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Jeroen Saeij

Title(s)Associate Professor, SCHOOL OF VETERINARY MEDICINE
SchoolUniversity of California, Davis
Phone530-752-1401
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mukhopadhyay D, Saeij JPJ. Assays to Evaluate Toxoplasma-Macrophage Interactions. Methods Mol Biol. 2020; 2071:347-370. PMID: 31758462.
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    2. Arranz-Solís D, Cordeiro C, Young LH, Dardé ML, Commodaro AG, Grigg ME, Saeij JPJ. Serotyping of Toxoplasma gondii Infection Using Peptide Membrane Arrays. Front Cell Infect Microbiol. 2019; 9:408. PMID: 31850240.
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    3. Sangaré LO, Ólafsson EB, Wang Y, Yang N, Julien L, Camejo A, Pesavento P, Sidik SM, Lourido S, Barragan A, Saeij JPJ. In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration. Cell Host Microbe. 2019 10 09; 26(4):478-492.e8. PMID: 31600500.
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    4. Paredes-Santos T, Wang Y, Waldman B, Lourido S, Saeij JP. The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability. Front Cell Infect Microbiol. 2019; 9:321. PMID: 31572690.
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    5. Sangaré LO, Yang N, Konstantinou EK, Lu D, Mukhopadhyay D, Young LH, Saeij JPJ. Toxoplasma GRA15 Activates the NF-?B Pathway through Interactions with TNF Receptor-Associated Factors. MBio. 2019 07 16; 10(4). PMID: 31311877.
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    6. Wang Y, Cirelli KM, Barros PDC, Sangaré LO, Butty V, Hassan MA, Pesavento P, Mete A, Saeij JPJ. Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis. MBio. 2019 01 08; 10(1). PMID: 30622189.
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    7. Hassan MA, Olijnik AA, Frickel EM, Saeij JP. Clonal and atypical Toxoplasma strain differences in virulence vary with mouse sub-species. Int J Parasitol. 2019 01; 49(1):63-70. PMID: 30471286.
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    8. Krishnamurthy S, Saeij JPJ. Toxoplasma Does Not Secrete the GRA16 and GRA24 Effectors Beyond the Parasitophorous Vacuole Membrane of Tissue Cysts. Front Cell Infect Microbiol. 2018; 8:366. PMID: 30406043.
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    9. Arranz-Solís D, Regidor-Cerrillo J, Lourido S, Ortega-Mora LM, Saeij JPJ. Toxoplasma CRISPR/Cas9 constructs are functional for gene disruption in Neospora caninum. Int J Parasitol. 2018 07; 48(8):597-600. PMID: 29625127.
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    10. Saeij JP, Frickel EM. Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death. Curr Opin Microbiol. 2017 Dec; 40:72-80. PMID: 29141239.
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    11. Krishnamurthy S, Konstantinou EK, Young LH, Gold DA, Saeij JP. The human immune response to Toxoplasma: Autophagy versus cell death. PLoS Pathog. 2017 03; 13(3):e1006176. PMID: 28278184.
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    12. Sidik SM, Huet D, Ganesan SM, Huynh MH, Wang T, Nasamu AS, Thiru P, Saeij JPJ, Carruthers VB, Niles JC, Lourido S. A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Cell. 2016 Sep 08; 166(6):1423-1435.e12. PMID: 27594426.
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    13. Fink A, Hassan MA, Okan NA, Sheffer M, Camejo A, Saeij JP, Kasper DL. Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19. MBio. 2016 Mar 15; 7(2):e02243. PMID: 26980837.
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    14. Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, Dubey JP, Fritz HM, Gennari SM, Gregory BD, Kim K, Saeij JP, Su C, White MW, Zhu XQ, Howe DK, Rosenthal BM, Grigg ME, Parkinson J, Liu L, Kissinger JC, Roos DS, Sibley LD. Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes. Nat Commun. 2016 Jan 07; 7:10147. PMID: 26738725.
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    15. Hassan MA, Jensen KD, Butty V, Hu K, Boedec E, Prins P, Saeij JP. Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection. PLoS Genet. 2015 Oct; 11(10):e1005619. PMID: 26510153.
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    16. Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP. The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole. Cell Host Microbe. 2015 May 13; 17(5):642-52. PMID: 25974303.
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    17. Jensen KD, Camejo A, Melo MB, Cordeiro C, Julien L, Grotenbreg GM, Frickel EM, Ploegh HL, Young L, Saeij JP. Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination. MBio. 2015 Feb 24; 6(2):e02280. PMID: 25714710.
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    18. Hassan MA, Saeij JP. Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits. Bioessays. 2014 Nov; 36(11):1032-40. PMID: 25171292.
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    19. Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 2014 Jul 17; 41(1):14-20. PMID: 25035950.
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    20. Cirelli KM, Gorfu G, Hassan MA, Printz M, Crown D, Leppla SH, Grigg ME, Saeij JP, Moayeri M. Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii. PLoS Pathog. 2014 Mar; 10(3):e1003927. PMID: 24626226.
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    21. Cannella D, Brenier-Pinchart MP, Braun L, van Rooyen JM, Bougdour A, Bastien O, Behnke MS, Curt RL, Curt A, Saeij JP, Sibley LD, Pelloux H, Hakimi MA. miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. Cell Rep. 2014 Mar 13; 6(5):928-37. PMID: 24582962.
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    22. Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME. Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii. MBio. 2014 Feb 18; 5(1). PMID: 24549849.
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    23. Melo MB, Nguyen QP, Cordeiro C, Hassan MA, Yang N, McKell R, Rosowski EE, Julien L, Butty V, Dardé ML, Ajzenberg D, Fitzgerald K, Young LH, Saeij JP. Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways. PLoS Pathog. 2013; 9(12):e1003779. PMID: 24367253.
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    24. Rosowski EE, Nguyen QP, Camejo A, Spooner E, Saeij JP. Toxoplasma gondii Inhibits gamma interferon (IFN-?)- and IFN-ß-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA. Infect Immun. 2014 Feb; 82(2):706-19. PMID: 24478085.
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    25. Hassan MA, Butty V, Jensen KD, Saeij JP. The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages. Genome Res. 2014 Mar; 24(3):377-89. PMID: 24249727.
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    26. Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JP. Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence. J Biol Chem. 2013 Nov 29; 288(48):34968-80. PMID: 24129568.
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    27. Camejo A, Gold DA, Lu D, McFetridge K, Julien L, Yang N, Jensen KD, Saeij JP. Identification of three novel Toxoplasma gondii rhoptry proteins. Int J Parasitol. 2014 Feb; 44(2):147-60. PMID: 24070999.
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    28. Niedelman W, Sprokholt JK, Clough B, Frickel EM, Saeij JP. Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication. Infect Immun. 2013 Dec; 81(12):4341-9. PMID: 24042117.
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    29. Yang N, Farrell A, Niedelman W, Melo M, Lu D, Julien L, Marth GT, Gubbels MJ, Saeij JP. Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains. BMC Genomics. 2013 Jul 10; 14:467. PMID: 23837824.
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    30. Jensen KD, Hu K, Whitmarsh RJ, Hassan MA, Julien L, Lu D, Chen L, Hunter CA, Saeij JP. Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infect Immun. 2013 Jun; 81(6):2156-67. PMID: 23545295.
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    31. Hassan MA, Melo MB, Haas B, Jensen KD, Saeij JP. De novo reconstruction of the Toxoplasma gondii transcriptome improves on the current genome annotation and reveals alternatively spliced transcripts and putative long non-coding RNAs. BMC Genomics. 2012 Dec 12; 13:696. PMID: 23231500.
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    32. Rosowski EE, Saeij JP. Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFN? induced gene expression and STAT1 phosphorylation. PLoS One. 2012; 7(12):e51448. PMID: 23240025.
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    33. Minot S, Melo MB, Li F, Lu D, Niedelman W, Levine SS, Saeij JP. Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13458-63. PMID: 22847430.
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    34. Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij JP. The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog. 2012; 8(6):e1002784. PMID: 22761577.
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    35. Szatanek T, Anderson-White BR, Faugno-Fusci DM, White M, Saeij JP, Gubbels MJ. Cactin is essential for G1 progression in Toxoplasma gondii. Mol Microbiol. 2012 May; 84(3):566-77. PMID: 22486860.
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    36. Lim DC, Cooke BM, Doerig C, Saeij JP. Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling. Int J Parasitol. 2012 Jan; 42(1):21-32. PMID: 22154850.
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    37. Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. PLoS One. 2011; 6(9):e24434. PMID: 21931713.
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    38. Melo MB, Jensen KD, Saeij JP. Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends Parasitol. 2011 Nov; 27(11):487-95. PMID: 21893432.
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    39. Jensen KD, Wang Y, Wojno ED, Shastri AJ, Hu K, Cornel L, Boedec E, Ong YC, Chien YH, Hunter CA, Boothroyd JC, Saeij JP. Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation. Cell Host Microbe. 2011 Jun 16; 9(6):472-83. PMID: 21669396.
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    40. Reese ML, Zeiner GM, Saeij JP, Boothroyd JC, Boyle JP. Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9625-30. PMID: 21436047.
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    41. Rosowski EE, Lu D, Julien L, Rodda L, Gaiser RA, Jensen KD, Saeij JP. Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. J Exp Med. 2011 Jan 17; 208(1):195-212. PMID: 21199955.
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    42. Blader IJ, Saeij JP. Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence. APMIS. 2009 May; 117(5-6):458-76. PMID: 19400868.
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    43. Boyle JP, Saeij JP, Harada SY, Ajioka JW, Boothroyd JC. Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression. Eukaryot Cell. 2008 Aug; 7(8):1403-14. PMID: 18552283.
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    44. Saeij JP, Arrizabalaga G, Boothroyd JC. A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence. Infect Immun. 2008 Jun; 76(6):2402-10. PMID: 18347037.
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    45. Boyle JP, Saeij JP, Boothroyd JC. Toxoplasma gondii: inconsistent dissemination patterns following oral infection in mice. Exp Parasitol. 2007 Jul; 116(3):302-5. PMID: 17335814.
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    46. Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature. 2007 Jan 18; 445(7125):324-7. PMID: 17183270.
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    47. Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC. Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science. 2006 Dec 15; 314(5806):1780-3. PMID: 17170306.
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    48. Boyle JP, Rajasekar B, Saeij JPJ, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC. Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10514-10519. PMID: 16801557.
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    49. Boyle JP, Saeij JP, Cleary MD, Boothroyd JC. Analysis of gene expression during development: lessons from the Apicomplexa. Microbes Infect. 2006 May; 8(6):1623-30. PMID: 16697685.
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    50. Saeij JP, Boyle JP, Boothroyd JC. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. Trends Parasitol. 2005 Oct; 21(10):476-81. PMID: 16098810.
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    51. Huttenhuis HB, Taverne-Thiele AJ, Grou CP, Bergsma J, Saeij JP, Nakayasu C, Rombout JH. Ontogeny of the common carp (Cyprinus carpio L.) innate immune system. Dev Comp Immunol. 2006; 30(6):557-74. PMID: 16406121.
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    52. Saeij JP, Boyle JP, Grigg ME, Arrizabalaga G, Boothroyd JC. Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains. Infect Immun. 2005 Feb; 73(2):695-702. PMID: 15664907.
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    53. Joerink M, Saeij JP, Stafford JL, Belosevic M, Wiegertjes GF. Animal models for the study of innate immunity: protozoan infections in fish. Symp Soc Exp Biol. 2004; (55):67-89; discussion 243-5. PMID: 15446445.
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    54. Saeij JP, Groeneveld A, Van Rooijen N, Haenen OL, Wiegertjes GF. Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates. Dis Aquat Organ. 2003 Dec 03; 57(1-2):67-75. PMID: 14735923.
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    55. Saeij JP, de Vries BJ, Wiegertjes GF. The immune response of carp to Trypanoplasma borreli: kinetics of immune gene expression and polyclonal lymphocyte activation. Dev Comp Immunol. 2003 Dec; 27(10):859-74. PMID: 12880636.
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    56. Saeij JP, van Muiswinkel WB, van de Meent M, Amaral C, Wiegertjes GF. Different capacities of carp leukocytes to encounter nitric oxide-mediated stress: a role for the intracellular reduced glutathione pool. Dev Comp Immunol. 2003 Jun-Jul; 27(6-7):555-68. PMID: 12697312.
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    57. Engelsma MY, Stet RJ, Saeij JP, Verburg-van Kemenade BM. Differential expression and haplotypic variation of two interleukin-1beta genes in the common carp (Cyprinus carpio L.). Cytokine. 2003 Apr; 22(1-2):21-32. PMID: 12946102.
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    58. Saeij JP, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF. Daily handling stress reduces resistance of carp to Trypanoplasma borreli: in vitro modulatory effects of cortisol on leukocyte function and apoptosis. Dev Comp Immunol. 2003 Mar; 27(3):233-45. PMID: 12590974.
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    59. Saeij JP, Stet RJ, de Vries BJ, van Muiswinkel WB, Wiegertjes GF. Molecular and functional characterization of carp TNF: a link between TNF polymorphism and trypanotolerance? Dev Comp Immunol. 2003 Jan; 27(1):29-41. PMID: 12477499.
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    60. Saeij JP, Van Muiswinkel WB, Groeneveld A, Wiegertjes GF. Immune modulation by fish kinetoplastid parasites: a role for nitric oxide. Parasitology. 2002 Jan; 124(Pt 1):77-86. PMID: 11817378.
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    61. Saeij JP, Stet RJ, Groeneveld A, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF. Molecular and functional characterization of a fish inducible-type nitric oxide synthase. Immunogenetics. 2000 Apr; 51(4-5):339-46. PMID: 10803847.
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    62. Saeij JP, Wiegertjes GF, Stet RJ. Identification and characterization of a fish natural resistance-associated macrophage protein (NRAMP) cDNA. Immunogenetics. 1999 Oct; 50(1-2):60-6. PMID: 10541807.
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    63. Stet RJ, Kruiswijk CP, Saeij JP, Wiegertjes GF. Major histocompatibility genes in cyprinid fishes: theory and practice. Immunol Rev. 1998 Dec; 166:301-16. PMID: 9914921.
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    64. Verburg-Van Kemenade BM, Saeij JP, Flik G, Willems PH. Ca2+ signals during early lymphocyte activation in carp Cyprinus carpio L. J Exp Biol. 1998 Feb; 201(Pt 4):591-8. PMID: 9438833.
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