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Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative. J Med Chem. 2021 02 25; 64(4):1856-1872.
Hammock BD, McReynolds CB, Wagner K, Buckpitt A, Cortes-Puch I, Croston G, Lee KSS, Yang J, Schmidt WK, Hwang SH. PMID: 33550801; PMCID: PMC7917437.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice. Toxicol Lett. 2016 Mar 30; 246:35-41.
Carratt SA, Morin D, Buckpitt AR, Edwards PC, Van Winkle LS. PMID: 26840748; PMCID: PMC4774530.
View in:
PubMed Mentions:
6 Fields:
Translation:
Animals
-
Alterations in the proteome of the respiratory tract in response to single and multiple exposures to naphthalene. Proteomics. 2015 Aug; 15(15):2655-68.
Kültz D, Li J, Sacchi R, Morin D, Buckpitt A, Van Winkle L. PMID: 25825134; PMCID: PMC4772669.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Simultaneous quantification of multiple urinary naphthalene metabolites by liquid chromatography tandem mass spectrometry. PLoS One. 2015; 10(4):e0121937.
Ayala DC, Morin D, Buckpitt AR. PMID: 25853821; PMCID: PMC4390350.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsPHPublic Health
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Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab Dispos. 2014 Jul; 42(7):1098-102.
Schebb NH, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH. PMID: 24733789; PMCID: PMC4170114.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Sex differences in the acute nasal antioxidant/antielectrophilic response of the rat to inhaled naphthalene. Toxicol Sci. 2014 May; 139(1):234-44.
Cichocki JA, Smith GJ, Mendoza R, Buckpitt AR, Van Winkle LS, Morris JB. PMID: 24563378.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsPHPublic Health
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Kinetics of naphthalene metabolism in target and non-target tissues of rodents and in nasal and airway microsomes from the Rhesus monkey. Toxicol Appl Pharmacol. 2013 Jul 15; 270(2):97-105.
Buckpitt A, Morin D, Murphy S, Edwards P, Van Winkle L. PMID: 23602890.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Characterization of model peptide adducts with reactive metabolites of naphthalene by mass spectrometry. PLoS One. 2012; 7(8):e42053.
Pham NT, Jewell WT, Morin D, Jones AD, Buckpitt AR. PMID: 22870282; PMCID: PMC3411726.
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PubMed Mentions:
5 Fields:
Translation:
Animals
-
Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma. Clin Exp Allergy. 2012 Jul; 42(7):1104-18.
Plopper CG, Joad JP, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Lasley WL, Buckpitt AR, Pinkerton KE, Tarkington BK, Davis S, Nishio SJ, Gershwin LJ, Wu R, Hyde DM. PMID: 22702509; PMCID: PMC3913647.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Analysis of naphthalene adduct binding sites in model proteins by tandem mass spectrometry. Chem Biol Interact. 2012 Aug 30; 199(2):120-8.
Pham NT, Jewell WT, Morin D, Buckpitt AR. PMID: 22659010; PMCID: PMC3579547.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Formation of covalently bound protein adducts from the cytotoxicant naphthalene in nasal epithelium: species comparisons. Environ Health Perspect. 2010 May; 118(5):647-52.
DeStefano-Shields C, Morin D, Buckpitt A. PMID: 20435546; PMCID: PMC2866680.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Free flow electrophoresis separation and AMS quantitation of C-naphthalene-protein adducts. Nucl Instrum Methods Phys Res B. 2010 Apr 01; 268(7-8):1324-1327.
Buchholz BA, Haack KW, Sporty JL, Buckpitt AR, Morin D. PMID: 20454606; PMCID: PMC2864045.
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PubMed Mentions:
6
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Protein thiol oxidation in murine airway epithelial cells in response to naphthalene or diethyl maleate. Am J Respir Cell Mol Biol. 2010 Sep; 43(3):316-25.
Spiess PC, Morin D, Williams CR, Buckpitt AR. PMID: 19843705; PMCID: PMC2933547.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Upper respiratory tract uptake of naphthalene. Toxicol Sci. 2009 Oct; 111(2):383-91.
Morris JB, Buckpitt AR. PMID: 19648534.
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PubMed Mentions:
10 Fields:
Translation:
Animals
-
Toxicity and metabolism of methylnaphthalenes: comparison with naphthalene and 1-nitronaphthalene. Toxicology. 2009 Jun 16; 260(1-3):16-27.
Lin CY, Wheelock AM, Morin D, Baldwin RM, Lee MG, Taff A, Plopper C, Buckpitt A, Rohde A. PMID: 19464565; PMCID: PMC2687406.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsPHPublic Health
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Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization. Arch Biochem Biophys. 2009 May 01; 485(1):49-55.
DiMaio Knych HK, DeStefano Shields C, Buckpitt AR, Stanley SD. PMID: 19245785.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Primate Models of Allergic Asthma. . 2008 Jul 25; 1185-1201.
Plopper PC, Smiley-Jewell SS, Miller ML, Fanucchi FM, Evans EM, Buckpitt BA, Avdalovic AM, Gershwin GL, Joad JJ, Kajekar KR, Larson LS, Pinkerton PK, Van Winkle VL, Schelegle SE, Pieczarka PE, Wu WR, Hyde HD. .
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Publisher Site Mentions:
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Measurement of protein sulfhydryls in response to cellular oxidative stress using gel electrophoresis and multiplexed fluorescent imaging analysis. Chem Res Toxicol. 2008 May; 21(5):1074-85.
Spiess PC, Morin D, Jewell WT, Buckpitt AR. PMID: 18416539; PMCID: PMC2582025.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chem Res Toxicol. 2008 Apr; 21(4):951-7.
Morisseau C, Newman JW, Wheelock CE, Hill Iii T, Morin D, Buckpitt AR, Hammock BD. PMID: 18363382.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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TRX-ASK1-JNK signaling regulation of cell density-dependent cytotoxicity in cigarette smoke-exposed human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5):L921-31.
Lee YC, Chuang CY, Lee PK, Lee JS, Harper RW, Buckpitt AB, Wu R, Oslund K. PMID: 18281606.
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PubMed Mentions:
13 Fields:
Translation:
HumansCellsPHPublic Health
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Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells. Biochim Biophys Acta. 2007 Jul; 1772(7):773-80.
Napoli E, Morin D, Bernhardt R, Buckpitt A, Cortopassi G. PMID: 17499976.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology? Toxicol Pathol. 2007 Jan; 35(1):97-110.
Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM. PMID: 17325978.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsPHPublic Health
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Use of a fluorescent internal protein standard to achieve quantitative two-dimensional gel electrophoresis. Proteomics. 2006 Mar; 6(5):1385-98.
Wheelock AM, Morin D, Bartosiewicz M, Buckpitt AR. PMID: 16429456.
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PubMed Mentions:
4 Fields:
Translation:
Animals
-
Identification of proteins adducted by reactive metabolites of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques. Proteomics. 2006 Feb; 6(3):972-82.
Lin CY, Boland BC, Lee YJ, Salemi MR, Morin D, Miller LA, Plopper CG, Buckpitt AR. PMID: 16453347.
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PubMed Mentions:
12 Fields:
Translation:
Animals
-
Software-induced variance in two-dimensional gel electrophoresis image analysis. Electrophoresis. 2005 Dec; 26(23):4508-20.
Wheelock AM, Buckpitt AR. PMID: 16315176.
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PubMed Mentions:
16 Fields:
Translation:
Animals
-
Identification of proteins adducted by reactive naphthalene metabolites in vitro. Proteomics. 2005 Nov; 5(16):4197-204.
Isbell MA, Morin D, Boland B, Buckpitt A, Salemi M, Presley J. PMID: 16206326.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells. Hum Mol Genet. 2005 Dec 15; 14(24):3787-99.
Schoenfeld RA, Napoli E, Wong A, Zhan S, Reutenauer L, Morin D, Buckpitt AR, Taroni F, Lonnerdal B, Ristow M, Puccio H, Cortopassi GA. PMID: 16239244.
View in:
PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Characterization of a structurally intact in situ lung model and comparison of naphthalene protein adducts generated in this model vs lung microsomes. Chem Res Toxicol. 2005 May; 18(5):802-13.
Lin CY, Isbell MA, Morin D, Boland BC, Salemi MR, Jewell WT, Weir AJ, Fanucchi MV, Baker GL, Plopper CG, Buckpitt AR. PMID: 15892573.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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In vivo effects of ozone exposure on protein adduct formation by 1-nitronaphthalene in rat lung. Am J Respir Cell Mol Biol. 2005 Aug; 33(2):130-7.
Wheelock AM, Boland BC, Isbell M, Morin D, Wegesser TC, Plopper CG, Buckpitt AR. PMID: 15845863; PMCID: PMC2715307.
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PubMed Mentions:
9 Fields:
Translation:
Animals
-
In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation. J Pharmacol Exp Ther. 2005 Jul; 314(1):103-10.
Lee MG, Phimister A, Morin D, Buckpitt A, Plopper C. PMID: 15833892.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCellsPHPublic Health
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Prevention of naphthalene-induced pulmonary toxicity by glutathione prodrugs: roles for glutathione depletion in adduct formation and cell injury. J Biochem Mol Toxicol. 2005; 19(1):42-51.
Phimister AJ, Nagasawa HT, Buckpitt AR, Plopper CG. PMID: 15736154.
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PubMed Mentions:
4 Fields:
Translation:
Animals
-
Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4. J Pharmacol Exp Ther. 2005 Feb; 312(2):857-65.
Baldwin RM, Shultz MA, Buckpitt AR. PMID: 15509722.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice. Toxicol Sci. 2004 Nov; 82(1):268-78.
Phimister AJ, Lee MG, Morin D, Buckpitt AR, Plopper CG. PMID: 15319489.
View in:
PubMed Mentions:
18 Fields:
Translation:
Animals
-
Site-specific metabolism of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques. J Pharmacol Exp Ther. 2004 Aug; 310(2):546-54.
Boland B, Lin CY, Morin D, Miller L, Plopper C, Buckpitt A. PMID: 15082753.
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PubMed Mentions:
6 Fields:
Translation:
Animals
-
Comparison of pulmonary/nasal CYP2F expression levels in rodents and rhesus macaque. J Pharmacol Exp Ther. 2004 Apr; 309(1):127-36.
Baldwin RM, Jewell WT, Fanucchi MV, Plopper CG, Buckpitt AR. PMID: 14724224.
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PubMed Mentions:
10 Fields:
Translation:
Animals
-
Assessing gene expression in lung subcompartments utilizing in situ RNA preservation. Toxicol Sci. 2004 Jan; 77(1):135-41.
Baker GL, Shultz MA, Fanucchi MV, Morin DM, Buckpitt AR, Plopper CG. PMID: 14600286.
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PubMed Mentions:
16 Fields:
Translation:
Animals
-
Isolation of rodent airway epithelial cell proteins facilitates in vivo proteomics studies of lung toxicity. Am J Physiol Lung Cell Mol Physiol. 2004 Feb; 286(2):L399-410.
Wheelock AM, Zhang L, Tran MU, Morin D, Penn S, Buckpitt AR, Plopper CG. PMID: 14594729.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Am J Respir Cell Mol Biol. 2004 Mar; 30(3):296-310.
Shultz MA, Zhang L, Gu YZ, Baker GL, Fannuchi MV, Padua AM, Gurske WA, Morin D, Penn SG, Jovanovich SB, Plopper CG, Buckpitt AR. PMID: 12947022.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Measurement of glutathione conjugates. Curr Protoc Toxicol. 2003; Chapter 6:Unit6.8.
Shultz MA, Morin D, Chan KW, Buckpitt AR. PMID: 23045094.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity. Drug Metab Rev. 2002 Nov; 34(4):791-820.
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C. PMID: 12487150.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimals
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Pharmacokinetics and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration. Biopharm Drug Dispos. 2002 Jul; 23(5):203-11.
Giri SN, Wang Q, Xie Y, Lango J, Morin D, Margolin SB, Buckpitt AR. PMID: 12116052.
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PubMed Mentions:
10 Fields:
Translation:
Animals
-
Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the glutathione pool. Am J Pathol. 2002 Mar; 160(3):1115-27.
West JA, Williams KJ, Toskala E, Nishio SJ, Fleschner CA, Forman HJ, Buckpitt AR, Plopper CG. PMID: 11891208; PMCID: PMC1867174.
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PubMed Mentions:
11 Fields:
Translation:
Animals
-
Urinary naphthalene mercapturates as biomarkers of exposure and stereoselectivity of naphthalene epoxidation. Drug Metab Dispos. 2002 Mar; 30(3):247-53.
Pakenham G, Lango J, Buonarati M, Morin D, Buckpitt A. PMID: 11854141.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsPHPublic Health
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Inhaled naphthalene causes dose dependent Clara cell cytotoxicity in mice but not in rats. Toxicol Appl Pharmacol. 2001 Jun 01; 173(2):114-9.
West JA, Pakehham G, Morin D, Fleschner CA, Buckpitt AR, Plopper CG. PMID: 11384213.
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PubMed Mentions:
20 Fields:
Translation:
Animals
-
Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants. J Pharmacol Exp Ther. 2001 Jun; 297(3):895-905.
Bartosiewicz MJ, Jenkins D, Penn S, Emery J, Buckpitt A. PMID: 11356909.
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PubMed Mentions:
20 Fields:
Translation:
Animals
-
Factors modulating the epithelial response to toxicants in tracheobronchial airways. Toxicology. 2001 Mar 07; 160(1-3):173-80.
Plopper CG, Buckpitt A, Evans M, Van Winkle L, Fanucchi M, Smiley-Jewell S, Lakritz J, West J, Lawson G, Paige R, Miller L, Hyde D. PMID: 11246137.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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Early events in naphthalene-induced acute Clara cell toxicity. II. Comparison of glutathione depletion and histopathology by airway location. Am J Respir Cell Mol Biol. 2001 Mar; 24(3):272-81.
Plopper CG, Van Winkle LS, Fanucchi MV, Malburg SR, Nishio SJ, Chang A, Buckpitt AR. PMID: 11245626.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Metabolic capabilities of CYP2F2 with various pulmonary toxicants and its relative abundance in mouse lung subcompartments. J Pharmacol Exp Ther. 2001 Feb; 296(2):510-9.
Shultz MA, Morin D, Chang AM, Buckpitt A. PMID: 11160638.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Applications of gene arrays in environmental toxicology: fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene. Environ Health Perspect. 2001 Jan; 109(1):71-4.
Bartosiewicz M, Penn S, Buckpitt A. PMID: 11171528; PMCID: PMC1242054.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae). Am J Pathol. 2001 Jan; 158(1):333-41.
Schelegle ES, Gershwin LJ, Miller LA, Fanucchi MV, Van Winkle LS, Gerriets JP, Walby WF, Omlor AM, Buckpitt AR, Tarkington BK, Wong VJ, Joad JP, Pinkerton KB, Wu R, Evans MJ, Hyde DM, Plopper CG. PMID: 11141508; PMCID: PMC1850255.
View in:
PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Long-term exposure to ozone increases acute pulmonary centriacinar injury by 1-nitronaphthalene: I. Region-specific enzyme activity. J Pharmacol Exp Ther. 2000 Dec; 295(3):934-41.
Paige RC, Royce FH, Plopper CG, Buckpitt AR. PMID: 11082426.
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PubMed Mentions:
3 Fields:
Translation:
Animals
-
Development of phase II xenobiotic metabolizing enzymes in differentiating murine clara cells. Toxicol Appl Pharmacol. 2000 Nov 01; 168(3):253-67.
Fanucchi MV, Buckpitt AR, Murphy ME, Storms DH, Hammock BD, Plopper CG. PMID: 11042098.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Elevated airway GSH resynthesis confers protection to Clara cells from naphthalene injury in mice made tolerant by repeated exposures. J Pharmacol Exp Ther. 2000 Aug; 294(2):516-23.
West JA, Buckpitt AR, Plopper CG. PMID: 10900227.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Heterogeneity of clara cell glutathione. A possible basis for differences in cellular responses to pulmonary cytotoxicants. Am J Respir Cell Mol Biol. 2000 Jul; 23(1):27-36.
West JA, Chichester CH, Buckpitt AR, Tyler NK, Brennan P, Helton C, Plopper CG. PMID: 10873150.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Development of a toxicological gene array and quantitative assessment of this technology. Arch Biochem Biophys. 2000 Apr 01; 376(1):66-73.
Bartosiewicz M, Trounstine M, Barker D, Johnston R, Buckpitt A. PMID: 10729191.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Species differences in the regio- and stereoselectivity of 1-nitronaphthalene metabolism. Drug Metab Dispos. 2000 Apr; 28(4):376-8.
Watt KC, Buckpitt AR. PMID: 10725302.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Hepatic and pulmonary enzyme activities in horses. Am J Vet Res. 2000 Feb; 61(2):152-7.
Lakritz J, Winder BS, Noorouz-Zadeh J, Huang TL, Buckpitt AR, Hammock BD, Plopper CG. PMID: 10685686.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Chem Res Toxicol. 1999 Sep; 12(9):831-9.
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR. PMID: 10490505.
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PubMed Mentions:
5 Fields:
Translation:
Animals
-
Role of murine cytochrome P-450 2F2 in metabolic activation of naphthalene and metabolism of other xenobiotics. J Pharmacol Exp Ther. 1999 Jul; 290(1):281-8.
Shultz MA, Choudary PV, Buckpitt AR. PMID: 10381788.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Relationship of inhaled ozone concentration to acute tracheobronchial epithelial injury, site-specific ozone dose, and glutathione depletion in rhesus monkeys. Am J Respir Cell Mol Biol. 1998 Sep; 19(3):387-99.
Plopper CG, Hatch GE, Wong V, Duan X, Weir AJ, Tarkington BK, Devlin RB, Becker S, Buckpitt AR. PMID: 9730866.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Site-selective differences in cytochrome P450 isoform activities. Comparison of expression in rat and rhesus monkey lung and induction in rats. Drug Metab Dispos. 1998 May; 26(5):396-400.
Lee C, Watt KC, Chang AM, Plopper CG, Buckpitt AR, Pinkerton KE. PMID: 9571220.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Cytochrome P450 2E1 in rat tracheobronchial airways: response to ozone exposure. Toxicol Appl Pharmacol. 1998 Apr; 149(2):195-202.
Watt KC, Plopper CG, Weir AJ, Tarkington B, Buckpitt AR. PMID: 9571988.
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PubMed Mentions: Fields:
Translation:
Animals
-
Pulmonary cytochrome P450 monooxygenase and Clara cell differentiation in mice. Am J Respir Cell Mol Biol. 1997 Sep; 17(3):302-14.
Fanucchi MV, Murphy ME, Buckpitt AR, Philpot RM, Plopper CG. PMID: 9308917.
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PubMed Mentions:
18 Fields:
Translation:
Animals
-
Measurement of cytochrome P450 2E1 activity in rat tracheobronchial airways using high-performance liquid chromatography with electrochemical detection. Anal Biochem. 1997 May 15; 248(1):26-30.
Watt KC, Plopper CG, Buckpitt AR. PMID: 9177721.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Naphthalene cytotoxicity of differentiating Clara cells in neonatal mice. Toxicol Appl Pharmacol. 1997 May; 144(1):96-104.
Fanucchi MV, Buckpitt AR, Murphy ME, Plopper CG. PMID: 9169074.
View in:
PubMed Mentions:
11 Fields:
Translation:
Animals
-
Validated high-performance liquid chromatography-electrochemical method for determination of glutathione and glutathione disulfide in small tissue samples. Anal Biochem. 1997 Apr 05; 247(1):63-8.
Lakritz J, Plopper CG, Buckpitt AR. PMID: 9126372.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Characterisation of the toxic metabolite(s) of naphthalene. Toxicology. 1996 Dec 18; 114(3):233-42.
Wilson AS, Davis CD, Williams DP, Buckpitt AR, Pirmohamed M, Park BK. PMID: 8980712.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Cellular and metabolic basis of Clara cell tolerance to multiple doses of cytochrome P450-activated cytotoxicants. I: Bronchiolar epithelial reorganization and expression of cytochrome P450 monooxygenases in mice exposed to multiple doses of naphthalene. J Pharmacol Exp Ther. 1996 Sep; 278(3):1408-18.
Lakritz J, Chang A, Weir A, Nishio S, Hyde D, Philpot R, Buckpitt A, Plopper C. PMID: 8819528.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Rates of glutathione synthesis in lung subcompartments of mice and monkeys: possible role in species and site selective injury. J Pharmacol Exp Ther. 1996 Jun; 277(3):1402-9.
Duan X, Plopper C, Brennan P, Buckpitt A. PMID: 8667203.
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PubMed Mentions:
6 Fields:
Translation:
Animals
-
Maintenance of differentiated murine Clara cells in microdissected airway cultures. Am J Respir Cell Mol Biol. 1996 Jun; 14(6):586-98.
Van Winkle LS, Buckpitt AR, Plopper CG. PMID: 8652187.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Ozone-induced alterations in glutathione in lung subcompartments of rats and monkeys. Am J Respir Cell Mol Biol. 1996 Jan; 14(1):70-5.
Duan X, Buckpitt AR, Pinkerton KE, Ji C, Plopper CG. PMID: 8534488.
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PubMed Mentions:
9 Fields:
Translation:
Animals
-
Postnatal development of cytochrome P4501A1 and 2B1 in rat lung and liver: effect of aged and diluted sidestream cigarette smoke. Toxicol Appl Pharmacol. 1995 Dec; 135(2):246-53.
Gebremichael A, Chang AM, Buckpitt AR, Plopper CG, Pinkerton KE. PMID: 8545834.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCellsPHPublic Health
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Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice. Am J Physiol. 1995 Dec; 269(6 Pt 1):L800-18.
Van Winkle LS, Buckpitt AR, Nishio SJ, Isaac JM, Plopper CG. PMID: 8572242.
View in:
PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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Pulmonary cytochrome P-450 monooxygenase system and Clara cell differentiation in rats. Am J Physiol. 1995 Sep; 269(3 Pt 1):L394-402.
Ji CM, Cardoso WV, Gebremichael A, Philpot RM, Buckpitt AR, Plopper CG, Pinkerton KE. PMID: 7573474.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. Arch Biochem Biophys. 1995 Feb 20; 317(1):275-84.
Overby LH, Buckpitt AR, Lawton MP, Atta-Asafo-Adjei E, Schulze J, Philpot RM. PMID: 7872795.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Relationship of cytochrome P450 activity to Clara cell cytotoxicity. IV. Metabolism of naphthalene and naphthalene oxide in microdissected airways from mice, rats, and hamsters. Mol Pharmacol. 1995 Jan; 47(1):74-81.
Buckpitt A, Chang AM, Weir A, Van Winkle L, Duan X, Philpot R, Plopper C. PMID: 7838135.
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PubMed Mentions:
49 Fields:
Translation:
Animals
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Biochemical factors important in Clara cell selective toxicity in the lung. Drug Metab Rev. 1995; 27(1-2):369-86.
Cho M, Chichester C, Plopper C, Buckpitt A. PMID: 7641583.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Dose-dependent tolerance to ozone. IV. Site-specific elevation in antioxidant enzymes in the lungs of rats exposed for 90 days or 20 months. Toxicol Appl Pharmacol. 1994 Jul; 127(1):124-31.
Plopper CG, Duan X, Buckpitt AR, Pinkerton KE. PMID: 8048044.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Covalent interactions of reactive naphthalene metabolites with proteins. J Pharmacol Exp Ther. 1994 May; 269(2):881-9.
Cho M, Chichester C, Morin D, Plopper C, Buckpitt A. PMID: 8182557.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Elevated susceptibility to 4-ipomeanol cytotoxicity in immature Clara cells of neonatal rabbits. J Pharmacol Exp Ther. 1994 May; 269(2):867-80.
Plopper CG, Weir AJ, Nishio SJ, Chang A, Voit M, Philpot RM, Buckpitt AR. PMID: 8182556.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Metabolism and cytotoxicity of naphthalene and its metabolites in isolated murine Clara cells. Mol Pharmacol. 1994 Apr; 45(4):664-72.
Chichester CH, Buckpitt AR, Chang A, Plopper CG. PMID: 8183245.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Ozone injury to alveolar epithelium in vitro does not reflect loss of antioxidant defenses. Toxicol Appl Pharmacol. 1994 Mar; 125(1):59-69.
Cheek JM, Buckpitt AR, Li C, Tarkington BK, Plopper CG. PMID: 8128496.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Reactive naphthalene metabolite binding to hemoglobin and albumin. Fundam Appl Toxicol. 1994 Jan; 22(1):26-33.
Cho M, Jedrychowski R, Hammock B, Buckpitt A. PMID: 8125210.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Variation in antioxidant enzyme activities in anatomic subcompartments within rat and rhesus monkey lung. Toxicol Appl Pharmacol. 1993 Nov; 123(1):73-82.
Duan X, Buckpitt AR, Plopper CG. PMID: 8236264.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Postnatal changes in the expression and distribution of pulmonary cytochrome P450 monooxygenases during Clara cell differentiation in rabbits. Mol Pharmacol. 1993 Jul; 44(1):51-61.
Plopper CG, Weir AJ, Morin D, Chang A, Philpot RM, Buckpitt AR. PMID: 8341279.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Bioavailability and disposition kinetics of HI-6 in Beagle dogs. Biopharm Drug Dispos. 1993 Mar; 14(2):93-105.
Baggot JD, Buckpitt A, Johnson D, Brennan P, Chung H. PMID: 8453028.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. III. Morphometric comparison of changes in the epithelial populations of terminal bronchioles and lobar bronchi in mice, hamsters, and rats after parenteral administration of naphthalene. Lab Invest. 1992 Nov; 67(5):553-65.
Plopper CG, Macklin J, Nishio SJ, Hyde DM, Buckpitt AR. PMID: 1434534.
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PubMed Mentions:
33 Fields:
Translation:
Animals
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Relationship of cytochrome P450 activity to Clara cell cytotoxicity. II. Comparison of stereoselectivity of naphthalene epoxidation in lung and nasal mucosa of mouse, hamster, rat and rhesus monkey. J Pharmacol Exp Ther. 1992 Apr; 261(1):364-72.
Buckpitt A, Buonarati M, Avey LB, Chang AM, Morin D, Plopper CG. PMID: 1560380.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. I. Histopathologic comparison of the respiratory tract of mice, rats and hamsters after parenteral administration of naphthalene. J Pharmacol Exp Ther. 1992 Apr; 261(1):353-63.
Plopper CG, Suverkropp C, Morin D, Nishio S, Buckpitt A. PMID: 1560379.
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PubMed Mentions:
46 Fields:
Translation:
Animals
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Development of airway epithelium. Patterns of expression for markers of differentiation. Chest. 1992 Mar; 101(3 Suppl):2S-5S.
Plopper C, St George J, Cardoso W, Wu R, Pinkerton K, Buckpitt A. PMID: 1371732.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Assessment of exposure to pulmonary toxicants: use of biological markers. Fundam Appl Toxicol. 1992 Feb; 18(2):161-74.
Bond JA, Wallace LA, Osterman-Golkar S, Lucier GW, Buckpitt A, Hendersen RF. PMID: 1601216.
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PubMed Mentions: Fields:
Translation:
HumansPHPublic Health
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Dermal absorption of niclosamide in rats and minipigs. Biopharm Drug Dispos. 1991 Oct; 12(7):547-56.
Brennan P, Johnson D, Rider S, Cone N, Goldman M, Buckpitt A, Chung H. PMID: 1932616.
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PubMed Mentions: Fields:
Translation:
Animals
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Use of microdissected airways to define metabolism and cytotoxicity in murine bronchiolar epithelium. Exp Lung Res. 1991 Mar-Apr; 17(2):197-212.
Plopper CG, Chang AM, Pang A, Buckpitt AR. PMID: 2050025.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Characterization of the cytochrome P-450 monooxygenase system in nonciliated bronchiolar epithelial (Clara) cells isolated from mouse lung. Am J Respir Cell Mol Biol. 1991 Feb; 4(2):179-86.
Chichester CH, Philpot RM, Weir AJ, Buckpitt AR, Plopper CG. PMID: 1991074.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Metabolism and cytotoxicity of naphthalene oxide in the isolated perfused mouse lung. J Pharmacol Exp Ther. 1991 Jan; 256(1):391-401.
Kanekal S, Plopper C, Morin D, Buckpitt A. PMID: 1988668.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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In vivo metabolism of isomeric naphthalene oxide glutathione conjugates. Drug Metab Dispos. 1990 Mar-Apr; 18(2):183-9.
Buonarati M, Jones AD, Buckpitt A. PMID: 1971571.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Metabolic activation and bronchiolar Clara cell necrosis from naphthalene in the isolated perfused mouse lung. J Pharmacol Exp Ther. 1990 Jan; 252(1):428-37.
Kanekal S, Plopper C, Morin D, Buckpitt A. PMID: 2299600.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Mechanisms of lung injury by systemically administered chemicals. Toxicol Appl Pharmacol. 1989 Nov; 101(2):179-95.
Yost GS, Buckpitt AR, Roth RA, McLemore TL. PMID: 2510367.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Tolerance to multiple doses of the pulmonary toxicant, naphthalene. Toxicol Appl Pharmacol. 1989 Jul; 99(3):487-500.
O'Brien KA, Suverkropp C, Kanekal S, Plopper CG, Buckpitt AR. PMID: 2749735.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Relationship of naphthalene and 2-methylnaphthalene metabolism to pulmonary bronchiolar epithelial cell necrosis. Pharmacol Ther. 1989; 41(1-2):393-410.
Buckpitt AR, Franklin RB. PMID: 2652157.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Glutathione depletion and cytotoxicity by naphthalene 1,2-oxide in isolated hepatocytes. Chem Biol Interact. 1989; 71(2-3):147-65.
Buonarati M, Morin D, Plopper C, Buckpitt A. PMID: 2598294.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Glutathione depletion by naphthalene in isolated hepatocytes and by naphthalene oxide in vivo. Biochem Pharmacol. 1988 Jun 15; 37(12):2473-8.
Richieri PR, Buckpitt AR. PMID: 3390209.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Efflux of naphthalene oxide and reactive naphthalene metabolites from isolated hepatocytes. J Pharmacol Exp Ther. 1987 Aug; 242(2):485-92.
Richieri PR, Buckpitt AR. PMID: 3612547.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Stereoselectivity of naphthalene epoxidation by mouse, rat, and hamster pulmonary, hepatic, and renal microsomal enzymes. Drug Metab Dispos. 1987 Jul-Aug; 15(4):491-8.
Buckpitt AR, Castagnoli N, Nelson SD, Jones AD, Bahnson LS. PMID: 2888622.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Naphthalene metabolism by human lung microsomal enzymes. Toxicology. 1986 Nov; 41(3):333-41.
Buckpitt AR, Bahnson LS. PMID: 3775781.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Comparison of the arachidonic acid and NADPH-dependent microsomal metabolism of naphthalene and 2-methylnaphthalene and the effect of indomethacin on the bronchiolar necrosis. Biochem Pharmacol. 1986 Feb 15; 35(4):645-50.
Buckpitt AR, Bahnson LS, Franklin RB. PMID: 3081009.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Evidence that 1-naphthol is not an obligate intermediate in the covalent binding and the pulmonary bronchiolar necrosis by naphthalene. Biochem Biophys Res Commun. 1985 Feb 15; 126(3):1097-103.
Buckpitt AR, Bahnson LS, Franklin RB. PMID: 3977906.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Hepatic and pulmonary microsomal metabolism of naphthalene to glutathione adducts: factors affecting the relative rates of conjugate formation. J Pharmacol Exp Ther. 1984 Nov; 231(2):291-300.
Buckpitt AR, Bahnson LS, Franklin RB. PMID: 6491983.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Glutathione and glutathione S-transferases in the urinary bladder of different species. Biochem Pharmacol. 1984 Jun 01; 33(11):1813-6.
Whyte WL, Pong RS, Buckpitt AR. PMID: 6732844.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Metabolism of bromobenzene to glutathione adducts in lung slices from mice treated with pneumotoxicants. Biochem Pharmacol. 1984 May 01; 33(9):1479-86.
Fakjian N, Buckpitt AR. PMID: 6732865.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Evidence for hepatic formation, export and covalent binding of reactive naphthalene metabolites in extrahepatic tissues in vivo. J Pharmacol Exp Ther. 1983 Apr; 225(1):8-16.
Buckpitt AR, Warren DL. PMID: 6834280.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Formation of reactive naphthalene metabolites by target vs non-target tissue microsomes: methods for the separation of three glutathione adducts. Biochem Pharmacol. 1983 Mar 01; 32(5):943-6.
Smart G, Buckpitt AR. PMID: 6838644.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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High-performance liquid chromatographic assay of cytosolic glutathione S-transferase activity with styrene oxide. J Chromatogr. 1982 Sep 10; 231(2):265-72.
Brown DL, Boda W, Stone MP, Buckpitt AR. PMID: 7130308.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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In vivo studies on the target tissue metabolism, covalent binding, glutathione depletion, and toxicity of 4-ipomeanol in birds, species deficient in pulmonary enzymes for metabolic activation. Toxicol Appl Pharmacol. 1982 Aug; 65(1):38-52.
Buckpitt AR, Statham CN, Boyd MR. PMID: 7147254.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Metabolic activation of 4-ipomeanol by avian tissue microsomes. Toxicol Appl Pharmacol. 1982 Aug; 65(1):53-62.
Buckpitt AR, Boyd MR. PMID: 7147255.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene. Chem Biol Interact. 1982 Jul 01; 40(3):287-303.
Warren DL, Brown DL, Buckpitt AR. PMID: 7083396.
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PubMed Mentions:
25 Fields:
Translation:
Animals
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The in vitro formation of glutathione conjugates with the microsomally activated pulmonary bronchiolar aklylating agent and cytotoxin, 4-ipomeanol. J Pharmacol Exp Ther. 1980 Oct; 215(1):97-103.
Buckpitt AR, Boyd MR. PMID: 7452496.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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A sensitive method for determination of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in human plasma by high-pressure liquid chromatography. Anal Biochem. 1980 Aug; 106(2):432-7.
Buckpitt AR, Boyd MR. PMID: 6449880.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Phase I and pharmacological studies of 5-fluorouracil administered intraperitoneally. Cancer Res. 1980 Mar; 40(3):567-72.
Speyer JL, Collins JM, Dedrick RL, Brennan MF, Buckpitt AR, Londer H, DeVita VT, Myers CE. PMID: 7471076.
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PubMed Mentions:
44 Fields:
Translation:
Humans
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Varying effects of sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation. Biochem Pharmacol. 1979 Oct 01; 28(19):2941-6.
Buckpitt AR, Rollins DE, Mitchell JR. PMID: 518690.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Liver cytosol catalyzed conjugation of reduced glutathione with a reactive metabolite of acetaminophen. Toxicol Appl Pharmacol. 1979 Feb; 47(2):331-9.
Rollins DE, Buckpitt AR. PMID: 452025.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Potential clinical applications of a new method for quantitation of plasma levels of 5-fluorouracil and 5-fluorodeoxyuridine. Bull Cancer. 1979; 66(1):75-8.
Jones RA, Buckpitt AR, Londer HH, Myers CE, Chabner BA, Boyd MR. PMID: 154353.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Deuterium isotope effects on the metabolism and toxicity of phenacetin in hamsters. Drug Metab Dispos. 1978 Jul-Aug; 6(4):363-7.
Nelson SD, Garland WA, Mitchell JR, Vaishnav Y, Statham CN, Buckpitt AR. PMID: 28914.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Pulmonary disposition of serotonin in the intact animal. Biochem Pharmacol. 1978 Feb 15; 27(4):569-74.
Buckpitt AR, Maickel RP, Bosin TR. PMID: 629817.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography. Anal Biochem. 1977 Nov; 83(1):168-77.
Buckpitt AR, Rollins DE, Nelson SD, Franklin RB, Mitchell JR. PMID: 920933.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Comparative gas-liquid chromatography of biologically important indoles, and their benzo(b)thiophene and 1-methylindole analogs. J Chromatogr. 1974 Jul 17; 94(0):316-20.
Bosin TR, Buckpitt AR, Maickel RP. PMID: 4844618.
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PubMed Mentions: Fields:
Translation:
Cells
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Substrate specificity of aromatic-L-amino adid decarboxylase. Life Sci. 1974 Mar 01; 14(5):899-908.
Bosin TR, Buckpitt AR, Maickel RP. PMID: 4828405.
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PubMed Mentions:
1 Fields:
Translation:
Animals