Christopher S Fraser

Title(s)Professor, Molecular and Cellular Biology
SchoolCollege of Biological Sciences
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    The mechanism of mRNA recruitment to the human ribosome.
    NIH/NIGMS R01GM092927Apr 5, 2010 - Apr 30, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human eukaryotic initiation factor 4G directly binds the 40S ribosomal subunit to promote efficient translation. J Biol Chem. 2024 Apr 01; 107242. Villa N, Fraser CS. PMID: 38569933.
      View in: PubMed   Mentions:    Fields:    
    2. It's a competitive business. Elife. 2024 Feb 23; 13. Sokabe M, Fraser CS. PMID: 38393777; PMCID: PMC10890784.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A. Nat Struct Mol Biol. 2024 Mar; 31(3):455-464. Brito Querido J, Sokabe M, Díaz-López I, Gordiyenko Y, Fraser CS, Ramakrishnan V. PMID: 38287194; PMCID: PMC10948362.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Human eukaryotic initiation factor 4G directly binds the 40S ribosomal subunit to promote efficient translation. bioRxiv. 2023 Sep 30. Villa N, Fraser CS. PMID: 37808713; PMCID: PMC10557762.
      View in: PubMed   Mentions:
    5. Cryo-EM Structure of Human Tumor Suppressor Protein Pdcd4 Bound to the Ribosome. Microsc Microanal. 2023 Jul 22; 29(29 Suppl 1):889. Querido JB, Sokabe M, Díaz-López I, Gordiyenko Y, Zuber P, Du Y, Albacete-Albacete L, Fraser CS, Ramakrishnan V. PMID: 37613482.
      View in: PubMed   Mentions:    Fields:    
    6. Monitoring RNA restructuring in a human cell-free extract reveals eIF4A-dependent and eIF4A-independent unwinding activity. J Biol Chem. 2023 07; 299(7):104936. O'Sullivan MH, Fraser CS. PMID: 37331603; PMCID: PMC10362145.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Human eukaryotic initiation factor 4E (eIF4E) and the nucleotide-bound state of eIF4A regulate eIF4F binding to RNA. J Biol Chem. 2022 10; 298(10):102368. Izidoro MS, Sokabe M, Villa N, Merrick WC, Fraser CS. PMID: 35963437; PMCID: PMC9483636.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining. Nature. 2022 07; 607(7917):185-190. Lapointe CP, Grosely R, Sokabe M, Alvarado C, Wang J, Montabana E, Villa N, Shin BS, Dever TE, Fraser CS, Fernández IS, Puglisi JD. PMID: 35732735; PMCID: PMC9728550.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    9. Structure of a human 48S translational initiation complex. Science. 2020 09 04; 369(6508):1220-1227. Brito Querido J, Sokabe M, Kraatz S, Gordiyenko Y, Skehel JM, Fraser CS, Ramakrishnan V. PMID: 32883864; PMCID: PMC7116333.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    10. The CXCR4-LASP1-eIF4F Axis Promotes Translation of Oncogenic Proteins in Triple-Negative Breast Cancer Cells. Front Oncol. 2019; 9:284. Howard CM, Bearss N, Subramaniyan B, Tilley A, Sridharan S, Villa N, Fraser CS, Raman D. PMID: 31106142; PMCID: PMC6499106.
      View in: PubMed   Mentions: 10  
    11. Toward a Kinetic Understanding of Eukaryotic Translation. Cold Spring Harb Perspect Biol. 2019 02 01; 11(2). Sokabe M, Fraser CS. PMID: 29959192; PMCID: PMC6360857.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    12. Molecular mechanism of poliovirus Sabin vaccine strain attenuation. J Biol Chem. 2018 10 05; 293(40):15471-15482. Avanzino BC, Jue H, Miller CM, Cheung E, Fuchs G, Fraser CS. PMID: 30126841; PMCID: PMC6177584.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation. Proc Natl Acad Sci U S A. 2017 09 05; 114(36):9611-9616. Avanzino BC, Fuchs G, Fraser CS. PMID: 28827335; PMCID: PMC5594656.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    14. A helicase-independent activity of eIF4A in promoting mRNA recruitment to the human ribosome. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):6304-6309. Sokabe M, Fraser CS. PMID: 28559306; PMCID: PMC5474785.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    15. Mapping surface residues of eIF5A that are important for binding to the ribosome using alanine scanning mutagenesis. Amino Acids. 2016 10; 48(10):2363-74. Barbosa NM, Boldrin PE, Rossi D, Yamamoto PA, Watanabe TF, Serrão VH, Hershey JW, Fraser CS, Valentini SR, Zanelli CF. PMID: 27388480; PMCID: PMC5897047.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome. PLoS One. 2016; 11(4):e0154205. Rossi D, Barbosa NM, Galvão FC, Boldrin PE, Hershey JW, Zanelli CF, Fraser CS, Valentini SR. PMID: 27115996; PMCID: PMC4845985.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. RNA BIOCHEMISTRY. Factor-dependent processivity in human eIF4A DEAD-box helicase. Science. 2015 Jun 26; 348(6242):1486-8. García-García C, Frieda KL, Feoktistova K, Fraser CS, Block SM. PMID: 26113725; PMCID: PMC4605566.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    18. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. PMID: 25875391; PMCID: PMC4426669.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCells
    19. Quantitative studies of mRNA recruitment to the eukaryotic ribosome. Biochimie. 2015 Jul; 114:58-71. Fraser CS. PMID: 25742741; PMCID: PMC4458453.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. Human eukaryotic initiation factor 2 (eIF2)-GTP-Met-tRNAi ternary complex and eIF3 stabilize the 43 S preinitiation complex. J Biol Chem. 2014 Nov 14; 289(46):31827-31836. Sokabe M, Fraser CS. PMID: 25246524; PMCID: PMC4231660.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    21. DEAD box unwinding caught in the act. Structure. 2014 Jul 08; 22(7):931-2. Avanzino BC, Fraser CS. PMID: 25007220; PMCID: PMC4122117.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    22. Phosphorylation stoichiometries of human eukaryotic initiation factors. Int J Mol Sci. 2014 Jun 27; 15(7):11523-38. Andaya A, Villa N, Jia W, Fraser CS, Leary JA. PMID: 24979134; PMCID: PMC4139797.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    23. Real-time fluorescence assays to monitor duplex unwinding and ATPase activities of helicases. Nat Protoc. 2014 Jul; 9(7):1645-61. Özes AR, Feoktistova K, Avanzino BC, Baldwin EP, Fraser CS. PMID: 24945382; PMCID: PMC5524973.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    24. Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. J Biol Chem. 2013 Nov 15; 288(46):32932-40. Villa N, Do A, Hershey JW, Fraser CS. PMID: 24092755; PMCID: PMC3829144.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    25. Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13339-44. Feoktistova K, Tuvshintogs E, Do A, Fraser CS. PMID: 23901100; PMCID: PMC3746923.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    26. Structural analysis of the DAP5 MIF4G domain and its interaction with eIF4A. Structure. 2013 Apr 02; 21(4):517-27. Virgili G, Frank F, Feoktistova K, Sawicki M, Sonenberg N, Fraser CS, Nagar B. PMID: 23478064; PMCID: PMC3659266.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    27. Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3). Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20473-8. Sun C, Todorovic A, Querol-Audí J, Bai Y, Villa N, Snyder M, Ashchyan J, Lewis CS, Hartland A, Gradia S, Fraser CS, Doudna JA, Nogales E, Cate JH. PMID: 22135459; PMCID: PMC3251073.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    28. The human translation initiation multi-factor complex promotes methionyl-tRNAi binding to the 40S ribosomal subunit. Nucleic Acids Res. 2012 Jan; 40(2):905-13. Sokabe M, Fraser CS, Hershey JW. PMID: 21940399; PMCID: PMC3258154.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    29. Phosphorylation of human eukaryotic initiation factor 2γ: novel site identification and targeted PKC involvement. J Proteome Res. 2011 Oct 07; 10(10):4613-23. Andaya A, Jia W, Sokabe M, Fraser CS, Hershey JW, Leary JA. PMID: 21854064; PMCID: PMC3210080.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    30. Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B. J Mol Biol. 2011 Sep 30; 412(4):674-87. Özes AR, Feoktistova K, Avanzino BC, Fraser CS. PMID: 21840318; PMCID: PMC3175293.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    31. Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1). Biochem J. 2011 Jan 01; 433(1):205-13. Lee SB, Park JH, Folk JE, Deck JA, Pegg AE, Sokabe M, Fraser CS, Park MH. PMID: 20942800; PMCID: PMC3003598.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    32. Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes. Protein Eng Des Sel. 2011 Mar; 24(3):301-9. Park JH, Dias CA, Lee SB, Valentini SR, Sokabe M, Fraser CS, Park MH. PMID: 21131325; PMCID: PMC3038461.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    33. The molecular basis of translational control. Prog Mol Biol Transl Sci. 2009; 90:1-51. Fraser CS. PMID: 20374738.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    34. The pathway of hepatitis C virus mRNA recruitment to the human ribosome. Nat Struct Mol Biol. 2009 Apr; 16(4):397-404. Fraser CS, Hershey JW, Doudna JA. PMID: 19287397; PMCID: PMC2689074.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    35. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18139-44. Zhou M, Sandercock AM, Fraser CS, Ridlova G, Stephens E, Schenauer MR, Yokoi-Fong T, Barsky D, Leary JA, Hershey JW, Doudna JA, Robinson CV. PMID: 18599441; PMCID: PMC2587604.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansCells
    36. The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation. Genes Dev. 2007 Dec 01; 21(23):3149-62. Pöyry TA, Kaminski A, Connell EJ, Fraser CS, Jackson RJ. PMID: 18056426; PMCID: PMC2081980.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    37. eIF3j is located in the decoding center of the human 40S ribosomal subunit. Mol Cell. 2007 Jun 22; 26(6):811-9. Fraser CS, Berry KE, Hershey JW, Doudna JA. PMID: 17588516.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    38. Quantitative studies of ribosome conformational dynamics. Q Rev Biophys. 2007 May; 40(2):163-89. Fraser CS, Doudna JA. PMID: 18072984.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    39. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol Cell Proteomics. 2007 Jul; 6(7):1135-46. Damoc E, Fraser CS, Zhou M, Videler H, Mayeur GL, Hershey JW, Doudna JA, Robinson CV, Leary JA. PMID: 17322308.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    40. Structural and mechanistic insights into hepatitis C viral translation initiation. Nat Rev Microbiol. 2007 Jan; 5(1):29-38. Fraser CS, Doudna JA. PMID: 17128284.
      View in: PubMed   Mentions: 113     Fields:    Translation:Cells
    41. Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science. 2005 Dec 02; 310(5753):1513-5. Siridechadilok B, Fraser CS, Hall RJ, Doudna JA, Nogales E. PMID: 16322461.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansCells
    42. Movement in ribosome translocation. J Biol. 2005; 4(2):8. Fraser CS, Hershey JW. PMID: 15985151; PMCID: PMC1175999.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    43. Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):16990-5. Ji H, Fraser CS, Yu Y, Leary J, Doudna JA. PMID: 15563596; PMCID: PMC534415.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    44. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. J Biol Chem. 2004 Mar 05; 279(10):8946-56. Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW. PMID: 14688252.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    45. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3. Eur J Biochem. 2003 Oct; 270(20):4133-9. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW. PMID: 14519125.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    46. The genome-linked protein VPg of the Norwalk virus binds eIF3, suggesting its role in translation initiation complex recruitment. EMBO J. 2003 Jun 02; 22(11):2852-9. Daughenbaugh KF, Fraser CS, Hershey JW, Hardy ME. PMID: 12773399; PMCID: PMC156748.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
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