Nadean L Brown

Title(s)Professor, MED: Cell Biology & Human Anat
SchoolSchool of Medicine
Address4407A Tupper Hall
CA 95616
Phone530-752-7806
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    Collapse Research 
    Collapse Research Activities and Funding
    2016 and 2018 Visual Systems Development Gordon Research Conference & Gordon Research Seminar
    NIH/NEI R13EY026282Dec 1, 2015 - Nov 30, 2018
    Role: Co-Principal Investigator
    Cell-Cell Signaling During Mammalian Early Eye Formation
    NIH/NEI R01EY018097Apr 1, 2007 - Nov 30, 2016
    Role: Principal Investigator
    Investigation of Mammalian Retinal Neuron Development
    NIH/NEI R01EY013612Aug 1, 2001 - Mar 31, 2021
    Role: Principal Investigator
    ROLE OF INTEGRINS IN GASTRULATION
    NIH/NINDS F32NS009746Apr 1, 1995
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Notch pathway mutants do not equivalently perturb mouse embryonic retinal development. PLoS Genet. 2023 09; 19(9):e1010928. Bosze B, Suarez-Navarro J, Cajias I, Brzezinski Iv JA, Brown NL. PMID: 37751417; PMCID: PMC10522021.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Notch directs telencephalic development and controls neocortical neuron fate determination by regulating microRNA levels. Development. 2023 06 01; 150(11). Han JS, Fishman-Williams E, Decker SC, Hino K, Reyes RV, Brown NL, Simó S, Torre A. PMID: 37272771; PMCID: PMC10309580.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Not all Notch pathway mutations are equal in the embryonic mouse retina. bioRxiv. 2023 Jan 12. Bosze B, Suarez-Navarro J, Cajias I, Brzezinski JA, Brown NL. PMID: 36711950; PMCID: PMC9882158.
      View in: PubMed   Mentions:
    4. Multiple roles for Pax2 in the embryonic mouse eye. Dev Biol. 2021 04; 472:18-29. Bosze B, Suarez-Navarro J, Soofi A, Lauderdale JD, Dressler GR, Brown NL. PMID: 33428890; PMCID: PMC7956245.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    5. The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell development. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21690-21700. Miesfeld JB, Ghiasvand NM, Marsh-Armstrong B, Marsh-Armstrong N, Miller EB, Zhang P, Manna SK, Zawadzki RJ, Brown NL, Glaser T. PMID: 32817515; PMCID: PMC7474671.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    6. Simultaneous Requirements for Hes1 in Retinal Neurogenesis and Optic Cup-Stalk Boundary Maintenance. J Neurosci. 2020 02 12; 40(7):1501-1513. Bosze B, Moon MS, Kageyama R, Brown NL. PMID: 31949107; PMCID: PMC7044741.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    7. Jagged1 protein processing in the developing mammalian lens. Biol Open. 2019 Mar 26; 8(3). Azimi M, Brown NL. PMID: 30890522; PMCID: PMC6451331.
      View in: PubMed   Mentions: 5     Fields:    
    8. Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens. Hum Genomics. 2019 02 15; 13(1):10. Lam PT, Padula SL, Hoang TV, Poth JE, Liu L, Liang C, LeFever AS, Wallace LM, Ashery-Padan R, Riggs PK, Shields JE, Shaham O, Rowan S, Brown NL, Glaser T, Robinson ML. PMID: 30770771; PMCID: PMC6377743.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    9. Eye organogenesis: A hierarchical view of ocular development. Curr Top Dev Biol. 2019; 132:351-393. Miesfeld JB, Brown NL. PMID: 30797514.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    10. Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens. Differentiation. 2018 Jul - Aug; 102:40-52. Azimi M, Le TT, Brown NL. PMID: 30059908; PMCID: PMC6089524.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis. Dev Biol. 2018 10 15; 442(2):220-235. Kowalchuk AM, Maurer KA, Shoja-Taheri F, Brown NL. PMID: 30048641; PMCID: PMC6143394.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina. Sci Rep. 2018 07 05; 8(1):10195. Miesfeld JB, Moon MS, Riesenberg AN, Contreras AN, Kovall RA, Brown NL. PMID: 29977079; PMCID: PMC6033939.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    13. Integral bHLH factor regulation of cell cycle exit and RGC differentiation. Dev Dyn. 2018 08; 247(8):965-975. Maurer KA, Kowalchuk A, Shoja-Taheri F, Brown NL. PMID: 29770538; PMCID: PMC6105502.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. All in the family: proneural bHLH genes and neuronal diversity. Development. 2018 05 02; 145(9). Baker NE, Brown NL. PMID: 29720483; PMCID: PMC5992591.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    15. The dynamics of native Atoh7 protein expression during mouse retinal histogenesis, revealed with a new antibody. Gene Expr Patterns. 2018 01; 27:114-121. Miesfeld JB, Glaser T, Brown NL. PMID: 29225067; PMCID: PMC5835195.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    16. Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye. Dev Dyn. 2018 01; 247(1):212-221. Riesenberg AN, Conley KW, Le TT, Brown NL. PMID: 28675662; PMCID: PMC5739946.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina. Development. 2017 05 01; 144(9):1698-1711. Zhang Q, Zagozewski J, Cheng S, Dixit R, Zhang S, de Melo J, Mu X, Klein WH, Brown NL, Wigle JT, Schuurmans C, Eisenstat DD. PMID: 28356311; PMCID: PMC5450843.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    18. Cell autonomous and nonautonomous requirements for Delltalike1 during early mouse retinal neurogenesis. Dev Dyn. 2016 06; 245(6):631-40. Riesenberg AN, Brown NL. PMID: 26947267; PMCID: PMC4873400.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    19. Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina. Development. 2014 Aug; 141(16):3243-54. Maurer KA, Riesenberg AN, Brown NL. PMID: 25100656; PMCID: PMC4197552.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    20. Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit. Mol Cell Neurosci. 2013 May; 54:108-20. Hufnagel RB, Riesenberg AN, Quinn M, Brzezinski JA, Glaser T, Brown NL. PMID: 23481413; PMCID: PMC3622171.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    21. Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn. 2012 Mar; 241(3):493-504. Le TT, Conley KW, Mead TJ, Rowan S, Yutzey KE, Brown NL. PMID: 22275127; PMCID: PMC3288604.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    22. Conditional ablation of the Notch2 receptor in the ocular lens. Dev Biol. 2012 Feb 15; 362(2):219-29. Saravanamuthu SS, Le TT, Gao CY, Cojocaru RI, Pandiyan P, Liu C, Zhang J, Zelenka PS, Brown NL. PMID: 22173065; PMCID: PMC3265577.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    23. The lens in focus: a comparison of lens development in Drosophila and vertebrates. Mol Genet Genomics. 2011 Oct; 286(3-4):189-213. Charlton-Perkins M, Brown NL, Cook TA. PMID: 21877135; PMCID: PMC5221490.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    24. A critical analysis of Atoh7 (Math5) mRNA splicing in the developing mouse retina. PLoS One. 2010 Aug 24; 5(8):e12315. Prasov L, Brown NL, Glaser T. PMID: 20808762; PMCID: PMC2927423.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. Hum Mol Genet. 2010 Jul 01; 19(13):2716-24. Macgregor S, Hewitt AW, Hysi PG, Ruddle JB, Medland SE, Henders AK, Gordon SD, Andrew T, McEvoy B, Sanfilippo PG, Carbonaro F, Tah V, Li YJ, Bennett SL, Craig JE, Montgomery GW, Tran-Viet KN, Brown NL, Spector TD, Martin NG, Young TL, Hammond CJ, Mackey DA. PMID: 20395239; PMCID: PMC2883339.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    26. Neurog2 controls the leading edge of neurogenesis in the mammalian retina. Dev Biol. 2010 Apr 15; 340(2):490-503. Hufnagel RB, Le TT, Riesenberg AL, Brown NL. PMID: 20144606; PMCID: PMC2854206.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    27. Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. J Neurosci. 2009 Oct 14; 29(41):12865-77. Riesenberg AN, Liu Z, Kopan R, Brown NL. PMID: 19828801; PMCID: PMC2788434.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    28. Pax6 regulation of Math5 during mouse retinal neurogenesis. Genesis. 2009 Mar; 47(3):175-87. Riesenberg AN, Le TT, Willardsen MI, Blackburn DC, Vetter ML, Brown NL. PMID: 19208436; PMCID: PMC2976517.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    29. Jagged 1 is necessary for normal mouse lens formation. Dev Biol. 2009 Apr 01; 328(1):118-26. Le TT, Conley KW, Brown NL. PMID: 19389370; PMCID: PMC2674137.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    30. Temporal regulation of Ath5 gene expression during eye development. Dev Biol. 2009 Feb 15; 326(2):471-81. Willardsen MI, Suli A, Pan Y, Marsh-Armstrong N, Chien CB, El-Hodiri H, Brown NL, Moore KB, Vetter ML. PMID: 19059393; PMCID: PMC2788623.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    31. Isolation and expression of Pax6 and atonal homologues in the American horseshoe crab, Limulus polyphemus. Dev Dyn. 2008 Aug; 237(8):2209-19. Blackburn DC, Conley KW, Plachetzki DC, Kempler K, Battelle BA, Brown NL. PMID: 18651657; PMCID: PMC2577597.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    32. Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina. Invest Ophthalmol Vis Sci. 2009 Jan; 50(1):432-40. Fuhrmann S, Riesenberg AN, Mathiesen AM, Brown EC, Vetter ML, Brown NL. PMID: 18599572; PMCID: PMC2615067.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    33. Notch signaling regulates growth and differentiation in the mammalian lens. Dev Biol. 2008 Sep 01; 321(1):111-22. Rowan S, Conley KW, Le TT, Donner AL, Maas RL, Brown NL. PMID: 18588871; PMCID: PMC2593917.
      View in: PubMed   Mentions: 68     Fields:    Translation:Animals
    34. Conserved regulation of Math5 and Math1 revealed by Math5-GFP transgenes. Mol Cell Neurosci. 2007 Dec; 36(4):435-48. Hufnagel RB, Riesenberg AN, Saul SM, Brown NL. PMID: 17900924; PMCID: PMC2095782.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    35. Evolution of arthropod visual systems: development of the eyes and central visual pathways in the horseshoe crab Limulus polyphemus Linnaeus, 1758 (Chelicerata, Xiphosura). Dev Dyn. 2006 Oct; 235(10):2641-55. Harzsch S, Vilpoux K, Blackburn DC, Platchetzki D, Brown NL, Melzer R, Kempler KE, Battelle BA. PMID: 16788994.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    36. Math5 is required for both early retinal neuron differentiation and cell cycle progression. Dev Biol. 2006 Jul 15; 295(2):764-78. Le TT, Wroblewski E, Patel S, Riesenberg AN, Brown NL. PMID: 16690048.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    37. Multiple requirements for Hes 1 during early eye formation. Dev Biol. 2005 Aug 15; 284(2):464-78. Lee HY, Wroblewski E, Philips GT, Stair CN, Conley K, Reedy M, Mastick GS, Brown NL. PMID: 16038893; PMCID: PMC4128414.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    38. Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice. Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2540-51. Brzezinski JA, Brown NL, Tanikawa A, Bush RA, Sieving PA, Vitaterna MH, Takahashi JS, Glaser T. PMID: 15980246; PMCID: PMC1570190.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    39. Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type. Dev Biol. 2005 Mar 15; 279(2):308-21. Philips GT, Stair CN, Young Lee H, Wroblewski E, Berberoglu MA, Brown NL, Mastick GS. PMID: 15733660; PMCID: PMC4128400.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    40. bHLH-dependent and -independent modes of Ath5 gene regulation during retinal development. Development. 2005 Feb; 132(4):829-39. Hutcheson DA, Hanson MI, Moore KB, Le TT, Brown NL, Vetter ML. PMID: 15677728.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    41. The cfy mutation disrupts cell divisions in a stage-dependent manner in zebrafish embryos. Dev Biol. 2004 Dec 01; 276(1):194-206. Song MH, Brown NL, Kuwada JY. PMID: 15531374.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    42. Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes. Evol Dev. 2003 Sep-Oct; 5(5):532-41. Sun Y, Kanekar SL, Vetter ML, Gorski S, Jan YN, Glaser T, Brown NL. PMID: 12950631; PMCID: PMC2262842.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    43. Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. Mamm Genome. 2002 Feb; 13(2):95-101. Brown NL, Dagenais SL, Chen CM, Glaser T. PMID: 11889557; PMCID: PMC2262845.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    44. The role of basic helix-loop-helix genes in vertebrate retinogenesis. Semin Cell Dev Biol. 2001 Dec; 12(6):491-8. Vetter ML, Brown NL. PMID: 11735385.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    45. The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene. Genesis. 2001 Sep; 31(1):43-53. Tucker P, Laemle L, Munson A, Kanekar S, Oliver ER, Brown N, Schlecht H, Vetter M, Glaser T. PMID: 11668677.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    46. Math5 is required for retinal ganglion cell and optic nerve formation. Development. 2001 Jul; 128(13):2497-508. Brown NL, Patel S, Brzezinski J, Glaser T. PMID: 11493566; PMCID: PMC1480839.
      View in: PubMed   Mentions: 241     Fields:    Translation:AnimalsCells
    47. Imaging gene expression using antibody probes. Methods Mol Biol. 1999; 122:75-91. Brown NL. PMID: 10231785.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    48. Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis. Development. 1998 Dec; 125(23):4821-33. Brown NL, Kanekar S, Vetter ML, Tucker PK, Gemza DL, Glaser T. PMID: 9806930.
      View in: PubMed   Mentions: 155     Fields:    Translation:AnimalsCells
    49. daughterless is required for Drosophila photoreceptor cell determination, eye morphogenesis, and cell cycle progression. Dev Biol. 1996 Oct 10; 179(1):65-78. Brown NL, Paddock SW, Sattler CA, Cronmiller C, Thomas BJ, Carroll SB. PMID: 8873754.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    50. Hairy and emc negatively regulate morphogenetic furrow progression in the Drosophila eye. Cell. 1995 Mar 24; 80(6):879-87. Brown NL, Sattler CA, Paddock SW, Carroll SB. PMID: 7697718.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    51. hairy gene function in the Drosophila eye: normal expression is dispensable but ectopic expression alters cell fates. Development. 1991 Dec; 113(4):1245-56. Brown NL, Sattler CA, Markey DR, Carroll SB. PMID: 1811940.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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