMC5006174.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    7. Design Space Toolbox V2: Automated Software Enabling a Novel Phenotype-Centric Modeling Strategy for Natural and Synthetic Biological Systems. Front Genet. 2016; 7:118. Lomnitz JG, Savageau MA. PMID: 27462346; PMCID: PMC4940394.
      View in: PubMed   Mentions: 5  
    8. Elucidating the genotype-phenotype map by automatic enumeration and analysis of the phenotypic repertoire. NPJ Syst Biol Appl. 2015; 1. Lomnitz JG, Savageau MA. PMID: 26998346; PMCID: PMC4794114.
      View in: PubMed   Mentions: 6     Fields:    
    9. Unrelated toxin-antitoxin systems cooperate to induce persistence. J R Soc Interface. 2015 Jul 06; 12(108):20150130. Fasani RA, Savageau MA. PMID: 26063817; PMCID: PMC4528579.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    10. Design principles of a conditional futile cycle exploited for regulation. Mol Biosyst. 2015 Jul; 11(7):1841-9. Tolla DA, Kiley PJ, Lomnitz JG, Savageau MA. PMID: 25851148; PMCID: PMC4470783.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    11. Evolution of a genome-encoded bias in amino acid biosynthetic pathways is a potential indicator of amino acid dynamics in the environment. Mol Biol Evol. 2014 Nov; 31(11):2865-78. Fasani RA, Savageau MA. PMID: 25118252; PMCID: PMC4209129.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    12. Strategy revealing phenotypic differences among synthetic oscillator designs. ACS Synth Biol. 2014 Sep 19; 3(9):686-701. Lomnitz JG, Savageau MA. PMID: 25019938; PMCID: PMC4210169.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    13. Relative amino acid composition signatures of organisms and environments. PLoS One. 2013; 8(10):e77319. Moura A, Savageau MA, Alves R. PMID: 24204807; PMCID: PMC3808408.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    14. Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):E2528-37. Fasani RA, Savageau MA. PMID: 23781105; PMCID: PMC3703989.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    15. Transcription factors in Escherichia coli prefer the holo conformation. PLoS One. 2013; 8(6):e65723. Balderas-Martínez YI, Savageau M, Salgado H, Pérez-Rueda E, Morett E, Collado-Vides J. PMID: 23776535; PMCID: PMC3680503.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    16. Phenotypic deconstruction of gene circuitry. Chaos. 2013 Jun; 23(2):025108. Lomnitz JG, Savageau MA. PMID: 23822506; PMCID: PMC3695976.
      View in: PubMed   Mentions: 7     Fields:    
    17. A bistable hysteretic switch in an activator-repressor regulated restriction-modification system. Nucleic Acids Res. 2013 Jul; 41(12):6045-57. Williams K, Savageau MA, Blumenthal RM. PMID: 23630319; PMCID: PMC3695507.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    18. Regulatory design governing progression of population growth phases in bacteria. PLoS One. 2012; 7(2):e30654. Martínez-Antonio A, Lomnitz JG, Sandoval S, Aldana M, Savageau MA. PMID: 22363461; PMCID: PMC3283595.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    19. Design of the lac gene circuit revisited. Math Biosci. 2011 May; 231(1):19-38. Savageau MA. PMID: 21414326; PMCID: PMC3126112.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    20. Biomedical engineering strategies in system design space. Ann Biomed Eng. 2011 Apr; 39(4):1278-95. Savageau MA. PMID: 21203848; PMCID: PMC3074507.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. Phenotypic repertoire of the FNR regulatory network in Escherichia coli. Mol Microbiol. 2011 Jan; 79(1):149-65. Tolla DA, Savageau MA. PMID: 21166900; PMCID: PMC3075585.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    22. Relating mutant genotype to phenotype via quantitative behavior of the NADPH redox cycle in human erythrocytes. PLoS One. 2010 Sep 28; 5(9). Coelho PM, Salvador A, Savageau MA. PMID: 20927393; PMCID: PMC2946920.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    23. Automated construction and analysis of the design space for biochemical systems. Bioinformatics. 2010 Oct 15; 26(20):2601-9. Fasani RA, Savageau MA. PMID: 20823298; PMCID: PMC3025649.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    24. Regulation of aerobic-to-anaerobic transitions by the FNR cycle in Escherichia coli. J Mol Biol. 2010 Apr 09; 397(4):893-905. Tolla DA, Savageau MA. PMID: 20156450; PMCID: PMC2867928.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    25. Duplication frequency in a population of Salmonella enterica rapidly approaches steady state with or without recombination. Genetics. 2010 Apr; 184(4):1077-94. Reams AB, Kofoid E, Savageau M, Roth JR. PMID: 20083614; PMCID: PMC2865909.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    26. Qualitatively distinct phenotypes in the design space of biochemical systems. FEBS Lett. 2009 Dec 17; 583(24):3914-22. Savageau MA, Fasani RA. PMID: 19879266; PMCID: PMC2888490.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    27. Quantifying global tolerance of biochemical systems: design implications for moiety-transfer cycles. PLoS Comput Biol. 2009 Mar; 5(3):e1000319. Coelho PM, Salvador A, Savageau MA. PMID: 19300483; PMCID: PMC2650413.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    28. Phenotypes and tolerances in the design space of biochemical systems. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6435-40. Savageau MA, Coelho PM, Fasani RA, Tolla DA, Salvador A. PMID: 19279208; PMCID: PMC2672487.
      View in: PubMed   Mentions: 35     Fields:    
    29. Hysteretic and graded responses in bacterial two-component signal transduction. Mol Microbiol. 2008 Jun; 68(5):1196-215. Igoshin OA, Alves R, Savageau MA. PMID: 18363790; PMCID: PMC4372536.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    30. Distinctive topologies of partner-switching signaling networks correlate with their physiological roles. J Mol Biol. 2007 Jun 22; 369(5):1333-52. Igoshin OA, Brody MS, Price CW, Savageau MA. PMID: 17498739; PMCID: PMC2727513.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    31. Signalling network with a bistable hysteretic switch controls developmental activation of the sigma transcription factor in Bacillus subtilis. Mol Microbiol. 2006 Jul; 61(1):165-84. Igoshin OA, Price CW, Savageau MA. PMID: 16824103.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    32. Evolution of enzymes in a series is driven by dissimilar functional demands. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2226-31. Salvador A, Savageau MA. PMID: 16461898; PMCID: PMC1413729.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    33. Evidence of selection for low cognate amino acid bias in amino acid biosynthetic enzymes. Mol Microbiol. 2005 May; 56(4):1017-34. Alves R, Savageau MA. PMID: 15853887; PMCID: PMC1839009.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    34. Design of gene circuits: lessons from bacteria. Nat Rev Genet. 2004 Jan; 5(1):34-42. Wall ME, Hlavacek WS, Savageau MA. PMID: 14708014.
      View in: PubMed   Mentions: 78     Fields:    Translation:Cells
    35. Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14463-8. Salvador A, Savageau MA. PMID: 14614139; PMCID: PMC283614.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    36. Design principles for regulator gene expression in a repressible gene circuit. J Mol Biol. 2003 Sep 26; 332(4):861-76. Wall ME, Hlavacek WS, Savageau MA. PMID: 12972257.
      View in: PubMed   Mentions: 19     Fields:    
    37. Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli. Cell. 2003 May 30; 113(5):597-607. Atkinson MR, Savageau MA, Myers JT, Ninfa AJ. PMID: 12787501.
      View in: PubMed   Mentions: 231     Fields:    Translation:Cells
    38. Comparative analysis of prototype two-component systems with either bifunctional or monofunctional sensors: differences in molecular structure and physiological function. Mol Microbiol. 2003 Apr; 48(1):25-51. Alves R, Savageau MA. PMID: 12657043.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    39. Alternative designs for a genetic switch: analysis of switching times using the piecewise power-law representation. Math Biosci. 2002 Nov-Dec; 180:237-53. Savageau MA. PMID: 12387925.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    40. Design principles for elementary gene circuits: Elements, methods, and examples. Chaos. 2001 Mar; 11(1):142-159. Savageau MA. PMID: 12779449.
      View in: PubMed   Mentions: 61     Fields:    
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