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Craig H Warden

TitlePROF-FY
InstitutionUniversity of California Davis
DepartmentMED: GENERAL PEDIATRICS
Address4435 Tupper Hall
CA 95616
Phone530-752-4187
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    Collapse Research 
    Collapse Research Activities and Funding
    Positional cloning of obesity genes from congenic mice
    NIH/NIDDK R01DK069978Apr 15, 2006 - Mar 31, 2011
    Role: Principal Investigator
    GENES CAUSING SPONTANEOUS OBESITY
    NIH/NIDDK R01DK053993Jun 1, 1998 - May 31, 2003
    Role: Principal Investigator
    Rapid isolation of diet-responsive obesity genes
    NIH/NIDDK R01DK052581Sep 1, 1996 - Feb 28, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Warden C, Bettaieb A, Min E, Fisler JS, Haj FG, Stern JS. Chow fed UC Davis strain female Lepr fatty Zucker rats exhibit mild glucose intolerance, hypertriglyceridemia, and increased urine volume, all reduced by a Brown Norway strain chromosome 1 congenic donor region. PLoS One. 2017; 12(12):e0188175. PMID: 29211750.
      View in: PubMed
    2. Gularte-Mérida R, Farber CR, Verdugo RA, Islas-Trejo A, Famula TR, Warden C, Medrano JF. Overlapping mouse subcongenic strains successfully separate two linked body fat QTL on distal MMU 2. BMC Genomics. 2015 Jan 23; 16:16. PMID: 25613955; PMCID: PMC4308015.
    3. Warden C, Slupsky C, Griffey SM, Bettaieb A, Min E, Le A, Fisler JS, Hansen S, Haj F, Stern JS. Brown Norway chromosome 1 congenic reduces symptoms of renal disease in fatty Zucker rats. PLoS One. 2014; 9(1):e87770. PMID: 24498189; PMCID: PMC3909223.
    4. Warden C, Gularte-Mérida R, Fisler JS, Hansen S, Shibata N, Le A, Medrano JF, Stern JS. Leptin receptor interacts with rat chromosome 1 to regulate renal disease traits. Physiol Genomics. 2012 Nov 01; 44(21):1052-62. PMID: 22968639; PMCID: PMC3615576.
    5. Sarahan KA, Fisler JS, Warden C. Four out of eight genes in a mouse chromosome 7 congenic donor region are candidate obesity genes. Physiol Genomics. 2011 Sep 22; 43(18):1049-55. PMID: 21730028; PMCID: PMC3180740.
    6. Verdugo RA, Farber CR, Warden C, Medrano JF. Serious limitations of the QTL/microarray approach for QTL gene discovery. BMC Biol. 2010 Jul 12; 8:96. PMID: 20624276; PMCID: PMC2919467.
    7. Haines BA, Mehta SL, Pratt SM, Warden C, Li PA. Deletion of mitochondrial uncoupling protein-2 increases ischemic brain damage after transient focal ischemia by altering gene expression patterns and enhancing inflammatory cytokines. J Cereb Blood Flow Metab. 2010 Nov; 30(11):1825-33. PMID: 20407461; PMCID: PMC2948647.
    8. Kim K, Warden C, Griffey SM, Vilches-Moure JG, Hansen S, Cuppen E, Nijman IJ, Chiu S, Stern JS. Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats. Physiol Genomics. 2010 May; 41(3):297-305. PMID: 20159938.
      View in: PubMed
    9. Slavin BG, Zarow C, Warden C, Fisler JS. Histological, immunocytochemical, and morphometrical analyses of pancreatic islets in the BSB mouse model of obesity. Anat Rec (Hoboken). 2010 Jan; 293(1):108-16. PMID: 19798700.
      View in: PubMed
    10. Warden C, Fisler JS. Obesity: from animal models to human genetics to practical applications. Prog Mol Biol Transl Sci. 2010; 94:373-89. PMID: 21036332.
      View in: PubMed
    11. Pratt SM, Chiu S, Espinal GM, Shibata NM, Wong H, Warden C. Mouse hepatic lipase alleles with variable effects on lipoprotein composition and size. J Lipid Res. 2010 May; 51(5):1035-48. PMID: 19965617; PMCID: PMC2853430.
    12. Wallingford N, Perroud B, Gao Q, Coppola A, Gyengesi E, Liu ZW, Gao XB, Diament A, Haus KA, Shariat-Madar Z, Mahdi F, Wardlaw SL, Schmaier AH, Warden C, Diano S. Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents. J Clin Invest. 2009 Aug; 119(8):2291-303. PMID: 19620781; PMCID: PMC2719925.
    13. Warden C, Fisler JS, Espinal G, Graham J, Havel PJ, Perroud B. Maternal influence of prolyl endopeptidase on fat mass of adult progeny. Int J Obes (Lond). 2009 Sep; 33(9):1013-22. PMID: 19564876; PMCID: PMC2743752.
    14. Perroud B, Alvarado RJ, Espinal GM, Morado AR, Phinney BS, Warden C. In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice. Mol Brain. 2009 Jun 02; 2:14. PMID: 19490636; PMCID: PMC2698928.
    15. Casellas J, Farber CR, Gularte RJ, Haus KA, Warden C, Medrano JF. Evidence of maternal QTL affecting growth and obesity in adult mice. Mamm Genome. 2009 May; 20(5):269-80. PMID: 19399551; PMCID: PMC2690847.
    16. Warden C, Fisler JS. Gene-nutrient and gene-physical activity summary--genetics viewpoint. Obesity (Silver Spring). 2008 Dec; 16 Suppl 3:S55-9. PMID: 19037215.
      View in: PubMed
    17. Asami DK, McDonald RB, Hagopian K, Horwitz BA, Warman D, Hsiao A, Warden C, Ramsey JJ. Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice. Exp Gerontol. 2008 Dec; 43(12):1069-76. PMID: 18852040; PMCID: PMC2614627.
    18. McDonald RB, Walker KM, Warman DB, Griffey SM, Warden C, Ramsey JJ, Horwitz BA. Characterization of survival and phenotype throughout the life span in UCP2/UCP3 genetically altered mice. Exp Gerontol. 2008 Dec; 43(12):1061-8. PMID: 18854208.
      View in: PubMed
    19. Warden C, Fisler JS. Comparisons of diets used in animal models of high-fat feeding. Cell Metab. 2008 Apr; 7(4):277. PMID: 18396128; PMCID: PMC2394560.
    20. Deierborg T, Deierborg Olsson T, Wieloch T, Diano S, Warden C, Horvath TL, Mattiasson G. Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse. J Cereb Blood Flow Metab. 2008 Jun; 28(6):1186-95. PMID: 18301432; PMCID: PMC2642535.
    21. Halsted CH, Wong DH, Peerson JM, Warden C, Refsum H, Smith AD, Nygård OK, Ueland PM, Vollset SE, Tell GS. Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study. Am J Clin Nutr. 2007 Aug; 86(2):514-21. PMID: 17684227.
      View in: PubMed
    22. Oort PJ, Warden C, Baumann TK, Knotts TA, Adams SH. Characterization of Tusc5, an adipocyte gene co-expressed in peripheral neurons. Mol Cell Endocrinol. 2007 Sep 30; 276(1-2):24-35. PMID: 17689857.
      View in: PubMed
    23. Chiu S, Kim K, Haus KA, Espinal GM, Millon LV, Warden C. Identification of positional candidate genes for body weight and adiposity in subcongenic mice. Physiol Genomics. 2007 Sep 19; 31(1):75-85. PMID: 17536020.
      View in: PubMed
    24. Fisler JS, Warden C. The current and future search for obesity genes. Am J Clin Nutr. 2007 Jan; 85(1):1-2. PMID: 17209169.
      View in: PubMed
    25. Fisler JS, Warden C. Uncoupling proteins, dietary fat and the metabolic syndrome. Nutr Metab (Lond). 2006 Sep 12; 3:38. PMID: 16968550; PMCID: PMC1592539.
    26. Fisler JS, Warden C. Genetics of obesity in Hispanic children. Am J Clin Nutr. 2006 Sep; 84(3):473-4. PMID: 16960158.
      View in: PubMed
    27. Kaput J, Ordovas JM, Ferguson L, van Ommen B, Rodriguez RL, Allen L, Ames BN, Dawson K, German B, Krauss R, Malyj W, Archer MC, Barnes S, Bartholomew A, Birk R, van Bladeren P, Bradford KJ, Brown KH, Caetano R, Castle D, Chadwick R, Clarke S, Clément K, Cooney CA, Corella D, Manica da Cruz IB, Daniel H, Duster T, Ebbesson SO, Elliott R, Fairweather-Tait S, Felton J, Fenech M, Finley JW, Fogg-Johnson N, Gill-Garrison R, Gibney MJ, Gillies PJ, Gustafsson JA, Hartman JL, He L, Hwang JK, Jais JP, Jang Y, Joost H, Junien C, Kanter M, Kibbe WA, Koletzko B, Korf BR, Kornman K, Krempin DW, Langin D, Lauren DR, Ho Lee J, Leveille GA, Lin SJ, Mathers J, Mayne M, McNabb W, Milner JA, Morgan P, Muller M, Nikolsky Y, van der Ouderaa F, Park T, Pensel N, Perez-Jimenez F, Poutanen K, Roberts M, Saris WH, Schuster G, Shelling AN, Simopoulos AP, Southon S, Tai ES, Towne B, Trayhurn P, Uauy R, Visek WJ, Warden C, Weiss R, Wiencke J, Winkler J, Wolff GL, Zhao-Wilson X, Zucker JD. The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr. 2005 Nov; 94(5):623-32. PMID: 16277761.
      View in: PubMed
    28. Fisler JS, Warden C. Dietary fat and genotype: toward individualized prescriptions for lifestyle changes. Am J Clin Nutr. 2005 Jun; 81(6):1255-6. PMID: 15941873.
      View in: PubMed
    29. Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004 Nov; 36(11):1133-7. PMID: 15514660.
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    30. Yi N, Chiu S, Allison DB, Fisler JS, Warden C. Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice. J Lipid Res. 2004 Nov; 45(11):2063-70. PMID: 15314098.
      View in: PubMed
    31. Chiu S, Fisler JS, Espinal GM, Havel PJ, Stern JS, Warden C. The yellow agouti mutation alters some but not all responses to diet and exercise. Obes Res. 2004 Aug; 12(8):1243-55. PMID: 15340107.
      View in: PubMed
    32. Diament AL, Farahani P, Chiu S, Fisler J, Warden C. A novel mouse Chromosome 2 congenic strain with obesity phenotypes. Mamm Genome. 2004 Jun; 15(6):452-9. PMID: 15181537.
      View in: PubMed
    33. Warden C, Stone S, Chiu S, Diament AL, Corva P, Shattuck D, Riley R, Hunt SC, Easlick J, Fisler JS, Medrano JF. Identification of a congenic mouse line with obesity and body length phenotypes. Mamm Genome. 2004 Jun; 15(6):460-71. PMID: 15181538.
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    34. Yi N, Diament A, Chiu S, Kim K, Allison DB, Fisler JS, Warden C. Characterization of epistasis influencing complex spontaneous obesity in the BSB model. Genetics. 2004 May; 167(1):399-409. PMID: 15166164; PMCID: PMC1470871.
    35. Farahani P, Chiu S, Bowlus CL, Boffelli D, Lee E, Fisler JS, Krauss RM, Warden C. Obesity in BSB mice is correlated with expression of genes for iron homeostasis and leptin. Obes Res. 2004 Feb; 12(2):191-204. PMID: 14981211.
      View in: PubMed
    36. Farahani P, Fisler JS, Wong H, Diament AL, Yi N, Warden C. Reciprocal hemizygosity analysis of mouse hepatic lipase reveals influence on obesity. Obes Res. 2004 Feb; 12(2):292-305. PMID: 14981222.
      View in: PubMed
    37. Warden C, Yi N, Fisler J. Epistasis among genes is a universal phenomenon in obesity: evidence from rodent models. Nutrition. 2004 Jan; 20(1):74-7. PMID: 14698018.
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    38. Moreno-Aliaga MJ, Stanhope KL, Gregoire FM, Warden C, Havel PJ. Effects of inhibiting transcription and protein synthesis on basal and insulin-stimulated leptin gene expression and leptin secretion in cultured rat adipocytes. Biochem Biophys Res Commun. 2003 Aug 08; 307(4):907-14. PMID: 12878197.
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    39. Mattiasson G, Shamloo M, Gido G, Mathi K, Tomasevic G, Yi S, Warden C, Castilho RF, Melcher T, Gonzalez-Zulueta M, Nikolich K, Wieloch T. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med. 2003 Aug; 9(8):1062-8. PMID: 12858170.
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    40. Horvath B, Spies C, Warden C, Diano S, Horvath TL. Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord. Brain Res. 2002 Nov 15; 955(1-2):260-3. PMID: 12419545.
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    41. Bechmann I, Diano S, Warden C, Bartfai T, Nitsch R, Horvath TL. Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol. 2002 Aug 01; 64(3):363-7. PMID: 12147286.
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    42. Horvath B, Spies C, Horvath G, Kox WJ, Miyamoto S, Barry S, Warden C, Bechmann I, Diano S, Heemskerk J, Horvath TL. Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. Biochem Pharmacol. 2002 Aug 01; 64(3):369-74. PMID: 12147287.
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    43. Schonfeld-Warden NA, Warden C. Uncoupling proteins: a molecular basis for racial differences in energy expenditure (and obesity?). Am J Clin Nutr. 2002 Apr; 75(4):607-8. PMID: 11916746.
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    44. Warden C. Genetics of uncoupling proteins in humans. Int J Obes Relat Metab Disord. 1999 Jun; 23 Suppl 6:S46-8. PMID: 10454122.
      View in: PubMed