Michael A Savageau

Title(s)PROF IN RES-HCOMP, Biomedical Engineering
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    Collapse Research 
    Collapse Research Activities and Funding
    International Conference on Molecular Systems Biology
    NIH/NIGMS R13GM071521Aug 1, 2004 - Jul 31, 2005
    Role: Principal Investigator
    Cellular Biotechnology Training Program (CBTP)
    NIH/NIGMS T32GM008353Jul 1, 1991 - Jun 30, 2022
    Role: Co-Principal Investigator
    Analysis of Molecular Networks and Control Systems
    NIH/NIGMS R01GM030054Apr 1, 1982 - Apr 30, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Valderrama-Gómez MA, Parales RE, Savageau MA. Phenotype-centric modeling for elucidation of biological design principles. J Theor Biol. 2018 Oct 14; 455:281-292. PMID: 30036529.
      View in: PubMed
    2. Lomnitz JG, Savageau MA. Rapid Discrimination Among Putative Mechanistic Models of Biochemical Systems. Sci Rep. 2016 08 31; 6:32375. PMID: 27578053.
      View in: PubMed
    3. Lomnitz JG, Savageau MA. Design Space Toolbox V2: Automated Software Enabling a Novel Phenotype-Centric Modeling Strategy for Natural and Synthetic Biological Systems. Front Genet. 2016; 7:118. PMID: 27462346.
      View in: PubMed
    4. Lomnitz JG, Savageau MA. Elucidating the genotype-phenotype map by automatic enumeration and analysis of the phenotypic repertoire. NPJ Syst Biol Appl. 2015; 1. PMID: 26998346.
      View in: PubMed
    5. Fasani RA, Savageau MA. Unrelated toxin-antitoxin systems cooperate to induce persistence. J R Soc Interface. 2015 Jul 06; 12(108):20150130. PMID: 26063817; PMCID: PMC4528579.
    6. Tolla DA, Kiley PJ, Lomnitz JG, Savageau MA. Design principles of a conditional futile cycle exploited for regulation. Mol Biosyst. 2015 Jul; 11(7):1841-9. PMID: 25851148; PMCID: PMC4470783.
    7. Fasani RA, Savageau MA. Evolution of a genome-encoded bias in amino acid biosynthetic pathways is a potential indicator of amino acid dynamics in the environment. Mol Biol Evol. 2014 Nov; 31(11):2865-78. PMID: 25118252; PMCID: PMC4209129.
    8. Lomnitz JG, Savageau MA. Strategy revealing phenotypic differences among synthetic oscillator designs. ACS Synth Biol. 2014 Sep 19; 3(9):686-701. PMID: 25019938; PMCID: PMC4210169.
    9. Fasani RA, Savageau MA. Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):E2528-37. PMID: 23781105; PMCID: PMC3703989.
    10. Lomnitz JG, Savageau MA. Phenotypic deconstruction of gene circuitry. Chaos. 2013 Jun; 23(2):025108. PMID: 23822506; PMCID: PMC3695976.
    11. Martínez-Antonio A, Lomnitz JG, Sandoval S, Aldana M, Savageau MA. Regulatory design governing progression of population growth phases in bacteria. PLoS One. 2012; 7(2):e30654. PMID: 22363461; PMCID: PMC3283595.
    12. Savageau MA. Design of the lac gene circuit revisited. Math Biosci. 2011 May; 231(1):19-38. PMID: 21414326; PMCID: PMC3126112.
    13. Savageau MA. Biomedical engineering strategies in system design space. Ann Biomed Eng. 2011 Apr; 39(4):1278-95. PMID: 21203848; PMCID: PMC3074507.
    14. Tolla DA, Savageau MA. Phenotypic repertoire of the FNR regulatory network in Escherichia coli. Mol Microbiol. 2011 Jan; 79(1):149-65. PMID: 21166900; PMCID: PMC3075585.
    15. Coelho PM, Salvador A, Savageau MA. Relating mutant genotype to phenotype via quantitative behavior of the NADPH redox cycle in human erythrocytes. PLoS One. 2010 Sep 28; 5(9). PMID: 20927393; PMCID: PMC2946920.
    16. Fasani RA, Savageau MA. Automated construction and analysis of the design space for biochemical systems. Bioinformatics. 2010 Oct 15; 26(20):2601-9. PMID: 20823298; PMCID: PMC3025649.
    17. Tolla DA, Savageau MA. Regulation of aerobic-to-anaerobic transitions by the FNR cycle in Escherichia coli. J Mol Biol. 2010 Apr 09; 397(4):893-905. PMID: 20156450; PMCID: PMC2867928.
    18. Reams AB, Kofoid E, Savageau M, Roth JR. Duplication frequency in a population of Salmonella enterica rapidly approaches steady state with or without recombination. Genetics. 2010 Apr; 184(4):1077-94. PMID: 20083614; PMCID: PMC2865909.
    19. Savageau MA, Fasani RA. Qualitatively distinct phenotypes in the design space of biochemical systems. FEBS Lett. 2009 Dec 17; 583(24):3914-22. PMID: 19879266; PMCID: PMC2888490.
    20. Coelho PM, Salvador A, Savageau MA. Quantifying global tolerance of biochemical systems: design implications for moiety-transfer cycles. PLoS Comput Biol. 2009 Mar; 5(3):e1000319. PMID: 19300483; PMCID: PMC2650413.
    21. Savageau MA, Coelho PM, Fasani RA, Tolla DA, Salvador A. Phenotypes and tolerances in the design space of biochemical systems. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6435-40. PMID: 19279208; PMCID: PMC2672487.
    22. Igoshin OA, Brody MS, Price CW, Savageau MA. Distinctive topologies of partner-switching signaling networks correlate with their physiological roles. J Mol Biol. 2007 Jun 22; 369(5):1333-52. PMID: 17498739; PMCID: PMC2727513.
    23. Igoshin OA, Price CW, Savageau MA. Signalling network with a bistable hysteretic switch controls developmental activation of the sigma transcription factor in Bacillus subtilis. Mol Microbiol. 2006 Jul; 61(1):165-84. PMID: 16824103.
      View in: PubMed
    24. Salvador A, Savageau MA. Evolution of enzymes in a series is driven by dissimilar functional demands. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2226-31. PMID: 16461898; PMCID: PMC1413729.
    25. Alves R, Savageau MA. Evidence of selection for low cognate amino acid bias in amino acid biosynthetic enzymes. Mol Microbiol. 2005 May; 56(4):1017-34. PMID: 15853887; PMCID: PMC1839009.
    26. Salvador A, Savageau MA. Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14463-8. PMID: 14614139; PMCID: PMC283614.
    27. Wall ME, Hlavacek WS, Savageau MA. Design principles for regulator gene expression in a repressible gene circuit. J Mol Biol. 2003 Sep 26; 332(4):861-76. PMID: 12972257.
      View in: PubMed
    28. Savageau MA. Alternative designs for a genetic switch: analysis of switching times using the piecewise power-law representation. Math Biosci. 2002 Nov-Dec; 180:237-53. PMID: 12387925.
      View in: PubMed