Nicholas Marsh-Armstrong

Title(s)Professor, Ophthalmology
SchoolSchool of Veterinary Medicine
AddressTupper Hall
CA 95616
Phone530-752-8174
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    Collapse Research 
    Collapse Research Activities and Funding
    Optic nerve head glymphatics and debris clearance in glaucoma
    NIH R01EY029087Jul 17, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Axonal mitochondria degradation as the Achilles heel of retinal ganglion cells
    NIH R01EY026471Jan 1, 2016 - Dec 31, 2020
    Role: Principal Investigator
    Transcellular Degradation of Mitochondria in the Central Nervous System
    NIH R01EY022680Sep 1, 2012 - Jun 30, 2016
    Role: Principal Investigator
    Optic nerve head synucleinopathy in glaucoma and the function of gamma-synuclein
    NIH R01EY019960Aug 1, 2011 - Jul 31, 2014
    Role: Principal Investigator
    Role of a Novel Corepressor in Nuclear Receptor Action
    NIH R01DK071683Apr 5, 2006 - Mar 31, 2012
    Role: Principal Investigator
    Photoreceptor Degeneration Assay-Transgenic Xenopus(RMI)
    NIH R21NS053696Sep 30, 2005 - Aug 31, 2006
    Role: Principal Investigator
    Thyroid hormone &metamorphic ipsilateral projection
    NIH R01EY016097Dec 1, 2004 - Nov 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Evaluating the performance of OCT in assessing static and potential dynamic properties of the retinal ganglion cells and nerve fiber bundles in the living mouse eye. Biomed Opt Express. 2023 Dec 01; 14(12):6422-6441. Zhang P, Vafaeva O, Dolf C, Ma Y, Wang G, Cho J, Chan HH, Marsh-Armstrong N, Zawadzki RJ. PMID: 38420317; PMCID: PMC10898556.
      View in: PubMed   Mentions:
    2. Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve. bioRxiv. 2023 May 30. Jeong Y, Davis CO, Muscarella AM, Deshpande V, Kim KY, Ellisman MH, Marsh-Armstrong N. PMID: 37398269; PMCID: PMC10312487.
      View in: PubMed   Mentions:
    3. Dual leucine zipper kinase is necessary for retinal ganglion cell axonal regeneration in Xenopus laevis. PNAS Nexus. 2023 May; 2(5):pgad109. Fague L, Marsh-Armstrong N. PMID: 37152673; PMCID: PMC10162689.
      View in: PubMed   Mentions:
    4. Optic Nerve Head Myelin-Related Protein, GFAP, and Iba1 Alterations in Non-Human Primates With Early to Moderate Experimental Glaucoma. Invest Ophthalmol Vis Sci. 2022 10 03; 63(11):9. Chaudhary P, Stowell C, Reynaud J, Gardiner SK, Yang H, Williams G, Williams I, Marsh-Armstrong N, Burgoyne CF. PMID: 36239974; PMCID: PMC9586137.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Neuron-astrocyte transmitophagy is altered in Alzheimer's disease. Neurobiol Dis. 2022 08; 170:105753. Lampinen R, Belaya I, Saveleva L, Liddell JR, Rait D, Huuskonen MT, Giniatullina R, Sorvari A, Soppela L, Mikhailov N, Boccuni I, Giniatullin R, Cruz-Haces M, Konovalova J, Koskuvi M, Domanskyi A, Hämäläinen RH, Goldsteins G, Koistinaho J, Malm T, Chew S, Rilla K, White AR, Marsh-Armstrong N, Kanninen KM. PMID: 35569719.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    6. Analysis of the retinal capillary plexus layers in a murine model with diabetic retinopathy: effect of intravitreal injection of human CD34+ bone marrow stem cells. Ann Transl Med. 2021 Aug; 9(15):1273. Cheung KW, Yazdanyar A, Dolf C, Cary W, Marsh-Armstrong N, Nolta JA, Park SS. PMID: 34532410; PMCID: PMC8421965.
      View in: PubMed   Mentions: 3  
    7. The basic science of optic nerve regeneration. Ann Transl Med. 2021 Aug; 9(15):1276. Fague L, Liu YA, Marsh-Armstrong N. PMID: 34532413; PMCID: PMC8421956.
      View in: PubMed   Mentions: 13  
    8. The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell development. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21690-21700. Miesfeld JB, Ghiasvand NM, Marsh-Armstrong B, Marsh-Armstrong N, Miller EB, Zhang P, Manna SK, Zawadzki RJ, Brown NL, Glaser T. PMID: 32817515; PMCID: PMC7474671.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    9. Programmed switch in the mitochondrial degradation pathways during human retinal ganglion cell differentiation from stem cells is critical for RGC survival. Redox Biol. 2020 07; 34:101465. Das A, Bell CM, Berlinicke CA, Marsh-Armstrong N, Zack DJ. PMID: 32473993; PMCID: PMC7327961.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Effects of intravitreal injection of human CD34+ bone marrow stem cells in a murine model of diabetic retinopathy. Exp Eye Res. 2020 01; 190:107865. Yazdanyar A, Zhang P, Dolf C, Smit-McBride Z, Cary W, Nolta JA, Zawadzki RJ, Marsh-Armstrong N, Park SS. PMID: 31682846; PMCID: PMC6957710.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    11. Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool. Cell Stem Cell. 2018 09 06; 23(3):444-452.e4. Zhou Y, Bond AM, Shade JE, Zhu Y, Davis CO, Wang X, Su Y, Yoon KJ, Phan AT, Chen WJ, Oh JH, Marsh-Armstrong N, Atabai K, Ming GL, Song H. PMID: 30174295; PMCID: PMC6128767.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    12. Neuroinflammation in glaucoma: A new opportunity. Exp Eye Res. 2017 04; 157:20-27. Williams PA, Marsh-Armstrong N, Howell GR, Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants. PMID: 28242160; PMCID: PMC5497582.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    13. Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells. Elife. 2016 08 08; 5. Miraucourt LS, Tsui J, Gobert D, Desjardins JF, Schohl A, Sild M, Spratt P, Castonguay A, De Koninck Y, Marsh-Armstrong N, Wiseman PW, Ruthazer ES. PMID: 27501334; PMCID: PMC4987138.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    14. Translational profiling of retinal ganglion cell optic nerve regeneration in Xenopus laevis. Dev Biol. 2017 06 15; 426(2):360-373. Whitworth GB, Misaghi BC, Rosenthal DM, Mills EA, Heinen DJ, Watson AH, Ives CW, Ali SH, Bezold K, Marsh-Armstrong N, Watson FL. PMID: 27471010; PMCID: PMC5897040.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    15. Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sci Rep. 2015 Nov 13; 5:16595. Sluch VM, Davis CH, Ranganathan V, Kerr JM, Krick K, Martin R, Berlinicke CA, Marsh-Armstrong N, Diamond JS, Mao HQ, Zack DJ. PMID: 26563826; PMCID: PMC4643248.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    16. Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury. Exp Neurol. 2015 Nov; 273:168-76. Xu L, Ryu J, Nguyen JV, Arena J, Rha E, Vranis P, Hitt D, Marsh-Armstrong N, Koliatsos VE. PMID: 26311071.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    17. Astrocytes phagocytose focal dystrophies from shortening myelin segments in the optic nerve of Xenopus laevis at metamorphosis. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10509-14. Mills EA, Davis CH, Bushong EA, Boassa D, Kim KY, Ellisman MH, Marsh-Armstrong N. PMID: 26240339; PMCID: PMC4547286.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    18. Repetitive mild traumatic brain injury with impact acceleration in the mouse: Multifocal axonopathy, neuroinflammation, and neurodegeneration in the visual system. Exp Neurol. 2016 Jan; 275 Pt 3:436-449. Xu L, Nguyen JV, Lehar M, Menon A, Rha E, Arena J, Ryu J, Marsh-Armstrong N, Marmarou CR, Koliatsos VE. PMID: 25450468.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    19. Transcellular degradation of axonal mitochondria. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):9633-8. Davis CH, Kim KY, Bushong EA, Mills EA, Boassa D, Shih T, Kinebuchi M, Phan S, Zhou Y, Bihlmeyer NA, Nguyen JV, Jin Y, Ellisman MH, Marsh-Armstrong N. PMID: 24979790; PMCID: PMC4084443.
      View in: PubMed   Mentions: 308     Fields:    Translation:AnimalsCells
    20. Discovery and implications of transcellular mitophagy. Autophagy. 2014; 10(12):2383-4. Davis CH, Marsh-Armstrong N. PMID: 25484086; PMCID: PMC4502649.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    21. Synucleins antagonize endoplasmic reticulum function to modulate dopamine transporter trafficking. PLoS One. 2013; 8(8):e70872. Oaks AW, Marsh-Armstrong N, Jones JM, Credle JJ, Sidhu A. PMID: 23967127; PMCID: PMC3742698.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    22. Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):4045-50. Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, DiAntonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ. PMID: 23431148; PMCID: PMC3593842.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    23. Cell type-specific translational profiling in the Xenopus laevis retina. Dev Dyn. 2012 Dec; 241(12):1960-72. Watson FL, Mills EA, Wang X, Guo C, Chen DF, Marsh-Armstrong N. PMID: 23074098; PMCID: PMC4536902.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    24. Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis. Neurobiol Dis. 2012 Oct; 48(1):124-31. Peters OM, Millership S, Shelkovnikova TA, Soto I, Keeling L, Hann A, Marsh-Armstrong N, Buchman VL, Ninkina N. PMID: 22750530; PMCID: PMC3457776.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    25. Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1):434-41. Soto I, Pease ME, Son JL, Shi X, Quigley HA, Marsh-Armstrong N. PMID: 20811062; PMCID: PMC3053289.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    26. Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma. Proc Natl Acad Sci U S A. 2011 Jan 18; 108(3):1176-81. Nguyen JV, Soto I, Kim KY, Bushong EA, Oglesby E, Valiente-Soriano FJ, Yang Z, Davis CH, Bedont JL, Son JL, Wei JO, Buchman VL, Zack DJ, Vidal-Sanz M, Ellisman MH, Marsh-Armstrong N. PMID: 21199938; PMCID: PMC3024691.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    27. Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss. Glia. 2010 May; 58(7):780-9. Son JL, Soto I, Oglesby E, Lopez-Roca T, Pease ME, Quigley HA, Marsh-Armstrong N. PMID: 20091782.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    28. Neurodevelopmental effects of chronic exposure to elevated levels of pro-inflammatory cytokines in a developing visual system. Neural Dev. 2010 Jan 12; 5:2. Lee RH, Mills EA, Schwartz N, Bell MR, Deeg KE, Ruthazer ES, Marsh-Armstrong N, Aizenman CD. PMID: 20067608; PMCID: PMC2819242.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    29. Temporal regulation of Ath5 gene expression during eye development. Dev Biol. 2009 Feb 15; 326(2):471-81. Willardsen MI, Suli A, Pan Y, Marsh-Armstrong N, Chien CB, El-Hodiri H, Brown NL, Moore KB, Vetter ML. PMID: 19059393; PMCID: PMC2788623.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    30. Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1437-46. Bosco A, Inman DM, Steele MR, Wu G, Soto I, Marsh-Armstrong N, Hubbard WC, Calkins DJ, Horner PJ, Vetter ML. PMID: 18385061.
      View in: PubMed   Mentions: 175     Fields:    Translation:AnimalsCells
    31. Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. J Neurosci. 2008 Mar 12; 28(11):2735-44. Buckingham BP, Inman DM, Lambert W, Oglesby E, Calkins DJ, Steele MR, Vetter ML, Marsh-Armstrong N, Horner PJ. PMID: 18337403; PMCID: PMC6670674.
      View in: PubMed   Mentions: 250     Fields:    Translation:AnimalsCells
    32. Xenopus laevis P23H rhodopsin transgene causes rod photoreceptor degeneration that is more severe in the ventral retina and is modulated by light. Exp Eye Res. 2008 Apr; 86(4):612-21. Zhang R, Oglesby E, Marsh-Armstrong N. PMID: 18291367; PMCID: PMC4127875.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    33. Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model. J Neurosci. 2008 Jan 09; 28(2):548-61. Soto I, Oglesby E, Buckingham BP, Son JL, Roberson ED, Steele MR, Inman DM, Vetter ML, Horner PJ, Marsh-Armstrong N. PMID: 18184797; PMCID: PMC6670511.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    34. Use of a ROSA26:GFP transgenic line for long-term Xenopus fate-mapping studies. J Anat. 2006 Sep; 209(3):401-13. Gross JB, Hanken J, Oglesby E, Marsh-Armstrong N. PMID: 16928208; PMCID: PMC2100324.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    35. Thyroid hormone controls multiple independent programs required for limb development in Xenopus laevis metamorphosis. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12455-8. Brown DD, Cai L, Das B, Marsh-Armstrong N, Schreiber AM, Juste R. PMID: 16129821; PMCID: PMC1194953.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    36. An outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase. J Neurosci. 2004 Mar 17; 24(11):2623-32. Luo W, Marsh-Armstrong N, Rattner A, Nathans J. PMID: 15028754; PMCID: PMC6729528.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    37. Thyroid hormone controls the development of connections between the spinal cord and limbs during Xenopus laevis metamorphosis. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):165-70. Marsh-Armstrong N, Cai L, Brown DD. PMID: 14691251; PMCID: PMC314156.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    38. Role of visual pigment properties in rod and cone phototransduction. Nature. 2003 Oct 02; 425(6957):526-31. Kefalov V, Fu Y, Marsh-Armstrong N, Yau KW. PMID: 14523449; PMCID: PMC2581816.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    39. Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10739-44. Schreiber AM, Das B, Huang H, Marsh-Armstrong N, Brown DD. PMID: 11517345; PMCID: PMC58545.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    40. Germ-line transmission of transgenes in Xenopus laevis. Proc Natl Acad Sci U S A. 1999 Dec 07; 96(25):14389-93. Marsh-Armstrong N, Huang H, Berry DL, Brown DD. PMID: 10588715; PMCID: PMC24446.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    41. Asymmetric growth and development of the Xenopus laevis retina during metamorphosis is controlled by type III deiodinase. Neuron. 1999 Dec; 24(4):871-8. Marsh-Armstrong N, Huang H, Remo BF, Liu TT, Brown DD. PMID: 10624950.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    42. Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase. Proc Natl Acad Sci U S A. 1999 Feb 02; 96(3):962-7. Huang H, Marsh-Armstrong N, Brown DD. PMID: 9927676; PMCID: PMC15333.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    43. Retinoic acid establishes ventral retinal characteristics. Development. 1996 Jan; 122(1):195-204. Hyatt GA, Schmitt EA, Marsh-Armstrong N, McCaffery P, Dräger UC, Dowling JE. PMID: 8565830.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    44. Retinoic acid in the anteroposterior patterning of the zebrafish trunk. Rouxs Arch Dev Biol. 1995 Nov; 205(3-4):103-113. Marsh-Armstrong N, McCaffery P, Hyatt G, Alonso L, Dowling JE, Gilbert W, Dräger UC. PMID: 28306071.
      View in: PubMed   Mentions: 1  
    45. Retinoic acid is necessary for development of the ventral retina in zebrafish. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7286-90. Marsh-Armstrong N, McCaffery P, Gilbert W, Dowling JE, Dräger UC. PMID: 8041782; PMCID: PMC44384.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    46. Retinoic acid-induced duplication of the zebrafish retina. Proc Natl Acad Sci U S A. 1992 Sep 01; 89(17):8293-7. Hyatt GA, Schmitt EA, Marsh-Armstrong NR, Dowling JE. PMID: 1518861; PMCID: PMC49904.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
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