Audrey Fan • UC Davis Profiles

Audrey P Fan

Title(s)	Assistant Professor, Neurology
School	School of Medicine
Phone	909-895-9858
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Research

Research Activities and Funding

Quantitative PET/MRI of brain oxygenation in cerebrovascular disease
NIH R00NS102884Apr 15, 2018 - Mar 31, 2023
Role: Principal Investigator

Quantitative PET/MRI of brain oxygenation in cerebrovascular disease
NIH K99NS102884Apr 15, 2018 - Mar 31, 2020
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: Acquisition, quantification, and clinical applications. Magn Reson Med. 2024 Apr 09. Woods JG, Achten E, Asllani I, Bolar DS, Dai W, Detre JA, Fan AP, Fernández-Seara MA, Golay X, Günther M, Guo J, Hernandez-Garcia L, Ho ML, Juttukonda MR, Lu H, MacIntosh BJ, Madhuranthakam AJ, Mutsaerts HJ, Okell TW, Parkes LM, Pinter N, Pinto J, Qin Q, Smits M, Suzuki Y, Thomas DL, Van Osch MJP, Wang DJJ, Warnert EAH, Zaharchuk G, Zelaya F, Zhao M, Chappell MA, ISMRM Perfusion Study Group. PMID: 38594906.

View in: PubMed Mentions:
Neural Underpinnings of Learning in Dementia Populations: A Review of Motor Learning Studies Combined with Neuroimaging. J Cogn Neurosci. 2024 Jan 27; 1-22. Korte JA, Weakley A, Donjuan Fernandez K, Joiner WM, Fan AP. PMID: 38285732.

View in: PubMed Mentions: Fields:
Neu Neurology
Non-invasive quantification of 18F-florbetaben with total-body EXPLORER PET. Res Sq. 2023 Dec 27. Holy EN, Li E, Bhattarai A, Fletcher E, Alfaro ER, Harvey DJ, Spencer BA, Cherry SR, DeCarli CS, Fan AP. PMID: 38234716; PMCID: PMC10793501.

View in: PubMed Mentions:
Characterizing systemic physiological effects on the blood oxygen level dependent signal of resting-state fMRI in time-frequency space using wavelets. Hum Brain Mapp. 2023 Dec 15; 44(18):6537-6551. Lee QN, Chen JE, Wheeler GJ, Fan AP. PMID: 37950750; PMCID: PMC10681653.

View in: PubMed Mentions: 1 Fields:
Bra Brain
Translation:Humans
Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation. Front Physiol. 2023; 14:1231793. Le LNN, Wheeler GJ, Holy EN, Donnay CA, Blockley NP, Yee AH, Ng KL, Fan AP. PMID: 37869717; PMCID: PMC10588655.

View in: PubMed Mentions:
Modeling venous bias in resting state functional MRI metrics. Hum Brain Mapp. 2023 10 01; 44(14):4938-4955. Huck J, Jäger AT, Schneider U, Grahl S, Fan AP, Tardif C, Villringer A, Bazin PL, Steele CJ, Gauthier CJ. PMID: 37498014; PMCID: PMC10472917.

View in: PubMed Mentions: 2 Fields:
Bra Brain
Translation:Humans
Dynamic Magnetic Resonance Vascular Fingerprinting During Hypercapnia for Quantitative and Multiparametric Cerebrovascular Reactivity Measures. Annu Int Conf IEEE Eng Med Biol Soc. 2023 07; 2023:1-4. Wheeler GJ, Lee QN, Fan AP. PMID: 38083275.

View in: PubMed Mentions: Fields:
Bio Biomedical Engineering
Translation:Humans
Multimodal comparisons of QSM and PET in neurodegeneration and aging. Neuroimage. 2023 06; 273:120068. Cogswell PM, Fan AP. PMID: 37003447.

View in: PubMed Mentions: 6 Fields:
Dia Diagnostic Imaging
Translation:Humans
Using arterial spin labeling to measure cerebrovascular reactivity in Moyamoya disease: Insights from simultaneous PET/MRI. J Cereb Blood Flow Metab. 2022 08; 42(8):1493-1506. Zhao MY, Fan AP, Chen DY, Ishii Y, Khalighi MM, Moseley M, Steinberg GK, Zaharchuk G. PMID: 35236136; PMCID: PMC9274857.

View in: PubMed Mentions: 8 Fields:
Bra Brain Met Metabolism Vas Vascular Diseases
Translation:Humans
18F-FSPG PET/CT Imaging of System xC- Transporter Activity in Patients with Primary and Metastatic Brain Tumors. Radiology. 2022 06; 303(3):620-631. Wardak M, Sonni I, Fan AP, Minamimoto R, Jamali M, Hatami N, Zaharchuk G, Fischbein N, Nagpal S, Li G, Koglin N, Berndt M, Bullich S, Stephens AW, Dinkelborg LM, Abel T, Manning HC, Rosenberg J, Chin FT, Gambhir SS, Mittra ES. PMID: 35191738; PMCID: PMC9131170.

View in: PubMed Mentions: 5 Fields:
Rad Radiology
Translation:Humans CTClinical Trials
Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniques. J Cereb Blood Flow Metab. 2022 05; 42(5):700-717. Zhao MY, Woodward A, Fan AP, Chen KT, Yu Y, Chen DY, Moseley ME, Zaharchuk G. PMID: 34806918; PMCID: PMC9254040.

View in: PubMed Mentions: 9 Fields:
Bra Brain Met Metabolism Vas Vascular Diseases
Translation:Humans
Reliability of arterial spin labeling derived cerebral blood flow in periventricular white matter. Neuroimage Rep. 2021 Dec; 1(4). Dolui S, Fan AP, Zhao MY, Nasrallah IM, Zaharchuk G, Detre JA. PMID: 35419550; PMCID: PMC9004331.

View in: PubMed Mentions: 4
Editorial for "Decreasing Spatial Variability of Individual Watershed Areas by Revascularization Therapy in Patients with High-Grade Carotid Artery Stenosis". J Magn Reson Imaging. 2021 12; 54(6):1890-1891. Fan AP. PMID: 34272783.

View in: PubMed Mentions: Fields:
Dia Diagnostic Imaging
Translation:Humans
Convolutional Neural Net Learning Can Achieve Production-Level Brain Segmentation in Structural Magnetic Resonance Imaging. Front Neurosci. 2021; 15:683426. Fletcher E, DeCarli C, Fan AP, Knaack A. PMID: 34234642; PMCID: PMC8255694.

View in: PubMed Mentions: 13
Cerebrovascular reactivity measurements using simultaneous 15O-water PET and ASL MRI: Impacts of arterial transit time, labeling efficiency, and hematocrit. Neuroimage. 2021 06; 233:117955. Zhao MY, Fan AP, Chen DY, Sokolska MJ, Guo J, Ishii Y, Shin DD, Khalighi MM, Holley D, Halbert K, Otte A, Williams B, Rostami T, Park JH, Shen B, Zaharchuk G. PMID: 33716155; PMCID: PMC8272558.

View in: PubMed Mentions: 12 Fields:
Dia Diagnostic Imaging
Translation:Humans
Simultaneous FDG-PET/MRI detects hippocampal subfield metabolic differences in AD/MCI. Sci Rep. 2020 07 21; 10(1):12064. Carlson ML, DiGiacomo PS, Fan AP, Goubran M, Khalighi MM, Chao SZ, Vasanawala M, Wintermark M, Mormino E, Zaharchuk G, James ML, Zeineh MM. PMID: 32694602; PMCID: PMC7374580.

View in: PubMed Mentions: 7 Fields:
Sci Science
Translation:Humans
Predicting PET Cerebrovascular Reserve with Deep Learning by Using Baseline MRI: A Pilot Investigation of a Drug-Free Brain Stress Test. Radiology. 2020 09; 296(3):627-637. Chen DYT, Ishii Y, Fan AP, Guo J, Zhao MY, Steinberg GK, Zaharchuk G. PMID: 32662761; PMCID: PMC7457949.

View in: PubMed Mentions: 9 Fields:
Rad Radiology
Translation:Humans
Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI. Neuroimage. 2020 10 15; 220:117136. Fan AP, An H, Moradi F, Rosenberg J, Ishii Y, Nariai T, Okazawa H, Zaharchuk G. PMID: 32634594; PMCID: PMC7592419.

View in: PubMed Mentions: 20 Fields:
Dia Diagnostic Imaging
Translation:Humans
Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases. Eur J Nucl Med Mol Imaging. 2021 07; 48(7):2233-2244. Mormino EC, Toueg TN, Azevedo C, Castillo JB, Guo W, Nadiadwala A, Corso NK, Hall JN, Fan A, Trelle AN, Harrison MB, Hunt MP, Sha SJ, Deutsch G, James M, Fredericks CA, Koran ME, Zeineh M, Poston K, Greicius MD, Khalighi M, Davidzon GA, Shen B, Zaharchuk G, Wagner AD, Chin FT. PMID: 32572562; PMCID: PMC7755737.

View in: PubMed Mentions: 22 Fields:
Nuc Nuclear Medicine Phy Physics
Translation:Humans
Predicting 15O-Water PET cerebral blood flow maps from multi-contrast MRI using a deep convolutional neural network with evaluation of training cohort bias. J Cereb Blood Flow Metab. 2020 11; 40(11):2240-2253. Guo J, Gong E, Fan AP, Goubran M, Khalighi MM, Zaharchuk G. PMID: 31722599; PMCID: PMC7585922.

View in: PubMed Mentions: 16 Fields:
Bra Brain Met Metabolism Vas Vascular Diseases
Translation:Humans
Assessment of acute bone loading in humans using [18F]NaF PET/MRI. Eur J Nucl Med Mol Imaging. 2019 Nov; 46(12):2452-2463. Haddock B, Fan AP, Uhlrich SD, Jørgensen NR, Suetta C, Gold GE, Kogan F. PMID: 31385012; PMCID: PMC6813760.

View in: PubMed Mentions: 11 Fields:
Nuc Nuclear Medicine Phy Physics
Translation:Humans
High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps. Brain Struct Funct. 2019 Sep; 224(7):2467-2485. Huck J, Wanner Y, Fan AP, Jäger AT, Grahl S, Schneider U, Villringer A, Steele CJ, Tardif CL, Bazin PL, Gauthier CJ. PMID: 31278570.

View in: PubMed Mentions: 12 Fields:
Bra Brain
Translation:Humans
Kinetic [18F]-Fluoride of the Knee in Normal Volunteers. Clin Nucl Med. 2019 May; 44(5):377-385. Haddock B, Fan AP, Jørgensen NR, Suetta C, Gold GE, Kogan F. PMID: 30888996; PMCID: PMC6449188.

View in: PubMed Mentions: 6 Fields:
Nuc Nuclear Medicine
Translation:Humans
Simultaneous phase-contrast MRI and PET for noninvasive quantification of cerebral blood flow and reactivity in healthy subjects and patients with cerebrovascular disease. J Magn Reson Imaging. 2020 01; 51(1):183-194. Ishii Y, Thamm T, Guo J, Khalighi MM, Wardak M, Holley D, Gandhi H, Park JH, Shen B, Steinberg GK, Chin FT, Zaharchuk G, Fan AP. PMID: 31044459; PMCID: PMC7212833.

View in: PubMed Mentions: 11 Fields:
Dia Diagnostic Imaging
Translation:Humans
Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke. J Cereb Blood Flow Metab. 2020 03; 40(3):539-551. Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ. PMID: 30732551; PMCID: PMC7026852.

View in: PubMed Mentions: 33 Fields:
Bra Brain Met Metabolism Vas Vascular Diseases
Translation:Humans CTClinical Trials
Identifying Hypoperfusion in Moyamoya Disease With Arterial Spin Labeling and an [15O]-Water Positron Emission Tomography/Magnetic Resonance Imaging Normative Database. Stroke. 2019 02; 50(2):373-380. Fan AP, Khalighi MM, Guo J, Ishii Y, Rosenberg J, Wardak M, Park JH, Shen B, Holley D, Gandhi H, Haywood T, Singh P, Steinberg GK, Chin FT, Zaharchuk G. PMID: 30636572; PMCID: PMC7161423.

View in: PubMed Mentions: 19 Fields:
Bra Brain Vas Vascular Diseases
Translation:Humans
Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease. J Cereb Blood Flow Metab. 2018 09; 38(9):1391-1417. Donahue MJ, Achten E, Cogswell PM, De Leeuw FE, Derdeyn CP, Dijkhuizen RM, Fan AP, Ghaznawi R, Heit JJ, Ikram MA, Jezzard P, Jordan LC, Jouvent E, Knutsson L, Leigh R, Liebeskind DS, Lin W, Okell TW, Qureshi AI, Stagg CJ, van Osch MJ, van Zijl PC, Watchmaker JM, Wintermark M, Wu O, Zaharchuk G, Zhou J, Hendrikse J. PMID: 28816594; PMCID: PMC6125970.

View in: PubMed Mentions: 37 Fields:
Bra Brain Met Metabolism Vas Vascular Diseases
Translation:Humans
Comparing accuracy and reproducibility of sequential and Hadamard-encoded multidelay pseudocontinuous arterial spin labeling for measuring cerebral blood flow and arterial transit time in healthy subjects: A simulation and in vivo study. J Magn Reson Imaging. 2018 04; 47(4):1119-1132. Guo J, Holdsworth SJ, Fan AP, Lebel MR, Zun Z, Shankaranarayanan A, Zaharchuk G. PMID: 28792653; PMCID: PMC5807238.

View in: PubMed Mentions: 14 Fields:
Dia Diagnostic Imaging
Translation:Humans
Long-Delay Arterial Spin Labeling Provides More Accurate Cerebral Blood Flow Measurements in Moyamoya Patients: A Simultaneous Positron Emission Tomography/MRI Study. Stroke. 2017 09; 48(9):2441-2449. Fan AP, Guo J, Khalighi MM, Gulaka PK, Shen B, Park JH, Gandhi H, Holley D, Rutledge O, Singh P, Haywood T, Steinberg GK, Chin FT, Zaharchuk G. PMID: 28765286; PMCID: PMC8006795.

View in: PubMed Mentions: 46 Fields:
Bra Brain Vas Vascular Diseases
Translation:Humans
Improved Quantification of Cerebral Vein Oxygenation Using Partial Volume Correction. Front Neurosci. 2017; 11:89. Ward PG, Fan AP, Raniga P, Barnes DG, Dowe DL, Ng AC, Egan GF. PMID: 28289372; PMCID: PMC5326785.

View in: PubMed Mentions: 7
Susceptibility-Based Neuroimaging: Standard Methods, Clinical Applications, and Future Directions. Curr Radiol Rep. 2017 Mar; 5(3). Soman S, Bregni JA, Bilgic B, Nemec U, Fan A, Liu Z, Barry RL, Du J, Main K, Yesavage J, Adamson MM, Moseley M, Wang Y. PMID: 28695062; PMCID: PMC5501163.

View in: PubMed Mentions: 4
Image-derived input function estimation on a TOF-enabled PET/MR for cerebral blood flow mapping. J Cereb Blood Flow Metab. 2018 01; 38(1):126-135. Khalighi MM, Deller TW, Fan AP, Gulaka PK, Shen B, Singh P, Park JH, Chin FT, Zaharchuk G. PMID: 28155582; PMCID: PMC5757438.

View in: PubMed Mentions: 26 Fields:
Bra Brain Met Metabolism Vas Vascular Diseases
Translation:Humans
Potential of PET-MRI for imaging of non-oncologic musculoskeletal disease. Quant Imaging Med Surg. 2016 Dec; 6(6):756-771. Kogan F, Fan AP, Gold GE. PMID: 28090451; PMCID: PMC5219958.

View in: PubMed Mentions: 10
PET/MRI of metabolic activity in osteoarthritis: A feasibility study. J Magn Reson Imaging. 2017 06; 45(6):1736-1745. Kogan F, Fan AP, McWalter EJ, Oei EHG, Quon A, Gold GE. PMID: 27796082; PMCID: PMC5761655.

View in: PubMed Mentions: 27 Fields:
Dia Diagnostic Imaging
Translation:Humans
Mitigation of partial volume effects in susceptibility-based oxygenation measurements by joint utilization of magnitude and phase (JUMP). Magn Reson Med. 2017 04; 77(4):1713-1727. McDaniel P, Bilgic B, Fan AP, Stout JN, Adalsteinsson E. PMID: 27059521; PMCID: PMC5052095.

View in: PubMed Mentions: 5 Fields:
Dia Diagnostic Imaging
Translation:Humans
Comparison of cerebral blood flow measurement with [15O]-water positron emission tomography and arterial spin labeling magnetic resonance imaging: A systematic review. J Cereb Blood Flow Metab. 2016 05; 36(5):842-61. Fan AP, Jahanian H, Holdsworth SJ, Zaharchuk G. PMID: 26945019; PMCID: PMC4853843.

View in: PubMed Mentions: 72 Fields:
Bra Brain Met Metabolism Vas Vascular Diseases
Translation:Humans
Susceptibility-based time-resolved whole-organ and regional tissue oximetry. NMR Biomed. 2017 Apr; 30(4). Wehrli FW, Fan AP, Rodgers ZB, Englund EK, Langham MC. PMID: 26918319; PMCID: PMC5001941.

View in: PubMed Mentions: 24 Fields:
Dia Diagnostic Imaging Nuc Nuclear Medicine
Translation:Humans Animals
Baseline oxygenation in the brain: Correlation between respiratory-calibration and susceptibility methods. Neuroimage. 2016 Jan 15; 125:920-931. Fan AP, Schäfer A, Huber L, Lampe L, von Smuda S, Möller HE, Villringer A, Gauthier CJ. PMID: 26549301.

View in: PubMed Mentions: 16 Fields:
Dia Diagnostic Imaging
Translation:Humans
Fast quantitative susceptibility mapping using 3D EPI and total generalized variation. Neuroimage. 2015 May 01; 111:622-30. Langkammer C, Bredies K, Poser BA, Barth M, Reishofer G, Fan AP, Bilgic B, Fazekas F, Mainero C, Ropele S. PMID: 25731991.

View in: PubMed Mentions: 57 Fields:
Dia Diagnostic Imaging
Translation:Humans
Reproducibility of T2 * mapping in the human cerebral cortex in vivo at 7 tesla MRI. J Magn Reson Imaging. 2015 Aug; 42(2):290-6. Govindarajan ST, Cohen-Adad J, Sormani MP, Fan AP, Louapre C, Mainero C. PMID: 25407671; PMCID: PMC4437971.

View in: PubMed Mentions: 13 Fields:
Dia Diagnostic Imaging
Translation:Humans
Quantitative oxygen extraction fraction from 7-Tesla MRI phase: reproducibility and application in multiple sclerosis. J Cereb Blood Flow Metab. 2015 Jan; 35(1):131-9. Fan AP, Govindarajan ST, Kinkel RP, Madigan NK, Nielsen AS, Benner T, Tinelli E, Rosen BR, Adalsteinsson E, Mainero C. PMID: 25352043; PMCID: PMC4294406.

View in: PubMed Mentions: 24 Fields:
Bra Brain Met Metabolism Vas Vascular Diseases
Translation:Humans
Regional quantification of cerebral venous oxygenation from MRI susceptibility during hypercapnia. Neuroimage. 2015 Jan 01; 104:146-55. Fan AP, Evans KC, Stout JN, Rosen BR, Adalsteinsson E. PMID: 25300201; PMCID: PMC4253073.

View in: PubMed Mentions: 24 Fields:
Dia Diagnostic Imaging
Translation:Humans
Wave-CAIPI for highly accelerated 3D imaging. Magn Reson Med. 2015 Jun; 73(6):2152-62. Bilgic B, Gagoski BA, Cauley SF, Fan AP, Polimeni JR, Grant PE, Wald LL, Setsompop K. PMID: 24986223; PMCID: PMC4281518.

View in: PubMed Mentions: 92 Fields:
Dia Diagnostic Imaging
Translation:Humans
Fast quantitative susceptibility mapping with L1-regularization and automatic parameter selection. Magn Reson Med. 2014 Nov; 72(5):1444-59. Bilgic B, Fan AP, Polimeni JR, Cauley SF, Bianciardi M, Adalsteinsson E, Wald LL, Setsompop K. PMID: 24259479; PMCID: PMC4111791.

View in: PubMed Mentions: 47 Fields:
Dia Diagnostic Imaging
Translation:Humans
Fast image reconstruction with L2-regularization. J Magn Reson Imaging. 2014 Jul; 40(1):181-91. Bilgic B, Chatnuntawech I, Fan AP, Setsompop K, Cauley SF, Wald LL, Adalsteinsson E. PMID: 24395184; PMCID: PMC4106040.

View in: PubMed Mentions: 43 Fields:
Dia Diagnostic Imaging
Translation:Humans
Quantitative oxygenation venography from MRI phase. Magn Reson Med. 2014 Jul; 72(1):149-59. Fan AP, Bilgic B, Gagnon L, Witzel T, Bhat H, Rosen BR, Adalsteinsson E. PMID: 24006229; PMCID: PMC4234149.

View in: PubMed Mentions: 76 Fields:
Dia Diagnostic Imaging
Translation:Humans
Phase-based regional oxygen metabolism (PROM) using MRI. Magn Reson Med. 2012 Mar; 67(3):669-78. Fan AP, Benner T, Bolar DS, Rosen BR, Adalsteinsson E. PMID: 21713981; PMCID: PMC3199031.

View in: PubMed Mentions: 57 Fields:
Dia Diagnostic Imaging
Translation:Humans
MicroRNA processing pathway regulates olfactory neuron morphogenesis. Curr Biol. 2008 Nov 25; 18(22):1754-9. Berdnik D, Fan AP, Potter CJ, Luo L. PMID: 19013069; PMCID: PMC2612040.

View in: PubMed Mentions: 34 Fields:
Bio Biology
Translation:Animals Cells