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Christopher S Fraser

Title(s)Assistant Professor, Molecular and Cellular Biology
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    Collapse Research 
    Collapse Research Activities and Funding
    The mechanism of mRNA recruitment to the human ribosome.
    NIH/NIGMS R01GM092927Apr 5, 2010 - Apr 30, 2019
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Avanzino BC, Jue H, Miller CM, Cheung E, Fuchs G, Fraser CS. Molecular mechanism of poliovirus Sabin vaccine strain attenuation. J Biol Chem. 2018 Oct 05; 293(40):15471-15482. PMID: 30126841.
      View in: PubMed
    2. Sokabe M, Fraser CS. Toward a Kinetic Understanding of Eukaryotic Translation. Cold Spring Harb Perspect Biol. 2018 Jun 29. PMID: 29959192.
      View in: PubMed
    3. Avanzino BC, Fuchs G, Fraser CS. Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation. Proc Natl Acad Sci U S A. 2017 09 05; 114(36):9611-9616. PMID: 28827335.
      View in: PubMed
    4. Sokabe M, Fraser CS. A helicase-independent activity of eIF4A in promoting mRNA recruitment to the human ribosome. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):6304-6309. PMID: 28559306.
      View in: PubMed
    5. Fraser CS. Quantitative studies of mRNA recruitment to the eukaryotic ribosome. Biochimie. 2015 Jul; 114:58-71. PMID: 25742741; PMCID: PMC4458453.
    6. Sokabe M, Fraser CS. Human eukaryotic initiation factor 2 (eIF2)-GTP-Met-tRNAi ternary complex and eIF3 stabilize the 43 S preinitiation complex. J Biol Chem. 2014 Nov 14; 289(46):31827-36. PMID: 25246524.
      View in: PubMed
    7. Avanzino BC, Fraser CS. DEAD box unwinding caught in the act. Structure. 2014 Jul 08; 22(7):931-2. PMID: 25007220; PMCID: PMC4122117.
    8. Andaya A, Villa N, Jia W, Fraser CS, Leary JA. Phosphorylation stoichiometries of human eukaryotic initiation factors. Int J Mol Sci. 2014 Jun 27; 15(7):11523-38. PMID: 24979134; PMCID: PMC4139797.
    9. Özes AR, Feoktistova K, Avanzino BC, Baldwin EP, Fraser CS. Real-time fluorescence assays to monitor duplex unwinding and ATPase activities of helicases. Nat Protoc. 2014 Jul; 9(7):1645-61. PMID: 24945382.
      View in: PubMed
    10. Villa N, Do A, Hershey JW, Fraser CS. Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. J Biol Chem. 2013 Nov 15; 288(46):32932-40. PMID: 24092755; PMCID: PMC3829144.
    11. Feoktistova K, Tuvshintogs E, Do A, Fraser CS. Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13339-44. PMID: 23901100; PMCID: PMC3746923.
    12. Sokabe M, Fraser CS, Hershey JW. The human translation initiation multi-factor complex promotes methionyl-tRNAi binding to the 40S ribosomal subunit. Nucleic Acids Res. 2012 Jan; 40(2):905-13. PMID: 21940399; PMCID: PMC3258154.
    13. Andaya A, Jia W, Sokabe M, Fraser CS, Hershey JW, Leary JA. Phosphorylation of human eukaryotic initiation factor 2?: novel site identification and targeted PKC involvement. J Proteome Res. 2011 Oct 07; 10(10):4613-23. PMID: 21854064; PMCID: PMC3210080.
    14. Özes AR, Feoktistova K, Avanzino BC, Fraser CS. Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B. J Mol Biol. 2011 Sep 30; 412(4):674-87. PMID: 21840318; PMCID: PMC3175293.
    15. Fraser CS. The molecular basis of translational control. Prog Mol Biol Transl Sci. 2009; 90:1-51. PMID: 20374738.
      View in: PubMed
    16. Fraser CS, Hershey JW, Doudna JA. The pathway of hepatitis C virus mRNA recruitment to the human ribosome. Nat Struct Mol Biol. 2009 Apr; 16(4):397-404. PMID: 19287397; PMCID: PMC2689074.
    17. Pöyry TA, Kaminski A, Connell EJ, Fraser CS, Jackson RJ. The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation. Genes Dev. 2007 Dec 01; 21(23):3149-62. PMID: 18056426; PMCID: PMC2081980.
    18. Fraser CS, Berry KE, Hershey JW, Doudna JA. eIF3j is located in the decoding center of the human 40S ribosomal subunit. Mol Cell. 2007 Jun 22; 26(6):811-9. PMID: 17588516.
      View in: PubMed
    19. Fraser CS, Doudna JA. Quantitative studies of ribosome conformational dynamics. Q Rev Biophys. 2007 May; 40(2):163-89. PMID: 18072984.
      View in: PubMed
    20. Damoc E, Fraser CS, Zhou M, Videler H, Mayeur GL, Hershey JW, Doudna JA, Robinson CV, Leary JA. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol Cell Proteomics. 2007 Jul; 6(7):1135-46. PMID: 17322308.
      View in: PubMed
    21. Siridechadilok B, Fraser CS, Hall RJ, Doudna JA, Nogales E. Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science. 2005 Dec 02; 310(5753):1513-5. PMID: 16322461.
      View in: PubMed
    22. Fraser CS, Hershey JW. Movement in ribosome translocation. J Biol. 2005; 4(2):8. PMID: 15985151; PMCID: PMC1175999.
    23. Ji H, Fraser CS, Yu Y, Leary J, Doudna JA. Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):16990-5. PMID: 15563596; PMCID: PMC534415.
    24. Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. J Biol Chem. 2004 Mar 05; 279(10):8946-56. PMID: 14688252.
      View in: PubMed
    25. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3. Eur J Biochem. 2003 Oct; 270(20):4133-9. PMID: 14519125.
      View in: PubMed