Richard L Applegate II

Title(s)Professor, Anesthesiology and Pain Medicine
SchoolSchool of Medicine
AddressPSSB/UCDMC
CA 95817
Phone916-734-5048
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery : A Randomized Clinical Trial. Ann Intern Med. 2022 07; 175(7):952-960. Neuman MD, Feng R, Ellenberg SS, Sieber F, Sessler DI, Magaziner J, Elkassabany N, Schwenk ES, Dillane D, Marcantonio ER, Menio D, Ayad S, Hassan M, Stone T, Papp S, Donegan D, Marshall M, Jaffe JD, Luke C, Sharma B, Azim S, Hymes R, Chin KJ, Sheppard R, Perlman B, Sappenfield J, Hauck E, Hoeft MA, Tierney A, Gaskins LJ, Horan AD, Brown T, Dattilo J, Carson JL, REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture) Investigat, Looke T, Bent S, Franco-Mora A, Hedrick P, Newbern M, Tadros R, Pealer K, Vlassakov K, Buckley C, Gavin L, Gorbatov S, Gosnell J, Steen T, Vafai A, Zeballos J, Hruslinski J, Cardenas L, Berry A, Getchell J, Quercetti N, Bajracharya G, Billow D, Bloomfield M, Cuko E, Elyaderani MK, Hampton R, Honar H, Khoshknabi D, Kim D, Krahe D, Lew MM, Maheshwer CB, Niazi A, Saha P, Salih A, de Swart RJ, Volio A, Bolkus K, DeAngelis M, Dodson G, Gerritsen J, McEniry B, Mitrev L, Kwofie MK, Belliveau A, Bonazza F, Lloyd V, Panek I, Dabiri J, Chavez C, Craig J, Davidson T, Dietrichs C, Fleetwood C, Foley M, Getto C, Hailes S, Hermes S, Hooper A, Koener G, Kohls K, Law L, Lipp A, Losey A, Nelson W, Nieto M, Rogers P, Rutman S, Scales G, Sebastian B, Stanciu T, Lobel G, Giampiccolo M, Herman D, Kaufman M, Murphy B, Pau C, Puzio T, Veselsky M, Apostle K, Boyer D, Fan BC, Lee S, Lemke M, Merchant R, Moola F, Payne K, Perey B, Viskontas D, Poler M, D'Antonio P, O'Neill G, Abdullah A, Fish-Fuhrmann J, Giska M, Fidkowski C, Guthrie ST, Hakeos W, Hayes L, Hoegler J, Nowak K, Beck J, Cuff J, Gaski G, Haaser S, Holzman M, Malekzadeh AS, Ramsey L, Schulman J, Schwartzbach C, Azefor T, Davani A, Jaberi M, Masear C, Haider SB, Chungu C, Ebrahimi A, Fikry K, Marcantonio A, Shelvan A, Sanders D, Clarke C, Lawendy A, Schwartz G, Garg M, Kim J, Caruci J, Commeh E, Cuevas R, Cuff G, Franco L, Furgiuele D, Giuca M, Allman M, Barzideh O, Cossaro J, D'Arduini A, Farhi A, Gould J, Kafel J, Patel A, Peller A, Reshef H, Safur M, Toscano F, Tedore T, Akerman M, Brumberger E, Clark S, Friedlander R, Jegarl A, Lane J, Lyden JP, Mehta N, Murrell MT, Painter N, Ricci W, Sbrollini K, Sharma R, Steel PAD, Steinkamp M, Weinberg R, Wellman DS, Nader A, Fitzgerald P, Ritz M, Bryson G, Craig A, Farhat C, Gammon B, Gofton W, Harris N, Lalonde K, Liew A, Meulenkamp B, Sonnenburg K, Wai E, Wilkin G, Troxell K, Alderfer ME, Brannen J, Cupitt C, Gerhart S, McLin R, Sheidy J, Yurick K, Chen F, Dragert K, Kiss G, Malveaux H, McCloskey D, Mellender S, Mungekar SS, Noveck H, Sagebien C, Biby L, McKelvy G, Richards A, Abola R, Ayala B, Halper D, Mavarez A, Rizwan S, Choi S, Awad I, Flynn B, Henry P, Jenkinson R, Kaustov L, Lappin E, McHardy P, Singh A, Donnelly J, Gonzalez M, Haydel C, Livelsberger J, Pazionis T, Slattery B, Vazquez-Trejo M, Baratta J, Cirullo M, Deiling B, Deschamps L, Glick M, Katz D, Krieg J, Lessin J, Mojica J, Torjman M, Jin R, Salpeter MJ, Powell M, Simmons J, Lawson P, Kukreja P, Graves S, Sturdivant A, Bryant A, Crump SJ, Verrier M, Green J, Menon M, Applegate R, Arias A, Pineiro N, Uppington J, Wolinsky P, Gunnett A, Hagen J, Harris S, Hollen K, Holloway B, Horodyski MB, Pogue T, Ramani R, Smith C, Woods A, Warrick M, Flynn K, Mongan P, Ranganath Y, Fernholz S, Ingersoll-Weng E, Marian A, Seering M, Sibenaller Z, Stout L, Wagner A, Walter A, Wong C, Orwig D, Goud M, Helker C, Mezenghie L, Montgomery B, Preston P, Schwartz JS, Weber R, Fleisher LA, Mehta S, Stephens-Shields AJ, Dinh C, Chelly JE, Goel S, Goncz W, Kawabe T, Khetarpal S, Monroe A, Shick V, Breidenstein M, Dominick T, Friend A, Mathews D, Lennertz R, Sanders R, Akere H, Balweg T, Bo A, Doro C, Goodspeed D, Lang G, Parker M, Rettammel A, Roth M, White M, Whiting P, Allen BFS, Baker T, Craven D, McEvoy M, Turnbo T, Kates S, Morgan M, Willoughby T, Weigel W, Auyong D, Fox E, Welsh T, Cusson B, Dobson S, Edwards C, Harris L, Henshaw D, Johnson K, McKinney G, Miller S, et al. PMID: 35696684.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    2. Effect of lipid-lowering medications in patients with coronary artery bypass grafting surgery outcomes. BMC Anesthesiol. 2022 04 26; 22(1):122. Shi C, Zhang Z, Goldhammer J, Li D, Kiaii B, Rudriguez V, Boyd D, Lubarsky D, Applegate R, Liu H. PMID: 35473580; PMCID: PMC9040242.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Comparison of Oral Loading Dose to Intravenous Acetaminophen in Children for Analgesia After Tonsillectomy and Adenoidectomy: A Randomized Clinical Trial. Anesth Analg. 2021 12 01; 133(6):1568-1576. Lammers CR, Schwinghammer AJ, Hall B, Kriss RS, Aizenberg DA, Funamura JL, Senders CW, Nittur V, Applegate RL. PMID: 34304234.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Perioperative dexmedetomidine and 5-year survival in patients undergoing cardiac surgery. Reply to Br J Anaesth 2021; 127: e127-8. Br J Anaesth. 2021 11; 127(5):e170-e171. Peng K, Shen YP, Applegate RL, Lubarsky DA, Liu H, Ji FH. PMID: 34454712.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Course of illness and outcomes in older COVID-19 patients treated with HFNC: a retrospective analysis. Aging (Albany NY). 2021 06 28; 13(12):15801-15814. Deng L, Lei S, Wang X, Jiang F, Lubarsky DA, Zhang L, Liu D, Han C, Zhou D, Wang Z, Sun X, Zhang Y, Cheung CW, Wang S, Xia Z, Applegate RL, Tang J, Mai Z, Liu H, Xia Z. PMID: 34182540; PMCID: PMC8266360.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    6. Perioperative dexmedetomidine and 5-year survival in patients undergoing cardiac surgery. Br J Anaesth. 2021 08; 127(2):215-223. Peng K, Shen YP, Ying YY, Kiaii B, Rodriguez V, Boyd D, Applegate RL, Lubarsky DA, Zhang Z, Xia Z, Feng XM, Yang JP, Liu H, Ji FH. PMID: 34082896.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    7. Correction to: Multicenter comparison of three intraoperative hemoglobin trend monitoring methods. J Clin Monit Comput. 2021 May; 35(3):677-678. Applegate Ii RL, Applegate PM, Cannesson M, Peiris P, Ladlie BL, Torp K. PMID: 32737748; PMCID: PMC8182879.
      View in: PubMed   Mentions: 1     Fields:    
    8. Simultaneous comparison of depth of sedation performance between SedLine and BIS during general anesthesia using custom passive interface hardware: study protocol for a prospective, non-blinded, non-randomized trial. BMC Anesthesiol. 2021 04 06; 21(1):105. Jones JH, Nittur VR, Fleming N, Applegate RL. PMID: 33823811; PMCID: PMC8022390.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    9. Oxygen Reserve Index: Utility as an Early Warning for Desaturation in High-Risk Surgical Patients. Anesth Analg. 2021 03 01; 132(3):770-776. Fleming NW, Singh A, Lee L, Applegate RL. PMID: 32815872.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    10. Frailty, Race/Ethnicity, Functional Status, and Adverse Outcomes After Total Hip/Knee Arthroplasty: A Moderation Analysis. J Arthroplasty. 2021 06; 36(6):1895-1903. Dharmasukrit C, Chan SYS, Applegate RL, Tancredi DJ, Harvath TA, Joseph JG. PMID: 33573811.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Remote Ischemic Pre-conditioning in Subarachnoid Hemorrhage: A Prospective Pilot Trial. Neurocrit Care. 2021 06; 34(3):968-973. Raval RN, Small O, Magsino K, Chakravarthy V, Austin B, Applegate R, Dorotta I. PMID: 33051793.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    12. Perioperative Dexmedetomidine Improves Outcomes of Kidney Transplant. Clin Transl Sci. 2020 11; 13(6):1279-1287. Chen J, Perez R, de Mattos AM, Wang C, Li Z, Applegate RL, Liu H. PMID: 32506659; PMCID: PMC7719359.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    13. Study of early warning for desaturation provided by Oxygen Reserve Index in obese patients. J Clin Monit Comput. 2021 08; 35(4):749-756. Tsymbal E, Ayala S, Singh A, Applegate RL, Fleming NW. PMID: 32424516; PMCID: PMC8286939.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    14. Impact of preoperative pectoralis plane nerve blocks for mastectomy on perioperative opioid consumption: a retrospective study. Pain Manag. 2020 May; 10(3):159-165. Kim SY, Avila J, Lee J, Lee T, Macres S, Applegate RL, Wilson MD, Zhou J. PMID: 32342719.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Multicenter comparison of three intraoperative hemoglobin trend monitoring methods. J Clin Monit Comput. 2020 Oct; 34(5):883-892. Applegate Ii RL, Applegate PM, Cannesson M, Peiris P, Ladlie BL, Torp K. PMID: 31797199; PMCID: PMC7447626.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. Retrospective Cohort Study on the Optimal Timing of Orogastric Tube/Nasogastric Tube Insertion in Infants With Pyloric Stenosis. Anesth Analg. 2019 10; 129(4):1079-1086. Lee LK, Burns RA, Dhamrait RS, Carter HF, Vadi MG, Grogan TR, Elashoff DA, Applegate RL, Iravani M. PMID: 30234537.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Effect of Dexmedetomidine on Cardiac Surgery-Associated Acute Kidney Injury: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials. J Cardiothorac Vasc Anesth. 2020 Mar; 34(3):603-613. Peng K, Li D, Applegate RL, Lubarsky DA, Ji FH, Liu H. PMID: 31587928.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    18. Inhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of asphyxia induced-cardiac arrest. Med Gas Res. 2019 Jul-Sep; 9(3):122-126. Huang L, Applegate Ii RL, Applegate PM, Gong L, Ocak U, Boling W, Zhang JH. PMID: 31552874; PMCID: PMC6779004.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    19. A comparison of postoperative outcomes with PDA ligation in the OR versus the NICU: a retrospective cohort study on the risks of transport. BMC Anesthesiol. 2018 12 22; 18(1):199. Lee LK, Woodfin MY, Vadi MG, Grogan TR, Ross PJ, Applegate RL, Iravani M. PMID: 30579349; PMCID: PMC6303951.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. A comparison of midazolam and zolpidem as oral premedication in children, a prospective randomized double-blinded clinical trial. Paediatr Anaesth. 2018 12; 28(12):1109-1115. Hanna AH, Ramsingh D, Sullivan-Lewis W, Cano S, Leiter P, Wallace D, Andrews G, Austin B, Applegate RL. PMID: 30328648.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest. Med Gas Res. 2018 Jul-Sep; 8(3):73-78. Huang L, Applegate RL, Applegate PM, Boling W, Zhang JH. PMID: 30319760; PMCID: PMC6178639.
      View in: PubMed   Mentions: 8     Fields:    
    22. Remote Limb Ischemic Preconditioning Attenuates Cerebrovascular Depression During Sinusoidal Galvanic Vestibular Stimulation via α1-Adrenoceptor-Protein Kinase Cε-Endothelial NO Synthase Pathway in Rats. J Am Heart Assoc. 2018 03 24; 7(7). McBride DW, Reis C, Zhang JH, Applegate R, Tang J. PMID: 29574462; PMCID: PMC5907579.
      View in: PubMed   Mentions:    Fields:    
    23. In Response: Sedation After Cardiac Surgery With Propofol or Dexmedetomidine: Between Scylla and Charybdis? Anesth Analg. 2017 11; 125(5):1822-1823. Liu H, Ji F, Peng K, Applegate RL, Fleming NW. PMID: 28914652.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Comparison of the GlideScope Cobalt® and Storz DCI® Video Laryngoscopes in Children Younger Than 2 Years of Age During Manual In-Line Stabilization: A Randomized Trainee Evaluation Study. Pediatr Emerg Care. 2017 Jul; 33(7):467-473. Vadi MG, Roddy KJ, Ghazal EA, Um M, Neiheisel AJ, Applegate RL. PMID: 26785097.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    25. Extreme Plasma Dilution Decreases Heparin and Protamine Cardiopulmonary Bypass Requirements: A Case Report on a Jehovah's Witness Patient. A A Case Rep. 2017 Jun 01; 8(11):291-293. Chang E, Gatling JW, Bode S, Herrmann PC, Bull BS, Applegate RL. PMID: 28328588.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Sedation After Cardiac Surgery: Is One Drug Better Than Another? Anesth Analg. 2017 04; 124(4):1061-1070. Liu H, Ji F, Peng K, Applegate RL, Fleming N. PMID: 27984229.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    27. Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. Biomed Res Int. 2017; 2017:4863079. Reis C, Akyol O, Ho WM, Araujo C, Huang L, Applegate R, Zhang JH. PMID: 28286764; PMCID: PMC5329656.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    28. Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury. Sci Rep. 2017 01 19; 7:40821. Kim CH, McBride DW, Raval R, Sherchan P, Hay KL, Gren EC, Kelln W, Lekic T, Hayes WK, Bull BS, Applegate R, Tang J, Zhang JH. PMID: 28102287; PMCID: PMC5244360.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    29. Use of Esophageal Hemoximetry to Assess the Effect of Packed Red Blood Cell Transfusion on Gastrointestinal Oxygenation in Newborn Infants. Am J Perinatol. 2017 07; 34(8):735-741. Vora FM, Gates J, Gerard K, Hanson S, Applegate RL, Blood AB. PMID: 28099981.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Pharmacological Management Options to Prevent and Reduce Ischemic Hemorrhagic Transformation. Curr Drug Targets. 2017; 18(12):1441-1459. Ho WM, Reis C, Akyol O, Akyol GY, Applegate R, Stier G, Martin R, Zhang JH. PMID: 27538508.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    31. Beta Blockade and Clinical Outcomes in Aneurysmal Subarachnoid Hemorrhage. Open Neurol J. 2016; 10:155-163. Chang MM, Raval RN, Southerland JJ, Adewumi DA, Bahjri KA, Samuel RK, Woods RO, Ajayi OO, Lee BS, Hsu FP, Applegate Ii RL, Dorotta IR. PMID: 28217182; PMCID: PMC5278558.
      View in: PubMed   Mentions: 1  
    32. In Response. Anesth Analg. 2016 12; 123(6):1643-1644. Applegate PM, Applegate RL. PMID: 27782946.
      View in: PubMed   Mentions: 1     Fields:    
    33. An Experimental Model of Vasovagal Syncope Induces Cerebral Hypoperfusion and Fainting-Like Behavior in Awake Rats. PLoS One. 2016; 11(9):e0163280. McBride DW, Reis C, Frank E, Klebe DW, Zhang JH, Applegate R, Tang J. PMID: 27658057; PMCID: PMC5033448.
      View in: PubMed   Mentions: 4     Fields:    
    34. Continuous Noninvasive Hemodynamic Monitoring in an Infant With Tetra-Amelia. A A Case Rep. 2016 Sep 15; 7(6):123-4. Vadi MG, Ghazal EA, Malkin MR, Ayodeji A, Applegate RL. PMID: 27513971.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. The Relationship Between Oxygen Reserve Index and Arterial Partial Pressure of Oxygen During Surgery. Anesth Analg. 2016 09; 123(3):626-33. Applegate RL, Dorotta IL, Wells B, Juma D, Applegate PM. PMID: 27007078; PMCID: PMC4979626.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    36. Intraoperative Red Blood Cell Transfusion in Infant Heart Transplant Patients Is Not Associated with Worsened Outcomes. Anesth Analg. 2016 May; 122(5):1567-77. Carter HF, Lau C, Juma D, Wells B, Applegate RL. PMID: 27101500.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. Comparison of web-based and face-to-face interviews for application to an anesthesiology training program: a pilot study. Int J Med Educ. 2016 Apr 03; 7:102-8. Vadi MG, Malkin MR, Lenart J, Stier GR, Gatling JW, Applegate RL. PMID: 27039029; PMCID: PMC4820321.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    38. Advanced Monitoring Is Associated with Fewer Alarm Events During Planned Moderate Procedure-Related Sedation: A 2-Part Pilot Trial. Anesth Analg. 2016 Apr; 122(4):1070-8. Applegate RL, Lenart J, Malkin M, Meineke MN, Qoshlli S, Neumann M, Jacobson JP, Kruger A, Ching J, Hassanian M, Um M. PMID: 26836134; PMCID: PMC4791313.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    39. COMPARISON OF INDIRECT VIDEO LARYNGOSCOPES IN CHILDREN YOUNGER THAN TWO YEARS OF AGE: A RANDOMIZED TRAINEE EVALUATION STUDY. Middle East J Anaesthesiol. 2016 Feb; 23(4):401-10. Vadi MG, Ghazal EA, Halverson B, Applegate RL. PMID: 27382808.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    40. Management of Near-Complete Airway Obstruction Caused by a Vallecular Cyst in an Infant Using a Tongue Tip Traction Suture. A A Case Rep. 2016 Jan 15; 6(2):31-3. Wong CM, Ghazal EA, Dyleski RA, Applegate RL. PMID: 26599736.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    41. Valproic Acid Pretreatment Reduces Brain Edema in a Rat Model of Surgical Brain Injury. Acta Neurochir Suppl. 2016; 121:305-10. Huang L, Woo W, Sherchan P, Khatibi NH, Krafft P, Rolland W, Applegate RL, Martin RD, Zhang J. PMID: 26463966.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    42. Epsilon Aminocaproic Acid Pretreatment Provides Neuroprotection Following Surgically Induced Brain Injury in a Rat Model. Acta Neurochir Suppl. 2016; 121:311-5. Komanapalli ES, Sherchan P, Rolland W, Khatibi N, Martin RD, Applegate RL, Tang J, Zhang JH. PMID: 26463967.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    43. Thrombin Preconditioning in Surgical Brain Injury in Rats. Acta Neurochir Suppl. 2016; 121:299-304. Benggon M, Chen H, Applegate RL, Zhang J. PMID: 26463965.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    44. Propofol Pretreatment Fails to Provide Neuroprotection Following a Surgically Induced Brain Injury Rat Model. Acta Neurochir Suppl. 2016; 121:323-7. Pakkianathan C, Benggon M, Khatibi NH, Chen H, Marcantonio S, Applegate R, Tang J, Zhang J. PMID: 26463969.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    45. Phosphoinositide 3-Kinase Gamma Contributes to Neuroinflammation in a Rat Model of Surgical Brain Injury. J Neurosci. 2015 Jul 22; 35(29):10390-401. Huang L, Sherchan P, Wang Y, Reis C, Applegate RL, Tang J, Zhang JH. PMID: 26203135; PMCID: PMC4510283.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    46. What's New in Traumatic Brain Injury: Update on Tracking, Monitoring and Treatment. Int J Mol Sci. 2015 May 26; 16(6):11903-65. Reis C, Wang Y, Akyol O, Ho WM, Ii RA, Stier G, Martin R, Zhang JH. PMID: 26016501; PMCID: PMC4490422.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    47. Ischemic conditioning-induced endogenous brain protection: Applications pre-, per- or post-stroke. Exp Neurol. 2015 Oct; 272:26-40. Wang Y, Reis C, Applegate R, Stier G, Martin R, Zhang JH. PMID: 25900056; PMCID: PMC4609591.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    48. Anti-neutrophil antibody enhances the neuroprotective effects of G-CSF by decreasing number of neutrophils in hypoxic ischemic neonatal rat model. Neurobiol Dis. 2014 Sep; 69:192-9. Doycheva DM, Hadley T, Li L, Applegate RL, Zhang JH, Tang J. PMID: 24874543; PMCID: PMC4109395.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    49. A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (part II-comprehensive protection). Med Gas Res. 2014; 4:10. Huang L, Applegate PM, Gatling JW, Mangus DB, Zhang J, Applegate RL. PMID: 25671079; PMCID: PMC4322492.
      View in: PubMed   Mentions: 13     Fields:    
    50. A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I - Protection via specific pathways). Med Gas Res. 2014; 4:9. Mangus DB, Huang L, Applegate PM, Gatling JW, Zhang J, Applegate RL. PMID: 24808942; PMCID: PMC4012247.
      View in: PubMed   Mentions: 12     Fields:    
    51. Analgesic effectiveness of acetaminophen for primary cleft palate repair in young children: a randomized placebo controlled trial. Paediatr Anaesth. 2014 Jun; 24(6):574-81. Nour C, Ratsiu J, Singh N, Mason L, Ray A, Martin M, Hassanian M, Uhler J, Applegate RL. PMID: 24697925.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    52. Cognitive dysfunction following desflurane versus sevoflurane general anesthesia in elderly patients: a randomized controlled trial. Med Gas Res. 2014 Mar 25; 4(1):6. Meineke M, Applegate RL, Rasmussen T, Anderson D, Azer S, Mehdizadeh A, Kim A, Allard M. PMID: 24666542; PMCID: PMC3976084.
      View in: PubMed   Mentions: 10     Fields:    
    53. Adverse effect of inhalational anesthetics on the developing brain. Med Gas Res. 2014 Feb 14; 4(1):2. Wang M, Zhang JH, Applegate RL. PMID: 24528992; PMCID: PMC3926857.
      View in: PubMed   Mentions: 9     Fields:    
    54. General anesthesia soon after dialysis may increase postoperative hypotension - A pilot study. Heart Lung Vessel. 2014; 6(1):52-9. Deng J, Lenart J, Applegate RL. PMID: 24800198; PMCID: PMC4009597.
      View in: PubMed   Mentions: 4  
    55. Isoflurane post-treatment ameliorates GMH-induced brain injury in neonatal rats. Stroke. 2013 Dec; 44(12):3587-90. Leitzke AS, Rolland WB, Krafft PR, Lekic T, Klebe D, Flores JJ, Van Allen NR, Applegate RL, Zhang JH. PMID: 24149004; PMCID: PMC3919515.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    56. Association of plasma dilution with cardiopulmonary bypass-associated bleeding and morbidity. J Cardiothorac Vasc Anesth. 2013 Oct; 27(5):845-52. Brauer SD, Applegate RL, Jameson JJ, Hay KL, Lauer RE, Herrmann PC, Bull BS. PMID: 23791494.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    57. Evaluation of multiple modes of oximetry monitoring as an index of splanchnic blood flow in a newborn lamb model of hypoxic, ischemic, and hemorrhagic stress. Shock. 2013 Jun; 39(6):501-6. Applegate RL, Ramsingh DS, Dorotta I, Sanghvi C, Blood AB. PMID: 23603766; PMCID: PMC4489682.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    58. The relationship of intravenous dextrose administration during emergence from anesthesia to postoperative nausea and vomiting: a randomized controlled trial. Anesth Analg. 2013 Jul; 117(1):34-42. Patel P, Meineke MN, Rasmussen T, Anderson DL, Brown J, Siddighi S, Applegate RL. PMID: 23687231.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    59. Telemedicine pre-anesthesia evaluation: a randomized pilot trial. Telemed J E Health. 2013 Mar; 19(3):211-6. Applegate RL, Gildea B, Patchin R, Rook JL, Wolford B, Nyirady J, Dawes TA, Faltys J, Ramsingh DS, Stier G. PMID: 23384334.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    60. Outcome impact of goal directed fluid therapy during high risk abdominal surgery in low to moderate risk patients: a randomized controlled trial. J Clin Monit Comput. 2013 Jun; 27(3):249-57. Ramsingh DS, Sanghvi C, Gamboa J, Cannesson M, Applegate RL. PMID: 23264068.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    61. Granulocyte-colony stimulating factor in combination with stem cell factor confers greater neuroprotection after hypoxic-ischemic brain damage in the neonatal rats than a solitary treatment. Transl Stroke Res. 2013 Apr; 4(2):171-8. Doycheva D, Shih G, Chen H, Applegate R, Zhang JH, Tang J. PMID: 23565130; PMCID: PMC3615723.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    62. The role of Volatile Anesthetics in Cardioprotection: a systematic review. Med Gas Res. 2012 Aug 28; 2(1):22. Van Allen NR, Krafft PR, Leitzke AS, Applegate RL, Tang J, Zhang JH. PMID: 22929111; PMCID: PMC3598931.
      View in: PubMed   Mentions: 23     Fields:    
    63. Vindication of Yb2Ti2O7 as a model exchange quantum spin ice. Phys Rev Lett. 2012 Aug 31; 109(9):097205. Applegate R, Hayre NR, Singh RR, Lin T, Day AG, Gingras MJ. PMID: 23002878.
      View in: PubMed   Mentions: 3     Fields:    
    64. Impact of rocuronium vs succinylcholine neuromuscular blocking drug choice for laparoscopic pyloromyotomy: is there a difference in time to transport to recovery? Paediatr Anaesth. 2013 Apr; 23(4):316-21. Ghazal E, Amin A, Wu A, Felema B, Applegate RL. PMID: 22784242.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    65. Effect of dexmedetomidine on brain edema and neurological outcomes in surgical brain injury in rats. Anesth Analg. 2012 Jul; 115(1):154-9. Benggon M, Chen H, Applegate R, Martin R, Zhang JH. PMID: 22584551; PMCID: PMC3382053.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    66. Evaluation of pulse cooximetry in patients undergoing abdominal or pelvic surgery. Anesthesiology. 2012 Jan; 116(1):65-72. Applegate RL, Barr SJ, Collier CE, Rook JL, Mangus DB, Allard MW. PMID: 22133758.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    67. Preoperative mucosal tolerance to brain antigens and a neuroprotective immune response following surgical brain injury. J Neurosurg. 2012 Jan; 116(1):246-53. Ayer RE, Jafarian N, Chen W, Applegate RL, Colohan AR, Zhang JH. PMID: 22017304; PMCID: PMC4373079.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    68. Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice. Anesth Analg. 2011 Aug; 113(2):343-8. Khatibi NH, Ma Q, Rolland W, Ostrowski R, Fathali N, Martin R, Applegate R, Stier G, Tang J, Zhang JH. PMID: 21596881; PMCID: PMC3144303.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    69. Successful labor epidural analgesia 10 days after an epidural blood patch. Int J Obstet Anesth. 2011 Apr; 20(2):194-5. Jafarian N, Neumann M, Applegate RL, Ayer R. PMID: 21376565.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    70. Mucosal tolerance to brain antigens preserves endogenous TGFβ-1 and improves neurological outcomes following experimental craniotomy. Acta Neurochir Suppl. 2011; 111:283-7. Jafarian N, Ayer R, Eckermann J, Tong W, Jafarian N, Applegate RL, Stier G, Martin R, Tang J, Zhang JH. PMID: 21725769.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    71. Endothelin receptor-A (ETa) inhibition fails to improve neonatal hypoxic-ischemic brain injury in rats. Acta Neurochir Suppl. 2011; 111:207-12. Khatibi NH, Lee LK, Zhou Y, Chen W, Rolland W, Fathali N, Martin R, Applegate R, Stier G, Zhang JH. PMID: 21725757.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    72. Prostaglandin E2 EP1 receptor inhibition fails to provide neuroprotection in surgically induced brain-injured mice. Acta Neurochir Suppl. 2011; 111:277-81. Khatibi NH, Jadhav V, Matus B, Fathali N, Martin R, Applegate R, Tang J, Zhang JH. PMID: 21725768; PMCID: PMC3569069.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    73. The accuracy of noninvasive and continuous total hemoglobin measurement by pulse CO-Oximetry in human subjects undergoing hemodilution. Anesth Analg. 2010 Dec; 111(6):1424-6. Macknet MR, Allard M, Applegate RL, Rook J. PMID: 21048100.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    74. Dexmedetomidine for awake fiberoptic intubation in a parturient with spinal muscular atrophy type III for cesarean delivery. Int J Obstet Anesth. 2009 Oct; 18(4):403-7. Neumann MM, Davio MB, Macknet MR, Applegate RL. PMID: 19733055.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    75. Deep hypothermia and circulatory arrest in adults. Semin Cardiothorac Vasc Anesth. 2007 Mar; 11(1):66-76. Dorotta I, Kimball-Jones P, Applegate R. PMID: 17484175.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    76. Accurate placement of the right atrial air aspiration catheter: a descriptive study and prospective trial of intravascular electrocardiography. Anesth Analg. 2006 Aug; 103(2):435-8, table of contents. Kerr RH, Applegate RL. PMID: 16861429.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    77. Serial proton magnetic resonance spectroscopy of the brain in children undergoing cardiac surgery. Pediatr Neurol. 2003 Aug; 29(2):99-110. Ashwal S, Holshouser BA, del Rio MJ, Tong KA, Applegate RL, Bailey LL. PMID: 14580652.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    78. The use of transesophageal echocardiography to guide sternal division for cardiac operations via mini-sternotomy. J Card Surg. 1997 Mar-Apr; 12(2):67-70. Sardari FF, Schlunt ML, Applegate RL, Gundry SR. PMID: 9271723.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    79. Effect of oncotic pressure of diaspirin cross-linked hemoglobin (DCLHb) on brain injury after temporary focal cerebral ischemia in rats. Anesth Analg. 1996 Aug; 83(2):342-7. Cole DJ, Drummond JC, Patel PM, Nary JC, Applegate RL. PMID: 8694316.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    80. Salt, starch, and water on the brain. J Neurosurg Anesthesiol. 1996 Apr; 8(2):178-82. Schell RM, Applegate RL, Cole DJ. PMID: 8829567.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    81. Bless the babies: one hundred fifteen late survivors of heart transplantation during the first year of life. The Loma Linda University Pediatric Heart Transplant Group. J Thorac Cardiovasc Surg. 1993 May; 105(5):805-14; discussion 814-5. Bailey LL, Gundry SR, Razzouk AJ, Wang N, Sciolaro CM, Chiavarelli M. PMID: 8487560.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    82. Accuracy of cardiac output estimation with biplane transesophageal echocardiography. J Am Soc Echocardiogr. 1993 Jan-Feb; 6(1):62-8. Hozumi T, Shakudo M, Applegate R, Shah PM. PMID: 8439424.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    83. Remote asynergy detected by biplane transesophageal echocardiography during myocardial revascularization without cardiopulmonary bypass. Anesth Analg. 1991 Nov; 73(5):642-5. Schell RM, Shah PM, Applegate RL, Shah PM, Schmidt CA. PMID: 1952148.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    84. Persistent sacral nerve root deficits after continuous spinal anaesthesia. Can J Anaesth. 1991 Oct; 38(7):908-11. Schell RM, Brauer FS, Cole DJ, Applegate RL. PMID: 1742828.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
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