Jeroen Saeij

Title(s)Professor, VM: Pathology, Microbiology, & Immunology
SchoolSchool of Veterinary Medicine
Address3325 VM3A
CA 95616
Phone530-752-1401
ORCID ORCID Icon0000-0003-0289-7109 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford University, Palo AltoPostdoctoral09/2007Parasitology
    Wageningen University, The NetherlandsPhD09/2002Immunology
    Wageningen University, The NetherlandsMaster's09/1998Bioprocess Technology
    Collapse Awards and Honors
    MIT2012  - 2014Swanson Career Development Professor of Life Sciences
    MIT2010  - 2014PEW scholar in the biomedical sciences

    Collapse Overview 
    Collapse Overview
    Parasites and their hosts co-evolve, leading to variation in both host and parasite genomes and to the emergence of differences in parasite virulence and host resistance. We are interested in host-parasite interactions between the obligate intracellular eukaryotic parasite Toxoplasma gondii and its mammalian hosts. The focus of my laboratory over the last years has been to identify genes of Toxoplasma that determine virulence, host genes and pathways that determine resistance/susceptibility, and to characterize their specific interactions. To achieve this we use a combination of genomics, biochemistry, genetics, microscopy, immunology and computational tools.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Identification of Toxoplasma genes that mediate its colonization of the eye
    NIH R21EY031799Sep 1, 2020 - Aug 31, 2022
    Role: Principal Investigator
    Genome-wide CRISPR/Cas9-mediated loss-of-function screens to identify Toxoplasma genes that determine fitness in gamma interferon-stimulated human cells
    NIH R21AI149071Feb 18, 2020 - Jan 31, 2022
    Role: Principal Investigator
    Identify Toxoplasma genes that determine in vivo fitness with CRISPR-Cas9 genetic screens
    NIH R21AI151084Feb 5, 2020 - Jan 31, 2022
    Role: Principal Investigator
    Synthetic lethality screens in a nutrient sensitized Toxoplasma strain to identify novel proteins that mediate nutrient acquisition in chronic Toxoplasma infection.
    NIH R21AI150326Feb 4, 2020 - Jan 31, 2022
    Role: Principal Investigator
    Identification of the mechanism by which Toxoplasma activates the NLRP1 inflammasome
    NIH R21AI151081Jan 21, 2020 - Dec 31, 2021
    Role: Principal Investigator
    Regulatory factors that determine Toxoplasma bradyzoite to merozoites conversion.
    NIH R21AI139387Jun 1, 2018 - Nov 30, 2020
    Role: Principal Investigator
    A serological test to determine strains associated with occular toxoplasmosis
    NIH R21EY024593Jun 1, 2015 - Nov 30, 2017
    Role: Principal Investigator
    Inhibiting Toxoplasma growth by disrupting its access to host small molecules
    NIH R21AI114930Dec 1, 2014 - Nov 30, 2016
    Role: Principal Investigator
    Toxoplasma proteins that modulate the host cell
    NIH R01AI080621Jul 10, 2009 - Mar 31, 2020
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates Toxoplasma dissemination. mBio. 2024 Aug 29; e0214024. Ten Hoeve AL, Rodriguez ME, Säflund M, Michel V, Magimel L, Ripoll A, Yu T, Hakimi M-A, Saeij JPJ, Ozata DM, Barragan A. PMID: 39207098.
      View in: PubMed   Mentions:
    2. The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2. Cell Mol Life Sci. 2024 Jul 09; 81(1):294. Morales P, Brown AJ, Sangaré LO, Yang S, Kuihon SVNP, Chen B, Saeij JPJ. PMID: 38977495; PMCID: PMC11335217.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2. Res Sq. 2024 Jun 26. Morales P, Brown AJ, Sangare LO, Yang S, Kuihon S, Chen B, Saeij J. PMID: 38978596; PMCID: PMC11230507.
      View in: PubMed   Mentions:
    4. A parasite odyssey: An RNA virus concealed in Toxoplasma gondii. Virus Evol. 2024; 10(1):veae040. Gupta P, Hiller A, Chowdhury J, Lim D, Lim DY, Saeij JPJ, Babaian A, Rodriguez F, Pereira L, Morales-Tapia A. PMID: 38817668; PMCID: PMC11137675.
      View in: PubMed   Mentions:
    5. Two Toxoplasma gondii putative pore-forming proteins, GRA47 and GRA72, influence small molecule permeability of the parasitophorous vacuole. mBio. 2024 Mar 13; 15(3):e0308123. Bitew MA, Gaete PS, Swale C, Maru P, Contreras JE, Saeij JPJ. PMID: 38380952; PMCID: PMC10936148.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. mBio. 2024 Mar 13; 15(3):e0330223. Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. PMID: 38376248; PMCID: PMC10936166.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates Toxoplasma dissemination. bioRxiv. 2024 Feb 06. Ten Hoeve AL, Rodriguez ME, Säflund M, Michel V, Magimel L, Ripoll A, Yu T, Hakimi MA, Saeij JPJ, Ozata DM, Barragan A. PMID: 38370679; PMCID: PMC10871220.
      View in: PubMed   Mentions:
    8. Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. bioRxiv. 2023 Dec 14. Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. PMID: 38168400; PMCID: PMC10760081.
      View in: PubMed   Mentions:
    9. GRA47 and GRA72 are Toxoplasma gondii pore-forming proteins that influence small molecule permeability of the parasitophorous vacuole. bioRxiv. 2023 Nov 15. Bitew MA, Gaete PS, Swale C, Maru P, Contreras JE, Saeij JPJ. PMID: 38014337; PMCID: PMC10680723.
      View in: PubMed   Mentions:
    10. Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma. PLoS Pathog. 2023 07; 19(7):e1011543. Paredes-Santos TC, Bitew MA, Swale C, Rodriguez F, Krishnamurthy S, Wang Y, Maru P, Sangaré LO, Saeij JPJ. PMID: 37498952; PMCID: PMC10409377.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells. mBio. 2023 04 25; 14(2):e0006023. Krishnamurthy S, Maru P, Wang Y, Bitew MA, Mukhopadhyay D, Yamaryo-Botté Y, Paredes-Santos TC, Sangaré LO, Swale C, Botté CY, Saeij JPJ. PMID: 36916910; PMCID: PMC10128063.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    12. Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses. mBio. 2023 04 25; 14(2):e0286822. Arranz-Solís D, Warschkau D, Fabian BT, Seeber F, Saeij JPJ. PMID: 36809045; PMCID: PMC10128015.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. Fatal Sarcocystis calchasi hepatitis in a captive Indian ringneck parakeet (Psittacula krameri manillensis). Vet Parasitol Reg Stud Reports. 2023 04; 39:100841. Gonzales-Viera O, Arranz-Solís D, Smith J, Saeij JPJ, Mete A. PMID: 36878626.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    14. The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages. Cell Host Microbe. 2022 11 09; 30(11):1570-1588.e7. Ten Hoeve AL, Braun L, Rodriguez ME, Olivera GC, Bougdour A, Belmudes L, Couté Y, Saeij JPJ, Hakimi MA, Barragan A. PMID: 36309013; PMCID: PMC9710525.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    15. NcGRA7 and NcROP40 Play a Role in the Virulence of Neospora caninum in a Pregnant Mouse Model. Pathogens. 2022 Aug 31; 11(9). Rico-San Román L, Amieva R, Regidor-Cerrillo J, García-Sánchez M, Collantes-Fernández E, Pastor-Fernández I, Saeij JPJ, Ortega-Mora LM, Horcajo P. PMID: 36145430; PMCID: PMC9506596.
      View in: PubMed   Mentions: 4  
    16. Toxoplasma effector-induced ICAM-1 expression by infected dendritic cells potentiates transmigration across polarised endothelium. Front Immunol. 2022; 13:950914. Ross EC, Hoeve ALT, Saeij JPJ, Barragan A. PMID: 35990682; PMCID: PMC9381734.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. New Avenues to Design Toxoplasma Vaccines Based on Oocysts and Cysts. Front Immunol. 2022; 13:910961. Arranz-Solís D, Saeij JPJ. PMID: 35734184; PMCID: PMC9207213.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    18. Sarcocystis calchasi and other Sarcocystidae detected in predatory birds in California, USA. Int J Parasitol Parasites Wildl. 2022 Apr; 17:91-99. Rogers KH, Arranz-Solís D, Saeij JPJ, Lewis S, Mete A. PMID: 35004169; PMCID: PMC8718662.
      View in: PubMed   Mentions: 4  
    19. The Toxoplasma Polymorphic Effector GRA15 Mediates Seizure Induction by Modulating Interleukin-1 Signaling in the Brain. mBio. 2021 06 29; 12(3):e0133121. Glausen TG, Carrillo GL, Jin RM, Boyle JP, Saeij JPJ, Wohlfert EA, Fox MA, Blader IJ. PMID: 34154412; PMCID: PMC8262954.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    20. Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector. mBio. 2021 05 18; 12(3). Tomita T, Mukhopadhyay D, Han B, Yakubu R, Tu V, Mayoral J, Sugi T, Ma Y, Saeij JPJ, Weiss LM. PMID: 34006649; PMCID: PMC8262993.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    21. CRISPR screen to determine the in vivo fitness of Toxoplasma genes. STAR Protoc. 2021 06 18; 2(2):100520. Sangaré LO, Wang Y, Arranz-Solís D, Saeij JPJ. PMID: 34013213; PMCID: PMC8113973.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    22. Toxoplasma GRA Peptide-Specific Serologic Fingerprints Discriminate Among Major Strains Causing Toxoplasmosis. Front Cell Infect Microbiol. 2021; 11:621738. Arranz-Solís D, Carvalheiro CG, Zhang ER, Grigg ME, Saeij JPJ. PMID: 33680990; PMCID: PMC7935526.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    23. Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages. Nat Commun. 2020 10 16; 11(1):5258. Wang Y, Sangaré LO, Paredes-Santos TC, Hassan MA, Krishnamurthy S, Furuta AM, Markus BM, Lourido S, Saeij JPJ. PMID: 33067458; PMCID: PMC7567896.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    24. Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection. Front Cell Infect Microbiol. 2020; 10:580425. Mukhopadhyay D, Arranz-Solís D, Saeij JPJ. PMID: 33178630; PMCID: PMC7593385.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    25. Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5. PLoS Pathog. 2020 08; 16(8):e1008327. Kongsomboonvech AK, Rodriguez F, Diep AL, Justice BM, Castallanos BE, Camejo A, Mukhopadhyay D, Taylor GA, Yamamoto M, Saeij JPJ, Reese ML, Jensen KDC. PMID: 32853276; PMCID: PMC7480859.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. Toxoplasma Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface. Annu Rev Microbiol. 2020 09 08; 74:567-586. Wang Y, Sangaré LO, Paredes-Santos TC, Saeij JPJ. PMID: 32680452; PMCID: PMC9934516.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    27. Protozoal encephalitis associated with Sarcocystis calchasi and S. falcatula during an epizootic involving Brandt's cormorants (Phalacrocorax penicillatus) in coastal Southern California, USA. Int J Parasitol Parasites Wildl. 2020 Aug; 12:185-191. Bamac OE, Rogers KH, Arranz-Solís D, Saeij JPJ, Lewis S, Duerr R, Skoglund J, Peronne L, Mete A. PMID: 32617260; PMCID: PMC7322481.
      View in: PubMed   Mentions: 5  
    28. Toxoplasma  GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11. PLoS Pathog. 2020 05; 16(5):e1008586. Mukhopadhyay D, Arranz-Solís D, Saeij JPJ. PMID: 32453782; PMCID: PMC7274473.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    29. Comparative tachyzoite proteome analyses among six Neospora caninum isolates with different virulence. Int J Parasitol. 2020 05; 50(5):377-388. Rico-San Román L, Horcajo P, Regidor-Cerrillo J, Fernández-Escobar M, Collantes-Fernández E, Gutiérrez-Blázquez D, Hernáez-Sánchez ML, Saeij JPJ, Ortega-Mora LM. PMID: 32360428.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    30. Toxoplasma GRA15 limits parasite growth in IFNγ-activated fibroblasts through TRAF ubiquitin ligases. EMBO J. 2020 05 18; 39(10):e103758. Mukhopadhyay D, Sangaré LO, Braun L, Hakimi MA, Saeij JP. PMID: 32293748; PMCID: PMC7232000.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    31. Identification of a Master Regulator of Differentiation in Toxoplasma. Cell. 2020 01 23; 180(2):359-372.e16. Waldman BS, Schwarz D, Wadsworth MH, Saeij JP, Shalek AK, Lourido S. PMID: 31955846; PMCID: PMC6978799.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    32. Assays to Evaluate Toxoplasma-Macrophage Interactions. Methods Mol Biol. 2020; 2071:347-370. Mukhopadhyay D, Saeij JPJ. PMID: 31758462; PMCID: PMC7048168.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    33. Serotyping of Toxoplasma gondii Infection Using Peptide Membrane Arrays. Front Cell Infect Microbiol. 2019; 9:408. Arranz-Solís D, Cordeiro C, Young LH, Dardé ML, Commodaro AG, Grigg ME, Saeij JPJ. PMID: 31850240; PMCID: PMC6895565.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    34. In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration. Cell Host Microbe. 2019 10 09; 26(4):478-492.e8. Sangaré LO, Ólafsson EB, Wang Y, Yang N, Julien L, Camejo A, Pesavento P, Sidik SM, Lourido S, Barragan A, Saeij JPJ. PMID: 31600500; PMCID: PMC7060943.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    35. The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability. Front Cell Infect Microbiol. 2019; 9:321. Paredes-Santos T, Wang Y, Waldman B, Lourido S, Saeij JP. PMID: 31572690; PMCID: PMC6751312.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    36. Toxoplasma GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors. mBio. 2019 07 16; 10(4). Sangaré LO, Yang N, Konstantinou EK, Lu D, Mukhopadhyay D, Young LH, Saeij JPJ. PMID: 31311877; PMCID: PMC6635525.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    37. Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis. mBio. 2019 01 08; 10(1). Wang Y, Cirelli KM, Barros PDC, Sangaré LO, Butty V, Hassan MA, Pesavento P, Mete A, Saeij JPJ. PMID: 30622189; PMCID: PMC6325250.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    38. Clonal and atypical Toxoplasma strain differences in virulence vary with mouse sub-species. Int J Parasitol. 2019 01; 49(1):63-70. Hassan MA, Olijnik AA, Frickel EM, Saeij JP. PMID: 30471286; PMCID: PMC6344230.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    39. Toxoplasma Does Not Secrete the GRA16 and GRA24 Effectors Beyond the Parasitophorous Vacuole Membrane of Tissue Cysts. Front Cell Infect Microbiol. 2018; 8:366. Krishnamurthy S, Saeij JPJ. PMID: 30406043; PMCID: PMC6201044.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    40. Toxoplasma CRISPR/Cas9 constructs are functional for gene disruption in Neospora caninum. Int J Parasitol. 2018 07; 48(8):597-600. Arranz-Solís D, Regidor-Cerrillo J, Lourido S, Ortega-Mora LM, Saeij JPJ. PMID: 29625127; PMCID: PMC7025762.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    41. Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death. Curr Opin Microbiol. 2017 Dec; 40:72-80. Saeij JP, Frickel EM. PMID: 29141239; PMCID: PMC7004510.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    42. The human immune response to Toxoplasma: Autophagy versus cell death. PLoS Pathog. 2017 03; 13(3):e1006176. Krishnamurthy S, Konstantinou EK, Young LH, Gold DA, Saeij JP. PMID: 28278184; PMCID: PMC5344534.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    43. A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Cell. 2016 Sep 08; 166(6):1423-1435.e12. Sidik SM, Huet D, Ganesan SM, Huynh MH, Wang T, Nasamu AS, Thiru P, Saeij JPJ, Carruthers VB, Niles JC, Lourido S. PMID: 27594426; PMCID: PMC5017925.
      View in: PubMed   Mentions: 359     Fields:    Translation:HumansAnimalsCells
    44. Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19. mBio. 2016 Mar 15; 7(2):e02243. Fink A, Hassan MA, Okan NA, Sheffer M, Camejo A, Saeij JP, Kasper DL. PMID: 26980837; PMCID: PMC4807373.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    45. Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes. Nat Commun. 2016 Jan 07; 7:10147. Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, Dubey JP, Fritz HM, Gennari SM, Gregory BD, Kim K, Saeij JP, Su C, White MW, Zhu XQ, Howe DK, Rosenthal BM, Grigg ME, Parkinson J, Liu L, Kissinger JC, Roos DS, Sibley LD. PMID: 26738725; PMCID: PMC4729833.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    46. Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection. PLoS Genet. 2015 Oct; 11(10):e1005619. Hassan MA, Jensen KD, Butty V, Hu K, Boedec E, Prins P, Saeij JP. PMID: 26510153; PMCID: PMC4625001.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    47. The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole. Cell Host Microbe. 2015 May 13; 17(5):642-52. Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP. PMID: 25974303; PMCID: PMC4435723.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    48. Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination. mBio. 2015 Feb 24; 6(2):e02280. Jensen KD, Camejo A, Melo MB, Cordeiro C, Julien L, Grotenbreg GM, Frickel EM, Ploegh HL, Young L, Saeij JP. PMID: 25714710; PMCID: PMC4358003.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    49. Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits. Bioessays. 2014 Nov; 36(11):1032-40. Hassan MA, Saeij JP. PMID: 25171292; PMCID: PMC4280019.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    50. Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines. Immunity. 2014 Aug 1; 41(2):339-340. Murray MP, Allen AJ, Biswas BS, Fisher FE, Gilroy GD, Goerdt GS, Gordon GS, Hamilton HJ, Ivashkiv IL, Lawrence LT, Locati LM, Mantovani MA, Martinez MF, Mege MJ, Mosser MD, Natoli NG, Saeij SJ, Schultze SJ, Shirey SK, Sica SA, Suttles SJ, Udalova UI, van Ginderachter vJ, Vogel VS, Wynn WT. .
      View in: Publisher Site   Mentions:
    51. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 2014 Jul 17; 41(1):14-20. Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA. PMID: 25035950; PMCID: PMC4123412.
      View in: PubMed   Mentions: 2716     Fields:    Translation:HumansAnimalsCells
    52. Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii. PLoS Pathog. 2014 Mar; 10(3):e1003927. Cirelli KM, Gorfu G, Hassan MA, Printz M, Crown D, Leppla SH, Grigg ME, Saeij JP, Moayeri M. PMID: 24626226; PMCID: PMC3953412.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    53. miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. Cell Rep. 2014 Mar 13; 6(5):928-37. Cannella D, Brenier-Pinchart MP, Braun L, van Rooyen JM, Bougdour A, Bastien O, Behnke MS, Curt RL, Curt A, Saeij JP, Sibley LD, Pelloux H, Hakimi MA. PMID: 24582962; PMCID: PMC4476055.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    54. Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii. mBio. 2014 Feb 18; 5(1). Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME. PMID: 24549849; PMCID: PMC3944820.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    55. Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways. PLoS Pathog. 2013; 9(12):e1003779. Melo MB, Nguyen QP, Cordeiro C, Hassan MA, Yang N, McKell R, Rosowski EE, Julien L, Butty V, Dardé ML, Ajzenberg D, Fitzgerald K, Young LH, Saeij JP. PMID: 24367253; PMCID: PMC3868521.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    56. Toxoplasma gondii Inhibits gamma interferon (IFN-γ)- and IFN-β-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA. Infect Immun. 2014 Feb; 82(2):706-19. Rosowski EE, Nguyen QP, Camejo A, Spooner E, Saeij JP. PMID: 24478085; PMCID: PMC3911376.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    57. The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages. Genome Res. 2014 Mar; 24(3):377-89. Hassan MA, Butty V, Jensen KD, Saeij JP. PMID: 24249727; PMCID: PMC3941103.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    58. Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence. J Biol Chem. 2013 Nov 29; 288(48):34968-80. Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JP. PMID: 24129568; PMCID: PMC3843107.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    59. Identification of three novel Toxoplasma gondii rhoptry proteins. Int J Parasitol. 2014 Feb; 44(2):147-60. Camejo A, Gold DA, Lu D, McFetridge K, Julien L, Yang N, Jensen KD, Saeij JP. PMID: 24070999; PMCID: PMC3946946.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    60. Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication. Infect Immun. 2013 Dec; 81(12):4341-9. Niedelman W, Sprokholt JK, Clough B, Frickel EM, Saeij JP. PMID: 24042117; PMCID: PMC3837980.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    61. Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains. BMC Genomics. 2013 Jul 10; 14:467. Yang N, Farrell A, Niedelman W, Melo M, Lu D, Julien L, Marth GT, Gubbels MJ, Saeij JP. PMID: 23837824; PMCID: PMC3710486.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    62. Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infect Immun. 2013 Jun; 81(6):2156-67. Jensen KD, Hu K, Whitmarsh RJ, Hassan MA, Julien L, Lu D, Chen L, Hunter CA, Saeij JP. PMID: 23545295; PMCID: PMC3676013.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    63. De novo reconstruction of the Toxoplasma gondii transcriptome improves on the current genome annotation and reveals alternatively spliced transcripts and putative long non-coding RNAs. BMC Genomics. 2012 Dec 12; 13:696. Hassan MA, Melo MB, Haas B, Jensen KD, Saeij JP. PMID: 23231500; PMCID: PMC3543268.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    64. Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFNγ induced gene expression and STAT1 phosphorylation. PLoS One. 2012; 7(12):e51448. Rosowski EE, Saeij JP. PMID: 23240025; PMCID: PMC3519884.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    65. Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13458-63. Minot S, Melo MB, Li F, Lu D, Niedelman W, Levine SS, Saeij JP. PMID: 22847430; PMCID: PMC3421188.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    66. The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog. 2012; 8(6):e1002784. Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij JP. PMID: 22761577; PMCID: PMC3386190.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimals
    67. Cactin is essential for G1 progression in Toxoplasma gondii. Mol Microbiol. 2012 May; 84(3):566-77. Szatanek T, Anderson-White BR, Faugno-Fusci DM, White M, Saeij JP, Gubbels MJ. PMID: 22486860; PMCID: PMC3331927.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    68. Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling. Int J Parasitol. 2012 Jan; 42(1):21-32. Lim DC, Cooke BM, Doerig C, Saeij JP. PMID: 22154850; PMCID: PMC3428259.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    69. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. PLoS One. 2011; 6(9):e24434. Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM. PMID: 21931713; PMCID: PMC3169597.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    70. Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends Parasitol. 2011 Nov; 27(11):487-95. Melo MB, Jensen KD, Saeij JP. PMID: 21893432; PMCID: PMC3200456.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimals
    71. Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation. Cell Host Microbe. 2011 Jun 16; 9(6):472-83. Jensen KD, Wang Y, Wojno ED, Shastri AJ, Hu K, Cornel L, Boedec E, Ong YC, Chien YH, Hunter CA, Boothroyd JC, Saeij JP. PMID: 21669396; PMCID: PMC3131154.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    72. Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9625-30. Reese ML, Zeiner GM, Saeij JP, Boothroyd JC, Boyle JP. PMID: 21436047; PMCID: PMC3111280.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    73. Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. J Exp Med. 2011 Jan 17; 208(1):195-212. Rosowski EE, Lu D, Julien L, Rodda L, Gaiser RA, Jensen KD, Saeij JP. PMID: 21199955; PMCID: PMC3023140.
      View in: PubMed   Mentions: 224     Fields:    Translation:HumansAnimalsCells
    74. Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence. APMIS. 2009 May; 117(5-6):458-76. Blader IJ, Saeij JP. PMID: 19400868; PMCID: PMC2810527.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    75. Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression. Eukaryot Cell. 2008 Aug; 7(8):1403-14. Boyle JP, Saeij JP, Harada SY, Ajioka JW, Boothroyd JC. PMID: 18552283; PMCID: PMC2519772.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    76. A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence. Infect Immun. 2008 Jun; 76(6):2402-10. Saeij JP, Arrizabalaga G, Boothroyd JC. PMID: 18347037; PMCID: PMC2423105.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    77. Toxoplasma gondii: inconsistent dissemination patterns following oral infection in mice. Exp Parasitol. 2007 Jul; 116(3):302-5. Boyle JP, Saeij JP, Boothroyd JC. PMID: 17335814.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    78. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature. 2007 Jan 18; 445(7125):324-7. Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC. PMID: 17183270; PMCID: PMC2637441.
      View in: PubMed   Mentions: 299     Fields:    Translation:HumansAnimalsCells
    79. Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science. 2006 Dec 15; 314(5806):1780-3. Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC. PMID: 17170306; PMCID: PMC2646183.
      View in: PubMed   Mentions: 294     Fields:    Translation:AnimalsCells
    80. Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10514-10519. Boyle JP, Rajasekar B, Saeij JPJ, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC. PMID: 16801557; PMCID: PMC1502489.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    81. Analysis of gene expression during development: lessons from the Apicomplexa. Microbes Infect. 2006 May; 8(6):1623-30. Boyle JP, Saeij JP, Cleary MD, Boothroyd JC. PMID: 16697685.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    82. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. Trends Parasitol. 2005 Oct; 21(10):476-81. Saeij JP, Boyle JP, Boothroyd JC. PMID: 16098810.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimals
    83. Ontogeny of the common carp (Cyprinus carpio L.) innate immune system. Dev Comp Immunol. 2006; 30(6):557-74. Huttenhuis HB, Taverne-Thiele AJ, Grou CP, Bergsma J, Saeij JP, Nakayasu C, Rombout JH. PMID: 16406121.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    84. Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains. Infect Immun. 2005 Feb; 73(2):695-702. Saeij JP, Boyle JP, Grigg ME, Arrizabalaga G, Boothroyd JC. PMID: 15664907; PMCID: PMC547072.
      View in: PubMed   Mentions: 109     Fields:    Translation:Animals
    85. Animal models for the study of innate immunity: protozoan infections in fish. Symp Soc Exp Biol. 2004; (55):67-89; discussion 243-5. Joerink M, Saeij JP, Stafford JL, Belosevic M, Wiegertjes GF. PMID: 15446445.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    86. Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates. Dis Aquat Organ. 2003 Dec 03; 57(1-2):67-75. Saeij JP, Groeneveld A, Van Rooijen N, Haenen OL, Wiegertjes GF. PMID: 14735923.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    87. The immune response of carp to Trypanoplasma borreli: kinetics of immune gene expression and polyclonal lymphocyte activation. Dev Comp Immunol. 2003 Dec; 27(10):859-74. Saeij JP, de Vries BJ, Wiegertjes GF. PMID: 12880636.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    88. Different capacities of carp leukocytes to encounter nitric oxide-mediated stress: a role for the intracellular reduced glutathione pool. Dev Comp Immunol. 2003 Jun-Jul; 27(6-7):555-68. Saeij JP, van Muiswinkel WB, van de Meent M, Amaral C, Wiegertjes GF. PMID: 12697312.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    89. Differential expression and haplotypic variation of two interleukin-1beta genes in the common carp (Cyprinus carpio L.). Cytokine. 2003 Apr; 22(1-2):21-32. Engelsma MY, Stet RJ, Saeij JP, Verburg-van Kemenade BM. PMID: 12946102.
      View in: PubMed   Mentions: 13  Translation:AnimalsCells
    90. Daily handling stress reduces resistance of carp to Trypanoplasma borreli: in vitro modulatory effects of cortisol on leukocyte function and apoptosis. Dev Comp Immunol. 2003 Mar; 27(3):233-45. Saeij JP, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF. PMID: 12590974.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    91. Molecular and functional characterization of carp TNF: a link between TNF polymorphism and trypanotolerance? Dev Comp Immunol. 2003 Jan; 27(1):29-41. Saeij JP, Stet RJ, de Vries BJ, van Muiswinkel WB, Wiegertjes GF. PMID: 12477499.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    92. Immune modulation by fish kinetoplastid parasites: a role for nitric oxide. Parasitology. 2002 Jan; 124(Pt 1):77-86. Saeij JP, Van Muiswinkel WB, Groeneveld A, Wiegertjes GF. PMID: 11817378.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    93. Molecular and functional characterization of a fish inducible-type nitric oxide synthase. Immunogenetics. 2000 Apr; 51(4-5):339-46. Saeij JP, Stet RJ, Groeneveld A, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF. PMID: 10803847.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    94. Identification and characterization of a fish natural resistance-associated macrophage protein (NRAMP) cDNA. Immunogenetics. 1999 Oct; 50(1-2):60-6. Saeij JP, Wiegertjes GF, Stet RJ. PMID: 10541807.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    95. Major histocompatibility genes in cyprinid fishes: theory and practice. Immunol Rev. 1998 Dec; 166:301-16. Stet RJ, Kruiswijk CP, Saeij JP, Wiegertjes GF. PMID: 9914921.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    96. Ca2+ signals during early lymphocyte activation in carp Cyprinus carpio L. J Exp Biol. 1998 Feb; 201(Pt 4):591-8. Verburg-Van Kemenade BM, Saeij JP, Flik G, Willems PH. PMID: 9438833.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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