Xiao-Jing Wang

Photo of Xiao-Jing Wang
Title(s)Professor, MED: Pathology & Lab Medicine
SchoolSchool of Medicine
ORCID ORCID Icon0000-0001-8695-7361 Additional info
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    Other Positions
    Title(s)Professor, Med: Otolaryngology


    Collapse Biography 
    Collapse education and training
    Beijing Medical University, ChinaMD07/1984Medicine
    Beijing Medical University, ChinaPhD05/1989Neruoscience
    MD Anderson Cancer Center, Texaspostdoc10/1991Carcinogenesis
    Collapse awards and honors
    Society of Investigative Dermatology2014William Montagna Award

    Collapse Research 
    Collapse Featured Publications
    Collapse research activities and funding
    IND-enabling toxicology studies to reach IND approval for a proprietary biologic to treat oral mucositis in cancer patients
    NIH SB1DE024659Sep 21, 2023 - Aug 31, 2025
    Role: Co-Investigator
    BLRD Research Career Scientist Award Application
    NIH IK6BX006039Apr 1, 2022 - Mar 31, 2027
    Role: Principal Investigator
    Colorado Head and Neck Cancer SPORE
    NIH P50CA261605Sep 1, 2021 - Aug 31, 2026
    Role: Co-Investigator
    Proprietary drug to treat radiodermatitis
    NIH R44AR078669Sep 24, 2020 - Aug 31, 2022
    Role: Co-Investigator
    Mechanisms of Dual Inhibition of TGFbeta/PD-L1 in HNSCC
    NIH R01DE028420Jan 1, 2019 - Dec 31, 2024
    Role: Principal Investigator
    Elucidating Mechanism of Immune Evasion in Head and Neck Cancers
    NIH R01DE027329Aug 9, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Mechanisms and Therapeutic Targets of SCC Metastasis
    NIH I01BX003232Oct 1, 2016 - Jun 30, 2026
    Role: Principal Investigator
    Topical proprietary biologic to treat oral mucositis
    NIH R44DE024659Sep 15, 2014 - Aug 31, 2021
    Role: Co-Investigator
    Smad7 use in oral mucositis treatment
    NIH R43DE024659Sep 15, 2014 - Feb 28, 2017
    Role: Co-Investigator
    Proprietary biologic treatment to heal skin wounds
    NIH R44DE028718Sep 1, 2014 - Aug 31, 2021
    Role: Co-Investigator
    Testing Smad7-based biologics for treating chronic wounds
    NIH R41AR067106Sep 1, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Identifying oral cancer stem cell properties affected by the microenvironment
    NIH R01DE024371Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Training in Translational Research of Lung, Head and Neck Cancer
    NIH T32CA174648Apr 1, 2013 - Jun 30, 2024
    Role: Co-Investigator
    Effects of Altering TGF Beta Signaling on Wound Healing
    NIH R01AR061792Jul 18, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Identification of normal and cancer stem cells and their niche in oral mucosa
    NIH RC1DE020649Sep 17, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Effects of altering TGF beta signaling on wound healing
    NIH R01GM070966Apr 1, 2004 - Mar 31, 2009
    Role: Principal Investigator
    Role of TGFbeta signaling in HNSCC progression
    NIH R01DE015953Mar 1, 2004 - Jan 31, 2016
    Role: Principal Investigator
    Role of Smads in the epidermis and skin carcinogenesis
    NIH R01CA087849Jul 1, 2000 - Jul 31, 2013
    Role: Principal Investigator
    Role of TGF beta Signaling in skin carcinogenesis
    NIH R01CA079998Jan 1, 1999 - Apr 30, 2011
    Role: Principal Investigator
    CARCINOGENICITY ASSAY USING TRANSGENIC KERATINOCYTES
    NIH R41ES007597Sep 30, 1995 - Sep 29, 1996
    Role: Principal Investigator

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    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ectopic integrin β1 overproduction by squamous carcinoma cells contributes to immune evasion-associated metastasis. Cancer Lett. 2026 Sep 28; 656:218635. Aleman JD, Young CD, Ke Y, Nguyen KA, Lu I, Goon JB, Abello AE, Lind HT, Karam SD, Birkeland AC, Wang XJ. PMID: 42217561.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs. Nat Commun. 2026 Mar 26; 17(1). Ke Y, Li BZ, Li F, Ravindran R, Wang D, Wang S, Hwang ST, Simon SI, Collins SR, Young CD, Wang XJ. PMID: 41888164; PMCID: PMC13187274.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Identifying Pathogenic Contributors of Radiodermatitis Ameliorated by Smad7-Based Targeting in Canine and Mouse Models. Int J Radiat Oncol Biol Phys. 2025 Nov 01; 123(3):852-859. Ke Y, Boss MK, Burdekin B, Li BZ, Bian L, Wang D, Wang S, Lee BI, Gualtieri P, Trageser E, Young CD, Wang XJ. PMID: 40532891.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCellsPHPublic Health
    4. MHC class I upregulation contributes to the therapeutic response to radiotherapy in combination with anti-PD-L1/anti-TGF-β in squamous cell carcinomas with enhanced CD8 T cell memory-driven response. Cancer Lett. 2025 Jan 01; 608:217347. Lind HT, Hall SC, Strait AA, Goon JB, Aleman JD, Chen SMY, Karam SD, Young CD, Wang JH, Wang XJ. PMID: 39580046; PMCID: PMC11875078.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    5. Inducible nitric oxide synthase (iNOS)-activated Cxcr2 signaling in myeloid cells promotes TGFβ-dependent squamous cell carcinoma lung metastasis. Cancer Lett. 2023 08 28; 570:216330. Li X, Ke Y, Hernandez AL, Yu J, Bian L, Hall SC, Nolan K, Wang JH, Young CD, Wang XJ. PMID: 37524225; PMCID: PMC10530117.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    6. IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis and Psoriatic Phenotypes in Mice. J Invest Dermatol. 2023 11; 143(11):2243-2254.e10. Ke Y, Li BZ, Nguyen K, Wang D, Wang S, Young CD, Wang XJ. PMID: 37211203; PMCID: PMC11127768.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
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