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Nadean L Brown

Title(s)Professor, Cell Biology and Human Anatomy
SchoolUniversity of California, Davis
Phone530-752-7806
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    Collapse Research 
    Collapse Research Activities and Funding
    2016 and 2018 Visual Systems Development Gordon Research Conference & Gordon Research Seminar
    NIH/NEI R13EY026282Dec 1, 2015 - Nov 30, 2018
    Role: Co-Principal Investigator
    Cell-Cell Signaling During Mammalian Early Eye Formation
    NIH/NEI R01EY018097Apr 1, 2007 - Nov 30, 2016
    Role: Principal Investigator
    Investigation of Mammalian Retinal Neuron Development
    NIH/NEI R01EY013612Aug 1, 2001 - Mar 31, 2021
    Role: Principal Investigator
    ROLE OF INTEGRINS IN GASTRULATION
    NIH/NINDS F32NS009746Apr 1, 1995
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Azimi M, Brown NL. Jagged1 protein processing in the developing mammalian lens. Biol Open. 2019 Mar 26; 8(3). PMID: 30890522.
      View in: PubMed
    2. Lam PT, Padula SL, Hoang TV, Poth JE, Liu L, Liang C, LeFever AS, Wallace LM, Ashery-Padan R, Riggs PK, Shields JE, Shaham O, Rowan S, Brown NL, Glaser T, Robinson ML. Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens. Hum Genomics. 2019 02 15; 13(1):10. PMID: 30770771.
      View in: PubMed
    3. Miesfeld JB, Brown NL. Eye organogenesis: A hierarchical view of ocular development. Curr Top Dev Biol. 2019; 132:351-393. PMID: 30797514.
      View in: PubMed
    4. Azimi M, Le TT, Brown NL. Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens. Differentiation. 2018 Jul - Aug; 102:40-52. PMID: 30059908.
      View in: PubMed
    5. Kowalchuk AM, Maurer KA, Shoja-Taheri F, Brown NL. Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis. Dev Biol. 2018 10 15; 442(2):220-235. PMID: 30048641.
      View in: PubMed
    6. Miesfeld JB, Moon MS, Riesenberg AN, Contreras AN, Kovall RA, Brown NL. Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina. Sci Rep. 2018 07 05; 8(1):10195. PMID: 29977079.
      View in: PubMed
    7. Maurer KA, Kowalchuk A, Shoja-Taheri F, Brown NL. Integral bHLH factor regulation of cell cycle exit and RGC differentiation. Dev Dyn. 2018 08; 247(8):965-975. PMID: 29770538.
      View in: PubMed
    8. Baker NE, Brown NL. All in the family: proneural bHLH genes and neuronal diversity. Development. 2018 05 02; 145(9). PMID: 29720483.
      View in: PubMed
    9. Miesfeld JB, Glaser T, Brown NL. The dynamics of native Atoh7 protein expression during mouse retinal histogenesis, revealed with a new antibody. Gene Expr Patterns. 2018 01; 27:114-121. PMID: 29225067.
      View in: PubMed
    10. Riesenberg AN, Conley KW, Le TT, Brown NL. Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye. Dev Dyn. 2018 01; 247(1):212-221. PMID: 28675662.
      View in: PubMed
    11. Zhang Q, Zagozewski J, Cheng S, Dixit R, Zhang S, de Melo J, Mu X, Klein WH, Brown NL, Wigle JT, Schuurmans C, Eisenstat DD. Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina. Development. 2017 05 01; 144(9):1698-1711. PMID: 28356311.
      View in: PubMed
    12. Riesenberg AN, Brown NL. Cell autonomous and nonautonomous requirements for Delltalike1 during early mouse retinal neurogenesis. Dev Dyn. 2016 06; 245(6):631-40. PMID: 26947267.
      View in: PubMed
    13. Maurer KA, Riesenberg AN, Brown NL. Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina. Development. 2014 Aug; 141(16):3243-54. PMID: 25100656.
      View in: PubMed
    14. Hufnagel RB, Riesenberg AN, Quinn M, Brzezinski JA, Glaser T, Brown NL. Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit. Mol Cell Neurosci. 2013 May; 54:108-20. PMID: 23481413.
      View in: PubMed
    15. Le TT, Conley KW, Mead TJ, Rowan S, Yutzey KE, Brown NL. Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn. 2012 Mar; 241(3):493-504. PMID: 22275127.
      View in: PubMed
    16. Saravanamuthu SS, Le TT, Gao CY, Cojocaru RI, Pandiyan P, Liu C, Zhang J, Zelenka PS, Brown NL. Conditional ablation of the Notch2 receptor in the ocular lens. Dev Biol. 2012 Feb 15; 362(2):219-29. PMID: 22173065.
      View in: PubMed
    17. Charlton-Perkins M, Brown NL, Cook TA. The lens in focus: a comparison of lens development in Drosophila and vertebrates. Mol Genet Genomics. 2011 Oct; 286(3-4):189-213. PMID: 21877135.
      View in: PubMed
    18. Prasov L, Brown NL, Glaser T. A critical analysis of Atoh7 (Math5) mRNA splicing in the developing mouse retina. PLoS One. 2010 Aug 24; 5(8):e12315. PMID: 20808762.
      View in: PubMed
    19. Macgregor S, Hewitt AW, Hysi PG, Ruddle JB, Medland SE, Henders AK, Gordon SD, Andrew T, McEvoy B, Sanfilippo PG, Carbonaro F, Tah V, Li YJ, Bennett SL, Craig JE, Montgomery GW, Tran-Viet KN, Brown NL, Spector TD, Martin NG, Young TL, Hammond CJ, Mackey DA. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. Hum Mol Genet. 2010 Jul 01; 19(13):2716-24. PMID: 20395239.
      View in: PubMed
    20. Hufnagel RB, Le TT, Riesenberg AL, Brown NL. Neurog2 controls the leading edge of neurogenesis in the mammalian retina. Dev Biol. 2010 Apr 15; 340(2):490-503. PMID: 20144606.
      View in: PubMed
    21. Riesenberg AN, Liu Z, Kopan R, Brown NL. Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. J Neurosci. 2009 Oct 14; 29(41):12865-77. PMID: 19828801.
      View in: PubMed
    22. Riesenberg AN, Le TT, Willardsen MI, Blackburn DC, Vetter ML, Brown NL. Pax6 regulation of Math5 during mouse retinal neurogenesis. Genesis. 2009 Mar; 47(3):175-87. PMID: 19208436.
      View in: PubMed
    23. Le TT, Conley KW, Brown NL. Jagged 1 is necessary for normal mouse lens formation. Dev Biol. 2009 Apr 01; 328(1):118-26. PMID: 19389370.
      View in: PubMed
    24. Willardsen MI, Suli A, Pan Y, Marsh-Armstrong N, Chien CB, El-Hodiri H, Brown NL, Moore KB, Vetter ML. Temporal regulation of Ath5 gene expression during eye development. Dev Biol. 2009 Feb 15; 326(2):471-81. PMID: 19059393.
      View in: PubMed
    25. Blackburn DC, Conley KW, Plachetzki DC, Kempler K, Battelle BA, Brown NL. Isolation and expression of Pax6 and atonal homologues in the American horseshoe crab, Limulus polyphemus. Dev Dyn. 2008 Aug; 237(8):2209-19. PMID: 18651657.
      View in: PubMed
    26. Fuhrmann S, Riesenberg AN, Mathiesen AM, Brown EC, Vetter ML, Brown NL. Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina. Invest Ophthalmol Vis Sci. 2009 Jan; 50(1):432-40. PMID: 18599572.
      View in: PubMed
    27. Rowan S, Conley KW, Le TT, Donner AL, Maas RL, Brown NL. Notch signaling regulates growth and differentiation in the mammalian lens. Dev Biol. 2008 Sep 01; 321(1):111-22. PMID: 18588871.
      View in: PubMed
    28. Hufnagel RB, Riesenberg AN, Saul SM, Brown NL. Conserved regulation of Math5 and Math1 revealed by Math5-GFP transgenes. Mol Cell Neurosci. 2007 Dec; 36(4):435-48. PMID: 17900924.
      View in: PubMed
    29. Harzsch S, Vilpoux K, Blackburn DC, Platchetzki D, Brown NL, Melzer R, Kempler KE, Battelle BA. Evolution of arthropod visual systems: development of the eyes and central visual pathways in the horseshoe crab Limulus polyphemus Linnaeus, 1758 (Chelicerata, Xiphosura). Dev Dyn. 2006 Oct; 235(10):2641-55. PMID: 16788994.
      View in: PubMed
    30. Le TT, Wroblewski E, Patel S, Riesenberg AN, Brown NL. Math5 is required for both early retinal neuron differentiation and cell cycle progression. Dev Biol. 2006 Jul 15; 295(2):764-78. PMID: 16690048.
      View in: PubMed
    31. Lee HY, Wroblewski E, Philips GT, Stair CN, Conley K, Reedy M, Mastick GS, Brown NL. Multiple requirements for Hes 1 during early eye formation. Dev Biol. 2005 Aug 15; 284(2):464-78. PMID: 16038893.
      View in: PubMed
    32. Brzezinski JA, Brown NL, Tanikawa A, Bush RA, Sieving PA, Vitaterna MH, Takahashi JS, Glaser T. Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice. Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2540-51. PMID: 15980246.
      View in: PubMed
    33. Philips GT, Stair CN, Young Lee H, Wroblewski E, Berberoglu MA, Brown NL, Mastick GS. Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type. Dev Biol. 2005 Mar 15; 279(2):308-21. PMID: 15733660.
      View in: PubMed
    34. Hutcheson DA, Hanson MI, Moore KB, Le TT, Brown NL, Vetter ML. bHLH-dependent and -independent modes of Ath5 gene regulation during retinal development. Development. 2005 Feb; 132(4):829-39. PMID: 15677728.
      View in: PubMed
    35. Song MH, Brown NL, Kuwada JY. The cfy mutation disrupts cell divisions in a stage-dependent manner in zebrafish embryos. Dev Biol. 2004 Dec 01; 276(1):194-206. PMID: 15531374.
      View in: PubMed
    36. Sun Y, Kanekar SL, Vetter ML, Gorski S, Jan YN, Glaser T, Brown NL. Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes. Evol Dev. 2003 Sep-Oct; 5(5):532-41. PMID: 12950631.
      View in: PubMed
    37. Brown NL, Dagenais SL, Chen CM, Glaser T. Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. Mamm Genome. 2002 Feb; 13(2):95-101. PMID: 11889557.
      View in: PubMed
    38. Vetter ML, Brown NL. The role of basic helix-loop-helix genes in vertebrate retinogenesis. Semin Cell Dev Biol. 2001 Dec; 12(6):491-8. PMID: 11735385.
      View in: PubMed
    39. Tucker P, Laemle L, Munson A, Kanekar S, Oliver ER, Brown N, Schlecht H, Vetter M, Glaser T. The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene. Genesis. 2001 Sep; 31(1):43-53. PMID: 11668677.
      View in: PubMed
    40. Brown NL, Patel S, Brzezinski J, Glaser T. Math5 is required for retinal ganglion cell and optic nerve formation. Development. 2001 Jul; 128(13):2497-508. PMID: 11493566.
      View in: PubMed
    41. Brown NL. Imaging gene expression using antibody probes. Methods Mol Biol. 1999; 122:75-91. PMID: 10231785.
      View in: PubMed
    42. Brown NL, Kanekar S, Vetter ML, Tucker PK, Gemza DL, Glaser T. Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis. Development. 1998 Dec; 125(23):4821-33. PMID: 9806930.
      View in: PubMed
    43. Brown NL, Paddock SW, Sattler CA, Cronmiller C, Thomas BJ, Carroll SB. daughterless is required for Drosophila photoreceptor cell determination, eye morphogenesis, and cell cycle progression. Dev Biol. 1996 Oct 10; 179(1):65-78. PMID: 8873754.
      View in: PubMed
    44. Brown NL, Sattler CA, Paddock SW, Carroll SB. Hairy and emc negatively regulate morphogenetic furrow progression in the Drosophila eye. Cell. 1995 Mar 24; 80(6):879-87. PMID: 7697718.
      View in: PubMed
    45. Brown NL, Sattler CA, Markey DR, Carroll SB. hairy gene function in the Drosophila eye: normal expression is dispensable but ectopic expression alters cell fates. Development. 1991 Dec; 113(4):1245-56. PMID: 1811940.
      View in: PubMed