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Jeroen Saeij

TitleASSOC PROF-SFT-VM
InstitutionUniversity of California Davis
DepartmentVM: PATHOLOGY, MICRO, & IMMUN
Address3325 VM3A
CA 95616
Phone530-752-1401
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Arranz-Solís D, Regidor-Cerrillo J, Lourido S, Ortega-Mora LM, Saeij J. Toxoplasma CRISPR/Cas9 constructs are functional for gene disruption in Neospora caninum. Int J Parasitol. 2018 Jul; 48(8):597-600. PMID: 29625127.
      View in: PubMed
    2. Saeij J, Frickel EM. Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death. Curr Opin Microbiol. 2017 Dec; 40:72-80. PMID: 29141239.
      View in: PubMed
    3. Krishnamurthy S, Konstantinou EK, Young LH, Gold DA, Saeij J. The human immune response to Toxoplasma: Autophagy versus cell death. PLoS Pathog. 2017 03; 13(3):e1006176. PMID: 28278184.
      View in: PubMed
    4. Sidik SM, Huet D, Ganesan SM, Huynh MH, Wang T, Nasamu AS, Thiru P, Saeij J, Carruthers VB, Niles JC, Lourido S. A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Cell. 2016 Sep 08; 166(6):1423-1435.e12. PMID: 27594426; PMCID: PMC5017925 [Available on 09/08/17].
    5. Fink A, Hassan MA, Okan NA, Sheffer M, Camejo A, Saeij J, Kasper DL. Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19. MBio. 2016 Mar 15; 7(2):e02243. PMID: 26980837; PMCID: PMC4807373.
    6. Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, Dubey JP, Fritz HM, Gennari SM, Gregory BD, Kim K, Saeij J, Su C, White MW, Zhu XQ, Howe DK, Rosenthal BM, Grigg ME, Parkinson J, Liu L, Kissinger JC, Roos DS, Sibley LD. Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes. Nat Commun. 2016 Jan 07; 7:10147. PMID: 26738725; PMCID: PMC4729833.
    7. Hassan MA, Jensen KD, Butty V, Hu K, Boedec E, Prins P, Saeij J. Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection. PLoS Genet. 2015 Oct; 11(10):e1005619. PMID: 26510153.
      View in: PubMed
    8. Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij J. The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole. Cell Host Microbe. 2015 May 13; 17(5):642-52. PMID: 25974303; PMCID: PMC4435723.
    9. Jensen KD, Camejo A, Melo MB, Cordeiro C, Julien L, Grotenbreg GM, Frickel EM, Ploegh HL, Young L, Saeij J. Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination. MBio. 2015 Feb 24; 6(2):e02280. PMID: 25714710; PMCID: PMC4358003.
    10. Hassan MA, Saeij J. Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits. Bioessays. 2014 Nov; 36(11):1032-40. PMID: 25171292.
      View in: PubMed
    11. Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij J, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 2014 Jul 17; 41(1):14-20. PMID: 25035950.
      View in: PubMed
    12. Cirelli KM, Gorfu G, Hassan MA, Printz M, Crown D, Leppla SH, Grigg ME, Saeij J, Moayeri M. Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii. PLoS Pathog. 2014 Mar; 10(3):e1003927. PMID: 24626226.
      View in: PubMed
    13. Cannella D, Brenier-Pinchart MP, Braun L, van Rooyen JM, Bougdour A, Bastien O, Behnke MS, Curt RL, Curt A, Saeij J, Sibley LD, Pelloux H, Hakimi MA. miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. Cell Rep. 2014 Mar 13; 6(5):928-37. PMID: 24582962; PMCID: PMC4476055.
    14. Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij J, Grigg ME. Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii. MBio. 2014 Feb 18; 5(1). PMID: 24549849; PMCID: PMC3944820.
    15. Melo MB, Nguyen QP, Cordeiro C, Hassan MA, Yang N, McKell R, Rosowski EE, Julien L, Butty V, Dardé ML, Ajzenberg D, Fitzgerald K, Young LH, Saeij J. Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways. PLoS Pathog. 2013; 9(12):e1003779. PMID: 24367253; PMCID: PMC3868521.
    16. Rosowski EE, Nguyen QP, Camejo A, Spooner E, Saeij J. Toxoplasma gondii Inhibits gamma interferon (IFN-?)- and IFN-ß-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA. Infect Immun. 2014 Feb; 82(2):706-19. PMID: 24478085; PMCID: PMC3911376.
    17. Hassan MA, Butty V, Jensen KD, Saeij J. The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages. Genome Res. 2014 Mar; 24(3):377-89. PMID: 24249727.
      View in: PubMed
    18. Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij J. Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence. J Biol Chem. 2013 Nov 29; 288(48):34968-80. PMID: 24129568; PMCID: PMC3843107.
    19. Camejo A, Gold DA, Lu D, McFetridge K, Julien L, Yang N, Jensen KD, Saeij J. Identification of three novel Toxoplasma gondii rhoptry proteins. Int J Parasitol. 2014 Feb; 44(2):147-60. PMID: 24070999; PMCID: PMC3946946.
    20. Niedelman W, Sprokholt JK, Clough B, Frickel EM, Saeij J. Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication. Infect Immun. 2013 Dec; 81(12):4341-9. PMID: 24042117; PMCID: PMC3837980.
    21. Yang N, Farrell A, Niedelman W, Melo M, Lu D, Julien L, Marth GT, Gubbels MJ, Saeij J. Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains. BMC Genomics. 2013 Jul 10; 14:467. PMID: 23837824; PMCID: PMC3710486.
    22. Jensen KD, Hu K, Whitmarsh RJ, Hassan MA, Julien L, Lu D, Chen L, Hunter CA, Saeij J. Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infect Immun. 2013 Jun; 81(6):2156-67. PMID: 23545295; PMCID: PMC3676013.
    23. Hassan MA, Melo MB, Haas B, Jensen KD, Saeij J. De novo reconstruction of the Toxoplasma gondii transcriptome improves on the current genome annotation and reveals alternatively spliced transcripts and putative long non-coding RNAs. BMC Genomics. 2012 Dec 12; 13:696. PMID: 23231500; PMCID: PMC3543268.
    24. Rosowski EE, Saeij J. Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFN? induced gene expression and STAT1 phosphorylation. PLoS One. 2012; 7(12):e51448. PMID: 23240025; PMCID: PMC3519884.
    25. Minot S, Melo MB, Li F, Lu D, Niedelman W, Levine SS, Saeij J. Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13458-63. PMID: 22847430; PMCID: PMC3421188.
    26. Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij J. The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog. 2012; 8(6):e1002784. PMID: 22761577; PMCID: PMC3386190.
    27. Szatanek T, Anderson-White BR, Faugno-Fusci DM, White M, Saeij J, Gubbels MJ. Cactin is essential for G1 progression in Toxoplasma gondii. Mol Microbiol. 2012 May; 84(3):566-77. PMID: 22486860; PMCID: PMC3331927.
    28. Lim DC, Cooke BM, Doerig C, Saeij J. Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling. Int J Parasitol. 2012 Jan; 42(1):21-32. PMID: 22154850.
      View in: PubMed
    29. Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij J, Ploegh HL, Frickel EM. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. PLoS One. 2011; 6(9):e24434. PMID: 21931713; PMCID: PMC3169597.
    30. Melo MB, Jensen KD, Saeij J. Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends Parasitol. 2011 Nov; 27(11):487-95. PMID: 21893432; PMCID: PMC3200456.
    31. Jensen KD, Wang Y, Wojno ED, Shastri AJ, Hu K, Cornel L, Boedec E, Ong YC, Chien YH, Hunter CA, Boothroyd JC, Saeij J. Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation. Cell Host Microbe. 2011 Jun 16; 9(6):472-83. PMID: 21669396; PMCID: PMC3131154.
    32. Reese ML, Zeiner GM, Saeij J, Boothroyd JC, Boyle JP. Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9625-30. PMID: 21436047; PMCID: PMC3111280.
    33. Rosowski EE, Lu D, Julien L, Rodda L, Gaiser RA, Jensen KD, Saeij J. Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. J Exp Med. 2011 Jan 17; 208(1):195-212. PMID: 21199955; PMCID: PMC3023140.
    34. Blader IJ, Saeij J. Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence. APMIS. 2009 May; 117(5-6):458-76. PMID: 19400868; PMCID: PMC2810527.
    35. Boyle JP, Saeij J, Harada SY, Ajioka JW, Boothroyd JC. Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression. Eukaryot Cell. 2008 Aug; 7(8):1403-14. PMID: 18552283; PMCID: PMC2519772.
    36. Saeij J, Arrizabalaga G, Boothroyd JC. A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence. Infect Immun. 2008 Jun; 76(6):2402-10. PMID: 18347037; PMCID: PMC2423105.
    37. Boyle JP, Saeij J, Boothroyd JC. Toxoplasma gondii: inconsistent dissemination patterns following oral infection in mice. Exp Parasitol. 2007 Jul; 116(3):302-5. PMID: 17335814.
      View in: PubMed
    38. Saeij J, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature. 2007 Jan 18; 445(7125):324-7. PMID: 17183270; PMCID: PMC2637441.
    39. Saeij J, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC. Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science. 2006 Dec 15; 314(5806):1780-3. PMID: 17170306; PMCID: PMC2646183.
    40. Boyle JP, Rajasekar B, Saeij J, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC. Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10514-10519. PMID: 16801557.
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    41. Boyle JP, Saeij J, Cleary MD, Boothroyd JC. Analysis of gene expression during development: lessons from the Apicomplexa. Microbes Infect. 2006 May; 8(6):1623-30. PMID: 16697685.
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    42. Saeij J, Boyle JP, Boothroyd JC. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. Trends Parasitol. 2005 Oct; 21(10):476-81. PMID: 16098810.
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    43. Huttenhuis HB, Taverne-Thiele AJ, Grou CP, Bergsma J, Saeij J, Nakayasu C, Rombout JH. Ontogeny of the common carp (Cyprinus carpio L.) innate immune system. Dev Comp Immunol. 2006; 30(6):557-74. PMID: 16406121.
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    44. Saeij J, Boyle JP, Grigg ME, Arrizabalaga G, Boothroyd JC. Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains. Infect Immun. 2005 Feb; 73(2):695-702. PMID: 15664907; PMCID: PMC547072.
    45. Joerink M, Saeij J, Stafford JL, Belosevic M, Wiegertjes GF. Animal models for the study of innate immunity: protozoan infections in fish. Symp Soc Exp Biol. 2004; (55):67-89; discussion 243-5. PMID: 15446445.
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    46. Saeij J, Groeneveld A, Van Rooijen N, Haenen OL, Wiegertjes GF. Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates. Dis Aquat Organ. 2003 Dec 03; 57(1-2):67-75. PMID: 14735923.
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    47. Saeij J, de Vries BJ, Wiegertjes GF. The immune response of carp to Trypanoplasma borreli: kinetics of immune gene expression and polyclonal lymphocyte activation. Dev Comp Immunol. 2003 Dec; 27(10):859-74. PMID: 12880636.
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    48. Saeij J, van Muiswinkel WB, van de Meent M, Amaral C, Wiegertjes GF. Different capacities of carp leukocytes to encounter nitric oxide-mediated stress: a role for the intracellular reduced glutathione pool. Dev Comp Immunol. 2003 Jun-Jul; 27(6-7):555-68. PMID: 12697312.
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    49. Engelsma MY, Stet RJ, Saeij J, Verburg-van Kemenade BM. Differential expression and haplotypic variation of two interleukin-1beta genes in the common carp (Cyprinus carpio L.). Cytokine. 2003 Apr; 22(1-2):21-32. PMID: 12946102.
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    50. Saeij J, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF. Daily handling stress reduces resistance of carp to Trypanoplasma borreli: in vitro modulatory effects of cortisol on leukocyte function and apoptosis. Dev Comp Immunol. 2003 Mar; 27(3):233-45. PMID: 12590974.
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    51. Saeij J, Stet RJ, de Vries BJ, van Muiswinkel WB, Wiegertjes GF. Molecular and functional characterization of carp TNF: a link between TNF polymorphism and trypanotolerance? Dev Comp Immunol. 2003 Jan; 27(1):29-41. PMID: 12477499.
      View in: PubMed
    52. Saeij J, Van Muiswinkel WB, Groeneveld A, Wiegertjes GF. Immune modulation by fish kinetoplastid parasites: a role for nitric oxide. Parasitology. 2002 Jan; 124(Pt 1):77-86. PMID: 11817378.
      View in: PubMed
    53. Saeij J, Stet RJ, Groeneveld A, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF. Molecular and functional characterization of a fish inducible-type nitric oxide synthase. Immunogenetics. 2000 Apr; 51(4-5):339-46. PMID: 10803847.
      View in: PubMed
    54. Saeij J, Wiegertjes GF, Stet RJ. Identification and characterization of a fish natural resistance-associated macrophage protein (NRAMP) cDNA. Immunogenetics. 1999 Oct; 50(1-2):60-6. PMID: 10541807.
      View in: PubMed
    55. Stet RJ, Kruiswijk CP, Saeij J, Wiegertjes GF. Major histocompatibility genes in cyprinid fishes: theory and practice. Immunol Rev. 1998 Dec; 166:301-16. PMID: 9914921.
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    56. Verburg-Van Kemenade BM, Saeij J, Flik G, Willems PH. Ca2+ signals during early lymphocyte activation in carp Cyprinus carpio L. J Exp Biol. 1998 Feb; 201(Pt 4):591-8. PMID: 9438833.
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